Research Topics
| James ZacnySummaryAffiliation: University of Chicago Country: USA Publications
Research Grants
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Detail Information
Publications
Profiling the subjective, psychomotor, and physiological effects of a hydrocodone/acetaminophen product in recreational drug usersJames P Zacny
Department of Anesthesia and Critical Care, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Drug Alcohol Depend 78:243-52. 2005..It was of particular interest to determine if HYD/ACET had abuse liability-related subjective effects in a population of recreational drug users...- Subjective and psychomotor effects of carisoprodol in combination with oxycodone in healthy volunteersJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, United States
Drug Alcohol Depend 120:229-32. 2012..It would be of relevance to characterize the effects of an opioid and carisoprodol when taken together to determine if abuse liability-related measures and psychomotor impairment are increased compared to when the drugs are taken alone... - Subjective, psychomotor, and physiological effects of pregabalin alone and in combination with oxycodone in healthy volunteersJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
Pharmacol Biochem Behav 100:560-5. 2012.... - Choice of sevoflurane and its subjective and psychomotor effects in light and moderate drinkersJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
Drug Alcohol Depend 94:101-8. 2008..We sought to determine if choice for subanesthetic doses of sevoflurane, and its subjective and psychomotor effects, would differ as a function of alcohol-drinking status in healthy volunteers... - Nonmedical use of prescription opioids: motive and ubiquity issuesJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
J Pain 9:473-86. 2008..Such information would allow for a better understanding of the problem. We invite discussion and commentaries regarding the issues we raise to more effectively address this public health issue... - Subjective, psychomotor, and physiological effects profile of hydrocodone/acetaminophen and oxycodone/acetaminophen combination productsJames P Zacny
Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
Pain Med 9:433-43. 2008..To compare within the same individuals two typically prescribed doses of hydrocodone/acetaminophen and oxycodone/acetaminophen products for their subjective, psychomotor, and physiological effects in healthy volunteers... - Choice of nitrous oxide and its subjective effects in light and moderate drinkersJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Drug Alcohol Depend 98:163-8. 2008..Using a methodology different from our previous studies, we sought to determine in a more definitive fashion the degree to which the choice of nitrous oxide and its subjective effects were modulated by drinking status... - Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteersJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
Drug Alcohol Depend 101:107-14. 2009..The purpose of this study was to directly compare the psychopharmacological profile of two widely prescribed and abused oral opioid combination products within the same subject... - The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteersJames P Zacny
Department of Anesthesia and Critical Care, MC4028, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Pharmacol Biochem Behav 94:108-13. 2009..Lack of effect on impulsivity stands in contrast to other studies in which other psychoactive drugs including ethanol, delta-9-tetrahydrocannabinol, and amphetamine altered behavior on one or more behavioral measures of impulsivity... - Psychopharmacological effects of oxycodone in healthy volunteers: roles of alcohol-drinking status and sexJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, 5841 South Maryland Avenue, Box MC 4028, Chicago, IL 60637, USA
Drug Alcohol Depend 107:209-14. 2010..We included sex of the volunteer in the statistical analyses since this is a factor that is known to alter several pharmacodynamic effects of opioids in nonhumans and humans... - A possible link between sensation-seeking status and positive subjective effects of oxycodone in healthy volunteersJames P Zacny
Department of Anesthesia and Critical Care, MC4028, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Pharmacol Biochem Behav 95:113-20. 2010.... - Lack of sex differences to the subjective effects of nitrous oxide in healthy volunteersJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Drug Alcohol Depend 112:251-4. 2010..Since sex differences have been reported in subjective effects of several drugs such as opioids, nicotine and alcohol, we sought to determine if sex modulates the subjective effects of the inhalant, nitrous oxide, in healthy volunteers... - Psychopharmacological effects of oxycodone in volunteers with and without generalized anxiety disorderJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Exp Clin Psychopharmacol 19:85-94. 2011..Anxiety ratings were low in the GAD group (in the absence of drug), and this may have lessened the possibility of detecting a more positive spectrum of oxycodone effects in this group than in the CTL group... - Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteersJames P Zacny
Department of Anesthesia and Critical Care MC4028, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Psychopharmacology (Berl) 218:471-81. 2011..Nonmedical use of prescription opioids is sometimes accompanied by the ingestion of ethanol. Whether ethanol increases the abuse liability-related effects of prescription opioids has not been determined... - Characterizing the subjective and psychomotor effects of carisoprodol in healthy volunteersJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
Pharmacol Biochem Behav 100:138-43. 2011.... - Within-subject comparison of the psychopharmacological profiles of oral oxycodone and oral morphine in non-drug-abusing volunteersJames P Zacny
