I H Zucker

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi Neurohumoral stimulation
    Irving H Zucker
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Heart Fail Clin 8:87-99. 2012
  2. ncbi Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure
    Irving H Zucker
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 50:904-10. 2007
  3. ncbi The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide
    Irving H Zucker
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198 4575, USA
    Prog Biophys Mol Biol 84:217-32. 2004
  4. ncbi Exercise training and sympathetic regulation in experimental heart failure
    Irving H Zucker
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Exerc Sport Sci Rev 32:107-11. 2004
  5. ncbi Novel mechanisms of sympathetic regulation in chronic heart failure
    Irving H Zucker
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Hypertension 48:1005-11. 2006
  6. ncbi Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure
    Irving H Zucker
    Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Heart Circ Physiol 297:H1557-66. 2009
  7. ncbi Angiotensin II--nitric oxide interactions in the control of sympathetic outflow in heart failure
    I H Zucker
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha 68198 4575, USA
    Heart Fail Rev 5:27-43. 2000
  8. ncbi Brain-selective overexpression of Angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure
    Liang Xiao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850
    Hypertension 58:1057-65. 2011
  9. ncbi The regulation of sympathetic outflow in heart failure. The roles of angiotensin II, nitric oxide, and exercise training
    I H Zucker
    Department of Physiology and Biophysics, University of Nebraska Medical Center, 984575 Nebraska Medical Center, Omaha, NE 68198 4575, USA
    Ann N Y Acad Sci 940:431-43. 2001
  10. ncbi Exercise training enhances baroreflex sensitivity by an angiotensin II-dependent mechanism in chronic heart failure
    Tarek M Mousa
    Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol 104:616-24. 2008

Research Grants

  1. SYMPATHETIC CONTROL IN HEART FAILURE: A ROLE FOR STATINS
    Irving Zucker; Fiscal Year: 2006
  2. CARDIOPULMONARY REFLEXES IN HEART FAILURE
    Irving Zucker; Fiscal Year: 1992
  3. CARDIAC AND ARTERIAL BAROREFLEXES IN HEART FAILURE
    Irving Zucker; Fiscal Year: 1991
  4. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010

