Research Topics
Species | Martin ZandSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
An age-dependent branching process model for the analysis of CFSE-labeling experimentsOllivier Hyrien
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
Biol Direct 5:41. 2010..Several mathematical models have been presented in the literature to describe cell kinetics during these experiments...- High mortality in orthotopic liver transplant recipients who require hemodialysisMartin S Zand
Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
Clin Transplant 25:213-21. 2011..5, and male gender. We conclude that renal failure requiring hemodialysis post liver transplant, irrespective of pre-transplant dialysis status, is a profound risk factor for death in liver transplant recipients... - B-cell activity of polyclonal antithymocyte globulinsMartin S Zand
Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
Transplantation 82:1387-95. 2006..In this paper, the experimental and clinical evidence supporting the B-cell activity of AThG preparations, and their mechanisms of action, are reviewed... - Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allograftsM S Zand
Division of Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Transplantation 70:1378-81. 2000..Several studies suggest that MHC-mismatched allografts reject with a Th1 or Th2 immune response, but these models all have low-level expression of the Th1 cytokines interleukin (IL)-2 and interferon-gamma (IFN-gamma)... - Immunosuppression and immune monitoring after renal transplantationMartin S Zand
Nephrology Unit, Kidney and Pancreas Transplant Programs, University of Rochester Medical Center, Rochester, New York 14642, USA
Semin Dial 18:511-9. 2005..Monitoring assays are discussed, as well as the frequency of monitoring and patient visits. Finally, we discuss several common clinical scenarios that often require adjustment of immunosuppression medications or regimens... - Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulinMartin S Zand
Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Ave, Box 675, Rochester, NY 14642, USA
Blood 107:2895-903. 2006..We conclude that rATG is an effective agent for in vitro induction of apoptosis in multiple myeloma, and that exploratory clinical trials may be warranted... - Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathwaysMartin S Zand
Nephrology Unit, University of Rochester Medical Center, Rochester, NY 14642, USA
Transplantation 79:1507-15. 2005..The authors recently demonstrated that rabbit (r) ATG can be used in combination with plasmapheresis to effectively treat antibody-mediated renal allograft rejection. This observation suggested that rATG may have anti-B cell activity... - A renewable source of donor cells for repetitive monitoring of T- and B-cell alloreactivityMartin S Zand
Nephrology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Am J Transplant 5:76-86. 2005..We conclude that sBc are a renewable source of donor-specific target/stimulator cells for use in repetitive and coordinate assays of B- and T-cell alloreactivity... - Discrete event modeling of CD4+ memory T cell generationMartin S Zand
Nephrology Unit, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 173:3763-72. 2004.... - Screening a living kidney donor for polycystic kidney disease using heavily T2-weighted MRIM S Zand
Department of Medicine, Nephrology Unit, Division of Solid Organ Transplantation, University of Rochester Medical Center, Rochester, NY, USA
Am J Kidney Dis 37:612-9. 2001..We conclude that ultrasound is not a sufficiently sensitive screening test for ADPKD in younger living related renal donors. HT2MRI has improved sensitivity and may be the best screening test for ADPKD in this population... - Minimizing morbidity of organ donation: analysis of factors for perioperative complications after living-donor nephrectomy in the United StatesSiddharth Patel
Division of Transplantation, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
Transplantation 85:561-5. 2008..Wide variability exists in reported donor complications, and associated risk factors are ill defined. Use of administrative data can overcome the bias of single-center studies and identify variables associated with untoward events... - Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell divisionAlicia D Henn
Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 183:3177-87. 2009..Finally, these data support a mixture model of IgG secretion in which IgG secreted over time is modulated by the frequency of IgG-SC and the distribution of their IgG secretion rates... - Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living-donor allograft in 100 consecutive liver transplant recipients receiving tacrolimusAdel Bozorgzadeh
Department of Surgery, University of Rochester, Rochester, New York 14642, USA
Transplantation 77:1066-70. 2004..Patient survival, graft survival, rate of HCV recurrence, severity of HCV recurrence, graft loss from HCV, and interval for recurrence in CLTx and LLTx were similar... - Modification of a biventricular assist device to facilitate preservative infusion and organ recovery in a nonheart-beating donorRon Angona
Department of Surgery, Division of Cardiothoracic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Extra Corpor Technol 38:157-60. 2006..This report discusses the technical aspects of this potentially beneficial procedure... - Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type modelsHa Youn Lee
