Research Topics
Species | Stephen R WisniewskiSummaryAffiliation: University of Pittsburgh Country: USA Publications
| Collaborators
|
Detail Information
Publications
International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocolLeanne M Williams
BRAINnet Foundation, 71 Stephenson Street, Suite 400, San Francisco, CA, 94105, USA
Trials 12:4. 2011..The aim of iSPOT-D is to identify pretreatment measures that predict or moderate MDD treatment response or remission to escitalopram, sertraline or venlafaxine; and develop a model that incorporates multiple predictors and moderators...- Impact of changing the measles vaccine vial size on Niger's vaccine supply chain: a computational modelTina Marie Assi
University of Pittsburgh, Pittsburgh, PA, USA
BMC Public Health 11:425. 2011..The measles vaccine is particularly important in Niger, a country prone to measles outbreaks... - Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D)Stephen R Wisniewski
Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Psychiatr Res 38:241-8. 2004..While the information gathered was useful, it did delay the initiation of the formal trial. We view this cost as an investment in the development of overall study procedures that should lead to a stronger study... - Prevention of missing data in clinical research studiesStephen R Wisniewski
Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Biol Psychiatry 59:997-1000. 2006..Despite efforts devoted to areas, no study is without missing data. Once the study is completed, it is essential to assess the pattern of missing data and apply the appropriate statistical analysis... - The Resources for Enhancing Alzheimer's Caregiver Health (REACH): project design and baseline characteristicsStephen R Wisniewski
Department of Epidemiology, University of Pittsburgh, Pennsylvania 15261, USA
Psychol Aging 18:375-84. 2003..Caregivers reported high levels of depressive symptoms and moderate burden. Care recipients were older, with a mean age of 79, and were moderately to severely impaired with mean Mini-Mental State Exam scores of 13/30... - Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D reportStephen R Wisniewski
Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, 127 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
Am J Psychiatry 166:599-607. 2009.... - Global benefit-risk analysis of adjunctive aripiprazole in the treatment of patients with major depressive disorderStephen R Wisniewski
University of Pittsburgh, PA 15261, USA
Pharmacoepidemiol Drug Saf 18:965-72. 2009..This study quantified the overall merit of adjunctive aripiprazole in major depressive disorder (MDD)... - Comparison of quality of life measures in a depressed populationStephen R Wisniewski
Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Nerv Ment Dis 195:219-25. 2007.... - Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) projectStephen R Wisniewski
Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Clin Trials 1:387-98. 2004.... - Acceptability of second-step treatments to depressed outpatients: a STAR*D reportStephen R Wisniewski
Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
Am J Psychiatry 164:753-60. 2007..This study sought to identify factors that affect patients' willingness to accept different second-step treatment approaches... - What predicts attrition in second step medication treatments for depression?: a STAR*D ReportDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
Int J Neuropsychopharmacol 12:459-73. 2009..Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes... - Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D reportMichael E Thase
Department of Psychiatry, University of Pittsburgh Medical Center, 3811 OHara St, Pittsburgh, PA 15213 2593, and Massachusetts General Hospital, USA
Am J Psychiatry 164:739-52. 2007..Cognitive therapy was compared with medication augmentation and switch strategies... - Income and attrition in the treatment of depression: a STAR*D reportDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9086, USA
Depress Anxiety 26:622-33. 2009..This report assessed whether attrition rates and predictors of attrition differed among depressed outpatients with different income levels... - Major depression symptoms in primary care and psychiatric care settings: a cross-sectional analysisBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Ann Fam Med 5:126-34. 2007.... - Family history of completed suicide and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) studyAndrew A Nierenberg
Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 01224, USA
J Affect Disord 108:129-34. 2008..It is unknown, however, whether patients with a family member who committed suicide differ from those without such a history... - Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D reportMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 165:342-51. 2008..The authors conducted a secondary data analysis to compare antidepressant treatment outcomes for patients with anxious and nonanxious major depression in Levels 1 and 2 of the STAR*D study... - Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D reportA John Rush
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
Am J Psychiatry 163:1905-17. 2006..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial... - Does recovery from substance use disorder matter in patients with bipolar disorder?Roger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, USA
