M G Ziegler

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure
    DANIEL T O'CONNOR
    Departments of Medicine and Pharmacology and Center for Human Genetics and Genomics, University of California at San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093 0838, USA
    Circulation 118:247-57. 2008
  2. ncbi Sleep disorders and the failure to lower nocturnal blood pressure
    Michael G Ziegler
    University of California San Diego, 92103 8341, USA
    Curr Opin Nephrol Hypertens 12:97-102. 2003
  3. ncbi Epinephrine and the metabolic syndrome
    Michael G Ziegler
    UCSD Medical Center, San Diego, CA 92103 8341, USA
    Curr Hypertens Rep 14:1-7. 2012
  4. ncbi Endogenous epinephrine protects against obesity induced insulin resistance
    Michael G Ziegler
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0838, United States
    Auton Neurosci 162:32-4. 2011
  5. ncbi Antihypertensive therapy for patients with obstructive sleep apnea
    Michael G Ziegler
    University of California San Diego, San Diego, California 92103 8341, USA
    Curr Opin Nephrol Hypertens 20:50-5. 2011
  6. ncbi Sources of human urinary epinephrine
    M G Ziegler
    Department of Medicine, University of California San Diego, USA
    Kidney Int 51:324-7. 1997
  7. ncbi Epinephrine regulation of hemodynamics in catecholamine knockouts and the pithed mouse
    Ping Sun
    Department of Medicine, University of California at San Diego, San Diego, California 92103 8341, USA
    Ann N Y Acad Sci 1148:325-30. 2008
  8. ncbi Effect of continuous positive airway pressure and placebo treatment on sympathetic nervous activity in patients with obstructive sleep apnea
    M G Ziegler
    Department of Medicine, University of California San Diego, San Diego, CA 92103, USA
    Chest 120:887-93. 2001
  9. ncbi Location, development, control, and function of extraadrenal phenylethanolamine N-methyltransferase
    Michael G Ziegler
    University of California San Diego Medical Center, San Diego, California 92103, USA
    Ann N Y Acad Sci 971:76-82. 2002
  10. ncbi Relationship of arousals from sleep to sympathetic nervous system activity and BP in obstructive sleep apnea
    J S Loredo
    Department of Medicine, University of California, San Diego, USA
    Chest 116:655-9. 1999

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure
    DANIEL T O'CONNOR
    Departments of Medicine and Pharmacology and Center for Human Genetics and Genomics, University of California at San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093 0838, USA
    Circulation 118:247-57. 2008
    ..We approached catestatin heritability using twin pairs, coupled with genome-wide linkage, in a series of twin and sibling pairs from 2 continents...
  2. ncbi Sleep disorders and the failure to lower nocturnal blood pressure
    Michael G Ziegler
    University of California San Diego, 92103 8341, USA
    Curr Opin Nephrol Hypertens 12:97-102. 2003
    ..The failure to lower systolic blood pressure at night (called non-dipping) and sleep apnea are both associated with adverse cardiovascular outcomes. Sleep apnea is a common cause of non-dipping blood pressure...
  3. ncbi Epinephrine and the metabolic syndrome
    Michael G Ziegler
    UCSD Medical Center, San Diego, CA 92103 8341, USA
    Curr Hypertens Rep 14:1-7. 2012
    ..The hyperglycemic influence of epinephrine is short-lived. Chronic administration of epinephrine and other ?2 agonists improves cellular glucose uptake and metabolism. Overall, epinephrine counteracts the metabolic syndrome...
  4. ncbi Endogenous epinephrine protects against obesity induced insulin resistance
    Michael G Ziegler
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0838, United States
    Auton Neurosci 162:32-4. 2011
    ..Endogenous E protects against overfeeding induced diabetes. Since adrenal E release can be impaired with aging and diabetes, endogenous E may help prevent adult onset diabetes...
  5. ncbi Antihypertensive therapy for patients with obstructive sleep apnea
    Michael G Ziegler
    University of California San Diego, San Diego, California 92103 8341, USA
    Curr Opin Nephrol Hypertens 20:50-5. 2011
    ..Patients with obstructive sleep apnea (OSA) often have hypertension that is difficult to control. We review the causes of OSA hypertension and evidence supporting specific therapies...
  6. ncbi Sources of human urinary epinephrine
    M G Ziegler
    Department of Medicine, University of California San Diego, USA
    Kidney Int 51:324-7. 1997
    ..This is an important factor in the interpretation of urine E levels. Renal E could alter renal blood flow, electrolyte reabsorption, and renin release prior to excretion into urine...
