Research Topics
| Richard J WhitleySummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Viral encephalitis: familiar infections and emerging pathogensRichard J Whitley
Department of Pediatrics, Microbiology and Medicine, University of Alabama at Birmingham, USA
Lancet 359:507-13. 2002..We review current understanding of viral encephalitides with particular reference to emerging viral infections and the availability of existing treatment regimens...- Oral acyclovir suppression and neurodevelopment after neonatal herpesDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
N Engl J Med 365:1284-92. 2011..Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease... - Oncolytic HSV-1 for the treatment of brain tumoursJames M Markert
Division of Neurosurgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 3410, USA
Herpes 13:66-71. 2006..In this review, the background of this approach will be discussed, followed by a discussion of the clinical trials, as well as potential directions for future trials... - Serial passage through human glioma xenografts selects for a Deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumorsAmish C Shah
Division of Neurosurgery, University of Alabama at Birmingham, 510 20th Street South, Birmingham, AL 35294-3410, USA
J Virol 80:7308-15. 2006..This finding emphasizes the contribution of the in vivo tumor environment for selecting novel oncolytic HSV specifically adapted for tumor cell destruction in vivo... - Seasonal and pandemic influenza preparedness: a global threatRichard J Whitley
Departments of Pediatrics, Microbiology, Medicine, and Neurosurgery and Center for Biodefense and Emerging Infections, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
J Infect Dis 194:S65-9. 2006.... - Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosidesMark N Prichard
Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA
Antimicrob Agents Chemother 53:5251-8. 2009.... - Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBMJames M Markert
Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 3410, USA
Mol Ther 17:199-207. 2009..Evidence of viral replication was demonstrated. G207 appears safe for multiple dose delivery, including direct inoculation into the brain surrounding tumor resection cavity... - Seasonal and pandemic influenza: recommendations for preparedness in the United StatesRichard J Whitley
Department of Pediatric, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
J Infect Dis 194:S155-61. 2006.... - Management of herpes zoster and post-herpetic neuralgia now and in the futureRichard J Whitley
University of Alabama at Birmingham, CHB 303, 1600 Seventh Avenue South, Birmingham, AL 35233, USA
J Clin Virol 48:S20-8. 2010..The role of translational neuroscience in moving towards a goal of finding disease-modifying treatments will be examined... - Cytomegalovirus and HIV: inextricably entwined pathogensRichard J Whitley
Departments of Pediatrics, Microbiology, Medicine, and Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Lancet 363:2101-2. 2004 - Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus diseaseDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Infect Dis 197:836-45. 2008..Intravenous ganciclovir administered for 6 weeks improves hearing outcomes in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system... - Therapy of herpes virus infections in childrenRichard J Whitley
The University of Alabama at Birmingham, AL 35233, USA
Adv Exp Med Biol 609:216-32. 2008..However, and notably so, numerous viral diseases of children represent unmet medical needs and warrant dedicated drug discovery efforts, including hepatitis B and C, and respiratory syncytial virus, among others... - Herpes simplex viruses: is a vaccine tenable?Richard J Whitley
Department of Pediatrics, Microbiology and Medicine, University of Alabama at Birmingham, 35233, USA
J Clin Invest 110:145-51. 2002 - Herpes simplex encephalitis: adolescents and adultsRichard J Whitley
Department of Pediatrics, Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue, CHB 303, Birmingham, AL 35233, United States
Antiviral Res 71:141-8. 2006.... - Herpes simplex virus infectionRichard J Whitley
Department of Pediatrics, University of Alabama at Birmingham, USA
Semin Pediatr Infect Dis 13:6-11. 2002..Its prodrug, valaciclovir, and the prodrug of penciclovir, famciclovir, have not been used in practice as long and, therefore, less is known about these agents; however, neither is available as a pediatric formulation... - Current non-AIDS antiviral chemotherapyScott T Rottinghaus
Infectious Diseases, The University of Alabama at Birmingham, Department of Medicine, 1530 Third Avenue South, Birmingham, AL 35294 0006, USA
Expert Rev Anti Infect Ther 5:217-30. 2007..Notably, considerable progress remains to be made in these areas. Moreover, a variety of additional viral diseases currently require the development of specific therapies... - Oseltamivir dosing for influenza infection in premature neonatesEdward P Acosta
Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
J Infect Dis 202:563-6. 2010..0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population... - Smallpox: a potential agent of bioterrorismRichard J Whitley
Department of Pediatrics, Microbiology and Medicine Children s Hospital, The University of Alabama at Birmingham, ACC 616, 1600 7th Avenue South, Birmingham, AL 35233, USA