J Clin Psychiatry 66:730-5; quiz 808-9. 2005..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria... - Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Roy H Perlis
Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
Am J Psychiatry 163:217-24. 2006..The authors looked for the features associated with risk of recurrence... - Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D reportMadhukar H Trivedi
Department of Psychiatry, University of Texas UT Southwestern Medical Center, Dallas 75390 9119, and the Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 67:185-95. 2006..The aim of this study was to examine sociodemographic and clinical correlates of HRQOL in a large cohort of outpatients with MDD... - Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment featuresA John Rush
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Arch Gen Psychiatry 65:870-80. 2008..Little is known about selecting among second-step medications for major depressive disorder after intolerance or lack of remission with an initial selective serotonin reuptake inhibitor... - Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trialEdward S Friedman
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Depress Anxiety 26:612-21. 2009..But nonresponse can include depression that worsened over the course of treatment, an outcome that has received scant attention... - Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D reportPatrick J McGrath
Department of Psychiatry, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
J Clin Psychiatry 69:1847-55. 2008.... - Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: an examination of citalopram in the STAR*D studySidney Zisook
Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, San Diego, California, USA
J Affect Disord 117:63-73. 2009..The purpose of this study was to determine whether, and in whom, treatment of MDD is associated with increased or emergent SI... - Concurrent anxiety and substance use disorders among outpatients with major depression: clinical features and effect on treatment outcomeRobert H Howland
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, United States
Drug Alcohol Depend 99:248-60. 2009.... - Medication augmentation after the failure of SSRIs for depressionMadhukar H Trivedi
Mood Disorder Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
N Engl J Med 354:1243-52. 2006..Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach... - Family history of depression and therapeutic outcome: findings from STAR*DMustafa M Husain
Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 8898, USA
J Clin Psychiatry 70:185-95. 2009.... - Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidoneAndrew A Nierenberg
Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
Am J Psychiatry 163:210-6. 2006..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone... - Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practiceMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
Am J Psychiatry 163:28-40. 2006.... - A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D reportAndrew A Nierenberg
Massachusetts General Hospital, 50 Staniford St, Boston, MA 02114, USA
Am J Psychiatry 163:1519-30; quiz 1665. 2006..This study compared the effectiveness of lithium versus triiodothyronine (T(3)) augmentation as a third-step treatment for patients with major depressive disorder... - Sequenced treatment alternatives to relieve depression (STAR*D): rationale and designA John Rush
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
Control Clin Trials 25:119-42. 2004..Participants with an adequate symptomatic response may enter the 12-month naturalistic follow-up phase with brief monthly and more complete quarterly assessments... - Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*DWilliam R Yates
Department of Psychiatry, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
Gen Hosp Psychiatry 26:421-9. 2004..A significant percentage of patients with major depressive disorder (MDD) suffer from concurrent general medical conditions (GMCs)... - Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Naomi M Simon
Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
Am J Psychiatry 161:2222-9. 2004..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients... - A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D reportMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Bulfinch 351, 55 Fruit St, Boston, MA 02114, USA
Am J Psychiatry 163:1161-72. 2006.... - Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression studySheila M Marcus
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48105, USA
Compr Psychiatry 49:238-46. 2008..This article examines sex differences in terms of illness attributes in a cohort of 2541 outpatients from across the United States who enrolled in the Sequenced Treatment Alternatives to Relieve Depression study... - Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D reportDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9086, USA
Am J Psychiatry 164:1189-97. 2007..The purpose of this study was to identify the pretreatment predictors of attrition during acute treatment with citalopram in a large, "real world" clinical trial... - Effect of age at onset on the course of major depressive disorderSidney Zisook
