Research Topics
Species | Christopher WilsonSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZRIvan Bilic
Institute of Immunology, Medical University of Vienna, Vienna 1090, Austria
Nat Immunol 7:392-400. 2006..Enforced' expression of MAZR led to impaired Cd8 activation and variegated CD8 expression. Our results demonstrate epigenetic control of the Cd8 loci and identify MAZR as an important regulator of Cd8 expression...- The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cellsL A Penix
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
J Biol Chem 271:31964-72. 1996..As a target for DNA methylation and for binding of transcription factors that mediate or impede transcription, this element appears to play a central role in controlling IFN-gamma expression... - DNA methylation and the expanding epigenetics of T cell lineage commitmentChristopher B Wilson
Department of Immunology, University of Washington, Seattle, WA 98195, USA
Semin Immunol 17:105-19. 2005..However, most of our knowledge is derived from in vitro studies, and the importance of DNA methylation in memory cell lineage fidelity in vivo remains to be shown convincingly... - Induction of antigen-specific immunity in human neonates and infantsChristopher B Wilson
Department of Immunology, University of Washington, Seattle, WA 98195, USA
Nestle Nutr Workshop Ser Pediatr Program 61:183-95. 2008.... - Chromatin structure and gene regulation in T cell development and functionChristopher B Wilson
Departments of Immunology and Pediatrics, University of Washington, Seattle, WA 98195, USA
Curr Opin Immunol 18:143-51. 2006..Together, these advances contribute to an understanding of how gene expression programs are established, maintained and modified during development... - Epigenetic control of T-helper-cell differentiationChristopher B Wilson
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Rev Immunol 9:91-105. 2009..In this Review, we describe these epigenetic processes and discuss how they collaborate to govern the fate and function of T helper cells... - Vaccine safety--vaccine benefits: science and the public's perceptionC B Wilson
Department of Immunology, University of Washington School of Medicine, Children s Hospital and Regional Medical Center, Seattle 98195, USA
Nat Rev Immunol 1:160-5. 2001..To further the control of disease by vaccination, we must develop safe and effective new vaccines to combat infectious diseases, and address the public's concerns... - Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administrationC B Wilson
Departments of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Virol 72:7542-50. 1998..This suggests that there are differences in the efficiency or nature of mechanisms limiting transgene expression in the airways and in the alveoli... - Epigenetic regulation of T cell fate and functionChristopher B Wilson
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Infect Dis 185:S37-45. 2002..Rather, these heritable programs of gene expression are imposed, at least in part, epigenetically through changes in chromatin structure and DNA methylation, allowing T cells to tune the threshold for expression of specific genes... - Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88Sing Sing Way
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
J Immunol 171:533-7. 2003..These results indicate that adaptive immune responses can be generated and provide protective immunity in the absence of MyD88... - Fidelity of pathogen-specific CD4+ T cells to the Th1 lineage is controlled by exogenous cytokines, interferon-gamma expression, and pathogen lifestyleMeredith M Curtis
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Cell Host Microbe 8:163-73. 2010..These findings illustrate the immune signals that induce memory CD4(+) T cell responses required for maintaining host defense against infection yet are adaptable in novel environmental contexts... - Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-betSing Sing Way
Department of Pediatrics, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Immunol 173:5918-22. 2004..Thus, host resistance and the generation of IFN-gamma-producing cells in response to LM infection are not substantially compromised in the absence of T-bet... - Increased dendritic cell numbers impair protective immunity to intracellular bacteria despite augmenting antigen-specific CD8+ T lymphocyte responsesRobert C Alaniz