Antiviral Res 57:7-12. 2003..The availability of a vaccine and antiviral drugs that are safe would significantly remove any major threat of smallpox deployment by a terrorist... - Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trialDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
J Pediatr 143:16-25. 2003..To evaluate the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease... - Enhanced inhibition of syngeneic murine tumors by combinatorial therapy with genetically engineered HSV-1 expressing CCL2 and IL-12Jacqueline N Parker
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294-3410, USA
Cancer Gene Ther 12:359-68. 2005..Our results demonstrate that combinatorial cytokine/chemokine gamma(1)34.5(-) HSV therapies can provide superior antitumor effects in experimental tumors as a model for malignancies arising in the brain... - Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous systemRussell D Bradford
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Infect Dis 191:227-33. 2005..CONCLUSION: In children with symptomatic congenital CMV infection involving the CNS, viremia during early infancy is associated with hearing loss and systemic CMV disease... - Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infectionScott H James
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1711, United States
Antiviral Res 83:207-13. 2009..Although advances in antiviral agents have led to improved outcomes, there is still a need for more effective treatments... - Varicella-zoster vaccine for the prevention of herpes zosterDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
N Engl J Med 356:1338-43. 2007 - Effect of adenine arabinoside on severe Herpesvirus hominis infections in man. 1973Nassif J Cannon
Department of Pediatrics, School of Medicine, The University of Alabama in Birmingham, USA
J Infect Dis 190:1362-7. 2004 - Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous systemSara E Oliver
Department of Pediatrics, University of Alabama at Birmingham, United States
J Clin Virol 46:S22-6. 2009..Ganciclovir protects against hearing deterioration in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system (CNS)... - Neonatal herpes: what have we learnedDavid W Kimberlin
Department of Pediatrics, The University of Alabama Birmingham, AL 35233, USA
Semin Pediatr Infect Dis 16:7-16. 2005..In the longer term, development of a bedside nucleic acid detection kit for real-time detection of HSV DNA in the maternal genital tract at the time of delivery could identify which babies are at risk of developing neonatal HSV disease... - Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitisMark J Abzug
Pediatric Infectious Disease, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, 1056 E Nineteenth Avenue, Denver, CO 80218, USA
Pediatr Infect Dis J 22:335-41. 2003..Treatment of older children and adults with pleconaril has been associated with reduced severity and duration of symptoms. This study evaluated the pharmacokinetics, safety and efficacy of pleconaril in infants with EV meningitis... - The role of oseltamivir in the treatment and prevention of influenza in childrenRichard J Whitley
University of Alabama at Birmingham, Department of Pediatrics, CHB 303, 1600 Seventh Avenue South, Birmingham, AL 35294 0011, USA
Expert Opin Drug Metab Toxicol 3:755-67. 2007..In the event of an influenza pandemic, oseltamivir is expected to be at the forefront of containment strategies. This article reviews the pharmacology, efficacy and tolerability of oseltamivir as treatment and prophylaxis in children... - A 70-year-old woman with shingles: review of herpes zosterRichard J Whitley
Department of Pediatrics, University of Alabama at Birmingham, CHB 303, 1600 Seventh Ave S, Birmingham, AL 35294 0011, USA
JAMA 302:73-80. 2009..Using her case as a springboard, the diagnosis, natural history, and treatment of herpes zoster and postherpetic neuralgia in immunocompetent older adults are reviewed, in addition to the effectiveness of the herpes zoster vaccine... - Safety of oseltamivir compared with the adamantanes in children less than 12 months of ageDavid W Kimberlin
Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama, Birmingham, Birmingham, AL 35233, USA
Pediatr Infect Dis J 29:195-8. 2010..To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine... - Recurrent benign lymphocytic meningitisMarwan Shalabi
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Clin Infect Dis 43:1194-7. 2006..This therapy is thought to be beneficial, although there is no controlled trial data to support efficacy and safety... - Regulatory challenges: lessons from recent West Nile virus trials in the United StatesPenelope M Jester
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Contemp Clin Trials 27:254-9. 2006.... - Prevention and treatment of influenza in high-risk groups: children, pregnant women, immunocompromised hosts, and nursing home residentsRichard J Whitley
University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
J Infect Dis 194:S133-8. 2006..The development of additional antiviral drugs is an important recommendation for the future, so that antiviral resistance can be circumvented. Similarly, availability of drugs for children <1 year of age is mandatory... - Herpes simplex encephalitis: children and adolescentsRichard J Whitley
Department of Pediatrics, The University of Alabama at Birmingham, AL, USA
