Research Topics
Species | S YendeSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deathsSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 6:e22847. 2011....- 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumoniaSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 176:1129-37. 2007..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown... - Influence of comorbid conditions on long-term mortality after pneumonia in older peopleSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:518-25. 2007..To test the hypothesis that increased long-term mortality after hospitalization for community-acquired pneumonia (CAP) is independent of comorbid conditions... - Understanding genetics of sepsis: will new technology help?Sachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
Crit Care 13:141. 2009..Careful attention should be paid to different aspects of study design and analyses as large, multicenter cohorts are assembled for genome-wide association studies... - Genetics and proteomics: deciphering gene association studies in critical illnessSachin Yende
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care 10:227. 2006.... - Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjectsS Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, PA 15238, USA
Thorax 61:10-6. 2006..Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance... - Preinfection systemic inflammatory markers and risk of hospitalization due to pneumoniaSachin Yende
Department of Critical Care Medicine, 3550 Terrace Street, Pittsburgh PA 15261, USA
Am J Respir Crit Care Med 172:1440-6. 2005..Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear... - The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studiesSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Thorax 65:870-7. 2010..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear... - Understanding the potential role of statins in pneumonia and sepsisSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 39:1871-8. 2011..To examine the association of statin use with clinical outcomes and circulating biomarkers in community-acquired pneumonia and sepsis... - Diabetes and sepsis outcomes--it is not all bad newsSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
Crit Care 13:117. 2009..Their main conclusion was that diabetes patients, relative to non-diabetics, were less likely to develop respiratory failure and more likely to develop renal failure during the course of sepsis... - Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survivalRaghavan Murugan
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 77:527-35. 2010..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death... - The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumoniaSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
FASEB J 23:2403-11. 2009..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia... - Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsisSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 177:1242-7. 2008..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown... - Differences in immune response may explain lower survival among older men with pneumoniaMichael C Reade
Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 37:1655-62. 2009..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response... - Do hospitals provide lower quality of care to black patients for pneumonia?Florian B Mayr
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 38:759-65. 2010..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals... - Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsisFlorian B Mayr
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
JAMA 303:2495-503. 2010..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear... - Genetic polymorphisms that predict outcome and need for treatment in cardiovascular diseaseSachin Yende
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Curr Opin Crit Care 12:420-5. 2006..SUMMARY: A familial risk of cardiovascular disease is well known. The specific genotypes at risk are increasingly being discovered. The science has progressed to the point that genotype-specific interventions are increasingly feasible... - Clinical relevance of angiotensin-converting enzyme gene polymorphisms to predict risk of mechanical ventilation after coronary artery bypass graft surgerySachin Yende
Physician Research Network SY, Methodist Healthcare Memphis, Memphis, TN, USA
Crit Care Med 32:922-7. 2004..Therefore, we examined interactions between these polymorphisms... - Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass surgerySachin Yende
Methodist Healthcare University Hospital, Memphis, TN, USA
Crit Care Med 31:133-40. 2003.... - Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgerySachin Yende
Methodist Healthcare and University of Tennessee, Memphis, TN 38104, USA
Chest 121:86S. 2002 - Role of toll-like receptor 4 mutations in gram-negative septic shockSachin Yende
Arch Intern Med 162:2496; author reply 2496. 2002