Research Topics
Genomes and Genes | Jing ZhangSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Proteomics of human neurodegenerative diseasesJing Zhang
Department of Pathology, University of Washington, Harborview Medical Centre, Seattle, Washington 98104, USA
J Neuropathol Exp Neurol 67:923-32. 2008..Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases...- Identification of glycoproteins in human cerebrospinal fluidHye Jin Hwang
Department of Pathology, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA, USA
Methods Mol Biol 566:263-76. 2009..This review centers on the technical details involved in various steps in sample preparation as well as proteomic analysis of CSF glycoproteins... - Proteomic biomarker discovery in cerebrospinal fluid for neurodegenerative diseasesJing Zhang
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Alzheimers Dis 8:377-86. 2005..Great attention has been directed to practical considerations and limitations of several major aspects of proteomic analysis of human CSF... - Proteomics of human cerebrospinal fluid - the good, the bad, and the uglyJing Zhang
Division of Neuropathology, Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
Proteomics Clin Appl 1:805-19. 2007..The potential future directions of CSF proteomics are also discussed with this analysis... - Quantitative proteomic analysis of age-related changes in human cerebrospinal fluidJing Zhang
Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
Neurobiol Aging 26:207-27. 2005..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases... - Proteomic approach to studying Parkinson's diseaseJing Zhang
University of Washington and Institute for Systems Biology, Seattle, WA
Mol Neurobiol 29:271-88. 2004..This review summarizes the current related research fields and proposes a proteomic approach to investigate the mechanisms that may dictate alpha-synuclein aggregation, Lewy body formation, and neurodegeneration... - Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunctionJing Zhang
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Neurochem 84:336-46. 2003.... - Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progressionMin Shi
Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
Ann Neurol 69:570-80. 2011..We and others have demonstrated that a decrease in DJ-1 and/or ?-synuclein in the cerebrospinal fluid (CSF) is a potential index for Parkinson disease diagnosis, but not for PD severity... - Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson diseaseJinghua Jin
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Mol Cell Proteomics 5:1193-204. 2006..Manipulations of mortalin level in dopaminergic neurons resulted in significant changes in sensitivity to PD phenotypes via pathways involving mitochondrial and proteasomal function as well as oxidative stress... - Analysis of alpha-synuclein-associated proteins by quantitative proteomicsYong Zhou
Department of Pathology and Medicinal Chemistry, University of Washington School of Medicine, Seattle, Washington 98104, USA
J Biol Chem 279:39155-64. 2004..Furthermore, the protection afforded by hsp70 transfection appeared to be related to suppression of rotenone-induced oxidative stress as well as mitochondrial and proteasomal dysfunction... - Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cellsJinghua Jin
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
BMC Neurosci 8:67. 2007..A comprehensive analysis of the mitochondrial protein expression profile affected by rotenone can provide important insight into the role of mitochondrial dysfunction in PD... - DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's diseaseZhen Hong
Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
Brain 133:713-26. 2010..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration... - Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's diseaseMin Shi
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Neurosci Lett 480:78-82. 2010..In conclusion, unlike in cerebrospinal fluid, total DJ-1 or alpha-synuclein in plasma alone is not useful as biomarkers for Parkinson's disease diagnosis or progression/severity... - Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's diseaseRandall L Woltjer
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA
FASEB J 19:1923-5. 2005..These results are consistent with the amyloid hypothesis of AD and extend it to include widespread protein insolubility, not exclusively Abeta insolubility, early in AD pathogenesis even before the onset of clinical dementia... - Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer diseaseJing Zhang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
J Alzheimers Dis 7:125-33; discussion 173-80. 2005.... - Characterization of proteome of human cerebrospinal fluidJing Xu
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Int Rev Neurobiol 73:29-98. 2006 - CSF A?(42) and tau in Parkinson's disease with cognitive impairmentThomas J Montine
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Mov Disord 25:2682-5. 2010..01), whereas average CSF T-tau and P181-tau were unchanged or decreased. One-third of PD-CIND and one-half of PD-D patients had the biomarker signature of AD. Abnormal metabolism of A?(42) may be a common feature of PD-CIND and PD-D... - A role for a novel protein, nucleolin, in Parkinson's diseaseW Michael Caudle
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, United States
Neurosci Lett 459:11-5. 2009..Interestingly, nucleolin expression did not influence mitochondrial complex I activity, suggesting a selective specificity for oxidative stress and proteasomal pathways... - Mortalin: a protein associated with progression of Parkinson disease?Min Shi
