Research Topics
Genomes and Genes | O O YangSummaryAffiliation: University of California Country: USA Publications
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Publications
Involvement of claudin-7 in HIV infection of CD4(-) cellsJunying Zheng
Jonsson Comprehensive Cancer Center, UCLA School of Dentistry, Dental Institute, Los Angeles, CA 90095, USA
Retrovirology 2:79. 2005..Human immunodeficiency virus (HIV) infection of CD4(-) cells has been demonstrated, and this may be an important mechanism for HIV transmission...- Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTLOtto O Yang
Division of Infectious Diseases and AIDS Institute, University of California, Los Angeles Medical Center, Los Angeles, CA 90095, USA
J Immunol 171:3718-24. 2003..These results suggest that CTL specificity may have a pivotal role in the immunopathogenesis of infection, and that simple quantitative measures of CTL may be insufficient indicators of the CTL response to HIV-1... - CTL ontogeny and viral escape: implications for HIV-1 vaccine designOtto O Yang
Division of Infectious Diseases/Department of Medicine, UCLA Medical Center, 37-121 Center for Health Sciences, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
Trends Immunol 25:138-42. 2004 - Determinant of HIV-1 mutational escape from cytotoxic T lymphocytesOtto O Yang
Division of Infectious Diseases, 37 121 CHS, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90095, USA
J Exp Med 197:1365-75. 2003.... - Delayed reconstitution of CD4+ iNKT cells after effective HIV type 1 therapyOtto O Yang
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
AIDS Res Hum Retroviruses 23:913-22. 2007.... - Effects of HIV-1 infection on lymphocyte phenotypes in blood versus lymph nodesOtto O Yang
Department of Medicine, Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, CA 90095, USA
J Acquir Immune Defic Syndr 39:507-18. 2005..Thus, blood indirectly reflects processes in lymphoid tissues, and caution should be applied when interpreting immunopathogenesis studies of blood... - Aiming for successful vaccine-induced HIV-1-specific cytotoxic T lymphocytesOtto O Yang
Division of Infectious Diseases, Department of Medicine and Department of Microbiology, Immunology, and Molecular Genetics, UCLA AIDS Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
AIDS 22:325-31. 2008 - Will we be able to 'spot' an effective HIV-1 vaccine?Otto O Yang
Division of Infectious Diseases AIDS Institute, 37 121 Center for Health Sciences, 10833 LeConte Avenue, UCLA Medical Center, Los Angeles, CA 90095, USA
Trends Immunol 24:67-72. 2003..To assess CTLs as a protective immune response, it will be crucial to elucidate these mechanisms and/or devise new assays that directly reflect the interaction of CTLs and HIV-1... - Human leukocyte antigen class I haplotypes of human immunodeficiency virus-1-infected persons on Likoma Island, MalawiOtto O Yang
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA
Hum Immunol 72:877-80. 2011..This is the first reported significant dataset of HLA class I allelic frequencies in Malawians... - Retracing our STEP towards a successful CTL-based HIV-1 vaccineOtto O Yang
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Vaccine 26:3138-41. 2008 - Candidate vaccine sequences to represent intra- and inter-clade HIV-1 variationOtto O Yang
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 4:e7388. 2009..These data suggest that vaccine delivery of a 16-valent mixture of these regions could focus the CTL response against conserved epitopes that are broadly representative of circulating HIV-1 strains... - Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5Otto O Yang
AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Infect Dis 185:1174-8. 2002..These data confirm that MCP-2 is a ligand for CCR5 on CD4(+) lymphocytes and can specifically block R5 HIV-1... - Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strainsOtto O Yang
37 121 Center for Health Sciences, Division of Infectious Diseases, 10833 LeConte Ave, UCLA Medical Center, Los Angeles, CA 90095, USA
J Virol 79:860-8. 2005..In conclusion, the rapid overgrowth of a superinfecting strain of HIV-1 of the same subtype raises major concerns for effective vaccine development... - Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytesOtto O Yang
Division of Infectious Diseases and AIDS Institute, UCLA Medical Center, Los Angeles, California 90095, USA
J Virol 76:1626-31. 2002..We conclude that Nef (and not Vpr) contributes to functional HIV-1 immune evasion and that this effect is mediated by diminished antigen presentation to CTL... - Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytesOtto O Yang