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Immunol 172:3725-35. 2004.... - Deviation from a strong Th1-dominated to a modest Th17-dominated CD4 T cell response in the absence of IL-12p40 and type I IFNs sustains protective CD8 T cellsNural N Orgun
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
J Immunol 180:4109-15. 2008..Thus, generation of protective CD8 T cell immunity was resilient to perturbations that replace a strong Th1-dominated to a reduced magnitude Th17-dominated Ag-specific CD4 T cell response... - Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemiaAnnalisa Lembo
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Immunol 180:7574-81. 2008..novicida, leading to protective immunity to pneumonic tularemia. This is the first report of the protective effect of a TLR ligand on resistance to F. novicida-induced pneumonic tularemia... - Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cellsKaren W Makar
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 4:1183-90. 2003..These results indicate that Dnmts, DNA and histone methylation, and transcription factors 'collaborate' to determine appropriate Il4 expression patterns... - Methylation and demethylation in the regulation of genes, cells, and responses in the immune systemDavid R Fitzpatrick
Immunological Systems Department, Amgen Inc, 51 University St, Seattle, WA 98101, USA
Clin Immunol 109:37-45. 2003..The immune system is a fertile field for studies of epigenetic regulation of cell fate and function... - Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gammaJamie R Schoenborn
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 8:732-42. 2007..Our findings suggest that proper expression of Ifng is maintained through the collective action of multiple distal regulatory elements present in a region of about 100 kilobases flanking Ifng... - Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cellsMaria Shnyreva
Department of Immunology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 101:12622-7. 2004..Like IFN-gamma expression, these histone modifications were T-bet-dependent in CD4+ cells, but not CD8+ T cells. These findings define two distal regulatory elements associated with T cell subset-specific IFN-gamma expression... - DNA methylation is a nonredundant repressor of the Th2 effector programKaren W Makar
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Immunol 173:4402-6. 2004.... - Induction of protective immunity to Listeria monocytogenes in neonatesTobias R Kollmann
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
J Immunol 178:3695-701. 2007..Based on these data, we propose that DeltaactA-Lm or derivatives thereof might serve as a vaccine vehicle for neonatal immunization... - Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosaShawn J Skerrett
Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359640, Seattle, WA 98104, USA
Am J Physiol Lung Cell Mol Physiol 292:L312-22. 2007..However, MyD88-dependent pathways, in addition to those downstream of TLR2, TLR4, and TLR5, are required for pulmonary defense against P. aeruginosa... - Regulation of interferon-gamma during innate and adaptive immune responsesJamie R Schoenborn
Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA
Adv Immunol 96:41-101. 2007.... - Human Toll-like receptor 4 recognizes host-specific LPS modificationsAdeline M Hajjar
Department of Immunology, University of Washington, Seattle, WA 98195, USA
Nat Immunol 3:354-9. 2002..Thus, in contrast to mice, humans use TLR4 to recognize a molecular signature of bacterial-host adaptation to modulate the innate immune response... - ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humansLichen Jing
Department of Medicine, University of Washington, 1616 Eastlake Avenue East, Suite 251, Seattle, WA 98102, USA
J Immunol Methods 347:36-45. 2009.... - IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferonsMeredith M Curtis
Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
J Immunol 183:381-7. 2009..Thus, CD8 T cells retain sufficient plasticity to respond to environmental cues and can acquire additional effector functions in response to their environmental context... - CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locusMasayuki Sekimata
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Immunity 31:551-64. 2009..The results demonstrate that cooperation between architectural (CTCF) and transcriptional enhancing (T-bet) factors and the elements to which they bind is required for proper Th1 cell-specific expression of Ifng... - The Mycobacterium tuberculosis ESAT-6 homologue in Listeria monocytogenes is dispensable for growth in vitro and in vivoSing Sing Way
Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357650, Seattle, WA 98195, USA
Infect Immun 73:6151-3. 2005..A targeted deletion of the homologous gene in Listeria was generated, and in contrast to that observed for mycobacteria, this locus was not required for Listeria virulence... - Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureusShawn J Skerrett
Department of Medicine, University of Washington, School of Medicine, Seattle, WA 98195, USA
J Immunol 172:3377-81. 2004..aeruginosa but not S. aureus... - Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxinShawn J Skerrett
Department of Medicine, University of Washington School of Medicine, Seattle, 98104, USA
Am J Physiol Lung Cell Mol Physiol 287:L143-52. 2004..These data provide causal evidence that distal airway epithelial cells and the signals they transduce play a physiological role in lung inflammation in vivo... - Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4Robert K Ernst
Department of Medicine, HSB K 155, Box 357710, University of Washington, Seattle, WA 98195, USA
J Endotoxin Res 9:395-400. 2003..P. aeruginosa adaptation to the human airway may, therefore, play a fundamental role in the progressive lung damage associated with cystic fibrosis... - Local role for tumor necrosis factor alpha in the pulmonary inflammatory response to Mycobacterium tuberculosis infectionSherilyn Smith
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Infect Immun 70:2082-9. 2002.... - Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1+ T cellsSean N Tucker
Department of Immunology, University of Washington, Seattle 98195, USA
Blood 99:513-9. 2002..The study concludes that modest changes in the ratio of short to long Ikaros isoforms can substantially perturb T-cell development, and the development of IELs and NK T cells is particularly sensitive to such changes... - An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumoniaAdeline M Hajjar
Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Am J Respir Cell Mol Biol 33:470-5. 2005..We conclude that lung parenchymal and BM-derived cells collaborate in the MyD88-dependent response to P. aeruginosa infection in the lungs in mice... - Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte developmentTian H Chi
Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
Immunity 19:169-82. 2003..Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals... - T cell lineage choice and differentiation in the absence of the RNase III enzyme DicerBradley S Cobb
Lymphocyte Development Group, Medical Research Council Clinical Sciences Centre, Imperial College London, London W12 0NN, England, UK
J Exp Med 201:1367-73. 2005..Thus, although Dicer seems to be critical for the development of the early embryo, it may have limited impact on the implementation of some lineage-specific gene expression programs... - Programming perpetual T helper cell plasticityEmily Rowell
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Immunity 30:7-9. 2009..In this issue of Immunity,Lee et al. (2009) and Wei et al. (2009) each investigate the stability of T helper cell lineages and find that commitment to these fates is more plastic than previously appreciated... - Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunitySing Sing Way
Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357650, H564, Seattle, WA 98195, USA
Cell Microbiol 6:235-42. 2004..These data indicate that flagellin is not essential for LM pathogenesis or for the induction of LM-specific adaptive immune responses in normal mice... - Long-range regulation of cytokine gene expressionEmily Rowell
Department of Immunology, University of Washington, Seattle, WA 98195, USA
Curr Opin Immunol 20:272-80. 2008.... - Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cellsTobias R Kollmann
Department of Immunology, Box 357650, University of Washington, Seattle, WA 98165, USA
Blood 103:4240-2. 2004..Deficient cross-presentation may contribute to the suboptimal CD8 T-cell response to vaccines in neonates... - RNAi and chromatin in T cell development and functionMatthias Merkenschlager
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Curr Opin Immunol 20:131-8. 2008..This year has seen exciting progress in our ability to map chromatin structure and chromatin-associated factors genome-wide as well as striking examples how individual miRNAs affect the development and the function of the immune system... - Role of B-cell proliferation in the establishment of gammaherpesvirus latencyJanice M Moser
