Research Topics
Species | Isaac YangSummaryAffiliation: University of California Country: USA Publications
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Publications
Heat shock proteins in glioblastomasIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, Room M779, Campus 0112, San Francisco, CA 94143, USA
Neurosurg Clin N Am 21:111-23. 2010....- Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case reportIsaac Yang
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Med Case Reports 3:88. 2009..We report the case of a patient with a giant thoracic schwannoma presenting unusually with acute abdominal pain and with delayed neurological impairment... - Heat-shock protein vaccines as active immunotherapy against human gliomasIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
Expert Rev Anticancer Ther 9:1577-82. 2009..They are now being investigated as a potential modality and adjuvant to immunotherapy, and they represent a promising novel treatment for human glioblastomas... - Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patientsSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
J Neurosurg 112:990-6. 2010..The authors present a large series of histologically confirmed SGSs, with follow-up to describe the clinical and radiological presentation, pathological diagnosis, and treatment outcomes... - Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngiomaMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
J Neurooncol 101:463-76. 2011..4%, P = 0.11). Given the difficulty in obtaining class 1 data regarding the treatment of this tumor, this study can serve as an estimate of expected outcomes for these patients, and guide decision making until these data are available... - Factors associated with preservation of facial nerve function after surgical resection of vestibular schwannomaOrin Bloch
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
J Neurooncol 102:281-6. 2011..Residual disease can be followed and controlled with radiosurgery if interval growth is noted... - A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannomaIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, California 94117, USA
J Neurosurg 112:851-9. 2010..Their aim was to objectively characterize the prognostic factors that contribute to hearing preservation after GKS, as well as methodically summarize the reported literature describing hearing preservation after GKS for VS... - A critical evaluation of vestibular schwannoma surgery for patients younger than 40 years of ageMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
Neurosurgery 67:1646-53; discussion 1653-4. 2010..There are few published prospective data sets specifically focusing on patients younger than 40 years old undergoing microsurgery for vestibular schwannoma... - The value of intraoperative facial nerve electromyography in predicting facial nerve function after vestibular schwannoma surgeryMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
J Clin Neurosci 17:849-52. 2010..In conclusion, while facial nerve EMG is a critical adjunct for locating the facial nerve intraoperatively, its predictive value for facial nerve function remains to be determined... - Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordomaBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, 505, Parnassus Ave, San Francisco, CA 94143, USA
J Neurooncol 98:101-8. 2010..Our data suggests that younger patients with chondroid type cranial chordoma treated with both surgery and radiation may have improved rates of tumor recurrence in the treatment of these tumors... - Tumor control after surgery and radiotherapy for pineocytomaAaron J Clark
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
J Neurosurg 113:319-24. 2010..Therefore, the authors performed a systematic review of the literature on tumor control after surgery for pineocytoma to determine the relative benefits of aggressive resection and postoperative adjuvant radiotherapy... - Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastomaJames S Waldron
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94123, USA
J Clin Neurosci 17:1543-7. 2010..In addition, our results raise the possibility of combining T-cell based immunotherapy protocols with clinical inhibitors of the PI3K/Akt/mTOR pathway... - Extent of resection and the long-term durability of vestibular schwannoma surgeryMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 114:1218-23. 2011..In this prospective study, the authors evaluated 772 patients who underwent microsurgical resection of VSs to analyze the association between total tumor resection and the tumor recurrence rate... - Intratumoral hemorrhage and fibrosis in vestibular schwannoma: a possible mechanism for hearing lossMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, 94143, USA
J Neurosurg 114:386-93. 2011..In this case-control study, the authors investigated the relationship between preoperative hearing loss and histological changes such as intratumoral microhemorrhage and extensive fibrosis... - Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannomaMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
Neurosurg Focus 27:E4. 2009..For this reason, the authors conducted a systematic review of the literature for non-audiofacial-related morbidity after the treatment of vestibular schwannoma with radiosurgery... - Implications of cystic features in vestibular schwannomas of patients undergoing microsurgical resectionBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Neurosurgery 68:874-80; discussion 879-80. 2011..Cystic vestibular schwannomas (VSs) are described as being more aggressive than solid tumors... - Surgical resection and adjuvant radiotherapy for a large pineal hemangiopericytomaBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
J Clin Neurosci 17:1209-11. 2010..The patient remains recurrence free 4 years after treatment... - Microglia and central nervous system immunityGurvinder Kaur
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, One Shrader Street, Suite 650, San Francisco, CA 94117, USA
