Research Topics
Genomes and Genes | Zhen YanSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Detail Information
Publications
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscleZhen Yan
Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
J Appl Physiol 110:264-74. 2011....- Exercise, PGC-1alpha, and metabolic adaptation in skeletal muscleZhen Yan
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Appl Physiol Nutr Metab 34:424-7. 2009..The signaling-transcription network that is responsible for exercise-induced skeletal muscle adaption remains to be fully elucidated... - Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in micePing Huang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
Nutr Metab (Lond) 7:59. 2010..The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance... - PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscleTuoyu Geng
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Am J Physiol Cell Physiol 298:C572-9. 2010..We conclude that PGC-1alpha is required for complete skeletal muscle adaptations induced by endurance exercise in mice... - Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathwayTakayuki Akimoto
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:19587-93. 2005..These findings suggest that contractile activity-induced activation of the p38 MAPK pathway promotes Pgc-1alpha gene expression and skeletal muscle adaptation... - Resident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growthPing Li
Department of Medicine, Duke University Medical Center, Independence Park Facility, 4321 Medical Park Dr, Durham, NC 27704, USA
Am J Physiol Cell Physiol 290:C1461-8. 2006..The origin of the angiogenic cells in this physiological exercise model remains to be determined... - Transcriptional control of the Pgc-1alpha gene in skeletal muscle in vivoZhen Yan
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
Exerc Sport Sci Rev 35:97-101. 2007..A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1alpha gene in skeletal muscle in vivo... - Functional interaction of regulatory factors with the Pgc-1alpha promoter in response to exercise by in vivo imagingTakayuki Akimoto
Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
Am J Physiol Cell Physiol 295:C288-92. 2008..These findings provide in vivo evidence for functional interactions between PKD/HDAC5 and ATF2 regulatory factors and the Pgc-1alpha gene in adult skeletal muscle... - PGC-1? promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in miceTuoyu Geng
Department of Medicine Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, USA
Am J Pathol 178:1738-48. 2011..These findings suggest that PGC-1? protects muscle from catabolic wasting in chronic heart failure through enhanced nitric oxide antioxidant defenses and inhibition of the forkhead transcription factor signaling pathways... - Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in micePing Li
Division of Cardiology, Department of Medicine, Duke University Medical Center, 4321 Medical Park Dr, Suite 200, Durham, NC 27704, USA
Am J Pathol 170:599-608. 2007..These findings suggest that exercise intolerance can occur in CHF without fiber type switching in skeletal muscle and that oxidative phenotype renders myofibers resistant to pathological insults induced by CHF... - PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivityVitor A Lira
Center for Skeletal Muscle Research, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA
Am J Physiol Endocrinol Metab 299:E145-61. 2010.... - Myocyte specific overexpression of myoglobin impairs angiogenesis after hind-limb ischemiaSurovi Hazarika
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Arterioscler Thromb Vasc Biol 28:2144-50. 2008..Myoglobin (Mb) is expressed exclusively in striated muscle cells. We hypothesized that myocyte specific overexpression of myoglobin attenuates ischemia-induced angiogenesis even in the presence of normal endothelium... - Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient miceTakayuki Akimoto
Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
Am J Physiol Cell Physiol 287:C1311-9. 2004..Other protein kinases sharing substrates with constitutively active CaMKIV may function as endogenous mediators of activity-dependent changes in myofiber phenotype... - Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscleRichard E Waters
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Cell Physiol 287:C1342-8. 2004..These findings suggest that endurance training induces angiogenesis in a subpopulation of type IIb + IId/x fibers before switching to type IIa fibers... - Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiencyTimothy R Koves
Department of Medicine, and Sarah W Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina 27710, USA
J Biol Chem 280:33588-98. 2005..We proposed that PGC1alpha enables muscle mitochondria to better cope with a high lipid load, possibly reflecting a fundamental metabolic benefit of exercise training... - Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivityChristoph Zechner
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Cell Metab 12:633-42. 2010..Taken together, we conclude that PGC-1 coactivators are necessary for the oxidative and mitochondrial programs of skeletal muscle but are dispensable for fundamental fiber type determination and insulin sensitivity... - MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiationJeffrey Gagan
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
J Biol Chem 286:19431-8. 2011..MyoR and miR-378 were anticorrelated during cardiotoxin-induced adult muscle regeneration in mice. Taken together, this shows a feed-forward loop where MyoD indirectly down-regulates MyoR via miR-378... - Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistanceAkshaya K Meher
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Free Radic Biol Med 52:1708-15. 2012..Together, our data demonstrate a dominant role for nonmyeloid Nrf2 in controlling HFD-induced adipose tissue inflammation and the development of insulin resistance... - Midlife gene expressions identify modulators of aging through dietary interventionsBing Zhou
Chinese Academy of Sciences Key Laboratory for Computational Biology, Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Proc Natl Acad Sci U S A 109:E1201-9. 2012.... - Highly coordinated gene regulation in mouse skeletal muscle regenerationZhen Yan
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:8826-36. 2003..This study identifies novel genes potentially important for muscle regeneration and reveals highly coordinated myogenic cell proliferation and differentiation programs in adult skeletal muscle regeneration in vivo...
Research Grants
- Exercise-Induced Mitochondrial BiogenesisZhen Yan; Fiscal Year: 2007..will not only provide information to guide the correct and efficient use of regular exercise training for preventing and treating the diseases, but also facilitate discovery of new therapeutic drugs to combat the diseases ..
- Exercise-Induced Mitochondrial BiogenesisZhen Yan; Fiscal Year: 2009..We anticipate important new information to emerge. Findings from this research will likely foster innovative approaches to improve skeletal muscle function and treat diseases related to skeletal muscle disorder. ..