Department of Pathology, University of Washington, School of Medicine, Seattle, Washington, USA
J Neuropathol Exp Neurol 67:117-24. 2008..Of those, mortalin, a mitochondrial protein, was decreased in the advanced PD cases and was further validated to be decreased using independent techniques. These results suggest a role for mortalin in PD progression... - Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophyYu Wang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Pathol 178:1509-16. 2011..Both C3 and FH correlated with the severity of impairment in AD as indicated using Mini-Mental State Examination scores... - Oligomeric alpha-synuclein inhibits tubulin polymerizationLeo Chen
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
Biochem Biophys Res Commun 356:548-53. 2007..Finally, we demonstrated that neurotoxicity induced by oligomeric alpha-synuclein was largely prevented by overexpressing the neuroprotective protein, DJ-1... - Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding proteinQin Wang
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, Washington 98105, USA
FASEB J 19:869-71. 2005.... - Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synucleinJinghua Jin
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
J Neuroinflammation 4:2. 2007..It has been demonstrated that aggregated alpha-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated alpha-synuclein activates microglia are not understood fully... - Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progressionMin Shi
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Pathol 175:54-65. 2009..These results have, for the first time, suggested that the levels of glutathione S-transferase Pi may play an important role in modulating the progression of PD... - A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometrySheng Pan
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Proteomics 7:469-73. 2007..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date... - Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's diseaseJinghua Jin
Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
Brain Res Mol Brain Res 134:119-38. 2005..In addition, DJ-1 was present in the halo but not in the core of classical LBs in patients with PD. Our findings suggested that DJ-1 might play an important role in mitochondrial dysfunction, as well as LB formation in PD... - Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicityPatrick McLaughlin
Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
Glia 53:567-82. 2006..SWR/J microglia with semiquantitative Western blot. Further analysis of our proteomic discovery data will likely reveal numerous novel proteins involved in inflammation-mediated neurotoxicity in PD... - CSF multianalyte profile distinguishes Alzheimer and Parkinson diseasesJing Zhang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Clin Pathol 129:526-9. 2008..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD... - Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsyWan Yang
Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
Am J Pathol 171:993-1002. 2007..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy... - Glycoproteomics in neurodegenerative diseasesHyejin Hwang
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Mass Spectrom Rev 29:79-125. 2010.... - Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approachSheng Pan
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Proteome Res 5:2769-79. 2006..This investigation, for the first time, not only categorized many glycoproteins in human CSF but also expanded the existing overall CSF protein database... - Proteomic identification of novel proteins in cortical lewy bodiesJames B Leverenz
Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
Brain Pathol 17:139-45. 2007..Further investigation of these novel candidates is also necessary to ensure that the potential proteins in cortical LBs are not identified incorrectly because of incomplete current human protein database... - Biomarker discovery in neurodegenerative diseases: a proteomic approachMin Shi
Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
Neurobiol Dis 35:157-64. 2009.... - Mass spectrometry based targeted protein quantification: methods and applicationsSheng Pan
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Proteome Res 8:787-97. 2009..This report reviews recently developed platform technologies for emerging applications of clinical proteomics and biomarker development... - Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's diseaseJames B Leverenz
Mental Illness Research, Education, and Clinical Center of Veterans Administration, Seattle, WA, USA
Parkinsonism Relat Disord 17:61-4. 2011.... - Identification of novel proteins associated with both alpha-synuclein and DJ-1Jinghua Jin
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Mol Cell Proteomics 6:845-59. 2007..Further characterization of these docking proteins will likely shed more light on the mechanisms by which DJ-1 modulates the function of alpha-synuclein, and vice versa, in the setting of PD... - Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's diseaseThomas J Montine
Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
NeuroRx 3:336-43. 2006..As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases... - Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletionRobert C Rostomily
Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
J Proteome Res 9:2610-8. 2010..Future analysis of larger patient samples are warranted to further refine biomarker panels to predict biological behavior and assist in the identification of deleted gene products that define the 1p/19q phenotype... - Identification of proteins involved in microglial endocytosis of alpha-synucleinJun Liu