Center for Emerging Infectious Diseases, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA
J Virol 79:9480-91. 2005..Thus, the studies provide direct evidence that the proliferation of latently infected B cells is critical for the establishment of chronic gammaHV68 infection... - Improving the performance of enteric vaccines in the developing worldAndrew C Serazin
The Global Health Program, The Bill and Melinda Gates Foundation, Seattle, WA, USA
Nat Immunol 11:769-73. 2010..The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases... - Cutting edge: recombinant Listeria monocytogenes expressing a single immune-dominant peptide confers protective immunity to herpes simplex virus-1 infectionMark T Orr
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Immunol 178:4731-5. 2007..Thus, recombinant Lm-expressing Ag from HSV represents a promising new class of vaccines against HSV infection... - BACing up the interferon-gamma locusChristopher B Wilson
Department of Immunology and University of Washington, Seattle, WA 98195, USA
Immunity 25:691-3. 2006..2006) identify evolutionarily conserved noncoding sequences (CNSs) upstream of the interferon-gamma gene, then show by using a BAC transgene reporter that CNS-22 is a key regulator of interferon-gamma expression... - Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptorsAdeline M Hajjar
Department of Medicine, University of Washington, Health Sciences Building, Box 357710, 1959 NE Pacific Street, Seattle, WA 98195, USA
Infect Immun 74:6730-8. 2006..These results suggest that poor innate recognition of F. tularensis allows the bacterium to evade early recognition by the host innate immune system to promote its pathogenesis for mammals... - Sounds of a silent Blimp-1Karen W Makar
Department of Immunology, Box 357650, University of Washington, Seattle, WA 98195, USA
Nat Immunol 5:241-2. 2004 - Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1Steven Z Josefowicz
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Immunol 182:6648-52. 2009.... - CD8 T cell control of HSV reactivation from latency is abrogated by viral inhibition of MHC class IMark T Orr
Department of Immunology, University of Washington, Seattle, WA 98195, USA
Cell Host Microbe 2:172-80. 2007..These findings suggest that efficient inhibition of MHC class I by HSV is a key factor in its ability to reactivate in humans... - Immunology at Asilomar: from molecules to miceChristopher B Wilson
University of Washington, Department of Immunology, Box 357650, Seattle, WA 98195, USA
Nat Immunol 4:300-2. 2003
Research Grants
- REGULATION OF PSEUDOMONAS INDUCED LUNG INFLAMMATIONChristopher Wilson; Fiscal Year: 2003..Hypothesis: CFTR KO mice will have excessive lung inflammation. This will reflect a process intrinsic to the lung and will parallel and be dependent, at least in part, on NF-kappaB activation in the airway epithelium. ..
- DNA METHYLATION IN T CELL DEVELOPMENT AND FUNCTIONChristopher Wilson; Fiscal Year: 2004..2) The increased numbers of TCRgammabeta thymocytes will reflect either increased locus accessibility and rearrangement of the relevant gammabeta TCR genes or reduced Notch signaling. ..
- LSR II ANALYZERChristopher Wilson; Fiscal Year: 2005..This application documents the limitations of our current facility in meeting the needs of these investigators for access to contemporary flow cytometry instruments and how an LSR II analyzer would allow us to meet these needs. ..
- Basic and Cancer ImmunologyChristopher Wilson; Fiscal Year: 2006..The goal of this training program is the selection and rigorous training of an outstanding group of young scientists, who will contribute disproportionately to the conduct of important research in cancer-related immunology. ..
- HOST DEFENSE TO NEONATAL INRACELLULAR PATHOGENSChristopher Wilson; Fiscal Year: 2007..These studies will provide insights into mechanisms for host defense against Lm and for the greater susceptibility of the neonate to this and related intracellular bacterial pathogens. ..
- TRANSCRIPTIONAL CONTROL OF INTERFERON-GAMMA IN T AND NK CELLSChristopher Wilson; Fiscal Year: 2007....
- TRAINING BASIC AND PEDIATRIC IMMUNOLOGISTSChristopher Wilson; Fiscal Year: 2007....
- MACROPHAGES AND T CELLS IN NEONATAL HOST DEFENSEChristopher Wilson; Fiscal Year: 2003..Aim 4. Determine the role of DNA methylation in the regulation of IFN-g production and greater dependence on costimulation of naive, neonatal T cells. ..
- EARLY PULMONARY HOST DEFENSE IN M. TUBERCULOSIS INFECTIOChristopher Wilson; Fiscal Year: 2002..abstract_text> ..