Research Topics
| Robert WolfeSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
Research Grants
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Detail Information
Publications
Influence of metformin on glucose intolerance and muscle catabolism following severe burn injuryDennis C Gore
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 1172, USA
Ann Surg 241:334-42. 2005..The purpose of this study was to determine the effect of metformin on glucose kinetics and muscle protein metabolism in severely burned patients and assess any potential benefit of metformin in this clinical setting...- The recommended dietary allowance of protein: a misunderstood conceptRobert R Wolfe
Center for Translational Research in Aging and Longevity, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 806, Little Rock, AR 72205, USA
JAMA 299:2891-3. 2008 - Optimal protein intake in the elderlyRobert R Wolfe
University of Arkansas for Medical Sciences, Department of Geriatrics, Center for Translational Research in Aging and Longevity, 4301W Markham Street, Slot 806, Little Rock, AR 72205, USA
Clin Nutr 27:675-84. 2008..It appears that an intake of 1.5 g protein/kg/day, or about 15-20% of total caloric intake, is a reasonable target for elderly individuals wishing to optimize protein intake in terms of health and function... - Protein Summit: consensus areas and future researchRobert R Wolfe
University of Arkansas for Medical Sciences, The Department of Geriatrics, the Center for Translational Research in Aging and Longevity, Little Rock, AR, USA
Am J Clin Nutr 87:1582S-1583S. 2008 - Total aminoacyl-transfer RNA pool is greater in liver than muscle in rabbitsRobert R Wolfe
Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Nutr 137:2333-8. 2007..05). The greater availability and charging efficiency of tRNA in liver as compared with muscle may influence the extent to which amino acid precursor availability regulates protein synthesis in these 2 tissues... - Functional impact of 10 days of bed rest in healthy older adultsPatrick Kortebein
University of Arkansas for Medical Sciences, Little Rock, AR, USA
J Gerontol A Biol Sci Med Sci 63:1076-81. 2008..This study reports on the effect of 10 days of bed rest on multiple functional parameters in healthy older adults... - Cachexia: a new definitionWilliam J Evans
Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
Clin Nutr 27:793-9. 2008..While this definition has not been tested in epidemiological or intervention studies, a consensus operational definition provides an opportunity for increased research... - EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderlyArny A Ferrando
University of Arkansas for Medical Sciences, USA
Clin Nutr 29:18-23. 2010..In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function... - Restoration of hormonal action and muscle proteinArny A Ferrando
Center for Translational Research on Aging and Longevity, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Crit Care Med 35:S630-4. 2007..To restore hormonal influence, clinicians should consider reestablishing anabolic stimuli and reducing catabolic stimuli... - Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned childrenRicki Y Fram
Metabolism Unit and Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
Crit Care Med 38:1475-83. 2010..To institute intensive insulin therapy protocol in an acute pediatric burn unit and study the mechanisms underlying its benefits... - Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistanceMelanie G Cree
University of Arkansas Medical Sciences, Donald W Reynolds Center on Aging, Nutrition, Metabolism and Exercise Lab, Little Rock, AR, USA
Crit Care Med 35:S476-83. 2007..Review current evidence on the role of fat in post-trauma insulin resistance, in reference to new studies with peroxisome proliferating activating receptor-alpha agonists... - Postburn trauma insulin resistance and fat metabolismMelanie G Cree
Donald W Reynolds Institute on Aging, 4301 W Markham St, Slot 806, Little Rock, AR 72205, USA
Am J Physiol Endocrinol Metab 294:E1-9. 2008..The resultant increases in intracellular TG or related lipid products may in turn contribute to alterations in insulin signaling... - Skeletal muscle protein metabolism and resistance exerciseRobert R Wolfe
Department of Surgery, The University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, Galveston, TX, USA
J Nutr 136:525S-528S. 2006.... - Aerobic exercise training increases skeletal muscle protein turnover in healthy adults at restMatthew A Pikosky
Department Nutritional Sciences, University of Connecticut, Storrs, CT, USA
J Nutr 136:379-83. 2006..072 +/- 0.012%/h, P < 0.05); FBR tended to increase (0.105+/- 0.014 vs. 0.143+/- 0.018%/h; P=0.06) after training. Findings show that aerobic training for 4 wk increases skeletal muscle protein turnover in previously unfit subjects... - Optimal nutrition, exercise, and hormonal therapy promote muscle anabolism in the elderlyRobert R Wolfe
University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX, USA
J Am Coll Surg 202:176-80. 2006 - Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MSDayong Sun
Metabolism Unit, Shriners Burn Hospital, University of Texas Medical Branch, Galveston, TX 77550