Department of Medicine Division of Infectious Diseases, UCLA Medical Center, Los Angeles, CA 90095 1688, USA
Virology 332:16-9. 2005..These results agree with other studies showing that HIV-1-specific CTL exhibit abnormal phenotypes in vivo, and suggest the possibility that chronic turnover is an important mechanism of antiviral failure in HIV-1 infection... - CD1d on myeloid dendritic cells stimulates cytokine secretion from and cytolytic activity of V alpha 24J alpha Q T cells: a feedback mechanism for immune regulationO O Yang
Division of Infectious Diseases, University of California Medical Center, Los Angeles 90095, USA
J Immunol 165:3756-62. 2000..Because myeloid dendritic cells are a major source of IL-12 and control Th1 cell differentiation, their elimination by lysis is a mechanism for limiting the generation of Th1 cells and thus regulating Th1/Th2 responses... - Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twinsOtto O Yang
UCLA AIDS Institute and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Virol 79:15368-75. 2005..These results indicate that while CTL targeting is predominately genetically determined, stochastic influences render the interaction of HIV-1 and host immunity, and therefore viral escape and CTL efficacy, unpredictable... - Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequencesC Brander
AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Virol 73:10191-8. 1999..These data suggest that escape from this immunodominant CTL response is not frequently accomplished by changes in the epitope flanking sequences... - Persistent alterations in the T-cell repertoires of HIV-1-infected and at-risk uninfected menM Scott Killian
Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
AIDS 18:161-70. 2004..In addition, these findings underscore the necessity of selecting controls with similar antigenic exposure histories when investigating T-cell dynamics in HIV-infected individuals... - Evasion of cytotoxic T lymphocytes is a functional constraint maintaining HIV-1 Nef expressionAyub Ali
AIDS Institute, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Eur J Immunol 35:3221-8. 2005..These data indicate that MHC-I down-regulation is an important function favoring Nef maintenance due to a net selective advantage in the setting of the general CTL response... - The major genetic determinants of HIV-1 control affect HLA class I peptide presentationFlorencia Pereyra
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
Science 330:1551-7. 2010..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection... - Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytesAyub Ali
Department of Medicine, AIDS Institute, Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, Los Angeles, California 90095, USA
J Virol 78:561-7. 2004..The epitope targeting of CTL and viral control of class I therefore likely play important roles in the ability of CTL to exert pressure on HIV-1... - Clonal breadth of the HIV-1-specific T-cell receptor repertoire in vivo as determined by subtractive analysisM Scott Killian
AIDS Institute and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
AIDS 19:887-96. 2005.... - Rapid T cell receptor delineation reveals clonal expansion limitation of the magnitude of the HIV-1-specific CD8+ T cell responseArumugam Balamurugan
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Immunol 185:5935-42. 2010..Overall, these findings demonstrate that the magnitude of the CTL response in chronic HIV-1 infection is constrained by TCR clonal breadth, suggesting maximal expansion of CTLs in response to chronic antigenic stimulation... - Autologous CD4/CD8 co-culture assay: a physiologically-relevant composite measure of CD8+ T lymphocyte function in HIV-infected personsSteven R Fauce
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, United States
J Immunol Methods 327:75-81. 2007.... - A novel small reporter gene and HIV-1 fitness assayAyub Ali
Division of Infectious Diseases, Department of Medicine, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Virol Methods 133:41-7. 2006..These paired reporter viruses offer a potentially useful standardized method for measurement of HIV-1 fitness in competition assays... - Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 Gag vaccinationArumugam Balamurugan
Division of Infectious Diseases, 37 121 CHS, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90095, USA
J Virol 82:2784-91. 2008.... - Nef interference with HIV-1-specific CTL antiviral activity is epitope specificSama Adnan
Division of Infectious Diseases, 37-121 CHS, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90095, USA
