OWEN M contact WOLKOWITZ

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response
    O M Wolkowitz
    Department of Psychiatry, University of California, San Francisco UCSF, School of Medicine, San Francisco, CA, USA
    Mol Psychiatry 17:164-72. 2012
  2. ncbi Serum BDNF levels before treatment predict SSRI response in depression
    Owen M Wolkowitz
    Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:1623-30. 2011
  3. ncbi Depression gets old fast: do stress and depression accelerate cell aging?
    Owen M Wolkowitz
    Department of Psychiatry, University of California School of Medicine, San Francisco, California, USA
    Depress Anxiety 27:327-38. 2010
  4. ncbi The "steroid dementia syndrome": a possible model of human glucocorticoid neurotoxicity
    Owen M Wolkowitz
    Department of Psychiatry, Medical Center, University of California, San Francisco, San Francisco, CA, USA
    Neurocase 13:189-200. 2007
  5. ncbi Glucocorticoids. Mood, memory, and mechanisms
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco UCSF School of Medicine, San Francisco, California, USA
    Ann N Y Acad Sci 1179:19-40. 2009
  6. ncbi Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, United States of America
    PLoS ONE 6:e17837. 2011
  7. ncbi Of sound mind and body: depression, disease, and accelerated aging
    Owen M Wolkowitz
    Department of Psychiatry, School of Medicine, University of California, San Francisco, California, USA
    Dialogues Clin Neurosci 13:25-39. 2011
  8. ncbi Repeated psychological stress testing in stimulant-dependent patients
    Debra S Harris
    Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:669-77. 2005
  9. ncbi Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation
    Sharon E Meieran
    University of California, San Francisco School of Medicine, San Francisco, CA, USA
    Psychoneuroendocrinology 29:486-500. 2004
  10. ncbi Cell aging in relation to stress arousal and cardiovascular disease risk factors
    Elissa S Epel
    UCSF Department of Psychiatry, San Francisco, CA, USA
    Psychoneuroendocrinology 31:277-87. 2006

Research Grants

  1. Neurosteroids and acute Alcohol Intoxication in Humans
    Owen Wolkowitz; Fiscal Year: 2007
  2. Cell Aging in Major Depression
    OWEN M contact WOLKOWITZ; Fiscal Year: 2010

