Research Topics
| Sherry A WuenschSummaryAffiliation: University of Rochester Country: USA Publications
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Detail Information
Publications
Local intrahepatic CD8+ T cell activation by a non-self-antigen results in full functional differentiationSherry A Wuensch
David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 177:1689-97. 2006..Local activation of naive CD8(+) T cells can therefore cause full CD8(+) T cell activation, and hepatocellular presentation cannot be used to explain the failure of CTL effector function against some liver pathogens such as hepatitis C...
Galactosylated LDL nanoparticles: a novel targeting delivery system to deliver antigen to macrophages and enhance antigen specific T cell responsesFang Wu
David H Smith Center for Vaccine Biology and Immunology, The Aab Institute for Biomedical Research, Department of Microbiology, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Pharm 6:1506-17. 2009..It may also be an effective way of delivering drugs or vaccines directly at macrophages...
Direct, help-independent priming of CD8+ T cells by adeno-associated virus-transduced hepatocytesSherry A Wuensch
The David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
Hepatology 52:1068-77. 2010..This could explain the impaired function of CD8+ T cells seen in chronic liver infection...
Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophagesIngo Klein
David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, NY, USA
Blood 110:4077-85. 2007..Our conclusions resolve a long-standing controversy and explain how different experimental approaches may reveal one or both of these subsets...
Biologic contribution of P1 promoter-mediated expression of ST6Gal I sialyltransferaseMichelle M Appenheimer
The Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Glycobiology 13:591-600. 2003..Siat1deltaP1 mice also exhibit a greater bacterial burden in liver and spleen, accompanied by more pronounced spleno-/hepatomegaly and greater leukocyte infiltration into affected organs than their wild-type counterparts...
