Research Topics
| Danny ZiprisSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Innate immunity and its role in type 1 diabetesDanny Zipris
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045 6511, USA
Curr Opin Endocrinol Diabetes Obes 15:326-31. 2008..This review focuses on recent studies on the role of Toll-like receptors and innate pathways in triggering type 1 diabetes...- Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanismsDanny Zipris
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
Clin Immunol 131:11-23. 2009..Understanding the link between environmental agents and innate immune pathways involved in early stages of diabetes may advance the design of immune interventions to prevent disease in genetically susceptible individuals... - Innate immunity in type 1 diabetesDanny Zipris
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
Diabetes Metab Res Rev 27:824-9. 2011..We have used the biobreeding diabetes resistant and LEW1.WR1 rat models to identify the role of virus-induced innate immunity in the mechanism of type 1 diabetes... - Brief dexamethasone treatment during acute infection prevents virus-induced autoimmune diabetesPilar Londono
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
Clin Immunol 135:401-11. 2010.... - Toll-like receptors and type 1 diabetesDanny Zipris
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
Adv Exp Med Biol 654:585-610. 2010..The new knowledge about the role of innate immune pathways in triggering islet destruction could lead to the discovery of new molecules that may be targeted for disease prevention... - DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetesTravis R Wolter
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, 1775 Aurora Ct, Mail Stop B 140, Aurora, CO 80045, USA
Clin Immunol 132:103-15. 2009..Our findings provide new insights into KRV-induced innate immune pathways that may play a role in early mechanisms leading to islet inflammation and diabetes... - A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) ratsDanny Zipris
The Institute of Endocrinology, Diabetes, and Metabolism, Rambam Medical Center B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
JOP 3:76-82. 2002..The BioBreeding rat is used as an animal model for the study of human Type 1 diabetes. In spite of a severe lymphopenia, these animals develop spontaneous diabetes at the age of 10-12 weeks... - Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populationsDanny Zipris
Program in Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 170:3592-602. 2003.... - TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant ratDanny Zipris
Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
J Immunol 178:693-701. 2007..Our data implicate the TLR9-signaling pathway in KRV-induced innate immune activation and autoimmune diabetes in the BBDR rat...