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Genomes and Genes | Zequan YangSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Infarct-sparing effect of A2A-adenosine receptor activation is due primarily to its action on lymphocytesZequan Yang
Department of Biomedical Engineering, of Virginia Health System, Charlottesville 22903, USA
Circulation 111:2190-7. 2005..A2A-adenosine receptor (A2AAR) activation on reperfusion after ischemia reduces the size of myocardial infarction, but the mechanism of action has not been fully defined...- Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytesZequan Yang
Department of Biomedical Engineering, University of Virginia Health System, Box 800759, Charlottesville, VA 22903, USA
Circulation 114:2056-64. 2006..In this study we show that CD4+ but not CD8+ T lymphocytes contribute to myocardial ischemia/reperfusion injury... - Acute hyperglycemia enhances oxidative stress and exacerbates myocardial infarction by activating nicotinamide adenine dinucleotide phosphate oxidase during reperfusionZequan Yang
Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 137:723-9. 2009..We hypothesized that the oxidative stress imposed by acute hyperglycemia contributes to the exacerbation of infarct size during reperfusion... - The angiotensin II type 2 receptor and improved adjacent region function post-MIChristina M Bove
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
J Cardiovasc Magn Reson 7:459-64. 2005..Thus, myocardial tagging can detect regional differences in contractile function post-MI in TG mice, and AT2-R overexpression is associated with improved contractile function in adjacent noninfarcted myocardium... - Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodelingDavid C Isbell
Cardiovascular Division, Department of Medicine, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 293:H3372-8. 2007..However, B(2)R does appear to have a role in the smaller cavity size and hyperdynamic function observed at baseline in AT(2)TG mice and in limiting collagen deposition during postinfarct remodeling... - Timing of adenosine 2A receptor stimulation relative to reperfusion has differential effects on infarct size and cardiac function as assessed in mice by MRIZequan Yang
Department of Surgery, University of Virginia, MR5 Bldg Rm 1219, Box 800759, 415 Lane Rd, Charlottesville, VA 22903, USA
Am J Physiol Heart Circ Physiol 295:H2328-35. 2008..The infarct size was significantly reduced by ATL when given just before reperfusion, but not 1 h postreperfusion. Either treatment window helped preserve the EF between 1 and 24 h postreperfusion... - Borderzone contractile dysfunction is transiently attenuated and left ventricular structural remodeling is markedly reduced following reperfused myocardial infarction in inducible nitric oxide synthase knockout miceWesley D Gilson
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA
J Am Coll Cardiol 50:1799-807. 2007..We sought to determine the effect of inducible nitric oxide synthase (iNOS) expression on regional contractile function and left ventricular (LV) remodeling after reperfused myocardial infarction (MI)... - Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injuryAshish K Sharma
Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 139:474-82. 2010..This study tests the hypothesis that adenosine A(2A) receptor activation attenuates ischemia-reperfusion injury by inhibiting CD4+ T cell activation and subsequent neutrophil infiltration... - NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injuryZequan Yang
Department of Surgery, University of Virginia Health System, P O Box 801359, Charlottesville, VA 22908, USA
Am J Respir Cell Mol Biol 40:375-81. 2009..NADPH oxidase may represent a novel therapeutic target for the treatment of IR injury after lung transplantation... - Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodelingChristina M Bove
University of Virginia Health System, Departments of Medicine and Radiology, Lee Street, Box 800170, Charlottesville, VA 22908, USA
Hypertension 43:680-5. 2004..Noninfarcted region interstitial collagen was similar between groups. Thus, the NO pathway may mediate much of the benefits of cardiac AT(2)-R overexpression during post-MI remodeling... - Complementary displacement-encoded MRI for contrast-enhanced infarct detection and quantification of myocardial function in miceWesley D Gilson
Department of Radiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Magn Reson Med 51:744-52. 2004..03 +/- 0.04 in infarcted regions, whereas E(cc) was -0.12 +/- 0.02 and E(rr) was 0.38 +/- 0.09 in noninfarcted regions. In vivo E(cc) as determined by DENSE correlated well with E(cc) obtained by conventional tag analysis (R = 0.90)... - Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodelingSzilard Voros