Department of Biostatistics and Computational Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Bull Math Biol 71:1649-70. 2009..The most profound effect of the presence of IL-4 was decreased death rates for smaller division classes, which supports a role of IL-4 in the protection of B cells from apoptosis... - Treatment of C4d-positive acute humoral rejection with plasmapheresis and rabbit polyclonal antithymocyte globulinAmish Shah
Nephrology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA
Transplantation 77:1399-405. 2004..We describe the ability of rATG to induce apoptosis in vitro peripheral blood and activated B cells. CONCLUSION: Combination therapy using PPH and rATG is an effective means of reversing AHR in renal allografts... - Mini-BEAM and autologous hematopoietic stem-cell transplant for treatment of post-transplant lymphoproliferative disordersRami S Komrokji
Department of Medicine, University of Cincinnati and Veterans Administration Medical Center, Cincinnati, Ohio 45267, USA
Am J Hematol 79:211-5. 2005..With over 30 months of follow-up, both patients remain in complete remission with excellent allograft function... - CpG DNA activation and plasma-cell differentiation of CD27- naive human B cellsJennifer Huggins
Department of Pathology, James P Wilmot Cancer Center, University of Rochester Medical Center, NY 14642, USA
Blood 109:1611-9. 2007..In addition to its immunologic significance, this system should be a valuable method to interrogate the antigenic specificity of naive B cells... - Simulation and prediction of the adaptive immune response to influenza A virus infectionHa Youn Lee
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 14642, USA
J Virol 83:7151-65. 2009..We further compared alternative model structures, for example, B-cell activation directly by the virus versus that through professional antigen-presenting cells or dendritic cell licensing of CD8 T cells... - De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathyJoshua Schwimmer
Department of Medicine, Nephrology Unit, University of Rochester Medical Center, Rochester, NY, USA
Am J Kidney Dis 41:471-9. 2003..CONCLUSION: Classifying patients with post-renal transplantation TMA into those with localized and systemic disease is clinically useful because each group has distinct characteristics and clinical courses... - Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cellsShuya Y Kyu
Division of Pulmonary and Critical Care Medicine, NY 14642, USA
J Immunol Methods 340:42-7. 2009..43, 0.28, 0.28 respectively). These results demonstrate feasibility of testing whether antigen-specific ASC from frozen PBMC are an early biomarker of long-term antibody responses in multi-center vaccine trials... - Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virusHongyu Miao
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 146421, USA
J Virol 84:6687-98. 2010..Also, simulation studies were performed to understand the relative contributions of biological parameters to IAV clearance. This study provides a basis to better understand and predict influenza virus immunity... - Elevated calcium phosphate product after renal transplantation is a risk factor for graft failureOgo I Egbuna
Division of Nephrology, Beth Israel Deaconess Medical Center, and Division of Endocrinology and Hypertension Calcium and Parathyroid Physiology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Clin Transplant 21:558-66. 2007..The effect of these abnormalities on recipient and graft survival after renal transplantation is unknown... - Home glucometer monitoring markedly improves diagnosis of post renal transplant diabetes mellitus in renal transplant recipientsAmish Shah
Division of Nephrology, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Transplantation 80:775-81. 2005..All diagnoses were made based on prelunch or supper FPG >200 mg/dl. CONCLUSIONS: Overnight FPG are inadequate for diagnosis of PTDM. All renal transplant recipients with impaired FPG should, at minimum, have home FPG testing... - Pretransplant cellular alloimmunity as assessed by a panel of reactive T cells assay correlates with acute renal graft rejectionEmilio D Poggio
Department of Nephrology and Hypertension, Transplant Center, Cleveland Clinic, Cleveland, OH 44195, USA
Transplantation 83:847-52. 2007.... - Zonal distribution of glomerular collapse in renal allografts: possible role of vascular changesTibor Nadasdy
Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA
Hum Pathol 33:437-41. 2002..Among other factors, hemodynamic disturbance may play a role in the development of the pattern of CG in renal allografts...
Research Grants
- TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICEMartin Zand; Fiscal Year: 2002..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets. ..
- Branching Stochastic Process Modeling of Human Plasma Cell DifferentiationMartin Zand; Fiscal Year: 2007..The stochastic branching process model developed in Aim 1 will be used to predict experimental outcomes and compare them with in vitro data. ..
- Branching Stochastic Process Modeling of Human Plasma Cell DifferentiationMartin S Zand; Fiscal Year: 2010..The stochastic branching process model developed in Aim 1 will be used to predict experimental outcomes and compare them with in vitro data. ..