STEPHEN WINTERS

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi PACAP, an autocrine/paracrine regulator of gonadotrophs
    Stephen J Winters
    Division of Endocrinology, Metabolism, and Diabetes, University of Louisville School of Medicine, 550 Jackson Street, Louisville, KY 40202, USA
    Biol Reprod 84:844-50. 2011
  2. ncbi LH and non-SHBG testosterone and estradiol levels during testosterone replacement of hypogonadal men: further evidence that steroid negative feedback increases as men grow older
    Stephen J Winters
    Division of Endocrinology, Metabolism, and Diabetes, University of Louisville, ACB 3G11, 550 Jackson Street, Louisville, KY 40202, USA
    J Androl 31:281-7. 2010
  3. ncbi Influence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women
    Stephen J Winters
    Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, KY 40202, USA
    Metabolism 58:438-42. 2009
  4. ncbi Paracrine control of gonadotrophs
    Stephen J Winters
    Division of Endocrinology, Metabolism and Diabetes, University of Louisville School of Medicine, 550 Jackson Street, Louisville, KY 40202, USA
    Semin Reprod Med 25:379-87. 2007
  5. ncbi Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling
    Stephen J Winters
    Division of Endocrinology and Metabolism, University of Louisville, Louisville, KY 40202, United States
    Mol Cell Endocrinol 271:45-54. 2007
  6. ncbi Inhibin-B levels in healthy young adult men and prepubertal boys: is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells?
    Stephen J Winters
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Androl 27:560-4. 2006
  7. ncbi Intra-pituitary regulation of gonadotrophs in male rodents and primates
    Stephen J Winters
    Division of Endocrinology, Metabolism and Diabetes, University of Louisville, ACB A3G11, 550 Jackson Street, Louisville, Kentucky 40202, USA
    Reproduction 128:13-23. 2004
  8. ncbi Evidence that PACAP and GnRH down-regulate follicle-stimulating hormone-beta mRNA levels by stimulating follistatin gene expression: effects on folliculostellate cells, gonadotrophs and LbetaT2 gonadotroph cells
    Yasuhisa Fujii
    Division of Endocrinology and Metabolism, University of Louisville Health Sciences Center, ACB A3G11, 530 S Jackson Street, Louisville, KY 40202, USA
    Mol Cell Endocrinol 192:55-64. 2002
  9. ncbi Paracrine regulation of FSH by follistatin in folliculostellate cell-enriched primate pituitary cell cultures
    Satoru Kawakami
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Endocrinology 143:2250-8. 2002
  10. ncbi Androgen receptors in gonadotrophs in pituitary cultures from adult male monkeys and rats
    Yohei Okada
    Division of Endocrinology and Metabolism, University of Louisville, Louisville, Kentucky 40202, USA
    Endocrinology 144:267-73. 2003