  7. ncbi Epinephrine regulation of hemodynamics in catecholamine knockouts and the pithed mouse
    Ping Sun
    Department of Medicine, University of California at San Diego, San Diego, California 92103 8341, USA
    Ann N Y Acad Sci 1148:325-30. 2008
    ..These targeted KO mice displayed significantly smaller pressor responses than pithed control mice. We find that E release during stress prevents an excessive increase in blood pressure...
  8. ncbi Effect of continuous positive airway pressure and placebo treatment on sympathetic nervous activity in patients with obstructive sleep apnea
    M G Ziegler
    Department of Medicine, University of California San Diego, San Diego, CA 92103, USA
    Chest 120:887-93. 2001
    ..We studied the effect of continuous positive airway pressure (CPAP) treatment on sympathetic nervous activity in 38 patients with obstructive sleep apnea...
  9. ncbi Location, development, control, and function of extraadrenal phenylethanolamine N-methyltransferase
    Michael G Ziegler
    University of California San Diego Medical Center, San Diego, California 92103, USA
    Ann N Y Acad Sci 971:76-82. 2002
    ..PNMT may also play a role in the regulation of fetal heart rate prior to development of the adrenal medulla...
  10. ncbi Relationship of arousals from sleep to sympathetic nervous system activity and BP in obstructive sleep apnea
    J S Loredo
    Department of Medicine, University of California, San Diego, USA
    Chest 116:655-9. 1999
    ..Obstructive sleep apnea (OSA) patients have a high frequency of arousals. We hypothesized that arousals significantly influence tonic sympathetic nervous system function...
  11. ncbi Overnight changes of immune parameters and catecholamines are associated with mood and stress
    Winfried Rief
    Department of Psychiatry, University of California, San Diego, San Diego, California, USA
    Psychosom Med 72:755-62. 2010
    ..To test the hypothesis that a nocturnal decrease of secretion of inflammation markers and catecholamines would be associated with mood and stress variables even after controlling for objective sleep variables...
  12. ncbi Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension
    Fangwen Rao
    Department of Medicine, University of California at San Diego, USA
    Circulation 115:2271-81. 2007
    ..We identified a natural nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and blood pressure...
  13. ncbi Continuous positive airway pressure normalizes cardiac autonomic and hemodynamic responses to a laboratory stressor in apneic patients
    R A Nelesen
    Departments of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Chest 119:1092-101. 2001
    ..Contractility and hemodynamics were determined with impedance cardiography, and parasympathetic activity was assessed by analysis of heart rate variability. Measures were determined at rest and in response to a stressor...
  14. ncbi Vulnerable caregivers of patients with Alzheimer's disease have a deficit in circulating CD62L- T lymphocytes
    P J Mills
    Department of Psychiatry, University of California, San Diego, USA
    Psychosom Med 61:168-74. 1999
    ..The objective of this study was to determine the effects of chronic stress on L-selectin expression on peripheral lymphocytes in elderly spousal caregivers of patients with Alzheimer's disease...
  15. ncbi Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins
    Lian Zhang
    Department of Medicine, University of California at San Diego, 92161, USA
    Physiol Genomics 19:277-91. 2004
    ....
  16. ncbi Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat
    M L Jirout
    Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
    Hum Mol Genet 19:2567-80. 2010
    ....
  17. ncbi Ontogeny of epinephrine metabolic pathways in the rat: role of glucocorticoids
    B Kennedy
    Department of Medicine, University of California San Diego, Medical Center, 200 West Arbor Drive, 8341, San Diego, CA, USA
    Int J Dev Neurosci 18:53-9. 2000
    ..We conclude that expression of PNMT in all three tissues is glucocorticoid independent until the latter part of gestation when it is readily enhanced by glucocorticoids...
  18. ncbi Sleep apnea, norepinephrine-release rate, and daytime hypertension
    M G Ziegler
    Department of Medicine, University of California-San Diego School of Medicine, USA
    Sleep 20:224-31. 1997
    ..These results suggest that apneics are susceptible to transient increases in sympathetic nervous activity and that hypertensive apneics maintain increased sympathetic nervous release of NE in the daytime...
  19. ncbi Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
    Lian Zhang
    Department of Medicine, UCSD School of Medicine, San Diego, California 92093 0838, USA
    J Clin Invest 117:2658-71. 2007
    ....
  20. ncbi Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function
    Xuping Bao
    Department of Medicine, University of California, San Diego, CA, USA
    Hypertension 46:301-7. 2005
    ..05) and decreased heart rate (7%; P<0.001). Our study suggests that age is an important modifier for the effects of ADRB2 polymorphisms on ADRB2 function and the development of hypertension...