J Lipid Res 47:431-9. 2006..Applying this protocol to biological muscle samples proves it to be a very sensitive, accurate, and precise analytical tool... - Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrationsChristos S Katsanos
Department of Surgery, Shriners Hospitals for Children-Galveston, and University of Texas Medical Branch, Galveston, TX 77550, USA
Am J Physiol Endocrinol Metab 289:E1064-70. 2005..We conclude that the protein NB in non-steady-state blood phenylalanine concentrations can be determined from the arteriovenous phenylalanine NB by accounting for changes in free phenylalanine within its volume of distribution... - Latency, duration and dose response relationships of amino acid effects on human muscle protein synthesisMichael J Rennie
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Scotland, United Kingdom
J Nutr 132:3225S-7S. 2002..The maximal capacity for storage of amino acids as muscle protein probably sets an upper value on the extent to which amino acids can be stored after a single meal... - Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exerciseDouglas R Bolster
Dept. of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
Am J Physiol Endocrinol Metab 289:E678-83. 2005..Future studies directed at mechanisms by which level of protein intake influences skeletal muscle turnover are needed... - Milk ingestion stimulates net muscle protein synthesis following resistance exerciseTabatha A Elliot
Metabolism Unit, Shriners Hospitals for Children and Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
Med Sci Sports Exerc 38:667-74. 2006..These results suggest that whole milk may have increased utilization of available amino acids for protein synthesis... - Bed rest and myopathiesArny A Ferrando
Department of Surgery, University of Texas Medical Branch, Shrine Hospital for Children, Galveston, Texas 77550, USA
Curr Opin Clin Nutr Metab Care 9:410-5. 2006..Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ameliorate the loss of skeletal muscle are highlighted... - Role of dietary protein in the sarcopenia of agingDouglas Paddon-Jones
Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
Am J Clin Nutr 87:1562S-1566S. 2008..However, renal function decreases with age, and high protein intake is contraindicated in individuals with renal disease. Assessment of renal function is recommended for older individuals before they adopt a higher-protein diet... - Acute responses of muscle protein metabolism to reduced blood flow reflect metabolic priorities for homeostasisXiao Jun Zhang
Metabolism Unit, Shriners Hospital for Children, The University of Texas Medical Branch, Galveston, Texas, USA
Am J Physiol Endocrinol Metab 294:E551-7. 2008..These findings cannot be extrapolated to more chronic conditions without experimental validation... - Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrateMelanie G Cree
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555, USA
Ann Surg 245:214-21. 2007..To determine some of the mechanisms involved in insulin resistance immediately following burn trauma, and to determine the efficacy of PPAR-alpha agonism for alleviating insulin resistance in this population... - Atrophy and impaired muscle protein synthesis during prolonged inactivity and stressDouglas Paddon-Jones
Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77550, USA
J Clin Endocrinol Metab 91:4836-41. 2006..We recently demonstrated that 28-d bed rest in healthy volunteers results in a moderate loss of lean leg mass and strength... - The underappreciated role of muscle in health and diseaseRobert R Wolfe
University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, TX 77550, USA
Am J Clin Nutr 84:475-82. 2006.... - Quantification of amino acid transport through interstitial fluid: assessment of four-compartment modeling for muscle protein kineticsDennis C Gore
Dept of Surgery, Univ of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
Am J Physiol Endocrinol Metab 292:E319-23. 2007..Therefore, any effective therapy to correct illness-induced muscle catabolism should be directed at altering the rates of breakdown and synthesis of muscle protein and are not likely related to tissue edema... - Stimulation of net muscle protein synthesis by whey protein ingestion before and after exerciseKevin D Tipton
The Univ of Birmingham, School of Sport and Exercise Sciences, Edgbaston, Birmington B15 2TT, UK
Am J Physiol Endocrinol Metab 292:E71-6. 2007..Thus the response of net muscle protein balance to timing of intact protein ingestion does not respond as does that of the combination of free amino acids and carbohydrate... - Quantification of protein metabolism in vivo for skin, wound, and muscle in severe burn patientsDennis C Gore
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 1172, USA
JPEN J Parenter Enteral Nutr 30:331-8. 2006..The purpose of this study is to assess a technique by which in vivo protein kinetics of muscle, wound, and normal skin can be quantified in burn-injured patients... - Amino acid control of muscle protein turnover in renal diseaseArny A Ferrando
Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