Semin Pediatr Infect Dis 16:17-23. 2005..Recent investigative efforts are assessing the value of PCR detection of viral DNA at the completion of therapy and the value of prolonged antiviral therapy... - Clinical practice. Herpes zosterJohn W Gnann
Departments of Medicine, University of Alabama at Birmingham, Birmingham, Ala 35294-2170, USA
N Engl J Med 347:340-6. 2002 - Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidatesJacqueline N Parker
Department of Pediatrics, Division of Infectious Diseases, The University of Alabama at Birmingham, CHB 118B, 1600 6th Avenue South, Birmingham, AL 35233, USA
Vaccine 24:1644-52. 2006..These data suggest that conditionally replicating, cytokine-expressing HSV are able to elicit protective immune responses while retaining safety in an experimental murine model... - Commentary: Ch'ien LT, Cannon NJ, Charamella LJ, et al. effect of adenine arabinoside on severe herpesvirus hominis infections in man: preliminary report. J Infect Dis 1973; 128:658-63Richard J Whitley
Department of Medicine, University of Alabama at Birmingham, Alabama 35233-0011, USA
J Infect Dis 190:1360-7. 2004 - Congenital cytomegalovirus infection: epidemiology and treatmentRichard J Whitley
University of Alabama at Birmingham, USA
Adv Exp Med Biol 549:155-60. 2004..Ideally, the best approach would be the development of an efficacious vaccine. Regardless, current clinical efforts define a new era for the treatment of congenital infections... - Clinical applications for change-point analysis of herpes zoster painRenee A Desmond
Medical Statistics Section, Department of Medicine, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
J Pain Symptom Manage 23:510-6. 2002..This model verifies three phases of zoster pain and delineates the impact of treatment and other factors on the phase-specific rates of pain cessation... - Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North AmericaGregory J Mertz
Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
Clin Infect Dis 39:1307-13. 2004..BACKGROUND. Ribavirin is active in vitro against hantaviruses, but the findings of an open trial of the use of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome (HCPS) were inconclusive... - Human herpesvirus 6 infection of the central nervous system: is it just a case of mistaken association?Richard J Whitley
Clin Infect Dis 40:894-5. 2005 - Seasonal and pandemic influenza: a 2007 update on challenges and solutionsArnold S Monto
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, USA
Clin Infect Dis 46:1024-31. 2008..These initiatives will also help control outbreaks of seasonal influenza... - Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma modelElizabeth K Hellums
Brain Tumor Research Laboratories, Division of Neurosurgery, Department of Surgery, University of Alabama School of Medicine, Birmingham AL 35294, USA
Neuro Oncol 7:213-24. 2005..We conclude that the 4C8/B6D2F1 syngeneic glioma model is suitable for preclinical evaluation of HSV-based therapies and that M002 is a superior virus for the treatment of murine glioma in this model... - Neonatal herpes should be a reportable diseaseH Hunter Handsfield
University of Washington, Center for AIDS and STD, Harborview Medical Center, Seattle, Washington 98104, USA
Sex Transm Dis 32:521-5. 2005..Neonatal herpes should be a reportable condition... - Recommendations for the management of herpes zosterRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 44:S1-26. 2007..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ... - HIV-1(89.6) Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in miceScott D Parker
Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, United States
Vaccine 25:6764-73. 2007..These data highlight the potential utility of neuroattenuated, replication competent HSV-1 vectors for delivery of HIV-1 immunogens... - Review of recent HSV recurrent-infection treatment studiesRaj Patel
Southampton University Hospitals, University of Southampton, UK
Herpes 14:23-6. 2007..This article reports on presentations given at the IHMF Annual Meeting and International Congress of Antimicrobial Agents and Chemotherapy, both of which took place in late 2006... - The incidence and severity of herpes simplex encephalitis in Sweden, 1990-2001Richard J Whitley
Clin Infect Dis 45:881-2. 2007 - Changing dynamics of varicella-zoster virus infections in the 21st century: the impact of vaccinationRichard J Whitley
J Infect Dis 191:1999-2001. 2005 - A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipientsGary L Davis
Division of Hepatology, Baylor University Medical Center, Dallas, TX 75246, USA
Liver Transpl 11:941-9. 2005..Further studies are required to determine whether the drug has beneficial effects in this group of patients... - Lessons learned from reconstructing the 1918 influenza pandemicAdolfo Garcia-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, 10029, USA
J Infect Dis 194:S127-32. 2006..Monitoring the sequences of avian influenza viruses for genetic changes and diversity may help us to predict the risks that these viruses pose of causing a new pandemic... - Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgiaRobert H Dworkin
Department of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Pain 9:S37-44. 2008..PERSPECTIVE: Comprehensive assessments of pain are necessary for clinical research on the epidemiology, natural history, pathophysiologic mechanisms, treatment, and prevention of pain in herpes zoster and PHN...