Research Topics
Species | Michael W YehSummaryAffiliation: University of California Country: USA Publications
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Publications
The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell linesJin-Woo Park
Department of Surgery, University of California, Mount Zion Medical Center, San Francisco, California 94143-1674, USA
J Clin Endocrinol Metab 88:3346-53. 2003..In conclusion, geldanamycin inhibited cancer cell proliferation, down-regulated oncoproteins, and inhibited EGF-induced invasion in thyroid cancer cell lines...- In vivo analysis of fracture toughness of thyroid gland tumorsNagesh Ragavendra
Department of Radiology, The David Geffen School of Medicine at UCLA, Box 957437, 757 Westwood Plaza, Los Angeles, CA 90095, USA
J Biol Eng 2:12. 2008..Here we present a fracture mechanics based in vivo approach for characterizing the fracture toughness of biological tissue of human thyroid gland tumors... - Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase AMichael W Yeh
Endocrine Surgery Laboratory, UCSF Mt Zion Medical Center, San Francisco, California 94115, USA
Endocr Relat Cancer 13:1173-83. 2006..MMP inhibitors and growth factor antagonists may be effective tumoristatic agents for the treatment of aggressive thyroid carcinomas... - Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathwayMichael Yeh
Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 279:30175-81. 2004..Taken together, these data demonstrate the role of the c-src kinase/STAT3 pathway in Ox-PAPC-mediated IL-8 expression in endothelial cells... - Population-level predictors of persistent hyperparathyroidismMichael W Yeh
Division of General Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
Surgery 150:1113-9. 2011..To avoid these biases, we evaluated parathyroidectomy (PTx) outcomes within an integrated health care system encompassing 3.25 million enrollees... - Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivoNima M Gharavi
Division of Cardiology, Department of Medicine, Department of Pathology, Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
J Biol Chem 282:31460-8. 2007..Taken together, these data demonstrate an important role for the JAK2/STAT3 pathway in Ox-PAPC-induced IL-8 transcription in vitro and in atherosclerosis in vivo... - Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation productsMichael Yeh
Department of Medicine, Geffen School of Medicine at University of California Los Angeles, USA
Circ Res 95:780-8. 2004..The current studies suggest a novel role for endothelial cholesterol depletion and subsequent SREBP activation in inflammatory processes in which phospholipid oxidation products accumulate... - Underutilization of parathyroidectomy in elderly patients with primary hyperparathyroidismBian Wu
Endocrine Surgical Unit, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
J Clin Endocrinol Metab 95:4324-30. 2010..Primary hyperparathyroidism (PHPT) disproportionately affects older patients, who may face higher thresholds for surgical intervention compared to young patients... - Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored proteinKimberly A Walton
Department of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 278:29661-6. 2003..Therefore, these studies suggest that ox-PAPC may initially bind to a 37-kDa GPI-anchored protein, which interacts with TLR4 to induce IL-8 transcription... - Transient increases in intraoperative parathyroid levels related to anesthetic techniqueJoe C Hong
Department of Anesthesiology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
Surgery 150:1069-75. 2011..We examined the effect of different anesthetic techniques on intraoperative PTH (IOPTH) levels in patients undergoing parathyroidectomy for primary hyperparathyroidism... - False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinomaMichael W Yeh
Endocrine Surgery Laboratory, UCSF/Mt. Zion Medical Center, San Francisco, California 94115, USA
Thyroid 14:207-15. 2004..28). False-negative results remain a concern in the cytologic diagnosis of thyroid cancer. Although FNA is a useful test, clinical findings should overrule cytologic data in order for timely treatment to occur... - Distal pancreatectomy: incidence of postoperative diabetesJonathan King
Department of Surgery, David Geffen School of Medicine, UCLA, 10833 Le Conte Ave, CHS 72 170, Los Angeles, CA 90095 6904, USA