Detail Information

Publications21

  1. ncbi Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response
    O M Wolkowitz
    Department of Psychiatry, University of California, San Francisco UCSF, School of Medicine, San Francisco, CA, USA
    Mol Psychiatry 17:164-72. 2012
    ..PBMC telomerase activity might reflect a novel aspect of depressive pathophysiology and might represent a novel biomarker of antidepressant responsiveness...
  2. ncbi Serum BDNF levels before treatment predict SSRI response in depression
    Owen M Wolkowitz
    Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:1623-30. 2011
    ..It is also unknown whether pre-treatment serum BDNF levels predict antidepressant response...
  3. ncbi Depression gets old fast: do stress and depression accelerate cell aging?
    Owen M Wolkowitz
    Department of Psychiatry, University of California School of Medicine, San Francisco, California, USA
    Depress Anxiety 27:327-38. 2010
    ....
  4. ncbi The "steroid dementia syndrome": a possible model of human glucocorticoid neurotoxicity
    Owen M Wolkowitz
    Department of Psychiatry, Medical Center, University of California, San Francisco, San Francisco, CA, USA
    Neurocase 13:189-200. 2007
    ..Although this syndrome is uncommon, it is consistent with evolving theories of the neurotoxic or neuroendangering potential of glucocorticoids in some situations...
  5. ncbi Glucocorticoids. Mood, memory, and mechanisms
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco UCSF School of Medicine, San Francisco, California, USA
    Ann N Y Acad Sci 1179:19-40. 2009
    ..The article concludes with a conceptual model of glucocorticoid actions in the brain that may lead to novel therapeutic opportunities...
  6. ncbi Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, United States of America
    PLoS ONE 6:e17837. 2011
    ..We sought to determine if leukocyte telomeres are shortened in Major Depressive Disorder (MDD), whether this is a function of lifetime depression exposure and whether this is related to putative mediators, oxidation and inflammation...
  7. ncbi Of sound mind and body: depression, disease, and accelerated aging
    Owen M Wolkowitz
    Department of Psychiatry, School of Medicine, University of California, San Francisco, California, USA
    Dialogues Clin Neurosci 13:25-39. 2011
    ..These factors interact in increasing the likelihood of physical disease and of accelerated aging at the cellular level. We conclude with suggestions for novel mechanism-based therapeutics based on these mediators...
  8. ncbi Repeated psychological stress testing in stimulant-dependent patients
    Debra S Harris
    Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:669-77. 2005
    ..Although less convincing because of the heterogeneity of the subjects, they also suggest that HPA axis responsivity is not clearly linked to acute stress-induced stimulant craving or affective response...
  9. ncbi Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation
    Sharon E Meieran
    University of California, San Francisco School of Medicine, San Francisco, CA, USA
    Psychoneuroendocrinology 29:486-500. 2004
    ..Further larger-scale studies, utilizing a broader range of doses and experimental conditions, are warranted...
  10. ncbi Cell aging in relation to stress arousal and cardiovascular disease risk factors
    Elissa S Epel
    UCSF Department of Psychiatry, San Francisco, CA, USA
    Psychoneuroendocrinology 31:277-87. 2006
    ..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
  11. ncbi Altering cortisol level does not change the pleasurable effects of methamphetamine in humans
    Debra S Harris
    Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Neuropsychopharmacology 28:1677-84. 2003
    ..Metyrapone was associated with significant premature ventricular complexes in two subjects during methamphetamine administration and may not be safe for those who use methamphetamine...
  12. ncbi Dynamics of telomerase activity in response to acute psychological stress
    Elissa S Epel
    Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
    Brain Behav Immun 24:531-9. 2010
    ....
  13. ncbi The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment
    Owen M Wolkowitz
    University of California, San Francisco, School of Medicine, 401 Parnassus Ave, Box F 0984, San Francisco, CA 94143 0984, USA
    Ann N Y Acad Sci 1032:191-4. 2004
    ..Several clinical cases of this syndrome, with shared phenomenological and neuropsychological features, are presented here...
  14. ncbi Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study
    Elysa J Marco
    University of California, Langley Porter Psychiatric Institute, San Francisco, USA
    World J Biol Psychiatry 3:156-61. 2002
    ..Further studies with larger sample sizes, more extensive endocrine assessments and longer duration of drug administration seem warranted...
  15. ncbi Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
    Nicole Maninger
    Department of Psychiatry, University of California San Francisco, School of Medicine, San Francisco 94143, USA
    Front Neuroendocrinol 30:65-91. 2009
    ..Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed...
  16. ncbi Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder
    William Berger
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:1279-84. 2010
    ..Some studies have found that antidepressants increase serum brain-derived neurotrophic factor (BDNF) levels in patients with major depression and the expression of BDNF mRNA in limbic structures of rats...
  17. ncbi Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression
    Firdaus S Dhabhar
    Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, Stanford, CA 94305, USA
    J Psychiatr Res 43:962-9. 2009
    ....
  18. ncbi When blue turns to grey: do stress and depression accelerate cell aging?
    Owen M Wolkowitz
    World J Biol Psychiatry 9:2-5. 2008
  19. ncbi Behavioral implications of lowering cholesterol levels: a double-blind pilot study
    Tom Ormiston
    Santa Clara Valley Medical Center, San Jose, CA 95128, USA
    Psychosomatics 44:412-4. 2003
    ..This pilot study, although limited in size, raises the possibility that cholesterol-lowering drugs are associated with mild, time-limited increases in impulsivity and with mild, time-delayed improvements in depression ratings...
  20. ncbi Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depression
    Owen M Wolkowitz
    World J Biol Psychiatry 4:98-102. 2003
  21. ncbi Benzodiazepines in schizophrenia: prefrontal cortex atrophy predicts clinical response to alprazolam augmentation
    William W Seeley
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    World J Biol Psychiatry 3:221-4. 2002
    ..Mechanistic considerations and suggestions for future research are discussed...

Research Grants6

  1. Neurosteroids and acute Alcohol Intoxication in Humans
    Owen Wolkowitz; Fiscal Year: 2007
    ..abstract_text> ..
  2. Cell Aging in Major Depression
    OWEN M contact WOLKOWITZ; Fiscal Year: 2010
    ..This in turn would yield new insights into the biology of depression and might spur the development of new treatments aimed at the molecular causes and consequences of depression. ..