Research Grants

  1. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002

Collaborators

Detail Information

Publications24

  1. ncbi PACAP, an autocrine/paracrine regulator of gonadotrophs
    Stephen J Winters
    Division of Endocrinology, Metabolism, and Diabetes, University of Louisville School of Medicine, 550 Jackson Street, Louisville, KY 40202, USA
    Biol Reprod 84:844-50. 2011
    ..These results provide further support for the notion that PACAP is a key player in reproduction through its actions as a pituitary autocrine/paracrine hormone...
  2. ncbi LH and non-SHBG testosterone and estradiol levels during testosterone replacement of hypogonadal men: further evidence that steroid negative feedback increases as men grow older
    Stephen J Winters
    Division of Endocrinology, Metabolism, and Diabetes, University of Louisville, ACB 3G11, 550 Jackson Street, Louisville, KY 40202, USA
    J Androl 31:281-7. 2010
    ..These results further suggest that estrogen receptor signaling might contribute to this effect...
  3. ncbi Influence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women
    Stephen J Winters
    Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, KY 40202, USA
    Metabolism 58:438-42. 2009
    ..These data confirm an interaction between race and obesity in vitamin D metabolism, and imply that the carrier protein is not an important determinant of circulating 25OHD in women, nor is it affected by race or adiposity...
  4. ncbi Paracrine control of gonadotrophs
    Stephen J Winters
    Division of Endocrinology, Metabolism and Diabetes, University of Louisville School of Medicine, 550 Jackson Street, Louisville, KY 40202, USA
    Semin Reprod Med 25:379-87. 2007
    ..Accordingly, PACAP differentially regulates FSH and LH, and may prove to be a key player in reproduction through a novel paracrine mechanism...
  5. ncbi Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling
    Stephen J Winters
    Division of Endocrinology and Metabolism, University of Louisville, Louisville, KY 40202, United States
    Mol Cell Endocrinol 271:45-54. 2007
    ..These results provide a mechanism linking GnRH pulsatility to the differential control of FSH-beta and LH-beta gene expression through follistatin...
  6. ncbi Inhibin-B levels in healthy young adult men and prepubertal boys: is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells?
    Stephen J Winters
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Androl 27:560-4. 2006
    ..We speculate that the escalating prevalence of obesity and insulin resistance among adolescents might negatively influence male reproductive function for the next generation...
  7. ncbi Intra-pituitary regulation of gonadotrophs in male rodents and primates
    Stephen J Winters
    Division of Endocrinology, Metabolism and Diabetes, University of Louisville, ACB A3G11, 550 Jackson Street, Louisville, Kentucky 40202, USA
    Reproduction 128:13-23. 2004
    ....
  8. ncbi Evidence that PACAP and GnRH down-regulate follicle-stimulating hormone-beta mRNA levels by stimulating follistatin gene expression: effects on folliculostellate cells, gonadotrophs and LbetaT2 gonadotroph cells
    Yasuhisa Fujii
    Division of Endocrinology and Metabolism, University of Louisville Health Sciences Center, ACB A3G11, 530 S Jackson Street, Louisville, KY 40202, USA
    Mol Cell Endocrinol 192:55-64. 2002
    ..These experiments suggest a mechanism by which PACAP influences FSH production selectively by an autocrine effect on gonadotrophs and by a paracrine mechanism through folliculostellate cells that involves follistatin...
  9. ncbi Paracrine regulation of FSH by follistatin in folliculostellate cell-enriched primate pituitary cell cultures
    Satoru Kawakami
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Endocrinology 143:2250-8. 2002
    ....
  10. ncbi Androgen receptors in gonadotrophs in pituitary cultures from adult male monkeys and rats
    Yohei Okada
    Division of Endocrinology and Metabolism, University of Louisville, Louisville, Kentucky 40202, USA
    Endocrinology 144:267-73. 2003
    ..GH expression is not required for AR expression in gonadotrophs. We conclude that the failure of T to inhibit LH secretion and decrease alpha-subunit mRNA expression in the male primate is not due a disturbance in AR nuclear shuttling...
  11. ncbi Effects of CDB-4022 on Leydig cell function in adult male rats
    Yu Chyu Chen
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky 40202, USA
    Biol Reprod 77:1017-26. 2007
    ..Our findings establish CDB-4022 as a new model to examine intratesticular control mechanisms that modulate Leydig cell gene expression and function...