J Gastrointest Surg 12:1548-53. 2008..The true rate of diabetes after distal pancreatectomy is not known, but we hypothesize that the risk is nominal... - Clinical pathways improve hospital resource use in endocrine surgeryRajan P Kulkarni
Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Am Coll Surg 212:35-41. 2011..Here, we describe novel clinical pathways developed for endocrine operations (ie, unilateral thyroid lobectomy, total thyroidectomy, parathyroidectomy) and evaluate their effects on economic end points at a major academic hospital... - Strategic impact of a new academic endocrine surgery programJames E Wiseman
Endocrine Surgical Unit, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ann Surg Oncol 18:2260-4. 2011..A minority of medical centers possess a dedicated endocrine surgery program. Here we assess the short-term impact of a new endocrine surgery program on institutional case volumes and financial endpoints... - An algorithm informed by the parathyroid hormone level reduces hypocalcemic complications of thyroidectomyJames E Wiseman
Endocrine Surgical Unit, Department of Surgery, University of California Los Angeles, 10833 Le Conte Avenue, 72 229 CHS, Los Angeles, CA 90095, USA
World J Surg 34:532-7. 2010..We present an algorithmic method of managing hypocalcemia pre-emptively, based on the PTH level 1 h after operation... - 18F-FDOPA PET and PET/CT accurately localize pheochromocytomasFarzin Imani
Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Nucl Med 50:513-9. 2009..Herein, we investigated the accuracy of PET using 3,4-dihydroxy-6-(18)F-fluoro-phenylalanine ((18)F-FDOPA), an amino acid transporter substrate, as an independent marker for detection of benign and malignant pheochromocytomas... - Parathyroid surgery in the elderlyLilah F Morris
Endocrine Surgical Unit, Department of General Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Oncologist 15:1273-84. 2010..This review discusses issues related to PHPT in the elderly population with a focus on differences in disease presentation, medical and surgical management, and outcomes... - Laparoscopic adrenalectomy after prior abdominal surgeryLilah Morris
Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
World J Surg 32:897-903. 2008..Some regard prior abdominal surgery as a contraindication to LA or suggest a retroperitoneoscopic approach. We studied the effect of prior abdominal surgery on the feasibility and safety of transabdominal LA... - Role of endothelial nitric oxide synthase in the regulation of SREBP activation by oxidized phospholipidsNima M Gharavi
Division of Cardiology, Department of Medicine, University of California, Los Angeles, USA
Circ Res 98:768-76. 2006..Taken together, these findings propose a novel role for eNOS in the activation of SREBP and SREBP-mediated inflammatory processes... - Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathwayTatyana Gurlo
Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7073, USA
Am J Pathol 176:861-9. 2010..Toxic oligomer-induced secretory pathway and mitochondrial membrane disruption is a novel mechanism to account for cellular dysfunction and apoptosis in T2DM... - The value of intraoperative parathyroid hormone monitoring in localized primary hyperparathyroidism: a cost analysisLilah F Morris
Division of General Surgery, Endocrine Surgical Unit, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ann Surg Oncol 17:679-85. 2010..We used a decision tree and cost analysis model to examine IOPTH monitoring in localized PHPT... - Web-based portfolios: a valuable tool for surgical educationCatherine E Lewis
Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California 90095 6904, USA
J Surg Res 161:40-6. 2010..In the present communication, we describe this system and provide an early analysis of its effect on competency-based performance and acceptance of the system by the residents... - Inherited endocrinopathies: an updateCatherine E Lewis
Department of General Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095 6904, USA
Mol Genet Metab 94:271-82. 2008..Here, we present a case-based review of recent advances in the genetics, diagnosis and management of inherited endocrinopathies... - Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2Kimberly A Walton
