Research Topics
| J C WinterSummaryAffiliation: University at Buffalo Country: USA Publications
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Publications
The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the ratJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214 3000, USA
Physiol Behav 63:425-33. 1998..Finally, the present results encourage a search for the pharmacologically active principles of EGb 761 and for their mechanisms of action...- The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated componentC J Reissig
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 88:312-7. 2008.... - Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopramJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, 102 Farber Hall, State University of New York at Buffalo, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 81:694-700. 2005.... - The stimulus properties of LSD in C57BL/6 miceJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 81:830-7. 2005..Lysergic acid diethylamide [LSD], the prototypic indoleamine hallucinogen, has not previously been trained as a discriminative stimulus in mice... - Marked decrease of LSD-induced stimulus control in serotonin transporter knockout miceC M Krall
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, SUNY Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 88:349-57. 2008..Taken together, these studies led us to hypothesize that the efficacy of LSD in establishing stimulus control is diminished or abolished in mice lacking the serotonin transporter... - The effects of sigma, PCP, and opiate receptor ligands in rats trained with ibogaine as a discriminative stimulusS Helsley
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214 3000, USA
Pharmacol Biochem Behav 59:495-503. 1998..Thus, the present study offers evidence that unlike NMDA receptors, both sigma2 and opiate receptors may be involved in the ibogaine discriminative stimulus... - A 5-HT(2C) receptor-mediated interaction between 2,5-dimethoxy-4-methylamphetamine and citalopram in the ratJ R Eckler
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214-3000, USA
Pharmacol Biochem Behav 79:25-30. 2004..In contrast, Hypothesis (c), a role for the 5-HT(2C) receptor, gained support from the observation of significant antagonism of the effects of citalopram on DOM by the selective 5-HT(2C) receptor antagonist, SB-242084... - Psilocybin-induced stimulus control in the ratJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 87:472-80. 2007..In addition, psilocybin differs from closely related hallucinogens such as 5-MeO-DMT in that agonism at 5-HT(1A) receptors appears to play no role in psilocybin-induced stimulus control... - Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists: a link between the glutamatergic and serotonergic hypotheses of schizophreniaJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214 3000, USA
Life Sci 68:337-44. 2000..These data suggest that the application of the technique of drug-induced stimulus control may prove useful in the reconciliation and integration of current hypotheses as to the etiology of psychotic disorders... - The 5-HT1A receptor and the stimulus effects of LSD in the ratC J Reissig
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA
Psychopharmacology (Berl) 182:197-204. 2005..It has been suggested that the 5-HT1A receptor plays a significant modulatory role in the stimulus effects of the indoleamine hallucinogen lysergic acid diethylamide (LSD)... - The interactions of typical and atypical antipsychotics with the (-)2, 5,-dimethoxy-4-methamphetamine (DOM) discriminative stimulusD Fiorella
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
Neuropharmacology 34:1297-303. 1995..Thus, these data are supportive of the hypothesis that the mechanism of action of atypical, but not typical, antipsychotics involves the antagonism of 5-HT2A receptors in vivo... - The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptorsJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
Pharmacol Biochem Behav 65:75-82. 2000.... - Further investigations of the serotonergic properties of the ibogaine-induced discriminative stimulusS Helsley
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
Prog Neuropsychopharmacol Biol Psychiatry 23:317-26. 1999..1%) failed to substitute. Furthermore, WAY-100635 failed to antagonize the ibogaine cue. 4. Unlike 5-HT2C receptors, 5-HT1A and 5-HT3 receptors do not appear to be involved in the ibogaine stimulus... - The effects of beta-carbolines in rats trained with ibogaine as a discriminative stimulusS Helsley
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
