Mingtao Zeng

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, New York 14642, USA
    Vaccine 25:3588-94. 2007
  2. ncbi Detoxified lethal toxin as a potential mucosal vaccine against anthrax
    Qingfu Xu
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Vaccine Immunol 15:612-6. 2008
  3. ncbi Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing
    Qingfu Xu
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Int J Pediatr Otorhinolaryngol 75:239-44. 2011
  4. ncbi Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore
    Qingfu Xu
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Microb Pathog 43:37-45. 2007
  5. ncbi Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung
    Maria T Arévalo
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    FEMS Immunol Med Microbiol 55:346-51. 2009
  6. ncbi N-fragment of edema factor as a candidate antigen for immunization against anthrax
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Vaccine 24:662-70. 2006
  7. ncbi Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Vaccine 25:7540-8. 2007
  8. ncbi Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media
    Ravinder Kaur
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
    Pediatr Infect Dis J 29:741-5. 2010
  9. ncbi Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children
    Qingfu Xu
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Emerg Infect Dis 15:547-51. 2009
  10. ncbi Adherence of Streptococcus pyogenes to human epithelial cells is modulated by Haemophilus influenzae
    Qingfu Xu
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Scand J Infect Dis 41:244-51. 2009

Research Grants

  1. Multi-component and easily administrated anthrax vaccine
    Mingtao Zeng; Fiscal Year: 2003
  2. New genetic vaccine to protect aganist botulism
    Mingtao Zeng; Fiscal Year: 2004
  3. Genetic immunization against pneumococcal disease
    Mingtao Zeng; Fiscal Year: 2004
  4. Development of a New Tularemia Vaccine
    Mingtao Zeng; Fiscal Year: 2006

Collaborators

Detail Information

Publications10

  1. ncbi Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, New York 14642, USA
    Vaccine 25:3588-94. 2007
    ..anthracis Sterne spores. The data suggests that intranasal administration may be an effective immunization modality for an improved immunization program against anthrax...
  2. ncbi Detoxified lethal toxin as a potential mucosal vaccine against anthrax
    Qingfu Xu
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Vaccine Immunol 15:612-6. 2008
    ..The data suggest that mLF and PA63 have a mutual enhancement effect for evoking systemic and mucosal immune responses and that the detoxified lethal toxin can be used as an efficient mucosal vaccine against anthrax...
  3. ncbi Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing
    Qingfu Xu
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Int J Pediatr Otorhinolaryngol 75:239-44. 2011
    ..This study aimed to develop a combined molecular method to accurately detect these otopathogens...
  4. ncbi Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore
    Qingfu Xu
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Microb Pathog 43:37-45. 2007
    ..These results suggest that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells...
  5. ncbi Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung
    Maria T Arévalo
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    FEMS Immunol Med Microbiol 55:346-51. 2009
    ..pneumoniae strain D39 colonization in mouse lungs. Taken together, these data demonstrate the feasibility of developing a mucosal vaccine against S. pneumoniae using recombinant adenoviruses for antigen delivery...
  6. ncbi N-fragment of edema factor as a candidate antigen for immunization against anthrax
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Vaccine 24:662-70. 2006
    ..Our data suggest that EF plays a role in eliciting protective immunity against anthrax, and that it should be included in a new generation multi-component subunit vaccine...
  7. ncbi Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Vaccine 25:7540-8. 2007
    ..The data suggest that an adenovirus-vectored genetic vaccine is a highly efficient prophylaxis candidate against botulism...
  8. ncbi Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media
    Ravinder Kaur
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
    Pediatr Infect Dis J 29:741-5. 2010
    ..Conventional culture methods detect these pathogens in only 60% to 70% of cases of AOM. Alloiococcus otitidis, another potential pathogen, has often been ignored...
  9. ncbi Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children
    Qingfu Xu
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Emerg Infect Dis 15:547-51. 2009
    ..pneumoniae in which all strains had 6 of the same alleles as ST-156. The multidrug-resistant strains related to ST-156 expressed different capsular serotypes: 9V, 14, 11A, 15C, and 19F...
  10. ncbi Adherence of Streptococcus pyogenes to human epithelial cells is modulated by Haemophilus influenzae
    Qingfu Xu
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Scand J Infect Dis 41:244-51. 2009
    ..influenzae. These results indicate that increases of S. pyogenes adherence to epithelial cells may be modulated species-specifically by H. influenzae, especially by piliated H. influenzae...

Research Grants4

  1. Multi-component and easily administrated anthrax vaccine
    Mingtao Zeng; Fiscal Year: 2003
    ..Specific Aim #2: To compare the systemic and mucosal immunity elicited by the vaccine developed in #1 through intranasal inoculation with that elicited by plasmid expression vectors through intramuscular injection. ..
  2. New genetic vaccine to protect aganist botulism
    Mingtao Zeng; Fiscal Year: 2004
    ..Specific Aim #2: To study the mucosal and systemic immunity elicited by the vectored vaccine developed in aim #1 through intranasal and transcutaneous immunization in a mouse model. ..
  3. Genetic immunization against pneumococcal disease
    Mingtao Zeng; Fiscal Year: 2004
    ....
  4. Development of a New Tularemia Vaccine
    Mingtao Zeng; Fiscal Year: 2006
    ..Since no previous research has shown that genetic immunization with adenovirus or plasmid vectors could elicit protective immunity to F. tularensis, the proposed project is exploratory and developmental in nature. ..