  21. ncbi Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins
    Rohit Loomba
    Department of Medicine, University of California at San Diego, La Jolla, California, USA
    Gastroenterology 139:836-45, 845.e1. 2010
    ..We estimated the heritability of GGT using a twin-study design and examined the genetic covariance between GGT levels, IR, hypertension, levels of low-density lipoproteins and triglycerides, and ADRB2 variants...
  22. ncbi The effect of hypoxia on baroreflexes and pressor sensitivity in sleep apnea and hypertension
    M G Ziegler
    Department of Medicine, University of California at San Diego 92103-8341, USA
    Sleep 18:859-65. 1995
    ..Our studies suggest that apneics could have an exaggerated pressor sensitivity to norepinephrine. They might also have difficulty returning BP to normal levels, because hypoxia impaired baroreflexes...
  23. ncbi Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved?
    J S Loredo
    Department of Medicine, University of California, San Diego, California, USA
    Med Hypotheses 56:17-9. 2001
    ..This implies that correcting the intermittent nocturnal hypoxemia alone may prevent the cardiovascular morbidity associated with obstructive sleep apnea...
  24. ncbi Altered cardiac contractility in sleep apnea
    R A Nelesen
    Department of Psychiatry, University of California, San Diego, USA
    Sleep 19:139-44. 1996
    ..The downregulation of cardiac beta-adrenergic receptor activity may explain the inability of people with sleep apnea to respond with appropriate cardiac contractility to a mild perturbation...
  25. ncbi Combination of caregiving stress and hormone replacement therapy is associated with prolonged platelet activation to acute stress among postmenopausal women
    Kirstin Aschbacher
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0680, USA
    Psychosom Med 69:910-7. 2007
    ..Both HRT and the chronic stress of caregiving have been associated with increased cardiovascular risk, potentially through a mechanism of platelet hyperactivity...
  26. ncbi Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog
    Nitish R Mahapatra
    Department of Medicine, UCSD, San Diego, CA, USA
    J Clin Invest 115:1942-52. 2005
    ..Loss of the physiological "brake" catestatin in Chga mice coupled with dysregulation of transmitter storage and release may act in concert to alter autonomic control of the circulation in vivo, eventuating in hypertension...
  27. ncbi Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs
    Brinda K Rana
    Departments of Psychiatry, University of California at San Diego, La Jolla, California 92093 0657, USA
    J Pharmacol Exp Ther 331:419-28. 2009
    ..These cellular events suggest a homeostatic mechanism underlying the pleiotropic actions of CHRNA3 genetic variation on autonomic function observed in twins...
  28. ncbi What do plasma and urinary measures of catecholamines tell us about human response to stressors?
    J E Dimsdale
    Department of Psychiatry, University of California San Diego, La Jolla
    Circulation 83:II36-42. 1991
    ..In response to stressors, diastolic blood pressure is better predicted by plasma levels of renin than of norepinephrine...
  29. ncbi Interleukin-6 and tumor necrosis factor-alpha production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways
    M U Goebel
    Department of Psychiatry, University of California, San Diego, La Jolla, USA
    Psychosom Med 62:591-8. 2000
    ....
  30. ncbi Does caffeine confound relationships among adrenergic tone, blood pressure and sleep apnoea?
    W A Bardwell
    Department of Psychiatry, University of California at San Diego, La Jolla, California 92093 0804, USA
    J Sleep Res 9:269-72. 2000
    ..While caffeine partially explains the increased adrenergic tone in patients with OSA and the relationship between BP and NE, it does not appear to contribute significantly to the relationship between OSA and elevated BP...
  31. ncbi Heredity and the autonomic nervous system in human hypertension
    D T O'Connor
    Departments of Medicine and Pharmacology and Center for Molecular Genetics, University of California, San Diego, and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Curr Hypertens Rep 2:16-22. 2000
    ..Such biochemical, physiologic, or pharmacologic autonomic traits may be especially valuable as phenotypic anchor points in linkage or association studies probing the genetic basis of human hypertension...
  32. ncbi Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function
    B P Kennedy
    Department of Medicine, University of California, San Diego Medical Center, San Diego, CA 92103 8341, USA
    J Neural Transm 111:547-67. 2004
    ..326), levels of synaptophysin (r=0.506), and negatively with tangles (r=-0.216 P=0.039). Elevated SAH in Alzheimer brain inhibits methyltransferases and is related to markers of disease progression and cognitive impairment...