Department of Psychiatry, University of California, San Diego, CA 92093, USA
Am J Psychiatry 164:1539-46. 2007..This report assesses whether age at onset defines a specific subgroup of major depressive disorder in 4,041 participants who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study... - Effectiveness of adjunctive antidepressant treatment for bipolar depressionGary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 356:1711-22. 2007..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania... - Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*DBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
J Gen Intern Med 23:551-60. 2008..Whether the acute outcomes of major depressive disorder (MDD) treated in primary (PC) or specialty care (SC) settings are different is unknown... - Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression studyRoy H Perlis
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 66:159-66; quiz 147, 273-4. 2005..Irritability with or without depression has been associated with risk for suicide, violence, and cardiovascular disease... - A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STAR*D clinical trialBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Gen Hosp Psychiatry 27:87-96. 2005..The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (http://www.star-d.org) provides a unique opportunity to provide this comparison for patients with a major depressive disorder (MDD) requiring treatment... - Randomized comparison of selective serotonin reuptake inhibitor (escitalopram) monotherapy and antidepressant combination pharmacotherapy for major depressive disorder with melancholic features: a CO-MED reportWilliam V Bobo
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
J Affect Disord 133:467-76. 2011..The clinical effects of antidepressant combinations vs. monotherapy as initial treatment for major depression with melancholic features (MDD-MF) are unknown... - Health-related quality of life in depression: a STAR*D reportElla J Daly
Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
Ann Clin Psychiatry 22:43-55. 2010..This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial... - Remission of maternal depression: relations to family functioning and youth internalizing and externalizing symptomsCynthia Ewell Foster
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
J Clin Child Adolesc Psychol 37:714-24. 2008..9% of the variance... - Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) studyAndrew A Nierenberg
Depression Clinical and Research Program, ACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 01224, USA
J Psychiatr Res 41:214-21. 2007.... - Insured and non-insured depressed outpatients: how do they compare?Ira M Lesser
Department of Psychiatry, Harbor UCLA Medical Center, The Los Angeles Biomedical Research Institute, Los Angeles, CA, USA
Ann Clin Psychiatry 19:73-82. 2007.... - Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participantsAndrew A Nierenberg
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
Biol Psychiatry 57:1467-73. 2005.... - Assessing anxious features in depressed outpatientsShawn M McClintock
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8898, USA
Int J Methods Psychiatr Res 20:e69-82. 2011..Both the HRSD(ANX) and IDS-C(ANX) subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes... - Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD studyRoy H Perlis
Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
Bipolar Disord 11:391-400. 2009..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms... - Factors associated with concomitant psychotropic drug use in the treatment of major depression: a STAR*D ReportRchard C Shelton
Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
CNS Spectr 14:487-98. 2009..Concomitant psychotropic medication (CPM) treatment is common in persons with major depression (MDD). However, relationships with patient characteristics and response to treatment are unclear... - Metabolic assessment of aripiprazole as adjunctive therapy in major depressive disorder: a pooled analysis of 2 studiesMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114 2696, USA
J Clin Psychopharmacol 29:362-7. 2009..Also, there was no apparent change in the incidence of National Cholesterol Education Program-defined abnormal metabolic measures after treatment with aripiprazole... - What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depressionBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Psychiatr Serv 60:1439-45. 2009..STAR*D demonstrated that inclusion of more real-world patients in clinical trials is both feasible and informative. Policy implications of the findings, as well as the study's limitations, are discussed... - Comorbid psychiatric disorders in depressed outpatients: demographic and clinical featuresA John Rush
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9086, USA