Blood 108:3414-9. 2006..The data thus indicate that HLA-C-restricted CTLs may have an under-appreciated antiviral role in the setting of Nef in vivo and suggest a benefit of promoting HLA-C-restricted CTLs for immunotherapy or vaccine development... - Parallel human immunodeficiency virus type 1-specific CD8+ T-lymphocyte responses in blood and mucosa during chronic infectionF Javier Ibarrondo
UCLA AIDS Institute, Department of Medicine, Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA 90095, USA
J Virol 79:4289-97. 2005..For protective or immunotherapeutic vaccination, it will be important to determine whether immunity is elicited in the mucosa, which is a key site of initial infection and subsequent HIV-1 replication in vivo... - Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutationsAyub Ali
Department of Medicine and AIDS Institute, Center for Health Sciences, University of California, Los Angeles, CA 90095, USA
J Immunol 171:3999-4005. 2003..Given the rarity of nef frameshifts in vivo, these data support the concept that the ability to down-regulate MHC-I could be a key constraint for preservation of Nef in vivo... - Immunologic profile of highly exposed yet HIV type 1-seronegative menOtto O Yang
Department of Medicine, UCLA Medical Center, Los Angeles, California 90095, USA
AIDS Res Hum Retroviruses 18:1051-65. 2002..General immune parameters reflected by CD8(+) T cell levels and activation, and monocyte concentrations may affect the risk of infection with HIV-1, and/or serve as markers of exposure... - Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cellsMichael S Bennett
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Virol 81:4973-80. 2007..Thus, defining KE(50) values is required to interpret the significance of functional avidity measurements and predict CTL efficacy against virus-infected cells in pathogenesis and vaccine studies... - Detection of HIV-1-specific CTL responses in Clade B infection with Clade C Peptides and not Clade B consensus peptidesRachel Lubong Sabado
Department of Medicine, Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles 90095, USA
J Immunol Methods 296:1-10. 2005.... - Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1C M Noviello
Biomedical Sciences Graduate Program, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
J Virol 81:4776-86. 2007..These data suggest that both functions are important for the successful establishment of infection in a new host... - A standardized, comprehensive magnetic resonance imaging protocol for rapid and precise quantification of HIV-1-associated lipodystrophyM Bickel
HIV Medical Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
HIV Med 8:413-9. 2007..Although multiple methods have been proposed, there is no current gold standard for assessing HIV-1-associated lipodystrophy... - Functional adaptation of Nef to the immune milieu of HIV-1 infection in vivoMartha J Lewis
Geffen School of Medicine, University of California, Department of Medicine, Division of Infectious Diseases, Los Angeles, CA 90095, USA
J Immunol 180:4075-81. 2008..Taken together, these data demonstrate the functionality of Nef to down-regulate MHC-I in vivo during stable chronic infection, and suggest that this function is maintained by the need of HIV-1 to cope with the antiviral CTL response... - Cross-clade detection of HIV-1-specific cytotoxic T lymphocytes does not reflect cross-clade antiviral activityMichael S Bennett
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Infect Dis 197:390-7. 2008..These data strongly support clade-specific antiviral activity of CTLs and call into question the validity of standard methods for assessing cross-clade CTL activity or CTL antiviral activity in general... - Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1Alexander M Cole
Department of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, 10833 Le Conte Ave, Room CHS 37 055, Los Angeles, CA 90095 1690, USA
FEBS Lett 535:195-9. 2003..The strategies employed herein could uncover additional antimicrobial peptides from envelope proteins of other lytic viruses... - Bronchoalveolar immunologic profile of acute human lung transplant allograft rejectionAric L Gregson
Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CA 90095, USA
Transplantation 85:1056-9. 2008..A unique BALF lymphocyte profile was associated with rejection and may provide insight into the pathogenesis of allograft rejection... - Proliferation and foxp3 expression in virus-specific memory CD8+ T lymphocytesAki Hoji
Division of Infectious Diseases, Department of Medicine, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