  33. ncbi The effect of sleep apnea on plasma and urinary catecholamines
    J E Dimsdale
    Department of Psychiatry, University of California, San Diego, La Jolla 92093-0804, USA
    Sleep 18:377-81. 1995
    ..Plasma norepinephrine levels were not significantly elevated in apneic patients but were elevated in hypertensive patients both during sleep and in the morning (p < 0.05)...
  34. ncbi Human autonomic activity and its response to acute oxygen supplement after high altitude acclimatization
    Xuping Bao
    Division of Nephrology, Department of Medicine, University of California, San Diego, 200 W. Arbor Drive, San Diego, CA 92103-8341, USA
    Auton Neurosci 102:54-9. 2002
    ..Acute oxygen replacement rapidly counteracted the parasympathetic, but not sympathetic hyperactivity that occurs at high altitude...
  35. ncbi Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo
    Fangwen Rao
    Department of Medicine, University of California at San Diego, San Diego, Calif, USA
    Circulation 116:993-1006. 2007
    ....
  36. ncbi Role of the autonomic nervous system in the reduced maximal cardiac output at altitude
    Harm J Bogaard
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    J Appl Physiol 93:271-9. 2002
    ..Therefore, this study suggests that, whereas the ANS may affect HR at altitude, peak QT is unaffected by ANS blockade. We conclude that the effect of altered ANS function on HR is not the cause of the reduced maximal QT at altitude...
  37. ncbi Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion
    Yuqing Chen
    Department of Medicine, Center for Human Genetics and Genomics, University of California at San Diego, San Diego, California 92093, USA
    J Am Coll Cardiol 52:1468-81. 2008
    ..We aimed to determine whether the common variation at the chromogranin A (CHGA) locus increases susceptibility to hypertension...
  38. ncbi Reduction of adrenal and kidney epinephrine and phenylethanolamine N-methyltransferase in AP-2 knockout mouse fetuses
    Brian Kennedy
    Department of Medicine, University of California San Diego Medical Center, 200 West Arbor Drive, San Diego, California 92103-8341, USA
    Ann N Y Acad Sci 971:92-4. 2002
  39. ncbi Ultradian rhythms of autonomic, cardiovascular, and neuroendocrine systems are related in humans
    D S Shannahoff-Khalsa
    Department of Medicine, University of California, San Diego 92103 8341, USA
    Am J Physiol 270:R873-87. 1996
    ..87% of the comparisons (subject range, 18.05-48-9.70%) with r > 0.30. These results suggest that either a common oscillator (the hypothalamus) or mutually entrained oscillators regulate these systems...
  40. ncbi Nonselective beta blockade attenuates the recruitment of CD62L(-)T lymphocytes following exercise
    P J Mills
    Department of Psychiatry, University of California, San Diego, USA
    Eur J Appl Physiol Occup Physiol 79:531-4. 1999
    ....
  41. ncbi Leptin is related to epinephrine levels but not reproductive hormone levels in cycling African-American and Caucasian women
    P J Mills
    UCSD Medical Center, University of California, San Diego 92093, USA
    Life Sci 63:617-23. 1998
    ..38, p=0.01). No such relationship was observed in men. The findings indicate that in women leptin levels are not associated with cyclic changes in estrogen or progesterone but may be associated with catecholamine levels...
  42. ncbi Relationship of insulin, race, and hypertension with hemodynamic reactivity to a behavioral challenge
    R A Nelesen
    Department of Psychiatry, University of California, San Diego, La Jolla 92093-0804, USA
    Am J Hypertens 8:12-9. 1995
    ..On the other hand, insulin level interacted with blood pressure level and race on the underlying hemodynamics controlling blood pressure, namely total peripheral resistance and stroke volume.(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure
    Yuqing Chen
    Department of Medicine, University of California at San Diego, La Jolla, California 92093 0838, USA
    J Hypertens 28:76-86. 2010
    ..Here we systematically investigated DBH polymorphisms associated with enzymatic activity as well as autonomic and blood pressure (BP)/disease phenotypes in vivo...
  44. ncbi Ethnicity, perceived discrimination, and vascular reactivity to phenylephrine
    KaMala S Thomas
    San Diego State University and University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA
    Psychosom Med 68:692-7. 2006
    ..Individuals who perceived more discrimination had a larger increase in diastolic blood pressure in response to PE. CONCLUSION: These data suggest perceived discrimination is associated with increased blood pressure responsiveness to PE...
  45. ncbi Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity
    Tammy M Seasholtz
    Department of Pharmacology, University of California, San Diego, CA, USA
    Hypertension 47:937-47. 2006
    ....
