Research Topics
| Joel O WertheimSummaryAffiliation: University of Arizona Country: USA Publications
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Detail Information
Publications
A challenge to the ancient origin of SIVagm based on African green monkey mitochondrial genomesJoel O Wertheim
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
PLoS Pathog 3:e95. 2007..This study substantially weakens the theory of ancient SIV infection followed by codivergence with its primate hosts...- Relaxed selection and the evolution of RNA virus mucin-like pathogenicity factorsJoel O Wertheim
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
J Virol 83:4690-4. 2009..This suggests that so long as these regions maintain sufficient O-linked glycosylation, they are free to evolve rapidly without loss of function as pathogenicity factors... - Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2Joel O Wertheim
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
PLoS Comput Biol 5:e1000377. 2009..Our results suggest either that SIV is a surprisingly young lentiviral lineage or that SIV and, perhaps, HIV dating estimates are seriously compromised by unaccounted-for biases... - A quick fuse and the emergence of Taura syndrome virusJoel O Wertheim
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Virology 390:324-9. 2009..Using a relaxed molecular clock, we determined that TSV is almost always discovered within a year of entering a new region. This suggests that current monitoring programs are effective at detecting novel TSV outbreaks... - Relaxed molecular clocks, the bias-variance trade-off, and the quality of phylogenetic inferenceJoel O Wertheim
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Syst Biol 59:1-8. 2010..We also compared the quality of inference between Bayesian and maximum likelihood time-free inference models and found them to be qualitatively similar... - Evolutionary history of chimpanzees inferred from complete mitochondrial genomesAdam Bjork
Department of Ecology and Evolutionary Biology, University of Arizona, USA
Mol Biol Evol 28:615-23. 2011..We also suggest that accurate tMRCA estimates from large computationally difficult sequence alignments may be obtained by implementing our novel method of bootstrapping smaller randomly subsampled alignments... - Estimating diversification rates: how useful are divergence times?Joel O Wertheim
Department of Pathology, University of California, San Diego, California 92103, USA
Evolution 65:309-20. 2011..Finally, because Bayesian and frequentist methods provided similar assessments of error, novel Bayesian approaches may provide a useful framework for tests of diversification rates in more complex contexts than are addressed here...