Collaborators

Detail Information

Publications66

  1. ncbi Neurohumoral stimulation
    Irving H Zucker
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Heart Fail Clin 8:87-99. 2012
    ..It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF...
  2. ncbi Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure
    Irving H Zucker
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 50:904-10. 2007
    ..6 pg/mL in control dogs versus 10.1+/-14.0 pg/mL in dogs receiving activation therapy; P<0.02). We conclude that chronic activation of the carotid BR improves survival and suppresses neurohormonal activation in chronic heart failure...
  3. ncbi The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide
    Irving H Zucker
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198 4575, USA
    Prog Biophys Mol Biol 84:217-32. 2004
    ..Lastly, clinical implications of this work are discussed...
  4. ncbi Exercise training and sympathetic regulation in experimental heart failure
    Irving H Zucker
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Exerc Sport Sci Rev 32:107-11. 2004
    ..Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory...
  5. ncbi Novel mechanisms of sympathetic regulation in chronic heart failure
    Irving H Zucker
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Hypertension 48:1005-11. 2006
  6. ncbi Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure
    Irving H Zucker
    Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Heart Circ Physiol 297:H1557-66. 2009
    ..Finally, exercise training reduces both central oxidative stress and AT(1)R expression in animals with CHF. These data strongly suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF...
  7. ncbi Angiotensin II--nitric oxide interactions in the control of sympathetic outflow in heart failure
    I H Zucker
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha 68198 4575, USA
    Heart Fail Rev 5:27-43. 2000
    ..It now seems clear that one mechanism which is important in regulating sympathetic outflow in this disease state depends upon a central interaction between Ang II and NO at the cellular and nuclear levels...
  8. ncbi Brain-selective overexpression of Angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure
    Liang Xiao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850
    Hypertension 58:1057-65. 2011
    ..The mechanism for this effect involves angiotensin (1-7) mas signaling, as well as a decrease in angiotensin II type 1 receptor signaling in the medulla...
  9. ncbi The regulation of sympathetic outflow in heart failure. The roles of angiotensin II, nitric oxide, and exercise training
    I H Zucker
    Department of Physiology and Biophysics, University of Nebraska Medical Center, 984575 Nebraska Medical Center, Omaha, NE 68198 4575, USA
    Ann N Y Acad Sci 940:431-43. 2001
    ..These data suggest that the sympatho-excitatory state that is typical of CHF is, in part, due to changes in AngII and NO. Depressed baroreflex function and the elevated SNA can be improved by EX in animals with CHF...
  10. ncbi Exercise training enhances baroreflex sensitivity by an angiotensin II-dependent mechanism in chronic heart failure
    Tarek M Mousa
    Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol 104:616-24. 2008
    ....
  11. ncbi Chronic endothelin-1 blockade reduces sympathetic nerve activity in rabbits with heart failure
    J L Liu
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198-4575, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1906-13. 2001
    ..These data suggest that ET-1 contributes to sympathoexcitation in the CHF state. Enhancement of arterial baroreflex sensitivity may further contribute to sympathoinhibition after ET-1 blockade in heart failure...
  12. ncbi Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Circ Res 95:937-44. 2004
    ..These data demonstrate intense radical stress in autonomic areas of the brain in experimental CHF and provide evidence for a tight relationship between Ang II and ROS as contributors to sympathoexcitation in CHF...
  13. ncbi Differential effects of cardiac sympathetic afferent stimulation on neurons in the nucleus tractus solitarius
    Wei-Zhong Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Neurosci Lett 409:146-50. 2006
    ....
  14. ncbi Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats
    Lie Gao
    Department of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol 102:37-43. 2007
    ..These results suggest that both the chemical and electrical stimulation of the CSAR augments chemoreceptor reflex and that central ANG II, specially located in the NTS, plays a major role in these reflex interactions...
  15. ncbi Sympathoexcitation by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
    Am J Physiol Heart Circ Physiol 288:H2271-9. 2005
    ....
  16. ncbi Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats
    Guo-Qing Zhu
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198-4575, USA
    Am J Physiol Heart Circ Physiol 282:H2039-45. 2002
    ..These central effects of ANG II are mediated by AT(1) receptors...
  17. ncbi Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons
    Dongmei Liu
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Circ Res 103:186-93. 2008
    ..Antioxidant agents may be beneficial in CHF and other states where brain Ang II is elevated by decreasing AT1R expression through the Jnk and AP1 pathway...
  18. ncbi Amelioration of depressed cardiopulmonary reflex control of sympathetic nerve activity by short-term exercise training in male rabbits with heart failure
    R U Pliquett
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4575, USA
    J Appl Physiol 95:1883-8. 2003