Eur J Pharmacol 345:139-43. 1998..These results provide evidence for an ibogaine-like ether this extends to the previously reported anti-addictive effects of ibogaine remains to be established... - Serotonergic/glutamatergic interactions: the effects of mGlu2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuliJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Psychopharmacology (Berl) 172:233-40. 2004..Taken together, these observations predict behaviorally significant interactions between ligands at mGlu(2/3) receptors and hallucinogens such as LSD and PCP... - Effects of clozapine and 2,5-dimethoxy-4-methylamphetamine [DOM] on 5-HT2A receptor expression in discrete brain areasM M Doat-Meyerhoefer
Department of Pharmacology and Toxicology, 102 Farber Hall, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
Pharmacol Biochem Behav 81:750-7. 2005..Both chronic treatment with DOM and clozapine decreased the stimulus effects of DOM. The present findings suggest a role for the olfactory nucleus in producing the stimulus effects of DOM... - Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugsJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 88:189-95. 2008..Instead, the data suggest complex interactions between PCP-induced stimulus control and a variety of psychoactive drugs including GHB, an agent with no known affinity for serotonergic receptors... - Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus controlJ R Eckler
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 75:405-10. 2003..Taken together, the present data suggest that (a) nefazodone acts as a partial agonist and (b) these effects are mediated by the 5-HT2A receptor... - Behavioral characterization of 2-O-desmethyl and 5-O-desmethyl metabolites of the phenylethylamine hallucinogen DOMJ R Eckler
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214 3000, USA
Pharmacol Biochem Behav 75:845-52. 2003..The present data do not permit unequivocal acceptance or rejection of the hypothesis that active metabolites of (-)-DOM provide a full explanation of the observed discrepancy between brain levels of (-)-DOM and maximal stimulus effects... - A sensitive method for determining levels of [-]-2,5,-dimethoxy-4-methylamphetamine in the brain tissueJ R Eckler
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214 3000, USA
J Pharmacol Toxicol Methods 46:37-43. 2001.... - Ibogaine and noribogaine potentiate the inhibition of adenylyl cyclase activity by opioid and 5-HT receptorsR A Rabin
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14214 3000, USA
Eur J Pharmacol 316:343-8. 1996..The present data indicate that ibogaine and noribogaine cause a selective increase in receptor-mediated inhibition of adenylyl cyclase activity. This potentiation may be involved in the pharmacological actions of these compounds... - Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptaminesJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Psychopharmacology (Berl) 203:251-63. 2009..Stimulus control by hallucinogens has provided an intuitively attractive approach to the study of these agents in nonverbal species... - Effects of ibogaine and noribogaine on phosphoinositide hydrolysisR A Rabin
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14214 3000, USA
Brain Res 731:226-9. 1996..The present study indicates a stimulation of phosphoinositide hydrolysis by noribogaine may be involved in the behavioral effects of ibogaine... - Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized miceJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 99:311-5. 2011..In both groups of mice, harmaline was found to enhance the stimulus effects of 5-MeO-DMT... - The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOMJ C Winter
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 74:95-101. 2002.... - Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and ratsW E Fantegrossi
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 83:122-9. 2006.... - Potentiation of DOM-induced stimulus control by fluoxetine and citalopram: role of pharmacokineticsJ R Eckler
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214 3000, USA
Life Sci 71:1341-7. 2002..It is concluded that the effects of DOM as a discriminative stimulus are potentiated by the acute administration of citalopram and this effect is not mediated by additivity or pharmacokinetic mechanisms... - 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogensRichard A Rabin
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, 102 Farber Hall, State University of New York at Buffalo, Buffalo, NY 14214 3000, USA
Pharmacol Biochem Behav 72:29-37. 2002..The present study indicates that 5-HT2A-mediated stimulation of phosphoinositide hydrolysis does not appear to be the sole critical signaling mechanism involved in the discriminative effects of hallucinogens... - Drug discrimination studies with ibogaineS Helsley
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Alkaloids Chem Biol 56:63-77. 2001..of harmaline? Can 10-hydroxyibogamine serve as a discriminative stimulus and, if so, what receptor interactions mediate its stimulus effects? Does the ibogaine-trained stimulus generalize to novel agents, including 18-methoxycoronaridine?..