Neurosurg Clin N Am 21:43-51. 2010..Microglia accumulation exists in almost every CNS disease process, including CNS tumors. This article discusses the role of microglia in CNS immunity and highlights key advances made in glioma immunology... - Preservation of facial nerve function after resection of vestibular schwannomaMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
Br J Neurosurg 24:666-71. 2010..The objective of this study was to provide a comprehensive assessment of reported outcomes for facial nerve preservation after VS surgery... - Immunological considerations of modern animal models of malignant primary brain tumorsMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
J Transl Med 7:84. 2009..As this review demonstrates, many of these models have inherent immune system limitations, and the impact of these limitations on studies on the influence of pre-clinical therapeutics testing warrants further attention... - CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survivalIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94117, USA
J Clin Neurosci 17:1381-5. 2010..006). Thus, CD8+ T-cell infiltrate is associated with prolonged survival. Our data provide the impetus for more sophisticated studies to further elucidate prospectively the specific T-cell subtypes associated with long-term survival... - A comprehensive analysis of intracranial chordoma and survival: a systematic reviewBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Br J Neurosurg 25:446-53. 2011..Here, we perform a systematic review of the literature to evaluate across multiple institutions the overall survival after treatment for intracranial chordoma... - Distinguishing glioma recurrence from treatment effect after radiochemotherapy and immunotherapyIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Neurosurg Clin N Am 21:181-6. 2010..Further investigations are necessary to assess the imaging algorithms and accuracy of these modalities to differentiate true glioma recurrence from radiotherapy or immunotherapy treatment effect... - Hearing preservation rates after microsurgical resection of vestibular schwannomaMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
J Clin Neurosci 17:1126-9. 2010..Use of the MCF demonstrates superior hearing outcomes to the RS approach, even after correcting for the effect of the increased size of tumors addressed by the RS approach... - Clinical characteristics and diagnostic imaging of epidermoid tumorsDaniel Nagasawa
Department of Neurological Surgery, University of California Los Angeles, 695 Charles E Young Drive South, Gonda 3357, Los Angeles, CA 90095 1761, USA
J Clin Neurosci 18:1158-62. 2011..While gross total resection of these tumors is the definitive treatment to prevent recurrence and aseptic meningitis, a subtotal resection may be necessary to preserve neurological function... - The natural history of untreated sporadic vestibular schwannomas: a comprehensive review of hearing outcomesMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
J Neurosurg 112:163-7. 2010..Their objective was to provide a comprehensive and unbiased description of outcomes in patients whose disease was managed conservatively... - Prognostic factors for post-operative seizure outcomes after cavernous malformation treatmentWon Kim
Department of Neurological Surgery, University of California Los Angeles, 695 Charles E Young Drive South, Gonda Room 3357, Los Angeles, California 90095 1761, USA
J Clin Neurosci 18:877-80. 2011..Prognostic features of cavernous malformations should be utilized for both guidance of lesion treatment, and prediction of post-operative seizure outcomes... - Cranial chondrosarcoma and recurrenceOrin G Bloch
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California
Skull Base 20:149-56. 2010..Our systematic review closely reflects the actuarial recurrence rate and provides predictive factors in the recurrence of cranial chondrosarcoma... - New advances that enable identification of glioblastoma recurrenceIsaac Yang
Department of Neurological Surgery, University of California, San Francisco, CA, USA
Nat Rev Clin Oncol 6:648-57. 2009..Further research will also be needed to develop improved algorithms that use these modalities, and to develop new modalities with even greater accuracy than those currently available... - Clinical characteristics and outcomes for a modern series of primary gliosarcoma patientsSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, CA, USA
Cancer 116:1358-66. 2010..In the current study, the authors present a modern series of confirmed PGS cases treated in the era of magnetic resonance imaging (MRI), after the accepted glioblastoma management of resection, radiation, and temozolomide... - Gamma interferon-mediated superinduction of B7-H1 in PTEN-deficient glioblastoma: a paradoxical mechanism of immune evasionSeunggu J Han
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94117, USA
Neuroreport 20:1597-602. 2009..The combination of PTEN loss and gamma-interferon exposure in glioblastoma patients results in an exceptionally immunoresistant phenotype that may negate adaptive immunity through induction of T-cell apoptosis... - Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomesIsaac Yang
Department of Neurological Surgery, University of California at Los Angeles, Los Angeles, California, USA
J Clin Neurosci 18:29-33. 2011..Our findings also support that an early surgical intervention is significantly associated with improved clinical seizure control... - Monitoring immune responses after glioma vaccine immunotherapyBrian Jian
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 21:195-9. 2010..Improvements in immunomonitoring should lead to an increase in the efficiency of identifying viable avenues of therapeutic research, and assess the efficacy of those currently employed... - Survival outcomes for radiotherapy treatment of epidermoid tumors with malignant transformationDaniel Nagasawa
Department of Neurological Surgery, University of California Los Angeles, 695 Charles E Young Drive South, Gonda 3357, Los Angeles, CA 90095 1761, USA