  46. ncbi Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregivers
    Susan K Roepke
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
    Am J Geriatr Psychiatry 16:310-7. 2008
    ..This study examines the relationship between mastery and sympathetic arousal in elderly caregivers, as measured by norepinephrine (NE) reactivity to an acute psychological stressor...
  47. ncbi Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function
    Elizabeth O Lillie
    Department of Medicine, University of California at San Diego, USA
    Circulation 115:2282-91. 2007
    ..CHGA, a candidate gene for intermediate phenotypes that contribute to hypertension, shows a pattern of single nucleotide polymorphism variations that alter the expression and function of this gene both in vivo and in vitro...
  48. ncbi Blood pressure variability in obstructive sleep apnea: role of sympathetic nervous activity and effect of continuous positive airway pressure
    Xuping Bao
    Department of Medicine, University of California San Diego, 92103-8341, USA
    Blood Press Monit 7:301-7. 2002
    ..Sympathetic nervous activity, as inferred from daytime urine NE, is related to changes in BP variability in OSA patients. BP variability is not specifically affected by CPAP...
  49. ncbi Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers
    Kirstin Aschbacher
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla CA 92093 0680, USA
    Brain Behav Immun 22:493-502. 2008
    ....
  50. ncbi A truncated mouse phenylethanolamine N-methyltransferase splice variant with dominant-negative activity
    Xuping Bao
    Department of Medicine, University of California, San Diego, California 92103-8341, USA
    Ann N Y Acad Sci 971:89-91. 2002
  51. ncbi Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers
    Kirstin Aschbacher
    Department of Psychiatry, University of California, San Diego, USA
    J Affect Disord 116:80-7. 2009
    ..The primary objective was to investigate whether persistent depressive symptoms would relate to elevated platelet activation in response to acute psychological stress over a three-year period...
  52. ncbi Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism
    Fangwen Rao
    Department of Medicine, Center for Human Genetics and Genomics, University of California at San Diego, La Jolla, CA 92093 0838, USA
    Hypertension 49:1015-31. 2007
    ..Such functional links between adrenergic activity and glomerular injury suggest novel approaches to its prediction, prevention, diagnosis, and treatment...
  53. ncbi Selective peripheral regulation of noradrenaline and adrenaline release by nitric oxide
    Hamzeh H Elayan
    UCSD Medical Center, San Diego, California 92103-8341, USA
    Clin Exp Pharmacol Physiol 29:589-94. 2002
    ..Stimulation of alpha(1)-adrenoceptors plays a major role in the pressor response to electrical stimulation of L-NAME-treated rats, but this is not due to L-NAME augmentation of noradrenaline release from vascular sympathetic nerves...
  54. ncbi Population-based sample reveals gene-gender interactions in blood pressure in White Americans
    Brinda K Rana
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093, USA
    Hypertension 49:96-106. 2007
    ..Such genetic variants may define genetically and etiologically distinct subgroups of men and women with essential hypertension and may have implications for rational treatment selection...
  55. ncbi Ischemia- and agonist-induced changes in alpha- and beta-adrenergic receptor traffic in guinea pig hearts
    A S Maisel
    Department of Medicine, University of California, San Diego
    Am J Physiol 253:H1159-66. 1987
    ..These results indicate that alpha 1- and beta-adrenergic receptors may undergo a different cellular itinerary in guinea pig myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)..
  56. ncbi Contributions of the sympathetic nervous system, glutathione, body mass and gender to blood pressure increase with normal aging: influence of heredity
    B P Kennedy
    Department of Medicine and Center for Molecular Genetics, University of California at San Diego, CA 92093-0838, USA
    J Hum Hypertens 19:951-69. 2005
    ..Substantial h(2) for plasma GSH, NE, and urine NE suggests that such traits may be useful 'intermediate phenotypes' in the search for genetic determinants of BP...
  57. ncbi Catecholamines in human saliva
    B Kennedy
    Department of Medicine, University of California, San Diego Medical Center, 92103, USA
    Life Sci 69:87-99. 2001
    ..The finding that diffusion of blood NE into saliva takes roughly 1 hour to complete suggests that NE in saliva is a poor index of acute changes in sympathetic activity...
  58. ncbi Factitious pheochromocytoma: novel mimickry by Valsalva maneuver and clues to diagnosis
    M T Kailasam
    Department of Medicine, University of California, San Diego 92161, USA
    Am J Hypertens 8:651-5. 1995
    ..We reproduced, in part, the hemodynamic and biochemical manifestations of this presentation with Valsalva maneuver in healthy subjects...