    ..normal animals. Ex substantially restored both CP reflex sensitivity and baseline RSNA in CHF animals. Thus Ex beneficially affects reflex regulation in CHF, thereby lowering resting sympathetic nerve activity...
  19. ncbi Central AT1 receptors are involved in the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure
    Guo-Qing Zhu
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha, NE 68198-4575, USA
    Basic Res Cardiol 97:320-6. 2002
    ..These results suggest that the CSAR induced by epicardial application of BK and capsaicin is enhanced in the rats with CHF, and the enhanced CSAR is mediated by central AT(1) receptors...
  20. ncbi NADPH oxidase-derived reactive oxygen species in skeletal muscle modulates the exercise pressor reflex
    Han Jun Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol 107:450-9. 2009
    ..These data suggest that NADPH oxidase-derived muscle ROS plays an excitatory role in the EPR control of blood pressure...
  21. ncbi Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure
    Sumit Kar
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    J Appl Physiol 108:923-32. 2010
    ..These data suggest that the activation of the central RAS in animals with CHF involves an imbalance of ACE and ACE2 in regions of the brain that regulate autonomic function and that EX can reverse this imbalance...
  22. ncbi Neuronal angiotensin II type 1 receptor upregulation in heart failure: activation of activator protein 1 and Jun N-terminal kinase
    Dongmei Liu
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Circ Res 99:1004-11. 2006
    ..These data suggest that central Ang II activates the AT(1)R, SAPK/JNK pathway. AP-1 may further regulate gene expression in RVLM in the CHF state...
  23. ncbi Exercise training prevents the exaggerated exercise pressor reflex in rats with chronic heart failure
    Han Jun Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol 108:1365-75. 2010
    ..These findings suggest a potential therapeutic role for ExT in minimizing arterial pressure and sympathetic outflow following activation of the EPR in the CHF state...
  24. ncbi Cardiac sympathetic afferent stimulation impairs baroreflex control of renal sympathetic nerve activity in rats
    Lie Gao
    Department of Physiology and Biophysics, University of Nebraska Medical Center, University of Nebraska College of Medicine, Omaha, Nebraska 68198-4575, USA
    Am J Physiol Heart Circ Physiol 286:H1706-11. 2004
    ....
  25. ncbi nNOS gene transfer to RVLM improves baroreflex function in rats with chronic heart failure
    Yu Wang
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198-4575, USA
    Am J Physiol Heart Circ Physiol 285:H1660-7. 2003
    ..This study represents the first demonstration of altered baroreflex function following increases in central nNOS in the CHF state. We conclude that delivery of Ad.nNOS into the RVLM improves baroreflex function in rats with CHF...
  26. ncbi AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure
    Guo-Qing Zhu
    Dept. of Cellular and Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Am J Physiol Heart Circ Physiol 287:H1828-35. 2004
    ....
  27. ncbi Effect of in vivo gene transfer of nNOS in the PVN on renal nerve discharge in rats
    Yi-Fan Li
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4575, USA
    Am J Physiol Heart Circ Physiol 282:H594-601. 2002
    ..This technique may be useful in pathological conditions know to have increased sympathetic outflow, such as hypertension or heart failure...
  28. ncbi Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Hypertension 45:1173-81. 2005
    ..9+/-0.2 to 3.1+/-0.2%/mm Hg; P<0.01). These results suggest that tonic cardiac sympathetic afferent input plays an important role in the blunted baroreflex associated with CHF, which is mediated by central AT1 receptors...
  29. ncbi Simvastatin normalizes autonomic neural control in experimental heart failure
    Rainer U Pliquett
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198-4575, USA
    Circulation 107:2493-8. 2003
    ..The precise neural and cellular pathways involved in these responses need further clarification. This finding may have important implications for the treatment of CHF and progression of the disease process...
  30. ncbi Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology
    Yi-Fan Li
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Med 112:59-79. 2005
    ....
  31. ncbi Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure
    Hong Zheng
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
    Am J Physiol Heart Circ Physiol 288:H2332-41. 2005
    ..17% at the highest dose). In conclusion, our data indicate that ExT improves the altered NO mechanism within the PVN and restores NO-mediated changes in RSNA in rats with HF...
  32. ncbi Exercise training prevents arterial baroreflex dysfunction in rats treated with central angiotensin II
    Yan Xia Pan
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 49:519-27. 2007
    ..These results indicate that EX improves arterial baroreflex function in conditions of high brain Ang II, which is mediated by the central Ang II type 1 receptor and associated with a reduction in central oxidative stress...
  33. ncbi Statin therapy restores sympathovagal balance in experimental heart failure
    Rainer U Pliquett
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198-4575, USA
    J Appl Physiol 95:700-4. 2003
    ..SIM beneficially affects autonomic tone in CHF as seen by the reversal of depressed HRV and total power of PSA. These data have important implications for the treatment of patients with autonomic imbalance...
  34. ncbi Interaction of transthoracic ultrasound and intravenous microbubbles with cardiac mechanoreceptors