Department of Medicine, University of Virginia Health System, Lee St, Box 800170, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 290:H1004-10. 2006..Pharmacological blockade of AT1-R is equivalent to AT2-R overexpression in attenuating post-MI remodeling. Genetic knockout of the AT1a-R is additive to AT2-R overexpression, due, at least in part, to blood pressure lowering... - Topoisomerase inhibition accelerates gene expression after adeno-associated virus-mediated gene transfer to the mammalian heartKonkal Matt R Prasad
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA
Mol Ther 15:764-71. 2007..Direct injection of the AAV2 vector and long-term luciferase gene expression had no detectable effects on normal cardiac function as assessed by magnetic resonance imaging... - Activated platelets contribute importantly to myocardial reperfusion injuryYaqin Xu
Dept of Biomedical Engineering, Univ of Virginia Health System, Charlottesville, VA 22903, USA
Am J Physiol Heart Circ Physiol 290:H692-9. 2006..Activated platelets play an important role in the process of myocardial ischemia-reperfusion injury, and platelet-derived P-selectin is a critical mediator... - Black blood gradient echo cine magnetic resonance imaging of the mouse heartStuart S Berr
Department of Radiology, University of Virginia, Charlottesville, USA
Magn Reson Med 53:1074-9. 2005..Black blood cine MRI in mice provides reduced interobserver variability and improved accuracy for the measurement of myocardial volumes and mass compared to the conventional bright blood technique... - Simultaneous evaluation of infarct size and cardiac function in intact mice by contrast-enhanced cardiac magnetic resonance imaging reveals contractile dysfunction in noninfarcted regions early after myocardial infarctionZequan Yang
Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA 22903, USA
Circulation 109:1161-7. 2004..05). CONCLUSIONS: MRI can accurately assess both infarct size and cardiac function in intact mice early after large, reperfused MI, revealing the existence of contractile dysfunction in noninfarcted regions of the heart... - Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioningAmy R Lankford
Dept of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 290:H1469-73. 2006..These findings demonstrate that A(1)ARs are critical for protection from myocardial I/R injury and that cardioprotection with IPC is relative to the level of A(1)AR gene expression... - Enhanced fibrinolysis protects against lung ischemia-reperfusion injuryChristine L Lau
Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA
J Thorac Cardiovasc Surg 137:1241-8. 2009..This study investigates the role of the fibrinolytic cascade in lung ischemia-reperfusion injury and investigates the interplay between the fibrinolytic system and the inflammatory response... - Stimulation of A2A-adenosine receptors after myocardial infarction suppresses inflammatory activation and attenuates contractile dysfunction in the remote left ventricleMarie-Claire Toufektsian
Dept. of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 290:H1410-8. 2006..05). In conclusion, A(2A)AR stimulation after MI suppresses inflammatory activation and preserves cardiac function, suggesting the potential utility of A(2A)AR agonists against acute heart failure in the immediate post-MI period... - Measurement of myocardial mechanics in mice before and after infarction using multislice displacement-encoded MRI with 3D motion encodingWesley D Gilson
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 288:H1491-7. 2005..07 +/- 0.54 degrees /mm (R = 0.96, P < 0.05). DENSE MRI can assess the 3D myocardial mechanics of the murine heart in <1 h of scan time at 4.7 T and may be applied to studies of myocardial mechanics in genetically engineered mice... - Alterations to myofibrillar protein function in nonischemic regions of the heart early after myocardial infarctionVijay S Rao
Department of Biomedical Engineering, University of Virginia, Box 800759, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 293:H654-9. 2007..We hypothesize that phosphorylation of tropomyosin may serve a compensatory role, augmenting contraction during periods of oxidative stress when myosin function is compromised... - Smooth muscle phenotypic modulation is an early event in aortic aneurysmsGorav Ailawadi
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 138:1392-9. 2009..However, little is known of the role of smooth muscle cells in aortic aneurysms. We hypothesized that smooth muscle cells undergo phenotypic modulation early in the development of aortic aneurysms... - CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injuryZequan Yang
Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 137:695-702; discussion 702. 2009..We hypothesized that T lymphocytes are recruited and activated during reperfusion and mediate subsequent neutrophil-induced lung ischemia-reperfusion injury... - Serial MRI evaluation of cardiac structure and function in mice after reperfused myocardial infarctionAntwone J Ross
Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Magn Reson Med 47:1158-68. 2002..The application of these imaging techniques in transgenic and knock-out mice will greatly expedite research aimed at defining the functional roles of individual genes in the pathophysiology of LV remodeling (LVR) after reperfused MI... - Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarctionZequan Yang
Department of Medicine and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville 22908, USA
Circulation 106:106-11. 2002..At day 28, blood pressure and LV dP/dt were higher in TG. CONCLUSIONS: Cardiac AT2-R overexpression improves LV systolic function at baseline and preserves function during post-MI remodeling... - Left ventricular remodeling subsequent to reperfused myocardial infarction: evaluation of a rat model using cardiac magnetic resonance imagingJeffrey R Jones
Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, USA
J Cardiovasc Magn Reson 4:317-26. 2002..The repeatability values indicate that cardiac MR could be used for evaluating new therapies for mitigating the effects of LV remodeling after reperfused MI... - 3D perfusion mapping in post-infarct mice using myocardial contrast echocardiographyBrent A French
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908-0759, USA
Ultrasound Med Biol 32:805-15. 2006.... - Stem cell therapy for ischemic heart disease: where are we?Damien J LaPar
Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
Curr Opin Organ Transplant 14:79-84. 2009..Substantial work in stem cell therapy for ischemic heart disease has recently been reported... - Activation of p38 mitogen-activated protein kinase abolishes insulin-mediated myocardial protection against ischemia-reperfusion injuryWeidong Chai
Div of Endocrinology and Metabolism, Dept of Medicine, Univ of Virginia Health System, PO Box 801410, Charlottesville, VA 22908, USA
Am J Physiol Endocrinol Metab 294:E183-9. 2008..We conclude that insulin protects myocardium against ischemia-reperfusion injury when given prior to ischemia or reperfusion, and activation of p38 MAPK abolishes insulin's cardioprotective effect... - Outcomes of reoperative aortic valve replacement after previous sternotomyDamien J LaPar
Department of Surgery, University of Virginia, Charlottesville, VA, USA
J Thorac Cardiovasc Surg 139:263-72. 2010..Effect of initial cardiac operation on reoperative aortic valve replacement was also investigated... - Cardiac overexpression of A1-adenosine receptor protects intact mice against myocardial infarctionZequan Yang
Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 282:H949-55. 2002..WT mice. Cardiac overexpression of A1-ARs reduces infarct size by 40% and preserves cardiac function in intact mice after MI... - Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strainAlistair A Young
Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
J Cardiovasc Magn Reson 8:685-92. 2006..3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework... - Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damageBasilia Zingarelli
Children s Hospital Medical Center, Division of Critical Care, Cincinnati, Ohio 45229, USA
FASEB J 16:327-42. 2002..Thus, we conclude that iNOS plays a beneficial role in modulating the early defensive inflammatory response against reperfusion injury through regulation of signal transduction... - Noninvasive tracking of cardiac embryonic stem cells in vivo using magnetic resonance imaging techniquesSteven N Ebert
Burnett College of Biomedical Sciences, University of Central Florida, 4000 Central Florida Boulevard, Orlando, Florida 32816, USA
Stem Cells 25:2936-44. 2007..These results demonstrate that it is feasible to simultaneously track transplanted stem cells and monitor cardiac function in vivo over an extended period using noninvasive MRI techniques... - MR tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regionsFrederick H Epstein
Department of Radiology, University of Virginia, Charlottesville 22908, USA
Magn Reson Med 48:399-403. 2002..2% in the remote zone. %CS was statistically different for all comparisons between the infarcted, adjacent, remote, and baseline groups (P < 0.01). MR tagging can detect regional differences in myocardial function post-MI in mice...