Jingsong Xu

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi Polarity reveals intrinsic cell chirality
    Jingsong Xu
    Departments of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:9296-300. 2007
  2. ncbi Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins
    Jingsong Xu
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Nat Immunol 9:880-6. 2008
  3. ncbi A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury
    Anke Di
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 285:15848-57. 2010
  4. ncbi Akt isoforms differentially regulate neutrophil functions
    Jia Chen
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 115:4237-46. 2010
  5. ncbi Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
    Jingsong Xu
    Department of Cellular and Molecular Pharmacology and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 114:201-14. 2003
  6. ncbi Neutrophil microtubules suppress polarity and enhance directional migration
    Jingsong Xu
    Department of Cellular and Molecular Pharmacology and Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0450, USA
    Proc Natl Acad Sci U S A 102:6884-9. 2005

Research Grants

  1. Role of Non-muscle MLCK in Neutrophil-mediated Acute Lung Injury
    Jingsong Xu; Fiscal Year: 2009
  2. Role of Non-muscle MLCK in Neutrophil-mediated Acute Lung Injury
    Jingsong Xu; Fiscal Year: 2010

Collaborators

Detail Information

Publications6

  1. ncbi Polarity reveals intrinsic cell chirality
    Jingsong Xu
    Departments of Cellular and Molecular Pharmacology, School of Medicine, University of California San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:9296-300. 2007
    ..Such a template could help to determine left-right asymmetry and planar polarity in development...
  2. ncbi Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins
    Jingsong Xu
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Nat Immunol 9:880-6. 2008
    ..Our results demonstrate that MYLK-mediated activation of beta(2) integrins through Pyk2 links beta(2) integrin signaling to the actin motile machinery of neutrophils...
  3. ncbi A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury
    Anke Di
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 285:15848-57. 2010
    ..Therefore, SphK1-mediated down-regulation of JNK activity serves to dampen inflammation and tissue injury...
  4. ncbi Akt isoforms differentially regulate neutrophil functions
    Jia Chen
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 115:4237-46. 2010
    ..These results demonstrate a predominant role of Akt2 in regulating neutrophil functions and provide evidence for differential activation of the 2 Akt isoforms in neutrophils...
  5. ncbi Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
    Jingsong Xu
    Department of Cellular and Molecular Pharmacology and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 114:201-14. 2003
    ..The latter effect explains both the neutrophil's ability to polarize in uniform concentrations of chemoattractant and its response to reversal of an attractant gradient by performing a U-turn...
  6. ncbi Neutrophil microtubules suppress polarity and enhance directional migration
    Jingsong Xu
    Department of Cellular and Molecular Pharmacology and Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0450, USA
    Proc Natl Acad Sci U S A 102:6884-9. 2005
    ..Thus, microtubules normally balance backness vs. frontness signals, preventing backness from reducing the strength of pseudopods and from impairing directional migration...

Research Grants2

  1. Role of Non-muscle MLCK in Neutrophil-mediated Acute Lung Injury
    Jingsong Xu; Fiscal Year: 2009
    ..We hope that through the understanding of the novel function of this MLCK isoform, more effective strategies will be developed for the prevention and treatment of lung inflammation and the resultant injury. ..
  2. Role of Non-muscle MLCK in Neutrophil-mediated Acute Lung Injury
    Jingsong Xu; Fiscal Year: 2010
    ..We hope that through the understanding of the novel function of this MLCK isoform, more effective strategies will be developed for the prevention and treatment of lung inflammation and the resultant injury. ..