J Ren Nutr 15:34-8. 2005..Despite the substantial evidence of ICAA regulation, its physiologic significance is not evident. However, the regulation of ICAAs represents a method by which skeletal muscle ensures its capacity for anabolism... - The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementationDouglas Paddon-Jones
Metabolism Unit, 815 Market Street, Galveston, Texas
J Clin Endocrinol Metab 90:1453-9. 2005..04%.h(-1)) and post-BR (EXP, 0.111 +/- 0.015, and CON, 0.05 +/- 0.002%.h(-1)). Unlike a typical clinical meal, AA/CHO supplementation stimulated net muscle protein synthesis despite acute hypercortisolemia and prolonged inactivity... - Regulation of skeletal muscle protein metabolism in catabolic statesRobert R Wolfe
The University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, Texas, USA
Curr Opin Clin Nutr Metab Care 8:61-5. 2005..Studies focused on molecular mechanisms of muscle catabolism are not reviewed... - Measurement of muscle protein fractional synthesis and breakdown rates from a pulse tracer injectionXiao-Jun Zhang
Metabolism Unit, Shriners Hospitals for Children, and Departments of Surgery and Anesthesiology, The University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 283:E753-64. 2002..This method can be completed in 1 h with one muscle biopsy and has technical advantages over currently used methods... - Gene expression profiles and protein balance in skeletal muscle of burned children after beta-adrenergic blockadeDavid N Herndon
Department of Surgery, The University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
Am J Physiol Endocrinol Metab 285:E783-9. 2003..The upregulation of genes involved in muscle metabolism correlates well with the increase in net protein balance across the leg... - Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burnedSteven E Wolf
Department of Surgery, Shriners Burns Hospital, University of Texas Medical Branch, 815 Market, Galveston, TX 77550, USA
Ann Surg 237:801-10; discussion 810-1. 2003..To determine the effects of the anabolic agent oxandrolone on muscle protein and gene expression in severely burned children... - Effects of early excision and aggressive enteral feeding on hypermetabolism, catabolism, and sepsis after severe burnDavid W Hart
Department of Surgery, The University of Texas Medical Branch, Galveston, USA
J Trauma 54:755-61; discussion 761-4. 2003..Wound colonization and sepsis were diminished in the early treatment group as well. CONCLUSION: Early excision and concurrent aggressive feeding attenuate muscle catabolism and improve infectious outcomes after burn... - Measurement of protein metabolism in epidermis and dermisXiao-Jun Zhang
Shriners Hospitals for Children, Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 284:E1191-201. 2003..We conclude that, in the skin, efficient reutilization of amino acids from proteolysis for synthesis enables the maintenance of protein mass in the postabsorptive state... - Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acidsDouglas Paddon-Jones
Department of Surgery, University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
Am J Physiol Endocrinol Metab 284:E946-53. 2003..180 min) in the C + AA group. Thus, although differences in protein metabolism were evident, EAA ingestion improved muscle protein anabolism during acute hypercortisolemia and may help minimize muscle loss following debilitating injury... - Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2BHisamine Kobayashi
Department of Surgery, Shriners Burns Hospital, University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 284:E488-98. 2003.... - Differential anabolic effects of testosterone and amino acid feeding in older menArny A Ferrando
Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
J Clin Endocrinol Metab 88:358-62. 2003..Taken together, however, these diverse stimulatory effects can increase lean body mass and muscle strength over time... - Regulation of muscle protein by amino acidsRobert R Wolfe
University of Texas Medical Branch and Shriners Burns Hospital, Department of Surgery, Galveston 77550, USA
J Nutr 132:3219S-24S. 2002..Finally, acute anabolic responses in net MPS correspond quantitatively to differences in 24-h net muscle balances... - Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestionKevin D Tipton
Metabolism Unit, Shriners Hospitals for Children, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 284:E76-89. 2003..Results for other amino acids were similar. The acute anabolic response of muscle to EAA intake and exercise is additive to the response at rest and thus reflects the 24-h response... - Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patientsDennis C Gore
The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1172, USA
Am J Physiol Endocrinol Metab 286:E529-34. 2004..In conclusion, this study demonstrates that insulin directly stimulates muscle protein synthesis in severely injured patients... - Relative influence of glucose and insulin on peripheral amino acid metabolism in severely burned patientsDennis C Gore
