Research Topics
Species | P E WischmeyerSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
The glutamine story: where are we now?Paul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Curr Opin Crit Care 12:142-8. 2006....- Glutamine: the first clinically relevant pharmacological regulator of heat shock protein expression?Paul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Curr Opin Clin Nutr Metab Care 9:201-6. 2006..The purpose of this review is to examine recent data supporting the use of glutamine as a clinically relevant enhancer of heat shock protein expression... - Glutamine: role in gut protection in critical illnessPaul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Curr Opin Clin Nutr Metab Care 9:607-12. 2006..Thus, the therapeutic potential for an agent to prevent gut barrier compromise and attenuate gut-derived inflammatory response is significant... - Glutamine: mode of action in critical illnessPaul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
Crit Care Med 35:S541-4. 2007..Presently, randomized, multicenter, clinical trials utilizing glutamine as a pharmacologic and a nutritional agent are ongoing... - A survey of propofol abuse in academic anesthesia programsPaul E Wischmeyer
Department of Anesthesiology, University of Colorado, Denver, Colorado, USA
Anesth Analg 105:1066-71, table of contents. 2007..Although propofol has not traditionally been considered a drug of abuse, subanesthetic doses may have an abuse potential. We used this survey to assess prevalence and outcome of propofol abuse in academic anesthesiology programs... - John M. Kinney International Award for General Nutrition. Glutamine, heat shock protein, and inflammation--opportunity from the midst of difficultyPaul Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nutrition 20:583-5. 2004 - Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injuryPaul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
JPEN J Parenter Enteral Nutr 27:396-403. 2003..Thus, we hypothesized that GLN pretreatment given to the rat in vivo would protect the myocardium against I/R-induced dysfunction... - Glutamine: role in critical illness and ongoing clinical trialsPaul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Curr Opin Gastroenterol 24:190-7. 2008..This review will assess recent clinical and mechanistic data examining glutamine's ability to reduce morbidity and mortality in critical illness... - Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injuryPaul E Wischmeyer
Department of Anesthesiology, University of Colorado, Denver 80262, USA
JPEN J Parenter Enteral Nutr 27:116-22. 2003..We tested the hypothesis that glutamine can enhance heat shock protein 72 (HSP 72) expression, attenuate intracellular oxidant generation, and protect cardiomyocytes against ischemia/reperfusion (I/R) injury... - Role of L-glutamine in critical illness: new insightsDavid Kelly
Valparaiso University, Valparaiso, Indiana and Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Curr Opin Clin Nutr Metab Care 6:217-22. 2003..It will try to present the concept of glutamine as a 'drug' or 'nutraceutical', given in addition to standard nutritional support... - Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cellsPaul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nutrition 19:1-6. 2003..However, data on the effect of GLN on direct attenuation of cytokine release and HSP 72 expression in human peripheral blood polymorphonuclear cells (PBMCs) is lacking... - Glutamine and heat shock protein expressionPaul E Wischmeyer
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nutrition 18:225-8. 2002..g., cardiac, vascular, and transplantation) or in the critically ill... - Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous controlP E Wischmeyer
Department of Anesthesia and Critical Care and Clinical Pharmacology, The University of Chicago, Chicago, IL, USA
Crit Care Med 29:2075-80. 2001..Previous clinical studies in seriously ill patients suggest a beneficial effect of glutamine on infectious morbidity, but no trials have examined possible clinical benefits in severely burned patients... - Glutamine induces heat shock protein and protects against endotoxin shock in the ratP E Wischmeyer
Division of Clinical Pharmacology, The University of Chicago, Chicago, Illinois 60637, USA
J Appl Physiol 90:2403-10. 2001..Thus glutamine appears to be a clinically viable enhancer of HSP expression and may prove beneficial in the therapy of sepsis and sepsis-induced organ injury... - Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemiaP E Wischmeyer
Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
Shock 16:398-402. 2001..Thus, one explanation for the clinical benefits observed from GLN-supplementation may be related to the attenuation of pro-inflammatory cytokines... - Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expressionZhi Yong Peng
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, 80262, USA
JPEN J Parenter Enteral Nutr 30:373-8; discussion 379. 2006..Thus, GLN's beneficial effect on cellular metabolic dysfunction and cell survival appears to be dependent on HSF-1 expression... - Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expressionKristen D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
Crit Care Med 33:1206-13. 2005..Our results indicate GLN may prevent the occurrence of lung injury, lung tissue metabolic dysfunction, and mortality after sepsis via enhancement of deficient lung heat shock factor-1 phosphorylation/activation and HSP expression... - Glutamine in critical illness: the time has come, the time is nowLindsay Rae B Weitzel
Department of Anesthesiology, Translational Pharmaconutrition TPN Research Laboratories, University of Colorado Denver, Research Complex 2, Box 8602, 12700 East 19th Avenue, Aurora, CO 80045, USA
Crit Care Clin 26:515-25, ix-x. 2010..A large and growing body of clinical data shows that in well-defined critically ill patient groups GLN can be a life-saving intervention... - Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylationKristen D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Leprino Office Building LOB, 12401 East 17th Avenue, B113, Aurora, CO 80045, USA
Biochem Biophys Res Commun 373:445-9. 2008..These are the first data describing a direct effect of GLN on Cul-1 deneddylation and provide a possible mechanistic explanation for GLN's anti-inflammatory effects... - Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70Kristen D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Nutrition 21:214-23. 2005..Further, GLN can attenuate endotoxin-induced lung metabolic dysfunction. GLN's beneficial effect on lung tissue after metabolic dysfunction caused by sublethal endotoxemia may be mediated in part by enhanced HSP-70... - A survey of inhalational anaesthetic abuse in anaesthesia training programmesJ E Wilson
Department of Anaesthesia, University of Colorado Health Sciences Center, Denver, Colorado, USA
Anaesthesia 63:616-20. 2008..The concern about substance abuse is not unique to American anaesthetists. Countries around the world deal with similar substance abuse issues... - Glutamine's protection against cellular injury is dependent on heat shock factor-1Angela L Morrison
Univ. of Colorado Health Sciences Center, Dept. of Anesthesiology, 4200 E. 9th Ave, Denver, CO 80262, USA
Am J Physiol Cell Physiol 290:C1625-32. 2006..Furthermore, the mechanism of GLN-mediated protection against injury appears to involve an increase in nuclear HSF-1 content before stress and increased HSF-1 promoter binding and phosphorylation... - Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patientsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
JPEN J Parenter Enteral Nutr 32:412-9. 2008..The purpose of this study is to evaluate erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric enteral nutrition (EN)... - Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illnessLindsay Rae B Weitzel
Department of Anesthesiology, Anschutz Medical Campus, University of Colorado Denver, Denver, Colorado 80045, USA
Curr Opin Anaesthesiol 22:177-83. 2009..Further, targeted administration of these 'pharmaconutrients' may reverse or improve this dysfunction and improve clinical outcome... - Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1Kristen D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
JPEN J Parenter Enteral Nutr 32:371-6. 2008..The authors hypothesized GLN-mediated enhancement of O-glycosylation and subsequent phosphorylation of key transcription factors in the HSP70 pathway would lead to increased HSP70 expression following experimental sepsis... - Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expressionKristen D Singleton
Univ of Colorado Health Sciences Center, Dept of Anesthesiology, Denver, CO 80262, USA
Am J Physiol Regul Integr Comp Physiol 292:R1839-45. 2007..These results confirm our hypothesis that HSP70 expression is required for GLN's effects on survival, tissue injury, and the inflammatory response after global inflammatory injury... - Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expressionZhi-yong Peng
Department of Anesthesiology, University of Colorado Health Science Center, Denver, 80262, USA