  59. ncbi Impedance cardiography-derived hemodynamic responses during baroreceptor testing with amyl nitrite and phenylephrine: a validity and reliability study
    R A Nelesen
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Psychophysiology 36:105-8. 1999
    ..The pharmacological interventions demonstrated that IC measures followed the course predicted by the actions of the drugs. Change in PEP and dZ/dt reflected increased contractility. The BR sensitivity was also reproducible...
  60. ncbi Peripheral blood mononuclear cell-endothelial adhesion in human hypertension following exercise
    P J Mills
    Department of Psychiatry, University of California, San Diego 92103 0804, USA
    J Hypertens 18:1801-6. 2000
    ..To determine the effects of hypertension and exercise on interleukin-6 (IL-6) levels and mononuclear cell adhesion to endothelial cells...
  61. ncbi The effects of ethnic discrimination and socioeconomic status on endothelin-1 among blacks and whites
    Denise C Cooper
    Department of Psychiatry, University of California, San Diego, California, USA
    Am J Hypertens 22:698-704. 2009
    ..Stress is associated with increased endothelin-1 (ET-1). This study examined the relationship of ET-1 to socioeconomic status (SES) and to perceived ethnic discrimination among black (n = 51) and white (n = 65) adults (mean age 36.5)...
  62. ncbi Association between chronic caregiving stress and impaired endothelial function in the elderly
    Brent T Mausbach
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0680, USA
    J Am Coll Cardiol 55:2599-606. 2010
    ..We examined the relationship between chronic caregiving stress and endothelial function...
  63. ncbi Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse
    Xuping Bao
    Department of Medicine, University of California San Diego, USA
    Circulation 116:1024-31. 2007
    ..Epinephrine (EPI) is an important neurotransmitter and hormone. Its role in regulating cardiovascular function at rest and with stress is unclear, however...
  64. ncbi The potential anti-inflammatory benefits of improving physical fitness in hypertension
    Kate M Edwards
    Department of Psychiatry, UCSD Medical Center, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Hypertens 25:1533-42. 2007
    ..Here, exercise is promoted as a potentially effective treatment for both the elevated blood pressure and chronic inflammation found in hypertension...
  65. ncbi Inflammation and sleep in healthy individuals
    Paul J Mills
    Department of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA
    Sleep 30:729-35. 2007
    ..Inflammation is relatively common in individuals with a sleep disorder and is associated with quality of sleep. The purpose of this study was to examine whether inflammation is associated with quality of sleep in healthy individuals...
  66. ncbi Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension
    DANIEL T O'CONNOR
    Department of Medicine and Center for Molecular Genetics, University of California and V A San Diego Healthcare System, San Diego, California, USA
    J Hypertens 20:1335-45. 2002
    ....
  67. ncbi Adrenergic polymorphism and the human stress response
    Fangwen Rao
    Department of Medicine, University of California at San Diego, La Jolla, California 92093 0838, USA
    Ann N Y Acad Sci 1148:282-96. 2008
    ..The results suggest novel pathophysiological links between a key adrenergic locus, catecholamine metabolism, and blood pressure, and suggest new strategies to approach the mechanism, diagnosis, and treatment of systemic hypertension...
  68. ncbi Impaired chronotropic response to exercise in mice lacking catecholamines in adrenergic cells
    Xuping Bao
    Department of Medicine, University of California San Diego, San Diego, California 92103 8341, USA
    Ann N Y Acad Sci 1148:297-301. 2008
    ..Thus, our data suggest that adrenergic CA is required for normal chronotropic responses to stress, but not required for prenatal and postnatal development or normal cardiovascular function at rest...
  69. ncbi Endothelial function: the impact of objective and subjective socioeconomic status on flow-mediated dilation
    Denise C Cooper
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Ann Behav Med 39:222-31. 2010
    ..Although objective and subjective indicators of socioeconomic status (SES) are linked to cardiovascular disease (CVD), little is known about their relationship to endothelial dysfunction, which often precedes CVD...
  70. ncbi Adverse impact of mood on flow-mediated dilation
    Denise C Cooper
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Psychosom Med 72:122-7. 2010
    ..Substantial literature indicates that negative mood is linked to cardiovascular disease (CVD). However, the mechanisms underlying this relationship are not well defined. CVD is often preceded by dysfunction of the endothelium...
  71. ncbi A comparison of pharmacologic and spontaneous baroreflex methods in aging and hypertension
    Milos Milic
    Department of Medicine, University of California at San Diego, San Diego, California 92103 8341, USA
    J Hypertens 27:1243-51. 2009
    ..We also examined whether heart rate variability (HRV) provides as much information as does BRS...