Department of Anesthesia and Critical Care MC4028, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Psychopharmacology (Berl) 196:105-16. 2008..Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids... - Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug usersJames P Zacny
Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Drug Alcohol Depend 80:273-8. 2005.... - The effects of a cold-water stimulus on butorphanol effects in males and femalesJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, MC 4028, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Pharmacol Biochem Behav 78:653-9. 2004..The differences in pain ratings and degree of analgesia between the sexes are discussed as a possible mechanism for the sex differences in modulatory effects... - Within-subject comparison of the subjective and psychomotor effects of a gaseous anesthetic and two volatile anesthetics in healthy volunteersNancy J Beckman
Department of Anesthesia and Critical Care, The University of Chicago, 5841 S. Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Drug Alcohol Depend 81:89-95. 2006..These results are consistent with the drugs' putative receptor mechanisms of action and confirm Balster's classification of the volatile anesthetics into a class distinct from N2O... - Preoperative dental anxiety and mood changes during nitrous oxide inhalationJames P Zacny
Department of Anesthesia and Critical Care, The University of Chicago, Ill 60637, USA
J Am Dent Assoc 133:82-8. 2002..The purpose of this study was to characterize mood changes during nitrous oxide inhalation in patients with different levels of preoperative dental anxiety... - Analysis of the reinforcing and subjective effects of different doses of nitrous oxide using a free-choice procedureDiana J Walker
Department of Anesthesia and Critical Care, The University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
Drug Alcohol Depend 66:93-103. 2002..Reinforcing effects were more correlated with subjective effects assessed after the session than with subjective effects obtained while subjects were under the influence of the drug... - Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteersJames P Zacny
Department of Anesthesia and Critical Care MC4028, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Psychopharmacology (Berl) 165:146-56. 2003.... - Bitonic dose-response functions for reinforcing and self-reported effects of nitrous oxide in humansDiana J Walker
Department of Anesthesia and Critical Care, The University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA
Pharmacol Biochem Behav 74:851-7. 2003..Bitonic dose-response functions for some subjects extend the generality of the phenomenon of bitonicity of drug effects to N(2)O effects in humans... - Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteersJames P Zacny
Department of Anesthesia and Critical Care MC 4028, The Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Psychopharmacology (Berl) 170:242-54. 2003..The subjective, psychomotor, and physiological effects of a widely prescribed and abused prescription opioid, oxycodone, have not been studied in a population of non-drug-abusing people... - Characterizing the subjective, psychomotor, and physiological effects of oral propoxyphene in non-drug-abusing volunteersJames P Zacny
Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Drug Alcohol Depend 73:133-40. 2004..The drug also has potential for abuse and it was of interest in the present study to determine if the drug had any abuse liability-related subjective effects in this population... - Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteersSandra Gutierrez
Department of Anesthesia and Critical Care, The University of Chicago, MC4028, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Pharmacol Biochem Behav 78:57-64. 2004..The data suggest that acute administration of valerian does not have mood-altering or psychomotor/cognitive effects in young healthy volunteers... - Reinforcing and subjective effects of the volatile anesthetic, sevofluraneDiana J Walker
Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Ave, MC 4028, Chicago, IL 60637, USA
Drug Alcohol Depend 76:191-201. 2004..This study shows that sevoflurane can function as a reinforcer and produce abuse liability-related subjective effects in some healthy volunteers... - College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statementJames Zacny
Department of Anesthesia and Critical Care, University of Chicago, Box MC4028, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Drug Alcohol Depend 69:215-32. 2003.... - Differential effects of morphine and codeine on pupil size: dosing issuesJames P Zacny
Anesth Analg 100:598; author reply 598. 2005 - Chronic pain and driving: proceed with cautionJames P Zacny
Pain 122:6-7. 2006
Research Grants
- CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTSJames Zacny; Fiscal Year: 2004..In short, in our two proposed series of studies, we are developing a human laboratory model of inhalant abuse by studying potential determinants of abuse liability of inhalants (volatile and gaseous) in healthy volunteers. ..
- Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain PatientsJames Zacny; Fiscal Year: 2007..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..
- BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERSJames Zacny; Fiscal Year: 2009..abstract_text> ..
- PSYCHOACTIVE EFFECTS OF NITROUS OXIDEJames Zacny; Fiscal Year: 1993..These studies should address several fundamental questions regarding the actions of N2O which may be related to its illicit use and its widespread acceptance (i.e., liking) amongst people undergoing dental/medical procedures...
- Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain PatientsJames P Zacny; Fiscal Year: 2010..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..