J Affect Disord 87:43-55. 2005..This study evaluated the clinical and sociodemographic features associated with various degrees of concurrent comorbidity in adult outpatients with nonpsychotic major depressive disorder (MDD)... - Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*DMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 34:1299-308. 2004..Anxious depression, defined as Major Depressive Disorder (MDD) with high levels of anxiety symptoms, may represent a relatively common depressive subtype, with distinctive features... - Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based careMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Neuropsychopharmacology 32:2479-89. 2007..This approach signals a paradigm shift toward the use of measurement-based clinical decisions, both at the point of care and following each visit, to deliver optimal pharmacotherapy for depression... - Diurnal mood variation in outpatients with major depressive disorderDavid W Morris
Mood Disorders Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Road, Suite 13 354, Dallas, TX 75390 9119, USA
Depress Anxiety 26:851-63. 2009..This report used data from the sequenced treatment alternatives to relieve depression study to determine whether DMV was associated with treatment outcome to citalopram... - Pain in depression: STAR*D study findingsMustafa M Husain
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8898, USA
J Psychosom Res 63:113-22. 2007..Pain complaints commonly accompany major depressive disorder (MDD). However, whether patients with MDD and pain complaints differ from those without pain complaints is not well studied... - Insomnia in patients with depression: a STAR*D reportPrabha Sunderajan
Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9119, USA
CNS Spectr 15:394-404. 2010..However, little is known about the prevalence and associated features of insomnia symptoms in representative treatment-seeking patients with depression... - What clinical and symptom features and comorbid disorders characterize outpatients with anxious major depressive disorder: a replication and extensionMaurizio Fava
Massachusetts General Hospital, Boston, Harvard Medical School, MA 02114, USA
Can J Psychiatry 51:823-35. 2006..This study was designed to replicate and extend our initial findings in a subsequent, larger cohort of outpatient STAR*D participants with nonpsychotic major depressive disorder (MDD)... - REVAMP - Research Evaluating the Value of Augmenting Medication with Psychotherapy: rationale and designMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Psychopharmacol Bull 41:5-33. 2008.... - Early adverse events and attrition in selective serotonin reuptake inhibitor treatment: a suicide assessment methodology study reportDiane Warden
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
J Clin Psychopharmacol 30:259-66. 2010..Neither global ratings nor specific adverse effects at week 2 were related to patient attrition during SSRI treatment. Other factors seem to contribute to patient decisions about continuing with treatment... - Identifying risk for attrition during treatment for depressionDiane Warden
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
Psychother Psychosom 78:372-9. 2009..Understanding patients' ambivalence about treatment persistence may be useful in tailoring retention interventions for individual patients with major depressive disorder... - Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal riskMadhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
J Clin Psychiatry 72:757-64. 2011..This report evaluates the psychometric properties of a brief self- and clinician-rated measure of factors related to the risk of suicide attempt or completion... - The relationship between adverse events during selective serotonin reuptake inhibitor treatment for major depressive disorder and nonremission in the suicide assessment methodology studyElla J Daly
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Clin Psychopharmacol 31:31-8. 2011.... - Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BDNaomi M Simon
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:512-20. 2004..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity... - Brief report: paroxetine in younger and adult individuals at high risk for suicideMark S Bauer
Department of Psychiatry, Brown University, USA
Psychopharmacol Bull 39:31-7. 2006..In fact, the younger group showed a trend for decreased suicidality (P = .13). Thus, increased suicidality risk with paroxetine exposure does not extend to this other high-risk mood disordered population, even among younger individuals... - Ethnicity/race and outcome in the treatment of depression: results from STAR*DIra M Lesser
Department of Psychiatry, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, 1000 W Carson Street, Torrance, CA 90509, USA
Med Care 45:1043-51. 2007.... - Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study dataDavid W Morris
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
J Clin Psychiatry 68:1339-47. 2007.... - Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement ProgramChristopher D Schneck
Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
Am J Psychiatry 161:1902-8. 2004..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status... - Treatment outcomes for older depressed patients with earlier versus late onset of first depressive episode: a Sequenced Treatment Alternatives to Relieve Depression (STAR*D) reportF Andrew Kozel