  72. ncbi Sleep and health-related quality of life in heart failure
    Paul J Mills
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Congest Heart Fail 15:228-33. 2009
    ..01) (model adjusted R(2)=.732; P<.001). Findings provide evidence that in addition to functional status and ongoing fatigue, poorer quality of life in HF is independently related to the severity of sleep-disordered breathing...
  73. ncbi Racial differences in the impact of social support on nocturnal blood pressure
    Denise C Cooper
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, 0804, La Jolla, CA 92093 0804, USA
    Psychosom Med 71:524-31. 2009
    ..To investigate whether black and white adults benefit similarly from perceived social support in relation to blood pressure (BP) dipping during sleep...
  74. ncbi Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis
    Yuqing Chen
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0838, USA
    J Am Soc Nephrol 20:1623-32. 2009
    ..In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function...
  75. ncbi The roles of TNF-alpha and the soluble TNF receptor I on sleep architecture in OSA
    Herbert J Yue
    Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Sleep Breath 13:263-9. 2009
    ..We hypothesized that the TNF receptor might play an important role in the inflammation as well as sleep architecture changes in patients with OSA...
  76. ncbi Job strain, ethnicity, and sympathetic nervous system activity
    KaMala S Thomas
    San Diego State University, CA, USA
    Hypertension 44:891-6. 2004
    ..These findings suggest possible mechanisms by which job strain may be associated with cardiovascular disease...
  77. ncbi Vulnerable caregivers of Alzheimer disease patients have a deficit in beta 2-adrenergic receptor sensitivity and density
    Paul J Mills
    Department of Psychiatry, University of California San Diego, 92103 0804, USA
    Am J Geriatr Psychiatry 12:281-6. 2004
    ..The authors examined the effects of being a spousal caregiver of a patient with Alzheimer disease (AD) on the lymphocyte beta(2)-adrenergic receptor...
  78. ncbi Hormone replacement therapy increases renal kallikrein excretion in healthy postmenopausal women
    Noha H Farag
    Department of Psychiatry, UCSD Medical Center, University of California, 200 West Arbor Drive, CTF A, 415, San Diego, La Jolla, CA 92103 0804, USA
    Life Sci 72:1279-88. 2003
    ....
  79. ncbi Effects of regular exercise on lymphocyte subsets and CD62L after psychological vs. physical stress
    Suzi Hong
    Department of Psychiatry, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA, USA
    J Psychosom Res 56:363-70. 2004
    ..To examine the effects of regular physical activity on lymphocyte responses to a speech stressor and an exercise challenge...
  80. ncbi Immune cell CD62L and CD11a expression in response to a psychological stressor in human hypertension
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Brain Behav Immun 17:260-7. 2003
    ..Exposure to repeated psychological stressors may further augment this potentially adverse circulatory environment...
  81. ncbi Relationship of systolic blood pressure with plasma homocysteine: importance of smoking status
    Brian P Kennedy
    Department of Medicine, University of California, San Diego Medical Center, California 92103 8341, USA
    J Hypertens 21:1307-12. 2003
    ..Elevated plasma homocysteine is a risk factor for cardiovascular disease. Elevations in plasma homocysteine occur in both smokers and hypertensives, but the combined effect of smoking and hypertension on homocysteine is unknown...
  82. ncbi The catecholamine release-inhibitory "catestatin" region of chromogranin a: early decline in humans at genetic risk of hypertension
    Mala T Kailasam
    Department of Medicine and Center for Molecular Genetics, University of California, and VA San Diego Healthcare System, San Diego, California 92037, USA
    Ann N Y Acad Sci 971:533-5. 2002
  83. ncbi Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovascular responses in obstructive sleep apnea
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    J Appl Physiol 100:343-8. 2006
    ..01). The findings indicate that one of the mechanisms through which CPAP reduces NE levels is through an increase in the clearance of NE from the circulation...
  84. ncbi Catecholamine secretory vesicle stimulus-transcription coupling in vivo. Demonstration by a novel transgenic promoter/photoprotein reporter and inhibition of secretion and transcription by the chromogranin A fragment catestatin
    Sushil K Mahata
    Department of Medicine and Center for Molecular Genetics, University of California, and Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Biol Chem 278:32058-67. 2003
    ..Catestatin itself blocks stimulation of both secretion and transcription in vivo. Thus, chromogranin A and its catestatin fragment may lie at the nexus of nicotinic cholinergic signaling in vivo...
  85. ncbi Physical fitness attenuates leukocyte-endothelial adhesion in response to acute exercise
    Paul J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    J Appl Physiol 101:785-8. 2006
    ..The findings provide evidence of how physical fitness might protect individuals from inflammatory responses to exercise...
