Research Topics
Genomes and Genes | Bruce L ZurawSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Clinical practice. Hereditary angioedemaBruce L Zuraw
University of California at San Diego and the Veterans Affairs Medical Center, San Diego, USA
N Engl J Med 359:1027-36. 2008- Pathophysiology of hereditary angioedemaBruce L Zuraw
Department of Medicine, University of California, San Diego, and San Diego Veteran s Affairs Medical Center, La Jolla, California, USA
Am J Rhinol Allergy 25:373-8. 2011..This study describes the clinical characteristics and pathophysiology of bradykinin-mediated angioedema... - HAE international home therapy consensus documentHilary J Longhurst
Department of Immunology, Barts and The London NHS Trust, London, UK
Allergy Asthma Clin Immunol 6:22. 2010..It represents the opinion of the authors who have a wide range of expert experience in the management of HAE... - 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedemaTom Bowen
Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
Allergy Asthma Clin Immunol 6:24. 2010.... - EcallantideBruce Zuraw
Bruce Zuraw is at the Allergy and Immunology Section, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92037 0635, USA
Nat Rev Drug Discov 9:189-90. 2010..In December 2009, ecallantide (Kalbitor; Dyax) - a recombinant protein inhibitor of plasma kallikrein - was approved by the US FDA for the treatment of acute attacks of hereditary angioedema... - Hereditary angiodema: a current state-of-the-art review, IV: short- and long-term treatment of hereditary angioedema: out with the old and in with the new?Bruce L Zuraw
Veterans Affairs Medical Center, San Diego, California, USA
Ann Allergy Asthma Immunol 100:S13-8. 2008..To provide a context to understand the opportunity for novel therapeutic modalities to transform the treatment of hereditary angioedema (HAE)... - New promise and hope for treating hereditary angioedemaBruce L Zuraw
Veterans Medical Research Foundation, University of California San Diego, La Jolla, CA 92093 0732, USA
Expert Opin Investig Drugs 17:697-706. 2008..While there is no approved effective therapy for the treatment of acute attacks of hereditary angioedema in the USA, four different drugs are completing or have recently completed Phase III clinical trials... - HAE therapies: past present and futureBruce L Zuraw
Department of Medicine, University of California San Diego and San Diego Veteran s Affairs Medical Center, La Jolla, CA, USA
Allergy Asthma Clin Immunol 6:23. 2010..This review will recap the past treatment options, review the new current treatment options, and discuss potential future treatment options for patients with HAE... - Pathogenesis and laboratory diagnosis of hereditary angioedemaBruce L Zuraw
Department of Medicine, University of California San Diego and San Diego Veteran s Affairs Medical Center, La Jolla, California, USA
Allergy Asthma Proc 30:487-92. 2009..The knowledge gained concerning the underlying mechanisms of the different types of HAE allow the clinician to approach the laboratory diagnosis with confidence and provides opportunities for novel therapeutic strategies... - Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedemaBruce L Zuraw
University of California, San Diego, USA
N Engl J Med 363:513-22. 2010..Hereditary angioedema due to C1 inhibitor deficiency is characterized by recurrent acute attacks of swelling that can be painful and sometimes life-threatening... - Novel therapies for hereditary angioedemaBruce L Zuraw
University of California San Diego, La Jolla, CA 92093 0732, USA
Immunol Allergy Clin North Am 26:691-708. 2006..This article reviews the rationale, development, and potential use of these novel therapeutics... - TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroidsAstrid M Doerner
Veterans Medical Research Foundation, La Jolla, California, USA
Respir Res 10:100. 2009.... - Current and future therapy for hereditary angioedemaBruce L Zuraw
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Clin Immunol 114:10-6. 2005..This article will review both the current and the future therapeutic options for the treatment of HAE... - Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic rhinitisJane Eddleston
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif 92037, USA
J Allergy Clin Immunol 111:106-12. 2003..CONCLUSION: This study demonstrates the in vivo regulation of chemokine receptors by means of bradykinin in human airway tissue in patients with allergic rhinitis... - Update on therapeutic developments for hereditary angioedemaSandra C Christiansen
Department of Allergy, Kaiser Permanente and Department of Medicine, University of California San Diego, La Jolla, California, USA
Allergy Asthma Proc 30:500-5. 2009..The arrival of these novel therapies promises to transform the future management of HAE... - Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infectionJane Eddleston
Veterans Medical Research Foundation, and Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0732, USA
Am J Respir Cell Mol Biol 44:118-26. 2011..A diminished, early epithelial-initiated antiviral response to rhinovirus infection could contribute to the increased susceptibility of subjects to prolonged respiratory viral infections after exposure to cigarette smoke... - Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediatorsJane Eddleston
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 169:6445-51. 2002..This may lead to enhanced activation of intracellular signaling pathways resulting in the release of mediators involved in inflammatory allergic airway disease... - Hereditary angioedema: management of laryngeal attacksSandra C Christiansen