Department of Medicine, University of California, Los Angeles, CA 90095-1732, USA
Arterioscler Thromb Vasc Biol 23:1197-203. 2003..These studies have broader implications for the role of ox-PAPC as a regulator of specific lipid raft/caveolar function... - Glucagon like peptide-1 receptor expression in the human thyroid glandBelinda Gier
Larry L Hillblom Islet Research Center, David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue 72 228 CHS, Los Angeles, California 90095 6904, USA
J Clin Endocrinol Metab 97:121-31. 2012..We sought to establish whether C cells in human medullary thyroid carcinoma, C cell hyperplasia, and normal human thyroid express the GLP-1 receptor... - Falsely elevated plasma parathyroid hormone level mimicking tertiary hyperparathyroidismOlga Levin
Endocrine Surgical Unit, Department of General Surgery, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
Endocr Pract 17:e8-11. 2011..To report a case of misdiagnosed tertiary hyperparathyroidism attributable to heterophile antibody interference in a parathyroid hormone (PTH) assay... - Incidentally discovered tumors of the endocrine glandsAndrew J Vardanian
UCLA David Geffen School of Medicine, Department of Surgery, Los Angeles, CA 90095, USA
Future Oncol 3:463-74. 2007..We review the detection and subsequent management of incidentalomas of the thyroid, adrenal and pancreas, with specific attention paid to the mode of detection and risk stratification of lesions... - The Hunterian Laboratory of Experimental MedicineKevin Ro
Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Ann Surg 253:1042-8. 2011..This article examines the conception and early years of the Laboratory... - Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgeryAlexandra I Stavrakis
Endocrine Surgical Unit and Center for Surgical Outcomes and Quality, VA Greater Los Angeles Healthcare System, Los Angeles, Calif, USA
Surgery 142:887-99; discussion 887-99. 2007..We examined the effect of surgeon volume on clinical and economic outcomes for thyroid, parathyroid, and adrenal surgery across inpatient and outpatient settings... - Glucose regulates monocyte adhesion through endothelial production of interleukin-8Suseela Srinivasan
Division of Cardiology, University of California Los Angeles, Los Angeles, Calif, USA
Circ Res 92:371-7. 2003..These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs... - Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in miceNobuko Hagiwara
University of California, Davis, Division of Cardiovascular Medicine Rowe Program in Human Genetics, Davis, California 95616, USA
Dev Dyn 236:2062-76. 2007..Together, our results suggest that Sox6 plays a critical role in the fiber type differentiation of fetal skeletal muscle... - Endovascular repair of an actively hemorrhaging gunshot injury to the abdominal aortaMichael W Yeh
Department of Surgery, San Francisco General Hospital, University of California San Francisco, CA 94110, USA
J Vasc Surg 42:1007-9. 2005..Endovascular approaches to aortic injuries may be valuable in settings where a hostile abdomen precludes traditional open repair... - Phaeochromocytoma: current conceptsYaser Alderazi
Royal North Shore Hospital and University of Sydney, Sydney, NSW, Australia
Med J Aust 183:201-4. 2005..With appropriate perioperative care, surgical management of phaeochromocytomas is safe and effective. Most tumours can be removed laparoscopically... - Potential pitfalls in the diagnosis of phaeochromocytomaJane L Harding
University of Sydney, Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia
Med J Aust 182:637-40. 2005..Tricyclic antidepressant use produced misleading elevations in urinary catecholamine levels in three patients. 24-hour urine studies should be performed at least twice, after eliminating confounding factors (stressors, medications)... - Completion thyroidectomy for malignancy after initial minimal access thyroid surgeryMichael W Yeh
Department of Surgery, University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia
ANZ J Surg 76:332-4. 2006..CONCLUSION: There is no demonstrable disadvantage when completion thyroidectomy for malignancy is required after MATS... - Virilizing adrenocortical carcinoma with cavoatrial extensionMichael W Yeh
Endocrine Surgical Unit, Wallace Freeborn Level 2, Royal North Shore Hospital, Pacific Hwy, St. Leonards, New South Wales, Australia
Am J Surg 192:209-10. 2006