Departments of Pathology and Materials Science and Engineering, University of Washington School of Medicine, Seattle, Washington 98104, USA
J Proteome Res 6:3614-27. 2007.... - Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platformSheng Pan
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Proteome Res 7:720-30. 2008.... - Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometerSheng Pan
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Mol Cell Proteomics 6:1818-23. 2007..Finally 140 proteins found in the cortical proteome were present in the proteome of cerebrospinal fluid, providing tissue-specific candidates for biomarker discovery in body fluid... - Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairmentJennifer L Bayer-Carter
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 68:743-52. 2011.... - Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body diseaseJoshua P Fessel
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Neurochem 85:645-50. 2003.... - Using 'omics' to define pathogenesis and biomarkers of Parkinson's diseaseW Michael Caudle
University of Washington, Seattle, WA, USA
Expert Rev Neurother 10:925-42. 2010..It is hoped that further integration of these techniques will yield a more comprehensive understanding of Parkinson's disease etiology and the biological pathways that mediate neurodegeneration... - Isoprostanes and related products of lipid peroxidation in neurodegenerative diseasesKathleen S Montine
Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, 325 9th Ave, Seattle, WA 98104, USA
Chem Phys Lipids 128:117-24. 2004..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD... - Microglial activation induced by neurodegeneration: a proteomic analysisYong Zhou
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Mol Cell Proteomics 4:1471-9. 2005..The search revealed numerous novel proteins that are potentially important in neurodegeneration-mediated microglial activation, a process believed to be critical in Parkinson disease progression... - Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative diseaseW Michael Caudle
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
Proteomics Clin Appl 2:1484-97. 2008.... - Identification of proteins in human substantia nigraEfstathia Kitsou
Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA
Proteomics Clin Appl 2:776-82. 2008..Further characterization of the SNpc proteome will significantly facilitate our understanding of the function and expression of proteins involved in PD, as well as provide potential proteins that may be utilized as biomarkers... - Salivary tau species are potential biomarkers of Alzheimer's diseaseMin Shi
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
J Alzheimers Dis 27:299-305. 2011..These results suggest that salivary tau species could be ideal biomarkers for AD diagnosis, especially at early stages of the disease or even screening asymptomatic subjects, allowing for a much larger therapeutic window for AD patients... - Biomarkers for cognitive impairment in Parkinson diseaseMin Shi
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Brain Pathol 20:660-71. 2010..The current findings and perspectives of applying these strategies and techniques are reviewed in this article, together with potential areas of advancement... - Biomarkers for Alzheimer's diseaseJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
Expert Rev Neurother 7:1021-8. 2007..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD... - Phosphorylated ?-synuclein in Parkinson's diseaseYu Wang
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
Sci Transl Med 4:121ra20. 2012.... - Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridineGuangyu Gu
Division of Neuropathology, Department of Pathology, University of Washington School of Medicine, Box 359660, Harborview Medical Center, Seattle, WA 98104, USA
Biochem Biophys Res Commun 308:197-205. 2003..None of these six genes are encoded by mitochondrial DNA. The potential significance of these gene alterations in the context of Parkinson's disease is discussed... - SNCA variant associated with Parkinson disease and plasma alpha-synuclein levelIgnacio F Mata
Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Mailstop S 182, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 67:1350-6. 2010..A functional repeat polymorphism in the SNCA promoter (REP1) conveys susceptibility for Parkinson disease (PD). There is also increasing evidence that single-nucleotide polymorphisms (SNPs) elsewhere in the gene are associated with PD risk... - Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disordersGuangyu Gu
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561, USA
J Neuropathol Exp Neurol 61:634-9. 2002..These data suggest that accumulation of total mtDNA deletions/rearrangements is a relatively specific characteristic of PD and may be one of the contributing factors leading to mitochondrial dysfunction and neurodegeneration in PD... - Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticidesVanessa A Fitsanakis
Departments of Pathology and Pharmacology and Centers for Molecular Toxicology and Molecular Neurosciences, Vanderbilt University Medical Center, Nashville, TN, USA
Free Radic Biol Med 33:1714-23. 2002..Our results point to the potential for manganese- and zinc-containing EBDC pesticides to promote oxidative stress in catecholaminergic regions of the brain... - Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolismElizabeth A Stoll
Neurobiology and Behavior Program, University of Washington, Seattle, Washington 98109, USA
