Melanie Wellington

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    FEMS Immunol Med Microbiol 51:70-83. 2007
  2. ncbi Live Candida albicans suppresses production of reactive oxygen species in phagocytes
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA
    Infect Immun 77:405-13. 2009
  3. ncbi 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans
    Melanie Wellington
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mycologia 98:393-8. 2006
  4. ncbi Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization
    Kristy Dolan
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 53:3337-46. 2009
  5. ncbi Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:7228-31. 2003
  6. ncbi 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans
    Melanie Wellington
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Yeast 22:57-70. 2005
  7. ncbi Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa
    Nadine E Van Alst
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 77:4446-54. 2009
  8. ncbi Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicans
    Ying-Kai Wang
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA
    Yeast 21:685-702. 2004
  9. ncbi Imaging morphogenesis of Candida albicans during infection in a live animal
    Soumya Mitra
    University of Rochester Medical Center, Department of Imaging Sciences, 601 Elmwood Avenue, Box 648, Rochester, New York 1462University of Rochester Medical Center, Department of Pediatrics, 601 Elmwood Avenue, Box 690, Rochester, New York 14642
    J Biomed Opt 15:010504. 2010

Collaborators

Detail Information

Publications9

  1. ncbi Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    FEMS Immunol Med Microbiol 51:70-83. 2007
    ..These data suggest that FcgammaR cooperates positively with antibody-independent recognition mechanisms in what may be a novel link between innate and adaptive immunity to C. albicans...
  2. ncbi Live Candida albicans suppresses production of reactive oxygen species in phagocytes
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA
    Infect Immun 77:405-13. 2009
    ..These studies indicate that live C. albicans actively suppresses ROS production in phagocytes in vitro, which may represent an important immune evasion mechanism...
  3. ncbi 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans
    Melanie Wellington
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mycologia 98:393-8. 2006
    ..However most of the "pop-outs" acquired various chromosome alterations. Thus constructs exposed to 5-FOA should be examined for chromosome alterations or the use of 5-FOA should be avoided...
  4. ncbi Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization
    Kristy Dolan
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 53:3337-46. 2009
    ..Taken together, these experiments indicate that the further study of compounds related to TAM as antifungal agents is warranted...
  5. ncbi Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:7228-31. 2003
    ..Furthermore, we have described a system using a recombinant human antibody single-chain variable fragment that allows a comparative study of phagocytosis of multiple Candida species opsonized via a common antigen...
  6. ncbi 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans
    Melanie Wellington
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Yeast 22:57-70. 2005
    ..Our results indicate the necessity of electrokaryotyping of strains that have been exposed to 5-FOA, especially with studies of gene function and with DNA microarray assays...
  7. ncbi Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa
    Nadine E Van Alst
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 77:4446-54. 2009
    ..These data suggest that NO generated via nitrite reductase NirS contributes to the regulation of expression of selected virulence factors in P. aeruginosa PA14...
  8. ncbi Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicans
    Ying-Kai Wang
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA
    Yeast 21:685-702. 2004
    ..albicans essential gene BMH1 as a negative regulator of the utilization of secondary carbon source in yeast, which further substantiates the involvement of 14-3-3 proteins in diverse functions...
  9. ncbi Imaging morphogenesis of Candida albicans during infection in a live animal
    Soumya Mitra
    University of Rochester Medical Center, Department of Imaging Sciences, 601 Elmwood Avenue, Box 648, Rochester, New York 1462University of Rochester Medical Center, Department of Pediatrics, 601 Elmwood Avenue, Box 690, Rochester, New York 14642
    J Biomed Opt 15:010504. 2010
    ..This model system will allow us to gain significant new information about C. albicans pathogenesis through studies of host-C. albicans interactions in the native environment...