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Am J Geriatr Psychiatry 16:58-64. 2008..In this study of older depressed outpatients, the authors evaluated whether the age at onset of the first major depressive episode (MDE) was related to clinical outcomes... - TREAD: TReatment with Exercise Augmentation for Depression: study rationale and designMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Clin Trials 3:291-305. 2006..However, no randomized controlled trials have evaluated exercise as an augmentation strategy for patients with carefully diagnosed MDD who remain symptomatic following an adequate acute phase trial of antidepressant therapy... - Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)Gary S Sachs
Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 53:1028-42. 2003.... - Care satisfaction, hope, and life functioning among adults with bipolar disorder: data from the first 1000 participants in the Systematic Treatment Enhancement ProgramChad D Morris
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
Compr Psychiatry 46:98-104. 2005..This prospective study examined the longitudinal relationships between patients' satisfaction with care, levels of hope, and life functioning in the first 1000 patients to enter STEP-BD... - Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP TrialJames H Kocsis
Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
Arch Gen Psychiatry 66:1178-88. 2009..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone... - Physical activity and risk of revision total knee arthroplasty in individuals with knee osteoarthritis: a matched case-control studyDina L Jones
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Rheumatol 31:1384-90. 2004..To determine if physical activity was a risk factor for revision arthroplasty after primary total knee arthroplasty (TKA) due to osteoarthritis (OA) within the previous 15 years... - Bone mineral density and prevalent vertebral fractures in men and womenJane A Cauley
Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
Osteoporos Int 15:32-7. 2004..Measures of bone mass that partially correct for gender differences in bone size may yield universal estimates of fracture risk. Prospective studies are needed to confirm this observation... - Introduction to the special section on Resources for Enhancing Alzheimer's Caregiver Health (REACH)Richard Schulz
Department of Psychiatry, University Center for Social and Urban Research, University of Pittsburgh, 121 University Place, Pennsylvania 15260, USA
Psychol Aging 18:357-60. 2003..The authors describe the design of the study, summarize the interventions implemented at each site, and provide an overview of the 4 articles in this special section... - How patients feel about prolonged mechanical ventilation 1 year laterAaron B Mendelsohn
Department of Epidemiology, University of Pittsburg, Pittsburg, PA, USA
Crit Care Med 30:1439-45. 2002..Many patients indicated that factors such as the amount of pain or discomfort from mechanical ventilation and their families' financial burden would cause them to refuse this potentially life-saving intervention... - Quality improvement methods as applied to a multicenter effectiveness trial--STAR*DDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX, USA
Contemp Clin Trials 26:95-112. 2005..This paper describes the background, rationale, development, and potential utility of implementing a quality improvement system to improve the performance and efficiency of the trial... - Serum S100B concentrations are increased after closed head injury in children: a preliminary studyRachel Pardes Berger
Department of Pediatrics, University of Pittsburgh School of Medicine, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
J Neurotrauma 19:1405-9. 2002..The increase is transient, lasting less than 12 h after injury, except in children with severe injury. Future research will focus on the possibility of using serum S100B as a screening test for inflicted CHI... - Agility and perturbation training techniques in exercise therapy for reducing pain and improving function in people with knee osteoarthritis: a randomized clinical trialG Kelley Fitzgerald
Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15101, USA
Phys Ther 91:452-69. 2011..It has previously been proposed that adding agility and perturbation training to exercise programs for people with knee OA may improve treatment effects for pain and function... - Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuseRachel Pardes Berger
Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
J Neurotrauma 21:1123-30. 2004..Higher initial and peak QUIN concentrations after iTBI may be due to severity of injury, young age, and/or delay in seeking medical care, which allows for increased secondary injury... - Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)Roy H Perlis
Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 55:875-81. 2004..CONCLUSIONS: Very early or early onset of bipolar disorder might herald a more severe disease course in terms of chronicity and comorbidity. Whether early intervention might modify this risk merits further investigation... - Development of an efficient SAS macro to perform permutation tests for two independent samplesG K Balasubramani
Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Comput Methods Programs Biomed 79:179-87. 2005.... - Clinical and demographic factors associated with DSM-IV melancholic depressionAhsan Y Khan
University of Kansas School of Medicine Wichita, Department of Psychiatry, Wichita, KS, USA