AIDS Res Hum Retroviruses 24:1087-95. 2008.... - Differential immunogenicity of vaccinia and HIV-1 components of a human recombinant vaccine in mucosal and blood compartmentsPeter A Anton
Center for Prevention Research and the UCLA AIDS Institute, David Geffen School of Medicine at UCLA, USA
Vaccine 26:4617-23. 2008..Although only eight volunteers were studied intensively, the discordance between mucosal and blood responses may highlight mechanisms contributing to recent vaccine failures... - Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vectorJohn P Miller
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, United States
Vaccine 27:3992-4000. 2009..These studies suggest that CVB3 vectors may be useful as vaccine vector candidates, if hurdles in class I antigen presentation and stability can be overcome... - Assessing the antiviral activity of HIV-1-specific cytotoxic T lymphocytesOtto O Yang
Division of Infectious Diseases, Department of Medicine, AIDS Institute, Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA, USA
Methods Mol Biol 485:407-15. 2009..Data from such experiments can be useful to elucidate the contribution of viral and CTL factors to the antiviral efficiency of CTL... - Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1Alexander M Cole
Department of Medicine, AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 99:1813-8. 2002..These findings suggest that retrocyclin interferes with an early stage of HIV-1 infection and that retrocyclin-like agents might be useful topical agents to prevent sexually acquired HIV-1 infections... - HIV-1 infected patients with suppressed plasma viremia on treatment have pro-inflammatory HDLTheodoros Kelesidis
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Lipids Health Dis 10:35. 2011..We hypothesized that HIV-1-infected persons on antiretroviral therapy would have pro-inflammatory high density lipoprotein (HDL), and that an apoA-1 mimetic peptide might reverse the inflammatory properties of HDL in these persons... - Pediatric HIV-1-specific cytotoxic T-lymphocyte responses suggesting ongoing viral replication despite combination antiretroviral therapyNatascha Ching
Department of Pediatrics, Division of Pediatric Infectious Diseases, David Gefen School of Medicine at UCLA and Mattel Children s Hospital at UCLA, Los Angeles, California 90095, USA
Pediatr Res 61:692-7. 2007..The long-term clinical implications of these findings remain to be determined... - Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cellsAric L Gregson
Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e11354. 2010..CCL21 may be pivotal for the recruitment of this distinct subset to the lung allograft and thereby decrease the risk for chronic rejection... - Epitope escape mutation and decay of human immunodeficiency virus type 1-specific CTL responsesBeth D Jamieson
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Immunol 171:5372-9. 2003..Our data show surprisingly consistent decay of CTL responses after epitope escape mutation and provide insight into potential mechanisms for both immune failure and shifting CTL specificities... - Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytesLivia Pedroza-Martins
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095-1747, USA
AIDS 20:939-42. 2006..Thus infection and depletion of functionally mature thymocytes that can produce endogenous IFN-gamma may mutually contribute to HIV-1 replication in the thymus and to reduced T-cell output... - In vitro inhibition of HIV-1 by Met-SDF-1beta alone or in combination with antiretroviral drugsS Rusconi
Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Antivir Ther 5:199-204. 2000..This compound is a promising new candidate in a receptor-based approach to HIV-1 infection in conjunction with currently available combination antiretroviral drug therapies... - Culturing of HIV-1-specific cytotoxic T lymphocytes with interleukin-7 and interleukin-15Rachel Lubong
Division of Infectious Diseases, Department of Medicine, UCLA Medical Center, Los Angeles, CA 90095, USA
Virology 325:175-80. 2004..Addition of IL-7 or IL-15 to IL-2 did not augment function of the cells. These data suggest that supplementing CTL cultures with these cytokines does not provide improvement of cell growth or function... - gp120-Independent infection of CD4(-) epithelial cells and CD4(+) T-cells by HIV-1Yen-Hung Chow
Division of Oral Biology and Medicine and University of California Los Angeles Dental Institute, UCLA School of Dentistry, Los Angeles, 90095-1668, USA