J Biol Chem 286:38592-601. 2011..These results demonstrate that aging NPCs display an altered metabolic phenotype, characterized by a coordinated shift in protein expression, subcellular structure, and metabolic physiology... - Mitochondrial therapeutics in Alzheimer's disease and Parkinson's diseaseJake G Hoekstra
Department of Pathology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
Alzheimers Res Ther 3:21. 2011..Recent discoveries pertaining to mitochondrial dynamics reveal that regulation of mitochondrial fission and fusion may play a key role in the pathogenesis of these diseases and consequently could be novel future therapeutic targets... - DJ-1 and ?SYN in LRRK2 CSF do not correlate with striatal dopaminergic functionMin Shi
Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
Neurobiol Aging 33:836.e5-7. 2012.... - UniPep--a database for human N-linked glycosites: a resource for biomarker discoveryHui Zhang
Institute for Systems Biology, Seattle, WA 98103, USA
Genome Biol 7:R73. 2006..Here, we describe UniPep http://www.unipep.org--a database of human N-linked glycosites--as a resource for biomarker discovery... - Predominant release of lysosomal enzymes by newborn rat microglia after LPS treatment revealed by proteomic studiesJun Liu
Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiatong University School of Medicine, Shanghai, China
J Proteome Res 7:2033-49. 2008.... - Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutaseYe Xiong
Institute of Environmental Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
J Neurochem 95:732-44. 2005..In conclusion, our results imply that mitochondrial dysfunction induced by superoxide anion radical contributes to lesion formation in mouse brain following physical trauma... - Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humansRudy J Castellani
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Neurosci Lett 319:25-8. 2002..These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation... - Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activationKenneth W Hewett
Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, United States
Cardiovasc Res 67:548-60. 2005..This abnormality in myocardial Cx40 led us to address whether 4-week-old HF-1b knockout postnates display other disruptions to ventricular structure and function... - Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's diseaseWei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 19:533-42. 2005..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity... - Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disordersFadi Abdi
Applied Biosystems, Framingham, MA, USA
J Alzheimers Dis 9:293-348. 2006.... - Exploring candidate genes for human brain diseases from a brain-specific gene networkBing Liu
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China
Biochem Biophys Res Commun 349:1308-14. 2006..And the higher score a gene has, the more likely this gene is a disease-related one. The results suggest that the proposed method is effective, convenient, and applicable in the future genetic studies... - Aquaporin 4 regulates the effects of ovarian hormones on monoamine neurotransmissionXiu Lan Sun
Laboratory of Reproductive Medicine and Neuropharmacology, Department of Anatomy, Histology and Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, PR China
Biochem Biophys Res Commun 353:457-62. 2007..These findings reveal for the first time that AQP4 regulates not only water and ion homeostasis but also the functions of ovarian hormone and neurotransmitter... - Proteomic discovery of CSF biomarkers for Alzheimer's diseaseJing Zhang
Ann Neurol 61:497; author reply 497-8. 2007 - Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synucleinWei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
Glia 55:1178-88. 2007..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein... - Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neuronsXiaochun Chen
Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
Brain Res 1200:99-106. 2008..The present study suggests that Ca(2+), calpain, and p25 in CDK5 pathway may play important roles in Abeta(25-35)-induced tau hyperphosphorylation... - Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivoJing Zhang
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 102:14605-10. 2005..Taken together, our data identify K-ras as the major regulator for cytokine-dependent Akt activation, which is important for erythroid differentiation in vivo... - The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylationChun Shui Pan
Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034, China
Peptides 28:900-9. 2007.... - Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathwaysWei Tong
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Blood 105:4604-12. 2005..Hence, Lnk, through its SH2 domain, negatively modulates EpoR signaling by attenuating JAK2 activation, and regulates Epo-mediated erythropoiesis... - Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiencyJing Zhang
Division of Hematology, Washington University, St Louis, MO, USA
Blood 111:4973-8. 2008..The studies in mice suggest that human PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype... - Effect of relaxin on myocardial ischemia injury induced by isoproterenolJing Zhang
Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
Peptides 26:1632-9. 2005.... - Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicityAndis Klegeris
Unit of Biology and Physical Geography, Barber School of Arts and Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
Glia 56:675-85. 2008..We found both to be partially protective in a concentration-dependent manner. Inhibition of PEP may be a therapeutic approach to neurodegenerative disorders including Alzheimer and Parkinson diseases... - [Influence of nanosized TiO2 catalyzed ozonation on the ammonia concentration in Songhua River water]Sheng Jun Wang