  12. ncbi Developmental changes in pituitary adenylate cyclase activating polypeptide expression during the perinatal period: possible role in fetal gonadotroph regulation
    Joseph P Moore
    Department of Anatomical Sciences, ivision of Endocrinology and Metabolism, University of Louisville, School of Medicine, Louisville, Kentucky 40292, USA
    Endocrinology 150:4802-9. 2009
    ....
  13. ncbi Gonadotropin-releasing hormone receptor: cloning, expression and transcriptional regulation
    Sham S Kakar
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Prog Brain Res 141:129-47. 2002
    ....
  14. ncbi Weaning and the developmental changes in follicle-stimulating hormone, pituitary adenylate cyclase-activating polypeptide, and inhibin B in the male rat
    Joseph P Moore
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Biol Reprod 78:752-60. 2008
    ....
  15. ncbi Differential expression of the pituitary gonadotropin subunit genes during male rat sexual maturation: reciprocal relationship between hypothalamic pituitary adenylate cyclase-activating polypeptide and follicle-stimulating hormone beta expression
    Joseph P Moore
    Division of Endocrinology and Metabolism, Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Biol Reprod 69:234-41. 2003
    ..We propose that PACAP contributes to the selective regulation of FSHbeta expression during maturation in the male rat, perhaps via regulation of follistatin...
  16. ncbi Identification of distinct gene expression profiles associated with treatment of LbetaT2 cells with gonadotropin-releasing hormone agonist using microarray analysis
    Sham S Kakar
    Department of Medicine, University of Louisville, 570 South Preston Street, Baxter Building, Room 204 C, Louisville, KY 40202, USA
    Gene 308:67-77. 2003
    ....
  17. ncbi Current controversies in testosterone testing: aging and obesity
    Ronald J Elin
    Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, 512 South Hancock Street, 203, Louisville, KY 40202, USA
    Clin Lab Med 24:119-39. 2004
    ..The controversies in evaluating gonadal function are illustrated by the andropause (elevated SHBG) and obese men (decreased SHBG)...
  18. ncbi Pituitary adenylate cyclase activating polypeptide messenger RNA in the paraventricular nucleus and anterior pituitary during the rat estrous cycle
    Joseph P Moore
    Division of Endocrinology and Metabolism, Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Biol Reprod 73:491-9. 2005
    ....
  19. ncbi Racial difference in circulating sex hormone-binding globulin levels in prepubertal boys
    Eiman Abdelrahaman
    Division of Endocrinology, Metabolism, and Diabetes, University of Louisville, Louisville, KY 40202, USA
    Metabolism 54:91-6. 2005
    ....
  20. ncbi Adipose tissue and reproduction in women
    HENRY BOHLER
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Women s Health, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Fertil Steril 94:795-825. 2010
    ..The distribution of adipose tissue may also have a significant impact on reproductive function...
  21. ncbi Evidence that gonadotropin-releasing hormone (GnRH) II stimulates luteinizing hormone and follicle-stimulating hormone secretion from monkey pituitary cultures by activating the GnRH I receptor
    Yohei Okada
    Division of Endocrinology and Metabolism, University of Louisville, Kentucky 40202, USA
    Biol Reprod 69:1356-61. 2003
    ..The GnRH II receptors may have a unique function in the monkey brain and pituitary other than regulation of gonadotropin secretion...
  22. ncbi Stimulation of spermatogenesis with recombinant human follicle-stimulating hormone (follitropin alfa; GONAL-f): long-term treatment in azoospermic men with hypogonadotropic hypogonadism
    Alvin M Matsumoto
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Fertil Steril 92:979-90. 2009
    ..To demonstrate the efficacy and safety of follitropin alfa administered with hCG on spermatogenesis in adult male hypogonadotropic hypogonadism (HH) patients...
  23. ncbi Gonadotropin-releasing hormone receptors: structure, expression, and signaling transduction
    Sham S Kakar
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Vitam Horm 69:151-207. 2004
  24. ncbi Does androgen excess contribute to the cardiovascular risk profile in postmenopausal women with type 2 diabetes?
    Mary T Korytkowski
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Metabolism 54:1626-31. 2005
    ..40), and TC/HDL (r = 0.41) (all P < .05) in the combined groups. Postmenopausal women with type 2 diabetes have both clinical and biochemical evidence of androgen excess that may contribute to more adverse cardiovascular risk profiles...

Research Grants7

  1. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002
    ..abstract_text> ..