J Clin Neurosci 19:21-6. 2012..When determining the management for malignant transformation of epidermoid tumors, the combination of surgical resection and radiotherapy may be associated with improved short-term survival... - Biologic principles of immunotherapy for malignant gliomasSeunggu J Han
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94117, USA
Neurosurg Clin N Am 21:1-16. 2010..This article describes the current strategies and principles of immunotherapy for malignant gliomas... - Secondary gliosarcoma: a review of clinical features and pathological diagnosisSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
J Neurosurg 112:26-32. 2010..In this article the authors review the literature on secondary gliosarcoma, with attention to clinical course and pathological features... - Craniopharyngioma: a comparison of tumor control with various treatment strategiesIsaac Yang
Department of Neurological Surgery, University of California, San Francisco, California, USA
Neurosurg Focus 28:E5. 2010..Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas... - A systematic review of intracranial chondrosarcoma and survivalOrin G Bloch
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
J Clin Neurosci 16:1547-51. 2009..The results of our systematic review provide useful data in predicting survival among intracranial chondrosarcoma patients... - The molecular biology and novel treatments of vestibular schwannomasBrendan Fong
Department of Neurological Surgery, University of California, Los Angeles, CA 90095 1761, USA
J Neurosurg 115:906-14. 2011..With further research it may be possible to significantly reduce morbidity and mortality rates by decreasing tumor burden, tumor volume, hearing loss, and cranial nerve deficits seen in vestibular schwannomas... - Interferon-gamma in brain tumor immunotherapyAri Kane
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Neurosurg Clin N Am 21:77-86. 2010..Here the authors review the published literature that highlights the potential role of IFNgamma in the treatment and immunotherapy of malignant gliomas... - The tumor biology and molecular characteristics of medulloblastoma identifying prognostic factors associated with survival outcomes and prognosisWon Kim
Department of Neurological Surgery, University of California, Los Angeles, 695 Charles E Young Drive South, Gonda 3357, Los Angeles, California 90095 1761, USA
J Clin Neurosci 18:886-90. 2011..Future development of novel therapies that target the heterogeneity of MB and are tailored to the tumor's unique molecular profile may yield improved outcomes for these patients... - Pineal cyst: a review of clinical and radiological featuresWinward Choy
Department of Neurological Surgery, University of California, Los Angeles, 695 Charles E Young Drive South, Gonda 3357, Los Angeles, CA 90095 1761, USA
Neurosurg Clin N Am 22:341-51, vii. 2011..This article reviews and discusses the characteristic features of PCs-clinical, histological, and identifiable by various imaging modalities-which assist clinicians in narrowing the differential diagnosis for pineal lesions... - Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entitySeunggu J Han
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
J Neurooncol 96:313-20. 2010..Clinical and pathologic characteristics distinct from GBM suggest that they may warrant specific treatment, separate from conventional GBM therapy... - The molecular genetics and tumor pathogenesis of meningiomas and the future directions of meningioma treatmentsWinward Choy
Department of Neurological Surgery, University of California Los Angeles, 695 Charles E Young Drive South, Los Angeles, CA 90095 1761, USA
Neurosurg Focus 30:E6. 2011..Future therapies will include combinations of targeted molecular agents as a result of continued progress in the understanding of genetic and biological changes associated with meningiomas... - The role of microglia in central nervous system immunity and glioma immunologyIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
J Clin Neurosci 17:6-10. 2010..The role of microglia in CNS immunity is reviewed, with a focus on key advances made in glioma immunology... - A systematic analysis of disease control in acromegaly treated with radiosurgeryIsaac Yang
Department of Neurological Surgery, University of California, Los Angeles, California 90095 6901, USA
Neurosurg Focus 29:E13. 2010..Here, the authors present a systematic analysis of SRS for growth hormone-secreting adenomas to characterize the efficacy of SRS in the treatment of acromegaly... - Sarcoidosis of the pineal gland: an unusual presentation of neurosarcoidosisIsaac Yang
Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, UCSF School of Medicine, 505 Parnassus Ave Rm M779, San Francisco, CA, 94143 0112, USA
J Neurooncol 91:113-6. 2009..We report an unusual case of sarcoidosis involving the pineal gland with radiographic, histopathology, and clinical data... - Delayed intracranial and bony metastasis of paragangliomaAndrew Yew
Department of Neurological Surgery, University of California Los Angeles, Los Angeles, CA, USA
Surg Neurol Int 2:62. 2011..Here we present the case of a patient who presented with a rare case of intracranial metastasis from abdominal paraganglioma... - Facial nerve preservation after vestibular schwannoma Gamma Knife radiosurgeryIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
J Neurooncol 93:41-8. 2009..In this study, we report the results of an objective analysis of reported facial nerve outcomes after the treatment of vestibular schwannomas with Gamma Knife radiosurgery... - Rib head disarticulation for multilevel transpedicular thoracic corpectomies and expandable cage reconstructionDean Chou
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
Neurol India 57:469-74. 2009..This avoids pleural dissection and affords expandable cage placement through a transpedicular approach... - Complications associated with the treatment for spinal ependymomasDaniel T Nagasawa
Department of Neurological Surgery, University of California Los Angeles, CA 90095 1761, USA
Neurosurg Focus 31:E13. 2011..Identification and acknowledgment of these potential problems may assist in their prevention, early detection, and increased quality of life for patients afflicted with this disease...