JPEN J Parenter Enteral Nutr 26:271-7. 2002..Protein catabolism and glucose intolerance are prominent in critically injured patients. The objective of this study was to assess if glucose or insulin availability influences the extent of protein catabolism in hypermetabolic patients... - Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestionDouglas Paddon-Jones
Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
Am J Physiol Endocrinol Metab 288:E761-7. 2005..2 +/- 8.5 nmol x min(-1) x 100 ml leg volume(-1). These data indicate that CAA supplementation produces a greater anabolic effect than ingestion of intact protein but does not interfere with the normal metabolic response to a meal... - Protein and amino acids for athletesKevin D Tipton
Department of Surgery, University of Texas Medical Branch, Shriner s Hospital for Children, 815 Market Street, Galveston, TX 77550, USA
J Sports Sci 22:65-79. 2004.... - Leucine supplementation has an anabolic effect on proteins in rabbit skin wound and muscleXiao-Jun Zhang
Metabolism Unit, Shriners Hospital for Children, Galveston, TX 77550, USA
J Nutr 134:3313-8. 2004..h)] or muscle [-2.7 +/- 0.7 micromol/(100 g . h)]. We conclude that leucine supplementation had an anabolic effect on proteins in skin wounds and muscle, provided that adequate additional amino acids were also available... - Effect of an amino acid, protein, and carbohydrate mixture on net muscle protein balance after resistance exerciseElisabet Borsheim
Metabolism Unit in the Department of Surgery at the Shriners Hospitals for Children/Galveston, University of Texas Medical Branch, 77550, USA
Int J Sport Nutr Exerc Metab 14:255-71. 2004..Further, compared to previously reported findings, the addition of protein to an AA+ CHO mixture seems to extend the anabolic effect... - Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patientsGianni Biolo
Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
J Clin Endocrinol Metab 87:3378-84. 2002..In contrast, transmembrane transport in the inward direction is impaired relatively to the increased delivery of circulating amino acid to skeletal muscle secondary to accelerated blood flow... - Testosterone administration to older men improves muscle function: molecular and physiological mechanismsArny A Ferrando
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 282:E601-7. 2002..We conclude that physiological and near-physiological increases of testosterone in older men will increase muscle protein anabolism and muscle strength... - Anabolic action of insulin on skin wound protein is augmented by exogenous amino acidsXiao-Jun Zhang
Metabolism Unit, Shriners Burns Hospital for Children and Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 282:E1308-15. 2002..We conclude that there is an interactive effect of insulin and sufficient amino acid supply on protein metabolism in skin wound, meaning that their combined anabolic effect is greater than the sum of their individual effects... - Incomplete financial disclosuresRobert R Wolfe
JAMA 300:1763. 2008 - Alterations in protein metabolism during space flight and inactivityArny A Ferrando
Department of Surgery, University of Texas Medical Branch, and the Metabolism Unit, Shriners Hospital for Children, Galveston, Texas 77550, USA
Nutrition 18:837-41. 2002.... - Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate dietBeatrice Morio
University of Texas Medical Branch, Department of Surgery, Shriners Burns Hospital, Metabolism Unit, Galveston, Texas 77550, USA
Ann Surg 236:218-25. 2002..58 micromol/kg/min after propranolol. CONCLUSIONS: Hepatic fat storage in burn patients is due to low rates of both fatty acid oxidation and VLDL-TAG secretion. Propranolol can decrease hepatic fat storage by limiting fatty acid delivery... - Human mitochondrial oxidative capacity is acutely impaired after burn traumaMelanie G Cree
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
Am J Surg 196:234-9. 2008..Mitochondrial proteins and genes are damaged after burn injury in animals and are assessed in human burn patients in this study... - Amino acid supplementation for reversing bed rest and steroid myopathiesDouglas Paddon-Jones
U TX Med Branch, Galveston
J Nutr 135:1809S-1812S. 2005..It may be necessary to concomitantly reduce the catabolic influence of cortisol or provide another anabolic stimulus... - Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapyE L Dillon
Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
Clin Nutr 26:736-43. 2007..Our considerable data showing the strong anabolic potential of amino acids (AA) led us to test whether AA can acutely stimulate muscle protein synthesis in cancer patients (CA) undergoing intense chemotherapy... - Determination of phenylalanine isotope ratio enrichment by liquid chromatography/time- of-flight mass spectrometryZhanpin Wu
Analytical Instrument Division, JEOL USA, Inc, 11 Dearborn Road, Peabody, MA 01960, USA
Eur J Mass Spectrom (Chichester, Eng) 10:619-23. 2004..9999. The coefficient of variation for the isotope ratio measurement was below 2%. The method is simple, rapid, and accurate and presents an attractive alternative to traditional GC/MS applications... - Fractional synthesis rates of DNA and protein in rabbit skin are not correlatedXiao-Jun Zhang
Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA
J Nutr 134:2401-6. 2004..This new approach enables investigations of metabolic disorders of skin diseases and regulation of skin wound healing by distinguishing the 2 principal components of skin metabolism, which are cell division and protein synthesis... - Compartmental distribution of amino acids during hemodialysis-induced hypoaminoacidemiaElisabet Børsheim
Metabolism Unit, Department of Surgery, Shriners Hospitals for Children Galveston, and University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 290:E643-52. 2006..In conclusion, intracellular concentrations of amino acids are regulated to maintain relatively constant values, even when plasma and interstitial concentrations fall as a consequence of hemodialysis... - Intramuscular and liver triglycerides are increased in the elderlyMelanie G Cree
Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
J Clin Endocrinol Metab 89:3864-71. 2004..Increases of IMCL and LFAT occur in elderly individuals and may be related to insulin resistance... - Fatiguing exercise reduces DNA binding activity of NF-kappaB in skeletal muscle nucleiWilliam J Durham
Pulmonary and Critical Care Medicine Section, Baylor College of Medicine, Houston, Texas 77030, USA
J Appl Physiol 97:1740-5. 2004..These data provide no support for our original hypothesis. Instead, acute fatiguing exercise appears to decrease NF-kappaB activity in muscle under a variety of conditions... - Insulin resistance of muscle protein metabolism in agingBlake B Rasmussen
Department of Kinesiology, University of Southern California, Los Angeles, California, USA
FASEB J 20:768-9. 2006..89; P=0.0001) and blood flow (R=0.90; P<0.0001). In conclusion, skeletal muscle protein synthesis is resistant to the anabolic action of insulin in older subjects, which may be an important contributor to the development of sarcopenia... - A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderlyChristos S Katsanos
Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 291:E381-7. 2006..We conclude that increasing the proportion of leucine in a mixture of EAA can reverse an attenuated response of muscle protein synthesis in elderly but does not result in further stimulation of muscle protein synthesis in young subjects... - Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site woundXiao Jun Zhang
Metabolism Unit, University of Texas Medical Branch, Galveston, TX, USA
Surgery 139:633-9. 2006..Whereas Sulfamylon is effective in treatment of burn wound infection, controversy exists regarding its effect on the healing process... - Independent and combined effects of amino acids and glucose after resistance exerciseSharon L Miller
Dairy Management, Inc, Rosemont, IL, USA
Med Sci Sports Exerc 35:449-55. 2003..Further, prior intake of amino acids and carbohydrate does not diminish the metabolic response to a second comparable dose ingested 1h later... - Aging does not impair the anabolic response to a protein-rich mealT Brock Symons
Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
Am J Clin Nutr 86:451-6. 2007..However, the ability of an actual protein-rich food to stimulate anabolism in the young and the elderly has not been explored...
Research Grants
- SUBSTRATE CYCLING IN ENERGY METABOLISMRobert R Wolfe; Fiscal Year: 2010..The results from these studies will have direct application in the nutritional care of severely burned or injured patients. ..
- EXERCISE, LIPOLYSIS AND FAT OXIDATIONRobert Wolfe; Fiscal Year: 1993..These will be the first quantitative studies of factors controlling lipid metabolism in exercising men and women...
- EFFECT OF EXERCISE ON PROTEIN METABOLISM IN HUMANSRobert Wolfe; Fiscal Year: 1993..These results will provide the fundamental knowledge necessary to formulate an optimal nutrition approach to the promotion of net protein synthesis following exercise...
- SUBSTRATE CYCLING IN ENERGY METABOLISMRobert Wolfe; Fiscal Year: 2002..This information will provide a physiological basis for the development of a practical approach to controlling increased triglyceride synthesis in insulin resistant states. ..
- EXERCISE EFFECTS ON PROTEIN METABOLISMRobert Wolfe; Fiscal Year: 2002..The results of this study will also contribute to our understanding of the mechanism whereby nutritional intake affects muscle protein metabolism. ..
- EXERCISE, LIPOLYSIS AND FAT OXIDATIONRobert Wolfe; Fiscal Year: 2002..abstract_text> ..
- SUBSTRATE CYCLING IN ENERGY METABOLISMRobert R Wolfe; Fiscal Year: 2010..The results from these studies will have direct application in the nutritional care of severely burned or injured patients. ..
- SUBSTRATE CYCLING IN ENERGY METABOLISMRobert Wolfe; Fiscal Year: 2007..abstract_text> ..
- Amino Acids and Muscle Protein SynthesisRobert Wolfe; Fiscal Year: 2006..abstract_text> ..
- MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLYRobert Wolfe; Fiscal Year: 2002..These studies will provide the metabolic basis for the formulation of a nutritional supplement that should optimally stimulate net muscle protein synthesis. ..
- THE ROLE OF SUBSTRATE CYCLING IN ENERGY METABOLISMRobert Wolfe; Fiscal Year: 1993..e., glycerol kinase or PEPCK), and in part by stimulation of pyruvate kinase...