JPEN J Parenter Enteral Nutr 30:400-6; discussion 406-7. 2006..CONCLUSIONS: This is the first demonstration that GLN-mediated cellular protection after inflammatory cytokine injury is due to HSF-1 expression and cellular capacity to activate an HSP response... - GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSISKristen D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Shock 24:583-9. 2005..GLN also showed an inhibition of increases in iNOS expression. The antiinflammatory effect of GLN was associated with attenuation of ARDS and mortality... - Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsisKristen D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Campus Box B113, 4200 E 9th Avenue, Denver, CO 80262, USA
Am J Physiol Lung Cell Mol Physiol 290:L956-61. 2006..The specific absence of HSP70 gene expression also leads to increased mortality after septic insult... - Performance-enhancing sports supplements: role in critical careLindsay Rae B Weitzel
Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
Crit Care Med 37:S400-9. 2009..It is very possible that, under the supervision of a physician, many of these agents may prove beneficial in the prevention and treatment of post-intensive care unit weakness... - Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activityChristine R Hamiel
Department of Anesthesiology, University of Colorado Health Sciences Center, Aurora, 80045, USA
Am J Physiol Cell Physiol 297:C1509-19. 2009..This is an important mechanistic description of a pathway that appears responsible for GLN-mediated HSP70 expression... - Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the ratK D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colo. 80262, USA
Eur Surg Res 35:486-91. 2003..Further, the mortality from this model can be adjusted to fit the individual needs of a particular experiment... - Oral glutamine enhances heat shock protein expression and improves survival following hyperthermiaKristen D Singleton
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Shock 25:295-9. 2006..Enhanced expression of HSP-70 may be an important mechanism leading to enhanced survival via GLN. These data indicate that oral GLN may useful in prevention of mortality from heatstroke in at risk populations... - The future of critical care nutrition therapyPaul E Wischmeyer
Department of Anesthesiology, University of Colorado at Denver School of Medicine, 12700 East 19th Avenue, Box 8602, RC2 P15 7120, Aurora, CO 80045, USA
Crit Care Clin 26:433-41, vii. 2010.... - Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutritionJames Landzinski
Department of Pharmacy, Georgetown University Hospital, Washington, DC, USA
JPEN J Parenter Enteral Nutr 32:45-50. 2008..This study evaluated gastric emptying in patients with limited GRV (tolerant group) vs volumes > or =150 mL (intolerant group) and whether prokinetic therapy improves gastric motility in intolerant patients... - Can glutamine turn off the motor that drives systemic inflammation?Paul E Wischmeyer
Crit Care Med 33:1175-8. 2005 - Parenteral glutamine increases serum heat shock protein 70 in critically ill patientsThomas R Ziegler
Department of Medicine/Center for Clinical and Molecular Nutrition, School of Medicine, Emory University, Atlanta, GA 30322, USA
Intensive Care Med 31:1079-86. 2005..These data indicate the need for larger, randomized trials of the Gln effect on serum and tissue HSP-70 expression in critical illness and relationship to clinical outcomes... - Prevention of chemotherapy and radiation toxicity with glutamineDiane M F Savarese
Division of Hematology Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Cancer Treat Rev 29:501-13. 2003..We reviewed the available data on the use of glutamine to decrease the incidence and severity of adverse effects due to chemotherapy and/or radiation in cancer patients...
Research Grants
- Glutamine's role in cardioprotection from cardiac bypassPaul Wischmeyer; Fiscal Year: 2007..Data will be collected on cardiac function (cardiac output), occurrence of arrhythmias, need for vasopressor therapy, length of post-operative ventilation, ICU stay; and survival trends. ..
- Effect of Glutamine on HSP-70 Expression in ICU patientsPaul Wischmeyer; Fiscal Year: 2007..We believe this study will demonstrate that GLN is the first clinically viable enhancer of HSP-70 expression. The potential for such an agent to reduce morbidity/mortality in surgical and critical illness is significant. ..
- Mechanism of Heat Shock Protein Induction by GlutaminePaul E Wischmeyer; Fiscal Year: 2010....