MARC WOLD

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
    M S Wold
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City 52242, USA
    Annu Rev Biochem 66:61-92. 1997
  2. ncbi Replication protein A interactions with DNA. III. Molecular basis of recognition of damaged DNA
    Y Lao
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, Iowa 52242 1109, USA
    Biochemistry 39:850-9. 2000
  3. ncbi A novel assay for examining the molecular reactions at the eukaryotic replication fork: activities of replication protein A required during elongation
    A P Walther
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Nucleic Acids Res 27:656-64. 1999
  4. ncbi Functional domains of the 70-kilodalton subunit of human replication protein A
    X V Gomes
    Department of Biochemistry, University of Iowa School of Medicine, Iowa City 52242 1109, USA
    Biochemistry 35:10558-68. 1996

Research Grants

  1. Functional Role of Cellular Proteins in DNA Replication
    MARC WOLD; Fiscal Year: 2007
  2. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 2002
  3. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 1993
  4. Functional Role of Cellular Proteins in DNA Replication
    MARC WOLD; Fiscal Year: 2009

Collaborators

  • X V Gomes
  • Y Lao
  • A P Walther
  • J S Taylor
  • Y Ren
  • M P Bjerke

Detail Information

Publications4

  1. ncbi Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
    M S Wold
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City 52242, USA
    Annu Rev Biochem 66:61-92. 1997
    ..Phosphorylation of RPA may play a role in coordinating DNA metabolism in the cell. RPA may also have a role in modulating gene expression...
  2. ncbi Replication protein A interactions with DNA. III. Molecular basis of recognition of damaged DNA
    Y Lao
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, Iowa 52242 1109, USA
    Biochemistry 39:850-9. 2000
    ..These findings suggest that RPA probably binds to both damaged and undamaged strands in the NER excision complex. RPA binding may be important for efficient excision of damaged DNA in NER...
  3. ncbi A novel assay for examining the molecular reactions at the eukaryotic replication fork: activities of replication protein A required during elongation
    A P Walther
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Nucleic Acids Res 27:656-64. 1999
    ..We have used this system to show that both RPA-protein and RPA-DNA interactions are important for RPA's function in elongation...
  4. ncbi Functional domains of the 70-kilodalton subunit of human replication protein A
    X V Gomes
    Department of Biochemistry, University of Iowa School of Medicine, Iowa City 52242 1109, USA
    Biochemistry 35:10558-68. 1996
    ..For all mutant complexes examined, both phosphorylation of the 32-kDa subunit of RPA and the ability to support T antigen-dependent, origin-dependent DNA unwinding correlated with ssDNA binding activity...

Research Grants16

  1. Functional Role of Cellular Proteins in DNA Replication
    MARC WOLD; Fiscal Year: 2007
    ..These studies will both elucidate the mechanism of the RPA regulatory switch and provide insights into RPA function in cellular DNA metabolism. ..
  2. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 2002
    ..These studies will lead to a better understanding of the molecular mechanism of DNA replication and cellular DNA metabolism. ..
  3. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 1993
    ..In the future, these studies will be expanded to examine the roles of other DNA replication proteins. One future direction will be to establish non- viral model reactions for chromosomal DNA replication...
  4. Functional Role of Cellular Proteins in DNA Replication
    MARC WOLD; Fiscal Year: 2009
    ..These studies will both elucidate the mechanism of the RPA regulatory switch and provide insights into RPA function in cellular DNA metabolism. ..