Research Topics
| Nancy A WilsonSummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsidJuan P Giraldo-Vela
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53711, USA
Immunogenetics 62:701-7. 2010..Analysis of SIV-specific CD4+ T-cell responses elicited by a successful vaccine may have important implications in the understanding of vaccine design...- Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239Nancy A Wilson
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
J Virol 80:5875-85. 2006.... - Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challengeNancy A Wilson
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
J Virol 83:6508-21. 2009.... - Is an HIV vaccine possible?Nancy A Wilson
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Wisconsin 53711, USA
Braz J Infect Dis 13:304-10. 2009..This review will focus on recent developments in HIV vaccine development. We will deal largely with attempts to develop a T cell-based vaccine using the non-human primate SIV challenge model... - Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive Simian immunodeficiency virus-infected rhesus macaquesNicholas J Maness
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
J Virol 82:5245-54. 2008..Most importantly, our data indicate that the important differences between Mamu-B*17-positive ECs and progressors are not readily discernible using standard assays to measure immune responses... - The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escapeJohn T Loffredo
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
J Virol 81:2624-34. 2007..Understanding antiviral efficacy and epitope variability, therefore, will be important in selecting candidate epitopes for an HIV vaccine... - Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infectionJonah B Sacha
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53715, USA
Proc Natl Acad Sci U S A 106:9791-6. 2009..These results suggest that retrovirus-specific CD4(+) T cells may contribute directly to elite control by inhibiting viral replication in macrophages... - Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaquesLaura E Valentine
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Virol 83:11514-27. 2009..04). Our results suggest that these epitope-specific CD8+ T-cell responses may play a role in establishing the control of viral replication in Mamu-B*08+ macaques... - Robust, vaccine-induced CD8(+) T lymphocyte response against an out-of-frame epitopeNicholas J Maness
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
J Immunol 184:67-72. 2010..Our data demonstrate both that the pathway from vaccination to immune response is not well understood and that products of alternate reading frames may be rich and untapped sources of T cell epitopes... - Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristicLara Vojnov
Department of Pathology, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
J Virol 84:753-64. 2010..Our results suggest that a single definitive correlate of immune control may not exist; rather, a successful CD8(+) T-cell response may be comprised of several factors... - The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infectionJason S Reed
Department of Pathology and Laboratory Medicine, University of Wisconsin, 555 Science Drive, Madison, WI, 53711, USA
Immunogenetics 63:789-807. 2011..Thus, it appears that Mamu-A1*007:01 presents SIV-derived peptides to antigen-specific CD8(+) T cells and is part of the immune response to SIV(mac)239... - Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replicationJohn T Loffredo
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
J Virol 82:1723-38. 2008..Natural containment of AIDS virus replication in Mamu-B*08-positive macaques may, therefore, be related to a combination of immunodominance and viral escape from CD8(+) T-cell responses... - AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escapeNicholas J Maness
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
J Exp Med 204:2505-12. 2007..The discovery of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope suggests that the AIDS virus-specific cellular immune response is likely far more complex than is generally assumed... - Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expressionJonah B Sacha
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
J Immunol 178:2746-54. 2007..0017) in SIV-infected rhesus macaques. These results suggest that HIV vaccines should focus CD8(+) T cell responses on Gag... - CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variationJohn T Loffredo
Wisconsin National Primate Research Center WNPRC, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS ONE 2:e1152. 2007..SIV replication was rapidly controlled with the reappearance of CD8+ cells, implicating that these cells actively suppress viral replication in ECs... - Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopesNicholas J Maness
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
J Virol 83:10280-5. 2009..Our data suggest that the translation of viral alternate reading frames may be an important source of T-cell epitopes, including epitopes normally derived from functional proteins... - Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulationJonah B Sacha
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
J Virol 81:11703-12. 2007..Finally, Pol-specific CD8+ T cells eliminated infected cells as early as 6 h postinfection, well before MHC-I downregulation, suggesting a previously underappreciated antiviral role for Pol-specific CD8+ T cells... - CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infectionNicholas J Maness
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53711, USA
J Virol 84:11569-74. 2010..The epitopes were targeted by high-frequency responses as early as 2 weeks postinfection and in the chronic phase. Hence, previously overlooked ARF-encoded epitopes could be important components of AIDS vaccines... - High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239Thomas C Friedrich
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 537061, USA
J Virol 84:5443-7. 2010..Our results suggest that a high level of MHC-I downregulation is a hallmark of fast disease progression in SIV infection... - Macaques vaccinated with live-attenuated SIV control replication of heterologous virusMatthew R Reynolds
AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
J Exp Med 205:2537-50. 2008.... - Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarityJohn T Loffredo
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA
J Immunol 182:7763-75. 2009.... - GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivoLara Vojnov
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS ONE 6:e23515. 2011..It is possible that these seven animals failed to control viral replication because of the narrow TCR repertoire expressed by the GagCM9-specific CD8(+) T cell population elicited by vaccination and infection... - Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaquesKatherine M Mladinich
Microbiology Doctoral Training Program, University of Wisconsin Madison, 1326 Microbial Sciences, 1550 Linden Drive, Madison, WI 53706, USA
Immunogenetics 64:111-21. 2012.... - The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques--implications for recombinant vaccine designPhilip A Mudd
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
