Research Topics
| Paul W WhitbySummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
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Detail Information
Publications
Characterization of the Haemophilus influenzae tehB gene and its role in virulencePaul W Whitby
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Microbiology 156:1188-200. 2010..influenzae tehB plays a role in both resistance to oxidative damage and haem uptake/utilization, protects H. influenzae from tellurite exposure, and is important for virulence of this organism in an animal model of invasive disease...- The iron/heme regulated genes of Haemophilus influenzae: comparative transcriptional profiling as a tool to define the species core modulonPaul W Whitby
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
BMC Genomics 10:6. 2009..These data are used to begin to define the core iron/heme modulon of the species... - The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinantDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Int J Med Microbiol 299:479-88. 2009..influenzae disease. In conclusion, HbpA is important for heme utilization by multiple H. influenzae strains and is a virulence determinant in a model of H. influenzae invasive disease... - Lipoprotein e (P4) of Haemophilus influenzae: role in heme utilization and pathogenesisDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Microbes Infect 9:932-9. 2007..In addition, a rat model of infection demonstrated a role for e (P4) in the pathogenesis of invasive disease... - Identification of a siderophore utilization locus in nontypeable Haemophilus influenzaeDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
BMC Microbiol 10:113. 2010..There are currently no reports of siderophore production or utilization by H. influenzae... - Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infectionThomas W Seale
Department of Pediatrics, CHO 2308, University of Oklahoma Health Sciences Center, 940 NE 13th Street, Oklahoma City, OK 73104, USA
Infect Immun 74:6213-25. 2006..Taken together, these data indicate that both the hgp genes and the hxuC gene are virulence determinants in the rat model of human invasive disease... - Identification of a haem-utilization protein (Hup) in Haemophilus influenzaeDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Microbiology 150:3923-33. 2004..The mutation also resulted in a reduced ability to utilize haem, haem-haemopexin, haem-albumin and haemoglobin-haptoglobin, thus identifying a general haem-utilization protein (Hup) in Haemophilus influenzae... - The haem-haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzaeDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Microbiology 153:215-24. 2007..These age-related differences in the impact of mutations in the hxuCBA gene cluster may be related to changes in levels of host haem-binding proteins during development of the rat... - Transcriptional profile of Haemophilus influenzae: effects of iron and hemePaul W Whitby
Department of Pediatrics, CHO 2308, 940 NE 13th St, Oklahoma City, OK 73104, USA
J Bacteriol 188:5640-5. 2006..5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions... - The heme-binding lipoprotein (HbpA) of Haemophilus influenzae: role in heme utilizationDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
FEMS Microbiol Lett 253:193-9. 2005..influenzae strain and demonstrated a role for the gene in utilization of multiple heme sources. This is the first report confirming a role for HbpA in utilization of heme... - Differential utilization by Haemophilus influenzae of haemoglobin complexed to the three human haptoglobin phenotypesDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
FEMS Immunol Med Microbiol 46:426-32. 2006..A strain expressing only HgpB was able to utilize haemoglobin bound to all haptoglobin phenotypes significantly better than strains expressing either HgpA or HgpC... - Utilization of myoglobin as a heme source by Haemophilus influenzae requires binding of myoglobin to haptoglobinDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
FEMS Microbiol Lett 258:235-40. 2006..Utilization of the haptoglobin-myoglobin complex was shown to be mediated by the previously described hemoglobin/hemoglobin-haptoglobin-binding proteins of H. influenzae... - Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis mediaDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, CHO 2308, 940 NE 13th Street, Oklahoma City, OK 73104, USA
Microb Pathog 36:25-33. 2004..These data indicate that the hemoglobin/hemoglobin-haptoglobin binding proteins are required for bacterial proliferation during H. influenzae-induced otitis media in chinchillas... - Burkholderia cenocepacia utilizes ferritin as an iron sourcePaul W Whitby
Department of Paediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Med Microbiol 55:661-8. 2006..Since it is known that the ferritin concentration is significantly higher in the CF lung than in healthy lungs, this novel iron-acquisition mechanism may contribute to infection by B. cenocepacia in people with CF... - Characterization of three new competence-regulated operons in Haemophilus influenzaeTimothy M VanWagoner
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Bacteriol 186:6409-21. 2004..An insertion in HI0939 abolished both DNA binding and uptake. The predicted product of this gene shares characteristics with PulJ, a pseudopilin involved in pullulanase export in Klebsiella oxytoca... - Identification of an RTX determinant of Burkholderia cenocepacia J2315 by subtractive hybridizationPaul W Whitby
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Med Microbiol 55:11-21. 2006.... - Catalase as a source of both X- and V-factor for Haemophilus influenzaeDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, 940 NE 13th Street, Oklahoma City, OK 73104, USA
FEMS Microbiol Lett 279:157-61. 2008..Mammalian catalases contain both bound heme and NADPH. This study shows that catalase can supply both factors X and V to H. influenzae in vitro, thus representing a potential in vivo source of these essential growth factors... - The dppBCDF gene cluster of Haemophilus influenzae: Role in heme utilizationDaniel J Morton
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA
BMC Res Notes 2:166. 2009..CONCLUSION: The dppCBDF gene cluster constitutes part of the periplasmic heme-acquisition systems of H. influenzae...