School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
Huan Jing Ke Xue 28:2520-5. 2007..While the increase of temperature yielded an increase of ammonia removal efficiency when using TiO2/zeolite as the catalyst... - SHIP2 controls PtdIns(3,4,5)P(3) levels and PKB activity in response to oxidative stressJing Zhang
Institut de Recherche Interdisciplinaire IRIBHM, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
Cell Signal 19:2194-200. 2007..We conclude that SHIP2 lipid phosphatase activity plays an important role in the metabolism PtdIns(3,4,5)P(3) which is demonstrated in oxygen stressed cells... - Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young ratsMingyi Wang
Laboratory of Cardiovascular Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr, 3-B-03, Baltimore, MD 21224-6825, USA
Am J Pathol 167:1429-42. 2005..Thus, Ang II-induced effects on MMP2, transforming growth factor-beta1, collagen, and VSMCs are central to the arterial remodeling that accompanies advancing age... - Fragile X-related proteins regulate mammalian circadian behavioral rhythmsJing Zhang
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Am J Hum Genet 83:43-52. 2008.... - Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microgliaXiao Dong Pan
Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, People s Republic of China
Biochem Pharmacol 76:362-72. 2008..Therefore, it is potentially a highly effective therapeutic agent in treating neuroninflammatory diseases... - [Studies on the antioxidative activity of polysaccharides from radix Saposhnikoviae]Ze Qing Zhang
Department of Food Engineering, Shanxi Normal University, Xi an 710062, China
Zhong Yao Cai 31:268-72. 2008..To research the antioxidant activity of polysaccharides from Saposhnikovia divaricata (Turez.) Schischk... - [Degradation of trace nitrobenzene by nanosized TiO2 catalyzed ozonation]Yi-xin Yang
School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
Huan Jing Ke Xue 27:2028-34. 2006..It was also observed that both ozonation and catalytic ozonation were significantly influenced by tert-butyl alcohol, which testified that nanosized TiO2 catalyzed ozonation of nitrobenzene follows a radicaltype mechanism... - [Difference analysis on proteome of Helicobacter pylori in patients with peptic ulcer, gastritis, and gastric cancer]Jing Zhang
Department of Gastroenterology, Third Hospital, Peking University, Beijing 100083, China
Zhonghua Yi Xue Za Zhi 86:2690-4. 2006..pylori. Proteomics technology has a widespread perspective in the field of relationship between pathogenic bacteria and gastric cancer... - Ginsenoside Rg1 delays tert-butyl hydroperoxide-induced premature senescence in human WI-38 diploid fibroblast cellsXiaochun Chen
Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, PR China
J Gerontol A Biol Sci Med Sci 63:253-64. 2008..These data indicate that ginsenoside Rg1 has an anti-aging effect on t-BHP-induced premature senescence in WI-38 cells. This effect may be mediated by regulating cell cycle proteins and enhancing mitochondrial functioning... - Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis miceJing Zhang
Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
J Neurosci Res 84:587-95. 2006..Our findings indicate that hBMSCs improve functional recovery and may provide a potential therapy aimed at axonal protection in EAE mice, in which NGF may play a vital role... - Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wallMingyi Wang
Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 6825, USA
Arterioscler Thromb Vasc Biol 26:1503-9. 2006..To study matrix metalloproteinase 2 (MMP-2) effects on transforming growth factor-beta1 (TGF-beta1) activation status and downstream signaling during arterial aging... - UV Raman spectroscopic study on TiO2. I. Phase transformation at the surface and in the bulkJing Zhang
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, P. O. Box 110, Dalian 116023, China
J Phys Chem B 110:927-35. 2006.... - [Impacts of AOC by O3/TiO2 catalytic oxidation in drinking water]Tao Liang
School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
Huan Jing Ke Xue 28:2004-8. 2007..In the processes, AOC-NOX consisting of carboxyl acid mostly increased rapidly, resulting in increase of the proportion of AOC-NOX in AOC over 90% and the majority of AOC turned from AOC-P17 to AOC-NOX...
Research Grants
- DITHIOCARBAMATE PESTICIDES IN PARKINSON'S DISEASEJing Zhang; Fiscal Year: 2003..The new information will shed more light on the mechanisms by which pesticides interact with aging and genetic vulnerability thereby contributing to development and progression of PD. ..
- Biomarkers for Preclinical Parkinson's diseaseJing Zhang; Fiscal Year: 2010..This proposal, if successful, can significantly increase the therapeutic window for Parkinson's patients. ..
- Microglial Phox Activity In Parkinson's DiseaseJing Zhang; Fiscal Year: 2010..Elucidation of the mechanisms involved in this interplay may yield new therapies for the devastating disease. ..
- Detecting Biomarkers in Plasma for Diagnosing Neurodegenerative DiseasesJing Zhang; Fiscal Year: 2007....
- Biomarkers for Parkinson's Disease (PD) and PD DementiaJing Zhang; Fiscal Year: 2007..abstract_text> ..
- Proteomic Studies in Parkinson's DiseaseJing Zhang; Fiscal Year: 2007....
- Post-translational Modifications of Proteins in Parkinson?s diseaseJing Zhang; Fiscal Year: 2010..Identification of these makers can increase therapeutic window for Parkinson's patients at risk for developing dementia that is associated with mortality, caregiver burden and risk for nursing home admission. ..