Ann Clin Psychiatry 18:91-8. 2006..The purpose of this paper is to use demographic and clinical data from a large diverse group of outpatients diagnosed with non-psychotic major depression to investigate the validity of the DSM-IV concept of melancholic depression... - Diabetes and postcataract extraction endophthalmitisBernard H Doft
Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Curr Opin Ophthalmol 13:147-51. 2002..A new clinical trial is needed to determine if in fact there is a difference in response to treatment among diabetic and nondiabetic patients who present with better than LP vision... - Vascular endothelial growth factor is increased in cerebrospinal fluid after traumatic brain injury in infants and childrenPaul M Shore
Department of Critical Care Medicine, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Neurosurgery 54:605-11; discussion 611-2. 2004..Further investigation is warranted to determine 1). whether this association is causative, 2). the role of adenosine in triggering the increase in CSF VEGF concentration, and 3). the exact role VEGF that plays after injury... - Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohortLori L Davis
Department of Veterans Affairs VA Medical Center, Tuscaloosa, Ala 35404, USA
J Clin Psychiatry 68:1931-8. 2007.... - Comparisons of perceived quality of life across clinical states in bipolar disorder: data from the first 2000 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) participantsHongwei Zhang
Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA 15261, USA
Compr Psychiatry 47:161-8. 2006..However, the pattern of specific deficits has not been well studied, and the role of potential confounders has received no attention... - The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) CohortMagnus Lekman
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Biol Psychiatry 63:1103-10. 2008..The present study aimed at studying the associated FKBP5 markers in the ethnically diverse Sequenced Treatment Alternatives to Relieve Depression (STAR*D) sample of non-hospitalized patients treated with citalopram... - Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injuryDonald W Marion
Brain Trauma Research Center, Department of Neurological Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Suite B400, Pittsburgh, PA 15213, USA
Crit Care Med 30:2619-25. 2002..To determine the potential adverse effects of brief periods of hyperventilation commonly used for acute neurologic deterioration... - The STAR*D Project results: a comprehensive review of findingsDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9086, USA
Curr Psychiatry Rep 9:449-59. 2007..These results highlight the prevalence of treatment-resistant depression and suggest potential benefit for using more vigorous treatments in the earlier steps... - A comparison of baseline sociodemographic and clinical characteristics between major depressive disorder patients with and without diabetes: a STAR*D reportCharlene J Bryan
School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Affect Disord 108:113-20. 2008.... - Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depressionXian Zhang Hu
Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:783-92. 2007.... - Clinical and demographic features of atypical depression in outpatients with major depressive disorder: preliminary findings from STAR*DJon S Novick
Zucker Hillside Hospital, Glen Oaks, NY, USA
J Clin Psychiatry 66:1002-11. 2005..CONCLUSION: Previously identified features of atypical depression were confirmed in this large and broadly representative, nonresearch clinical population... - Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participantsRoy H Perlis
Bipolar Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 58:549-53. 2005..We examined the hypothesis that a first depressive rather than manic episode in bipolar disorder might herald a subsequent course notable for greater burden of depressive symptoms... - Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement ProgramDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Arch Gen Psychiatry 64:419-26. 2007..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder... - Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohortLori L Davis
VA Medical Center, Tuscaloosa, AL 35404, USA
Am J Addict 15:278-85. 2006..048 to <0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities (p = 0.006 and 0.002, respectively)... - Clinical differences among depressed patients with and without a history of suicide attempts: findings from the STAR*D trialCynthia A Claassen
Department of Psychiatry and Division of Clinical Psychology, University of Texas Southwestern Medical School, Dallas, Texas 75235 9119, United States
J Affect Disord 97:77-84. 2007.... - Does the duration of index episode affect the treatment outcome of major depressive disorder? A STAR*D reportWilliam S Gilmer
Asher Center for the Study and Treatment of Depressive Disorders, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
J Clin Psychiatry 69:1246-56. 2008.... - Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and childrenRachel Pardes Berger
Department of Pediatrics, Pittsburgh Child Advocacy Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 5213, USA
Pediatrics 109:E31. 2002..In adults, CSF and serum concentrations of NSE and S100B have served as markers of neuronal damage after TBI. Neither NSE nor S100B has previously been studied in CSF after TBI in infants or children...