Immunogenetics 62:593-600. 2010..The data also suggest potential immunogenic regions of YF17D that could serve as the focus of recombinant T cell vaccine development... - CD8+ T Cell Escape Mutations in Simian Immunodeficiency Virus SIVmac239 Cause Fitness Defects In Vivo, and Many Revert after TransmissionPhilip A Mudd
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711
J Virol 85:12804-10. 2011..Two of the three viruses demonstrated reduced fitness in vivo, and 27% of the introduced mutations reverted. These findings suggest that T cell epitope diversity may not be such a daunting problem for the development of an HIV vaccine... - Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challengeMatthew R Reynolds
AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
J Virol 84:9190-9. 2010..Overall, our results suggest that a well-designed HIV vaccine might both reduce the rate of acquisition and control viral replication... - Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral proteinJonah B Sacha
Wisconsin National Primate Research Center WNPRC, Madison, WI 53711, USA
J Virol 82:9293-8. 2008..These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein... - Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replicationThomas C Friedrich
Wisconsin National Primate Research Center, 1220 Capitol Court, Madison, WI 53715 1299, USA
J Virol 81:3465-76. 2007..It is likely that subdominant CD8+ T-cell populations play a key role in maintaining this control... - Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infectionJonah B Sacha
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
J Virol 84:10907-12. 2010..These studies show for the first time that Vpr- and Rev-specific CD8(+) T cells recognize and kill simian immunodeficiency virus (SIV)-infected CD4(+) T cells early after SIV infection... - Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaquesMyrna C Bonaldo
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
J Virol 84:3699-706. 2010..These recombinant YF17D-induced SIV-specific CD8(+) T cells secreted several cytokines, were largely effector memory T cells, and suppressed viral replication in CD4(+) T cells... - Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virusJason T Weinfurter
Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin 53706, USA
J Virol 85:530-41. 2011..Our results suggest that escape mutations in epitopes bound by "protective" MHC-I molecules may not be sufficient to establish superinfection in LTNPs... - Pyrosequencing reveals restricted patterns of CD8+ T cell escape-associated compensatory mutations in simian immunodeficiency virusBenjamin J Burwitz
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 537061, USA
J Virol 85:13088-96. 2011..This is the first detailed report of the ontogeny of compensatory mutations that allow CD8+ T cell epitope escape in infected individuals... - The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllersJuan P Giraldo-Vela
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
J Virol 82:859-70. 2008..0001). The study of MHC-II alleles in macaques that control viral replication could improve our understanding of the role of CD4(+) T cells in suppressing HIV/SIV replication and further our understanding of HIV vaccine design... - Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequencesLaura E Valentine
Wisconsin National Primate Research Center, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA
J Virol 82:575-81. 2008.... - Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escapeNicholas James Maness
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, WI 53711, USA
Immunogenetics 63:587-97. 2011.... - T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challengeMauricio A Martins
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
J Virol 84:4352-65. 2010..Furthermore, the present study demonstrates that certain viral proteins may be more effective than others as vaccine immunogens... - Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencingBenjamin N Bimber
University of Wisconsin Madison, Madison, WI 53711, USA
J Virol 84:12087-92. 2010..While this work applies pyrosequencing to immunodeficiency viruses, this approach could be applied to virtually any viral pathogen... - DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4? T cells, but few subdominant epitope-specific CD8? T cellsLara Vojnov
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
Vaccine 29:7483-90. 2011..Broadening the CD8(+) T cell response against subdominant MHC class I epitopes was, therefore, more difficult than we initially anticipated... - Mamu-B*08-positive macaques control simian immunodeficiency virus replicationJohn T Loffredo
Wisconsin National Primate Research Center, University of Wisconsin Madison, 555 Science Drive, Madison, WI 53711, USA
J Virol 81:8827-32. 2007..002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers... - Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllersPhilip A Mudd
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
J Virol 85:7454-9. 2011..Viral loads remained stable throughout the experiment, suggesting that SIV-specific CD4(+) T cell responses may not play a direct role in controlling chronic viral replication in these elite controllers... - Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assayJohn T Loffredo
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA
J Virol 79:14986-91. 2005..Such differences in antigen-specific CD8+-T-lymphocyte efficacy may be important for selecting CD8+ T lymphocyte epitopes for inclusion in future HIV vaccines... - The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophagesLara Vojnov
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
J Virol 86:4682-7. 2012.... - The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challengeMatthew R Reynolds
AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
J Virol 85:9637-40. 2011..Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses... - Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replicationChungwon Chung
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53715 1299, USA
J Virol 81:1517-23. 2007..Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2... - Escape from CD8(+) T cell responses in Mamu-B*00801(+) macaques differentiates progressors from elite controllersPhilip A Mudd
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53711, USA
J Immunol 188:3364-70. 2012..By contrast, virus in elite controller macaques showed little evidence of variation in epitopes recognized by immunodominant CD8(+) T lymphocytes, implying that these cells play a role in viral control... - The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239John T Loffredo
Wisconsin National Primate Research Center (WNPRC, University of Wisconsin, Madison, WI 53715, USA
J Immunol 175:5986-97. 2005..Our results suggest that the high frequency MHC class I molecule, Mamu-B*01, is not involved in SIV-specific CD8+ T lymphocyte responses... - Identification of seventeen new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognitionJohn T Loffredo
National Primate Research Center, University of Wisconsin (WPRC, Madison 53715, USA
J Immunol 173:5064-76. 2004..This work enhances the use of the SIV-infected macaque model for HIV and increases our understanding of the breadth of CD8+ T cell responses in SIV infection...