Department of Allergy, Kaiser Permanente and University of California, San Diego, California, USA
Am J Rhinol Allergy 25:379-82. 2011..Acute therapy had been relegated to supportive care, intubation, and consideration of fresh frozen plasma (FFP)--the latter with the potential for actually accelerating the speed and severity of the swelling... - Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjectsSandra C Christiansen
Southern California Kaiser Permanente Medical Group, San Diego, Calif, USA
Int Arch Allergy Immunol 147:299-304. 2008..In this report we investigate the effect of experimental rhinovirus infection on hTK activity in the airways of atopic subjects with and without asthma... - Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAMSumanta Mukherjee
Department of Medicine, University of Toledo Medical Center, Toledo, Ohio 43614, USA
J Biol Chem 284:29391-8. 2009..These findings suggest a novel function of LPS and the signaling pathways in the induction of IL-4 gene expression... - The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cellsJane Eddleston
Veterans Medical Research Foundation, La Jolla, CA, USA
J Allergy Clin Immunol 119:115-22. 2007..A recently described anti-inflammatory protein, glucocorticoid-induced leucine zipper (GILZ), interferes with NF-kappaB-mediated gene transcription in T cells and macrophages... - The association of obesity and asthma severity and control in childrenKenneth B Quinto
Department of Allergy and Immunology, University of California, San Diego, La Jolla, Calif 92111, USA
J Allergy Clin Immunol 128:964-9. 2011..The association between obesity and asthma severity and control in children is not well understood... - Diagnosis and management of hereditary angioedema: an American approachBruce L Zuraw
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA
Transfus Apher Sci 29:239-45. 2003..Areas in which the diagnostic or therapeutic tools are deficient are discussed, and the prospects for improved therapeutic modalities highlighted... - Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flowSavita P Rao
Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
J Immunol 179:7800-7. 2007..These findings suggest that Gal-3 functions as a cell surface adhesion molecule to support eosinophil rolling and adhesion under conditions of flow... - IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcriptionLing Yu Chen
Department of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 169:3934-9. 2002..These results indicate that RhoA and IL-1R-associated kinase are novel signal transducers for LPS-induced Toll-like receptor 4-mediated proinflammatory cytokine synthesis in human monocytes... - Safety and efficacy of physician-supervised self-managed C1 inhibitor replacement therapyLouanne M Tourangeau
University of California, San Diego, La Jolla, CA 92093 0732, USA
Int Arch Allergy Immunol 157:417-24. 2012..Home infusion of C1INH allows for the earliest possible intervention since patients can initiate therapy at the first sign of symptoms... - Serving the underserved: school-based asthma intervention programsSandra C Christiansen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Asthma 39:463-72. 2002..Strategies are required that can specifically address the needs of underserved communities. We review the underlying rationale and progress of school-based programs designed to assist asthmatic children... - Up-regulation of functional kinin B1 receptors in allergic airway inflammationSandra C Christiansen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 169:2054-60. 2002..Taken together, these results show that functional B1 receptors are induced in the airway during allergic inflammation and suggest that they participate in the regulation of gene expression... - The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodelingTaylor A Doherty
Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
Nat Med 17:596-603. 2011.... - Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c releaseIchiro Kuwabara
Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Biol Chem 277:3487-97. 2002..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3... - A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytesLing Yu Chen
Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614, USA
J Biol Chem 279:7208-12. 2004..These results indicate that guanine nucleotide exchange factor Lbc is a novel signal transducer for RhoA-mediated NF-kappaB activation in human peripheral blood monocytes stimulated with bacterial products... - Kinin receptor expression during Staphylococcus aureus infectionSara H Bengtson
Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
Blood 108:2055-63. 2006..The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections... - Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytesLing Yu Chen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla 92037, California 92121, USA
Am J Physiol Lung Cell Mol Physiol 284:L607-13. 2003..These findings provide evidence that LPS-induced NF-kappaB activation and IL-8 gene expression use a signaling pathway requiring protein tyrosine kinase and that such regulation may occur through tyrosine phosphorylation of TLR4...
Research Grants
- GILZ Controls TLR-Induced NF-kB Activity In Acute AsthmaBruce Zuraw; Fiscal Year: 2007..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
- INITIATION AND PROPAGATION OF ASTHMATIC INFLAMMATIONBruce Zuraw; Fiscal Year: 2004..Efforts to elucidate and then modify key events leading to asthmatic inflammation may ultimately be exploited for prevention of asthmatic disease. ..
- RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATIONBruce Zuraw; Fiscal Year: 2002..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..