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Ultrasound Med Biol 33:136-44. 2007
    ..The changes in RSNA induced by TTU and MB in all rabbits were abolished by vagotomy. TTU, in the presence of MB, stimulates mechanoreceptors in the heart reflexively to reduce RSNA...
  35. ncbi Tonic glutamatergic input in the rostral ventrolateral medulla is increased in rats with chronic heart failure
    Wei Zhong Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 53:370-4. 2009
    ..These data suggest that upregulated glutamate receptors, including NMDA and non-NMDA, in the RVLM are involved in tonic control of elevated sympathetic tone in CHF...
  36. ncbi Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure
    Jun-Li Liu
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4575, USA
    J Appl Physiol 92:2403-8. 2002
    ..After atropine, there was no significant change in baroreflex slope or HR range between CHF Ex and CHF rabbits. These data support the view that enhancement of baroreflex control of HR after Ex is due to an augmentation of vagal tone...
  37. ncbi Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits
    Yu-Long Li
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
    Circ Res 97:260-7. 2005
    ..05). These results indicate that decreased endogenous nNOS activity in the CB plays an important role in the enhanced activity of the CB chemoreceptors and peripheral chemoreflex function in CHF rabbits...
  38. ncbi Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure
    Yu Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 4575, USA
    Am J Physiol Heart Circ Physiol 288:H205-13. 2005
    ..The pressor response is mediated by an elevated sympathetic tone, whereas the tachycardia is mediated by withdrawal of parasympathetic tone in sham rats. These data are consistent with a downregulation of nNOS within the PVN in CHF...
  39. ncbi Exercise training improves renal excretory responses to acute volume expansion in rats with heart failure
    Hong Zheng
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Am J Physiol Renal Physiol 291:F1148-56. 2006
    ..Thus the beneficial effects of ExT on cardiovascular regulation in HF may be partly due to improvement of the neural component of volume reflex...
  40. ncbi Endogenous reactive oxygen species modulates voltage-gated sodium channels in dorsal root ganglia of rats
    Han Jun Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol 110:1439-47. 2011
    ..These data suggest that ROS modulates the EPR by affecting the activity of the Na(v) channels on muscle afferents...
  41. ncbi Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 51:521-7. 2008
    ..1+/-0.5 microg in control rats and 2.4+/-0.5 microg in AT(2)R rats; P<0.05). These results suggest that overexpression of AT(2)R in the RVLM induced a diuresis that may be mediated, in part, by sympathoinhibition...
  42. ncbi Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism
    Lie Gao
    Department of Cellular and Integrative Physiology University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Pharmacol Exp Ther 326:278-85. 2008
    ....
  43. ncbi Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure
    Wei Zhong Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Ctr, 985850 Nebraska Medical Ctr, Omaha, NE 68198 5850, USA
    Am J Physiol Heart Circ Physiol 295:H1216-H1226. 2008
    ..These results demonstrate that the enhanced cardiac sympathetic afferent input contributes to an excitatory effect of chemoreflex function in CHF, which is mediated by an NTS-AT1R-dependent mechanism...
  44. ncbi Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 52:708-14. 2008
    ..These data implicate a downregulation in the AT(2)R as a contributory factor in the sympathoexcitation in CHF...
  45. ncbi Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure
    Lie Gao
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, 68198 5850, USA
    Am J Physiol Heart Circ Physiol 298:H945-55. 2010
    ..3 expression and subsequent decrease in K(+) current, thereby increasing the excitability of neurons in the RVLM. The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling...
  46. ncbi Alteration in skeletal muscle afferents in rats with chronic heart failure
    Han Jun Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Physiol 588:5033-47. 2010
    ..These data suggest that group III afferents are sensitized whereas group IV afferents are desensitized in CHF, which is related to the dysfunction of P2X and VR1 receptors...
  47. ncbi Novel mechanisms of sympatho-excitation in chronic heart failure
    Irving H Zucker
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198-4575, USA
    Heart Fail Monit 3:2-7. 2002
    ..While abnormal reflex regulation may predict a poor outcome, new treatment options may emerge from a better understanding of reflex regulation in CHF...
  48. ncbi Effects of angiotensin II on autonomic components of nasopharyngeal stimulation in male conscious rabbits
    Tarek M Mousa
    Department of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
    J Appl Physiol 98:1607-11. 2005
    ..This effect may be due to an augmentation of baseline sympathetic outflow and a reduction in reflex sensitivity similar to the effect of ANG II on baroreflex function...
  49. ncbi Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Circulation 115:3095-102. 2007
    ..In the present study, we therefore hypothesized that long-term exercise exerts its beneficial effect on autonomic activity in CHF via central antioxidative mechanisms...
  50. ncbi Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidase
    Lie Gao
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
