Research Topics
| DOMINIK F WODARZSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Towards predictive computational models of oncolytic virus therapy: basis for experimental validation and model selectionDominik Wodarz
Department of Ecology and Evolution, University of California Irvine, Irvine, California, United States of America
PLoS ONE 4:e4271. 2009..It can further serve as the basis for future, more complex models that take into account other clinically relevant factors such as immune responses...- Apparent competition and recovery from infectionDominik Wodarz
Department of Ecology and Evolutionary Biology, Steinhaus Hall, University of California, Irvine, CA 92697, USA
J Theor Biol 227:403-12. 2004..The models presented are related to the concept of apparent competition, and our results are discussed in relation to both theoretical and empirical studies... - On the relative fitness of early and late stage Simian immunodeficiency virus isolatesDominik Wodarz
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Theor Popul Biol 72:426-35. 2007..One possibility is that the ability of multiple virus particles to infect the same cell (coinfection) might be a pre-requisite for the emergence of the cytopathic strain SIVMne170 as the disease progresses... - Stem cell regulation and the development of blast crisis in chronic myeloid leukemia: Implications for the outcome of Imatinib treatment and discontinuationDominik Wodarz
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Med Hypotheses 70:128-36. 2008..Further, the model defines conditions when Imatinib treatment might lead to the eradication of CML, which is relevant in the context of recent data that show absence of relapse as long as two years after treatment cessation... - Human immunodeficiency virus evolution towards reduced replicative fitness in vivo and the development of AIDSDominik Wodarz
Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697, USA
Proc Biol Sci 274:2481-90. 2007.... - Immunity and protection by live attenuated HIV/SIV vaccinesDominik Wodarz
Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine CA 92697, USA
Virology 378:299-305. 2008..According to these arguments, an inverse correlation between the level of attenuation and the level of protection is expected, and this has indeed been observed in experimental data... - Use of oncolytic viruses for the eradication of drug-resistant cancer cellsDominik Wodarz
Department of Ecology and Evolution, University of California, Irvine, 321 Steinhaus Hall, Irvine, CA 92697, USA
J R Soc Interface 6:179-86. 2009..This is derived from a population dynamic principle known as apparent competition. Therefore, a sequential combination of oncolytic virus and targeted therapies can overcome major weaknesses of either approach alone... - Multiple HIV-1 infection of cells and the evolutionary dynamics of cytotoxic T lymphocyte escape mutantsDominik Wodarz
Department of Ecology and Evolutionary Biology and Department of Mathematics, 321 Steinhaus Hall, University of California, Irvine, California 92697, USA
Evolution 63:2326-39. 2009..It is hypothesized that an intermediate strength of the CTL response, and thus the suboptimal virus suppression observed in HIV-1 infection, might be adaptive to minimize the impact of existing CTL escape mutants on overall virus load... - Heterogeneity in chronic myeloid leukaemia dynamics during imatinib treatment: role of immune responsesDominik Wodarz
Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, CA 92607, USA
Proc Biol Sci 277:1875-80. 2010..Boosting immunity during drug therapy could enhance the response to treatment in patients... - Effect of different modes of viral spread on the dynamics of multiply infected cells in human immunodeficiency virus infectionDominik Wodarz
Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697, USA
J R Soc Interface 8:289-300. 2011.... - Can loss of apoptosis protect against cancer?Dominik Wodarz
Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Trends Genet 23:232-7. 2007.... - Infection dynamics in HIV-specific CD4 T cells: does a CD4 T cell boost benefit the host or the virus?Dominik Wodarz
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Math Biosci 209:14-29. 2007.... - Dynamics of killer T cell inflation in viral infectionsDominik Wodarz
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
J R Soc Interface 4:533-43. 2007..This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age... - Immune responses and the emergence of drug-resistant virus strains in vivoDominik Wodarz
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Proc Biol Sci 271:1101-9. 2004..Drug resistance is much more likely to be a problem in HIV than in acute and self-limiting infections... - Dynamical interactions between multiple cancersDominik Wodarz
Department of Ecology and Evolution, University of California, Irvine, California 92697, USA
Cell Cycle 4:764-71. 2005..We further discuss the inefficiency of metastatic cells to grow successfully, and suggest an explanation for the occurrence of multiple metastases with an unknown primary cancer... - Does programmed CTL proliferation optimize virus control?Dominik Wodarz
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
Trends Immunol 26:305-10. 2005..The 7-10 programmed cell divisions observed in vivo might be an optimization of this trade-off. We also discuss the conditions under which the program does or does not require CD4 T-cell help for clearance... - Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: implications for host adaptation mechanismsDominik Wodarz
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Exp Biol Med (Maywood) 236:926-37. 2011..Here, we review this topic and discuss how immune control of the infection and the ability of the virus to escape immune control is affected by co-infection... - Effect of the CTL proliferation program on virus dynamicsDominik Wodarz
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Int Immunol 17:1269-76. 2005..We discuss these results in the context of data from murine virus infections and explore implications for virus dynamics in CD4 helper-deficient hosts... - Emergence and prevention of resistance against small molecule inhibitorsDominik Wodarz
Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Semin Cancer Biol 15:506-14. 2005.... - Ecological and evolutionary principles in immunologyDominik Wodarz
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
Ecol Lett 9:694-705. 2006.... - Effect of stem cell turnover rates on protection against cancer and agingDominik Wodarz
Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
J Theor Biol 245:449-58. 2007..g. if DNA is hit by damaging agents), I find that a high cellular turnover rate protects against aging, while it promotes the development of cancer. Implications for optimal tissue design are discussed... - Effect of cellular quiescence on the success of targeted CML therapyNatalia L Komarova
Department of Mathematics, University of California Irvine, Irvine, California, United States of America
PLoS ONE 2:e990. 2007..Using mathematical models, we investigate the effect of cellular quiescence on the outcome of therapy with targeted small molecule inhibitors... - Stochastic modeling of cellular colonies with quiescence: an application to drug resistance in cancerNatalia L Komarova
Department of Mathematics, University of California, Irvine, CA 92697, USA
Theor Popul Biol 72:523-38. 2007..Finally, we study the influence of quiescence on the treatment phase. Starting from a given composition of mutants, the chances of treatment success are not influenced by the presence of quiescence... - ODE models for oncolytic virus dynamicsNatalia L Komarova
Department of Mathematics, 340 Rowland Hall, University of California, Irvine, CA 92697, USA
J Theor Biol 263:530-43. 2010..Our methodology can be used to study the dynamics of many biological systems, and thus has implications beyond the study of virus therapy of cancers... - Checkpoint genes, ageing, and the development of cancerDominik Wodarz
Department of Ecology and Evolution, Steinhaus Hall, University of California, Irvine, CA 92697, USA
Oncogene 23:7799-809. 2004..The models help to identify differences in the experimental protocols which could explain the seemingly contradictory observations... - Drug resistance in cancer: principles of emergence and preventionNatalia L Komarova
Department of Mathematics, 103 MSTB, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 102:9714-9. 2005.... - Combination therapies against chronic myeloid leukemia: short-term versus long-term strategiesNatalia L Komarova
Departments of Mathematics and Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
Cancer Res 69:4904-10. 2009....
Research Grants
- Mathematical Models of Programmed CTL ProliferationDominik Wodarz; Fiscal Year: 2009..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..