Chengfeng Yang

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis
    Chengfeng Yang
    University of Pennsylvania School of Medicine, Center for Experimental Therapeutics, 421 Curie Blvd, Philadelphia, PA 19104, USA
    J Environ Pathol Toxicol Oncol 21:331-42. 2002
  2. ncbi Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1
    Chengfeng Yang
    Department of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biochem J 410:167-75. 2008
  3. ncbi Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac
    Chengfeng Yang
    Department of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Biochem J 403:1-12. 2007
  4. ncbi Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells
    Chengfeng Yang
    Department of Environmental Medicine and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    Toxicology 213:81-96. 2005
  5. ncbi Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 280:24363-70. 2005
  6. ncbi Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling
    HongBin Wang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    EMBO J 25:2062-74. 2006
  7. ncbi Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania School of Medicine, 816 Biomedical Research Building II III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 26:831-42. 2006
  8. ncbi NFkappaB-independent signaling to the cyclin D1 gene by Rac
    Eric A Klein
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cell Cycle 6:1115-21. 2007
  9. ncbi Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
    Jisen Dai
    Department of Environmental Medicine, NYU Cancer Institute, New York University School of Medicine, PHL Room 802, New York, NY 10016, USA
    Toxicology 203:199-209. 2004
  10. ncbi Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer
    Maria Soledad Sosa
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell 40:877-92. 2010

Collaborators

Detail Information

Publications11

  1. ncbi Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis
    Chengfeng Yang
    University of Pennsylvania School of Medicine, Center for Experimental Therapeutics, 421 Curie Blvd, Philadelphia, PA 19104, USA
    J Environ Pathol Toxicol Oncol 21:331-42. 2002
    ....
  2. ncbi Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1
    Chengfeng Yang
    Department of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biochem J 410:167-75. 2008
    ..Taken together, these findings establish a central role for Rac1 in the control of HRG-induced breast cancer cell-cycle progression and proliferation through up-regulating the expression of cyclin D1 and p21(Cip1)...
  3. ncbi Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac
    Chengfeng Yang
    Department of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Biochem J 403:1-12. 2007
    ..In addition, vigorous recent studies have begun to decipher the critical roles of chimaerins in the central nervous system, development and tumour progression...
  4. ncbi Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells
    Chengfeng Yang
    Department of Environmental Medicine and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    Toxicology 213:81-96. 2005
    ..Overall, our findings suggest that inflammatory cytokines play an important role in the suppressive effects of CAPE on As-induced cell transformation and in the selective cytotoxicity of CAPE to As-transformed HOS cells...
  5. ncbi Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 280:24363-70. 2005
    ....
  6. ncbi Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling
    HongBin Wang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    EMBO J 25:2062-74. 2006
    ..Our results represent the first direct evidence of divergence in DAG signaling downstream of a tyrosine-kinase receptor via a PKC-independent mechanism...
  7. ncbi Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania School of Medicine, 816 Biomedical Research Building II III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 26:831-42. 2006
    ....
  8. ncbi NFkappaB-independent signaling to the cyclin D1 gene by Rac
    Eric A Klein
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cell Cycle 6:1115-21. 2007
    ..We conclude that, in MEFs, Rac-mediated induction of cyclin D1 mRNA requires activation of a parallel NFkappaB pathway whereas ERK induces cyclin D1 transcription independent of NFkappaB...
  9. ncbi Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
    Jisen Dai
    Department of Environmental Medicine, NYU Cancer Institute, New York University School of Medicine, PHL Room 802, New York, NY 10016, USA
    Toxicology 203:199-209. 2004
    ....
  10. ncbi Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer
    Maria Soledad Sosa
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell 40:877-92. 2010
    ..In addition to the prognostic and therapeutic implications, our findings reveal an ErbB effector pathway that is crucial for breast cancer progression...
  11. ncbi Divergence and complexities in DAG signaling: looking beyond PKC
    Chengfeng Yang
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA
    Trends Pharmacol Sci 24:602-8. 2003
    ....