J Acquir Immune Defic Syndr 30:1-8. 2002..Our results suggest that HIV-1 infects both CD4- and CD4+ cells using a gp120-independent mechanism. This infection mechanism may provide new explanations for HIV-1 latency and persistent infection in patients... - Transience of vaccine-induced HIV-1-specific CTL and definition of vaccine "response"Beth D Jamieson
UCLA AIDS Institute and Department of Medicine, Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, CA 90095, and Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
Vaccine 24:3426-31. 2006.... - TCR gamma delta+ and CD161+ thymocytes express HIV-1 in the SCID-hu mouse, potentially contributing to immune dysfunction in HIV infectionKevin B Gurney
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, School of Medicine, 90095, USA
J Immunol 169:5338-46. 2002..We conclude that HIV-1 infection and/or disruption of cells important in both innate and acquired immunity may contribute to the overall immune dysfunction seen in HIV-1 disease... - Half-genome human immunodeficiency virus type 1 constructs for rapid production of reporter virusesAyub Ali
Division of Infectious Diseases, Department of Medicine and AIDS Institute, Los Angeles Medical Center, University of California, 37-121 CHS, 10833 LeConte Avenue, Los Angeles, CA 90095-1688, USA
J Virol Methods 110:137-42. 2003..We provide an example of the utility of this system for studying the effects of Nef on infected cells... - Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infectionAyub Ali
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Virol Methods 161:297-304. 2009..These data demonstrated that this assay system allows rapid characterization of bulk and clonal Nef functional profiles that can be used in pathogenesis studies to define further its important role in pathogenesis... - Paradoxical effects of two theta-defensins on HIV type 1 infectionQiuwei Wang
UCLA School of Dentistry, and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA
AIDS Res Hum Retroviruses 23:508-14. 2007..The ability of RC-111 to enhance HIV-1 infection might prove useful in developing peptides that can enhance gene delivery by HIV-based lentiviral vectors... - Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytesMirabelle Dagarag
Departments of Pathology and Laboratory Medicine, Geffen School of Medicine, UCLA Medical Center, Los Angeles, California, USA
J Virol 77:3077-83. 2003..Telomerase transduction could therefore be a tool with which to explore a potential therapeutic approach to an important pathophysiologic process of immune dysfunction in chronic viral infection... - Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytesSteven Russell Fauce
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Immunol 181:7400-6. 2008..Our study is the first to use a pharmacological telomerase-based approach to enhance immune function, thus directly addressing the telomere loss immunopathologic facet of chronic viral infection... - gp120-independent HIV infection of cells derived from the female reproductive tract, brain, and colonJunying Zheng
UCLA School of Dentistry, UCLA Dental Institute, and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095-1668, USA
J Acquir Immune Defic Syndr 43:127-36. 2006..Infection of glial and neuronal cell lines suggests that HIV infection of these cells is a probable mechanism for HIV pathogenicity in the brain and a possible cause for persistent infection in patients... - Ethanol stimulation of HIV infection of oral epithelial cellsJun Zheng
Division of Oral Biology and Medicine and University of California at Los Angeles (UCLA) Dental Institute, UCLA School of Dentistry, Los Angeles, CA 90095, USA
J Acquir Immune Defic Syndr 37:1445-53. 2004..Our results indicate that in cell culture conditions, the ranges of concentrations of alcohol that are commercially available are able to stimulate the infection efficiency of HIV in POEs... - Antiviral activity of human immunodeficiency virus type 1 Gag-specific cytotoxic T lymphocyte targeting is not necessarily intrinsically superior to envelope targetingDiana Y Chen
Department of Microbiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Virol 85:2474-8. 2011..A virus expressing SL9 in Env was similar to the original virus in susceptibility to SL9-specific CTLS. This finding suggests that Env targeting is not intrinsically inferior to Gag targeting for CTL antiviral activity... - How many human immunodeficiency virus type 1-infected target cells can a cytotoxic T-lymphocyte kill?W David Wick
SCHARP, Fred Hutchinson CRC, 1100 Fairview Ave N, LE 400, Seattle, WA 98109, USA