    Circulation 112:1763-70. 2005
    ..These data also demonstrate that SIM improves left ventricular function in pacing-induced CHF rabbits...
  51. ncbi NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits
    Yu Long Li
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Cardiovasc Res 75:546-54. 2007
    ..NADPH oxidase-derived superoxide anion mediates the effects of Ang II in many organs. We investigated whether this signaling pathway may mediate the enhanced peripheral chemoreceptor sensitivity induced by Ang II in CHF rabbits...
  52. ncbi AT1 receptors in the nucleus tractus solitarii mediate the interaction between the baroreflex and the cardiac sympathetic afferent reflex in anesthetized rats
    Wei Zhong Wang
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1137-45. 2007
    ....
  53. ncbi Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs
    I H Zucker
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha 68105
    Circ Res 61:II54-60. 1987
    ..The response was abolished by vagotomy. We conclude that cardiac receptor stimulation causes a reflex decrease in coronary resistance in the awake dog that is completely accountable by a cholinergic mechanism...
  54. ncbi The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase
    Erin G Rosenbaugh
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Biomaterials 31:5218-26. 2010
    ..Importantly, neither the PEI-PEG polymer alone nor the CuZnSOD nanozyme induced neuronal toxicity. These findings indicate that CuZnSOD nanozyme inhibits AngII intra-neuronal signaling in vitro and in vivo...
  55. ncbi Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons
    Amit K Mitra
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Physiol Cell Physiol 299:C561-9. 2010
    ..a cell neuronal model. These data imply a positive feedback mechanism that may impact neuronal discharge sensitivity in response to ANG II...
  56. ncbi Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide
    Yu-Long Li
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
    J Physiol 555:219-29. 2004
    ..This effect is due mainly to the suppression of KCa channel activity caused by decreased availability of NO. In addition, intracellular cGMP is necessary for the KCa channel modulation by NO...
  57. ncbi Renal denervation modulates angiotensin receptor expression in the renal cortex of rabbits with chronic heart failure
    Sarah C Clayton
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Renal Physiol 300:F31-9. 2011
    ..These results suggest renal sympathetic nerve activity elicits a detrimental effect on renal blood flow and may be associated with alterations in the expression of angiotensin II receptors...
  58. ncbi Central angiotensin (1-7) enhances baroreflex gain in conscious rabbits with heart failure
    Sumit Kar
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Hypertension 58:627-34. 2011
    ..These data suggest that augmentation of central Ang-(1-7) inhibits sympathetic outflow and increases vagal outflow in CHF, thus contributing to enhanced baroreflex gain in this disease state...
  59. ncbi Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure
    Oliver Zolk
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstr 17, 91054 Erlangen, Germany
    Biochem Biophys Res Commun 293:1377-82. 2002
    ..Together, these findings raise the possibility that augmented ventricular CARP expression may play a role in the pathogenesis of human heart failure...
  60. ncbi Roles of nitric oxide and angiotensin II in the impaired baroreflex gain of pregnancy
    Daisy L Daubert
    Oregon Health and Science University, Department of Physiology and Pharmacology, Portland, Oregon 97239, USA
    Am J Physiol Regul Integr Comp Physiol 292:R2179-87. 2007
    ..Therefore, we conclude that NO, either alone or via an interaction with angiotensin II, is not responsible for decrease in baroreflex gain during pregnancy...
  61. ncbi The regulation of sympathetic nerve activity by angiotensin II involves reactive oxygen species and MAPK
    Irving H Zucker
    Circ Res 97:737-9. 2005
  62. ncbi Increased mechanoreceptor/metaboreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure
    Irving H Zucker
    J Appl Physiol 102:498; author reply 504-5. 2007
  63. ncbi ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure
    Guo-Qing Zhu
    Department of Physiology, Nanjing Medical University, Nanjing 210029, Peoples Republic of China
    J Appl Physiol 97:1746-54. 2004
    ....
  64. ncbi Angiotensin-converting enzyme 2: a new player in central sympathetic regulation?
    Irving H Zucker
    Circ Res 102:628-9. 2008
  65. ncbi Brain angiotensin II: new insights into its role in sympathetic regulation
    Irving H Zucker
    Circ Res 90:503-5. 2002
  66. ncbi Statins and sympathetic nerve activity in heart failure
    Irving H Zucker
    J Card Fail 12:759. 2006

Research Grants13

  1. SYMPATHETIC CONTROL IN HEART FAILURE: A ROLE FOR STATINS
    Irving Zucker; Fiscal Year: 2006
    ..The data accrued will have applicability to our understanding of autonomic regulation and therapeutics in this disease. ..
  2. CARDIOPULMONARY REFLEXES IN HEART FAILURE
    Irving Zucker; Fiscal Year: 1992
    ..Mechanical stimuli will include ascending aortic and vena caval occlusions. Chemical stimuli will include intracoronary and topical application of prostaglandins, arachidonic acid and bradykinin...
  3. CARDIAC AND ARTERIAL BAROREFLEXES IN HEART FAILURE
    Irving Zucker; Fiscal Year: 1991
    ..This 5-year program represents a multidisciplinary approach to investigate the reflex abnormalities which may contribute to the symptomatology of chronic heart failure...
  4. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..