  86. ncbi Beta-adrenergic or parasympathetic inhibition, heart rate and cardiac output during normoxic and acute hypoxic exercise in humans
    Susan R Hopkins
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Physiol 550:605-16. 2003
    ..It may be that cardiac alpha receptors play a primary role in elevating HR and Qt during hypoxic exercise, or perhaps offer an alternative mechanism when other ANS pathways are blocked...
  87. ncbi The effects of spaceflight on adrenergic receptors and agonists and cell adhesion molecule expression
    Paul J Mills
    Department of Psychiatry and Medicine, University of California, San Diego, La Jolla, CA 92103, USA
    J Neuroimmunol 132:173-9. 2002
    ..05). The data suggest that spaceflight leads to an environment that would support reduced leukocyte-endothelial adhesion. Sympathetic activation may contribute to this phenomenon...
  88. ncbi Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer disease
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, CA 92093 0682, USA
    Sleep 29:1347-52. 2006
    ..In this study, we examined if sleep disturbance of elderly caregivers was associated with physiologic markers of cardiovascular risk, including plasma norepinephrine, epinephrine, and the hemostasis marker D-dimer...
  89. ncbi Depressive symptoms predict norepinephrine response to a psychological stressor task in Alzheimer's caregivers
    Brent T Mausbach
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
    Psychosom Med 67:638-42. 2005
    ..The current study examined the relations between the level of depressive symptoms in spousal caregivers and the physiological response to a psychological stress task...
  90. ncbi Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure
    Daniel Norman
    Department of Medicine, School of Medicine, University of California, San Diego, CA, USA
    Hypertension 47:840-5. 2006
    ..We conclude that CPAP therapy reduces both daytime and nighttime blood pressure in patients with OSA, perhaps through mechanisms other than improvement of nocturnal oxyhemoglobin saturation...
  91. ncbi Hypertensives' pressor response to norepinephrine. Analysis by infusion rate and plasma levels
    M G Ziegler
    Department of Medicine, University of California, San Diego
    Am J Hypertens 4:586-91. 1991
    ..Analysis of pressor responses to plasma NE levels demonstrated that the hypertensives had an exaggerated pressor response to NE...
  92. ncbi Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration
    P J Mills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92103 0804, USA
    Psychosom Med 63:886-90. 2001
    ..The objective of this study was to determine the effects of spaceflight duration on immune cells and their relationship to catecholamine levels...
  93. ncbi Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure
    Y Chen
    Department of Medicine, Center for Human Genetics and Genomics, University of California at San Diego, San Diego, California 92093 0838, USA
    Kidney Int 74:115-25. 2008
    ..Our results suggest that common genetic variants in the CHGA promoter may regulate heritable changes in blood pressure...
  94. ncbi Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease
    B P Kennedy
    Department of Medicine, University of California, San Diego Medical Center, San Diego, CA 92103, USA
    J Neural Transm 110:789-801. 2003
    ..We conclude that the changes in MAO A and B in the prefrontal cortex occur very early in Alzheimer's disease and remain relatively constant as the disease progresses...
  95. ncbi Catecholamine storage vesicle protein expression in genetic hypertension
    D T O'Connor
    Department of Medicine, Center for Molecular Genetics, University of California, V A San Diego Healthcare System, USA
    Blood Press 8:285-95. 1999
    ..In one rodent model (the SHR), over-expression of chromogranin A is largely controlled by a single genetic locus, but the chromogranin A locus itself is not directly linked to determination of the blood pressure elevation of the SHR...
  96. ncbi Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension
    Steven H Platts
    NASA JSC
    Aviat Space Environ Med 75:554-6. 2004
    ..This is the first report showing that midodrine has the potential to improve post-spaceflight orthostatic hypotension and suggesting that reduced venous return contributes to the etiology...
  97. ncbi Does obstructive sleep apnea increase hematocrit?
    Jong Bae Choi
    Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Kyunggi-do, South Korea
    Sleep Breath 10:155-60. 2006
    ..05). The severity of OSA is significantly associated with increased hematocrit, even after controlling for possible confounding variables. However, nocturnal hypoxemia in OSA does not usually lead to clinical polycythemia...
  98. ncbi Attenuation of T-lymphocyte demargination and adhesion molecule expression in response to moderate exercise in physically fit individuals
    Suzi Hong
    Department of Psychiatry, University of California, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    J Appl Physiol 98:1057-63. 2005
    ..Being physically fit may offset exaggerated immune cell responses to stress...