J Virol 79:13579-86. 2005..These results are compatible with the observed decline in viremia after primary infection being primarily a consequence of CTL activity and have interesting implications for vaccine design... - Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitopeKeri L Schaubert
Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 178:7756-66. 2007.... - Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cellsPhilip J Norris
Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
J Virol 78:8844-51. 2004..While the antiviral effector activity of CD8(+) T cells has been well documented, these results strongly suggest that HIV-1-specific CD4(+) T cells are capable of directly contributing to antiviral immunity... - The theta-defensin, retrocyclin, inhibits HIV-1 entryCarsten Munk
Infectious Disease Laboratory, Salk Institute for Biological Studies, San Diego, CA 92037, USA
AIDS Res Hum Retroviruses 19:875-81. 2003..In the aggregate, these results suggest that retrocyclin blocks an entry step in HIV-1 replication. Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors... - Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL responseJune Kan-Mitchell
Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Immunol 176:6690-701. 2006..This study suggests that agonist sequences can replace aberrantly immunogenic native epitopes for the rational design of vaccines targeting HIV-1... - Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expressionJonah B Sacha
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
J Immunol 178:2746-54. 2007..0017) in SIV-infected rhesus macaques. These results suggest that HIV vaccines should focus CD8(+) T cell responses on Gag... - HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41Amy L Cole
Department of Molecular Biology and Microbiology, Burnett College of Biomedical Sciences, University of Central Florida, FL 32816, USA
J Immunol 176:6900-5. 2006..These findings also suggest that interactions between theta-defensins and gp41 may contribute to the ability of these cyclic minidefensins to prevent HIV-1 entry into target cells... - Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infectionMichael E Severino
AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
Virology 306:371-5. 2003..These results provide evidence that T cells can be redirected against novel targets, and that independence from the class I pathway may have distinct advantages...
Research Grants
- HIV-1 Excape from Inhibiton by Cytotoxic T LymphocytesOtto Yang; Fiscal Year: 2007....
- Mucosal and Peripheral NK-T Cells in HIV InfectionOtto Yang; Fiscal Year: 2007..Exploring NK-T cells in HIV-1 infection could there have a high impact on the development of new strategies in prevention and treatment. ..
- HIV-1 ESCAPE FROM INHIBITION BY CYTOTOXIC T LYMPHOCYTESOtto Yang; Fiscal Year: 2009..Understanding these mechanisms may be important for designing vaccine strategies that promote more effective responses than occur in nature. ..
- Immune Pressure on HIV-1 Nef by Cytotoxic T LymphocytesOtto Yang; Fiscal Year: 2009..To delineate in detail the kinetics of Nef-mediated HLA downregulation versus CTL clearance of acutely HIV-1-infected cells; and 3. To screen for small molecule inhibitors of Nef-mediated HLA downregulation and other functions. ..
- HIV-1 ESCAPE FROM INHIBITION BY CYTOTOXIC T LYMPHOCYTESOtto O Yang; Fiscal Year: 2010..Understanding these mechanisms may be important for designing vaccine strategies that promote more effective responses than occur in nature. ..
- Immune Pressure on HIV-1 Nef by Cytotoxic T LymphocytesOtto O Yang; Fiscal Year: 2010..To delineate in detail the kinetics of Nef-mediated HLA downregulation versus CTL clearance of acutely HIV-1-infected cells;and 3. To screen for small molecule inhibitors of Nef-mediated HLA downregulation and other functions. ..
- Immune Pressure on HIV-1 Nef by Cytotoxic T LymphocytesOtto Yang; Fiscal Year: 2006..To evaluate the functions of Nefmutants selected by Nef-specific CTL (in vitro); 3. To evaluate potential in vivo selective pressures for conservation of Nef. ..
- HIV-1 ESCAPE FROM INHIBITION BY CYTOTOXIC T LYMPHOCYTESOtto Yang; Fiscal Year: 2002..Use of polyclonal CD8+ lymphocytes from infected individuals will allow evaluation of the inhibitory activity of uncloned CTL and functional comparison to CTL clones. ..
- Immune Pressure on HIV-1 Nef by Cytotoxic T LymphocytesOtto Yang; Fiscal Year: 2009..To delineate in detail the kinetics of Nef-mediated HLA downregulation versus CTL clearance of acutely HIV-1-infected cells; and 3. To screen for small molecule inhibitors of Nef-mediated HLA downregulation and other functions. ..