J T Willie

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi To eat or to sleep? Orexin in the regulation of feeding and wakefulness
    J T Willie
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 75390 9050, USA
    Annu Rev Neurosci 24:429-58. 2001
  2. ncbi Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates
    J T Willie
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuroscience 130:983-95. 2005
  3. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
  4. ncbi Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression
    J T Willie
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 8584, USA
    Neuroscience 156:819-29. 2008
  5. ncbi Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    J Hara
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuron 30:345-54. 2001
  6. ncbi Orexin (hypocretin) neurons contain dynorphin
    T C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:RC168. 2001

Collaborators

Detail Information

Publications6

  1. ncbi To eat or to sleep? Orexin in the regulation of feeding and wakefulness
    J T Willie
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 75390 9050, USA
    Annu Rev Neurosci 24:429-58. 2001
    ....
  2. ncbi Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates
    J T Willie
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuroscience 130:983-95. 2005
    ..We conclude that the presence of orexin is not required for the wakefulness-prolonging action of modafinil, but orexin may mediate some of the alerting effects of the compound...
  3. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
    ..We propose that orexin regulates sleep/wakefulness states, and that orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation...
  4. ncbi Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression
    J T Willie
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 8584, USA
    Neuroscience 156:819-29. 2008
    ..When combined with caloric restriction, the treatment of healthy, obese subjects with this compound resulted in some subjects experiencing vivid dreams and sleep disturbances...
  5. ncbi Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    J Hara
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuron 30:345-54. 2001
    ..Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy...
  6. ncbi Orexin (hypocretin) neurons contain dynorphin
    T C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:RC168. 2001
    ..These findings suggest that dynorphin-A may play an important role in the function of the orexin neurons...