Research Topics
Species | RICHARD H WEINDRUCHSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional programMichael G Edwards
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI, USA
BMC Genomics 8:80. 2007..We have used high density oligonucleotide arrays and novel statistical methods to identify specific transcriptional classes that may uncover biological processes that play a central role in mammalian aging...- The retardation of aging by caloric restriction: studies in rodents and primatesR Weindruch
Department of Medicine, University of Wisconsin, Madison, USA
Toxicol Pathol 24:742-5. 1996.... - Effects of caloric restriction on gene expressionRichard Weindruch
Department of Medicine, University of Wisconsin-Madison and VA Hospital, Geriatric Research, Education and Clinical Center, USA
Nestle Nutr Workshop Ser Clin Perform Programme 6:17-28; discussion 28-32. 2002 - Caloric restriction mimetics: metabolic interventionsR Weindruch
Department of Medicine, University of Wisconsin, VA Hospital, Madison 53705 2286, USA
J Gerontol A Biol Sci Med Sci 56:20-33. 2001..Other recommendations were that transgenic approaches and adult-onset CR should be emphasized in future studies... - Microarray profiling of gene expression in aging and its alteration by caloric restriction in miceR Weindruch
University of Wisconsin Madison and Veterans Administration Hospital, Department of Medicine, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA
J Nutr 131:918S-923S. 2001.... - Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restrictionYoshikazu Higami
Wisconsin Primate Research Center, Madison, Wisconsin, USA
FASEB J 18:415-7. 2004..Our data provide new insights on the metabolic state associated with aging retardation by LCR... - The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in miceCheol-Koo Lee
Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706, USA
Free Radic Biol Med 36:1043-57. 2004.... - Metabolizable energy intake during long-term calorie restriction in rhesus monkeysAarthi Raman
Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
Exp Gerontol 42:988-94. 2007..Use of diet weight is a reasonable estimate of the level of CR when food waste is assessed... - Calorie restriction: progress during mid-2005-mid-2006Rozalyn M Anderson
University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Exp Gerontol 41:1247-9. 2006 - Will dietary restriction work in primates?Richard Weindruch
Department of Medicine, University of Wisconsin and Geriatric Research, Education, and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Biogerontology 7:169-71. 2006..Robust survival data for monkeys subjected to highly controlled DR will be available in approximately 25 years; similar data for large numbers of human practitioners of DR appear to be many decades away... - Metabolic reprogramming in dietary restrictionRozalyn M Anderson
Department of Medicine, University of Wisconsin, and VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Interdiscip Top Gerontol 35:18-38. 2007.... - Influences of calorie restriction and age on energy expenditure in the rhesus monkeyAarthi Raman
Nutritional Sciences, Univ of Wisconsin Madison, 1415 Linden Dr, Madison, WI 53607, USA
Am J Physiol Endocrinol Metab 292:E101-6. 2007..077). Night EE did not differ between calorie-restricted and C younger monkeys after adjusting for FFM and FM. In conclusion, CR did not alter the age-related decrease in EE with CR... - Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusisShinichi Someya
Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
Neurobiol Aging 28:1613-22. 2007..Taken together, our findings suggest that loss of critical cells through apoptosis is an important mechanism of presbycusis in mammals, and that CR can retard this process by suppressing apoptosis in the inner ear tissue... - Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeysCristin M Bruns
Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
J Clin Endocrinol Metab 89:6218-23. 2004..52, 711.89); P < 0.02]. PA males do not exhibit elevated androgens during adulthood, suggesting that insulin resistance and impaired pancreatic beta-cell function may result from fetal reprogramming of key metabolic tissues... - Muscle mass loss in Rhesus monkeys: age of onsetRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, 53715, USA
Exp Gerontol 40:573-81. 2005..5 years of age. Furthermore, our data indicate percentage declines in ESM similar to those seen in humans with advancing age. These data support the suitability of the Rhesus monkey as a primate sarcopenia model... - Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress responseRozalyn M Anderson
University of Wisconsin Madison, GRECC VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Aging Cell 7:101-11. 2008..Our data show how mitochondrial function may be adapted in response to external stimuli, and support the concept that such adaptation is critically involved in cellular survival and in lifespan extension by calorie restriction... - Tympanometry in rhesus monkeys: effects of aging and caloric restrictionCynthia G Fowler
Department of Communicative Disorders, University of Wisconsin Madison, WI 53706, USA
Int J Audiol 47:209-14. 2008..These results parallel many findings in middle-ear function in aging humans. Longitudinal studies are planned... - Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years laterCynthia G Fowler
Department of Communicative Disorders, University of Wisconsin Madison, 1975 Willow Drive, Madison, WI 53706, USA
Hear Res 261:75-81. 2010..Because the rhesus monkeys have a maximum longevity of 40 years, the full benefits of CR may not yet be realized... - Metabolic reprogramming, caloric restriction and agingRozalyn M Anderson
Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, Madison, WI 53705, USA
Trends Endocrinol Metab 21:134-41. 2010..We discuss recent advances in understanding the function of key metabolic regulators that probably coordinate the response to altered nutrient availability with CR and how the pathways they regulate can retard the aging process... - Caloric restriction and aging: studies in mice and monkeysRozalyn M Anderson
Wisconsin National Primate Research Center, Madison, Wisconsin, USA
Toxicol Pathol 37:47-51. 2009..A new finding from this project is that CR reduces the rate of age-associated muscle loss (sarcopenia) in monkeys (Colman et al. 2008)... - Longitudinal analysis of early stage sarcopenia in aging rhesus monkeysSusan H McKiernan
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Exp Gerontol 44:170-6. 2009..The longitudinal approach of this study demonstrated that significant muscle changes occurred during middle age in a cohort of aging rhesus monkeys... - Caloric restriction, gene expression, and agingRichard Weindruch
Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA
Alzheimer Dis Assoc Disord 17:S58-9. 2003 - Attenuation of sarcopenia by dietary restriction in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin Madison, 1220 Capitol Ct, Madison, WI 53715, USA
J Gerontol A Biol Sci Med Sci 63:556-9. 2008..Body weight-adjusted skeletal muscle mass declined somewhat in both groups but was far more rapid in the control group. We have shown that moderate, adult-onset DR can attenuate sarcopenia in a nonhuman primate model... - Caloric restriction delays disease onset and mortality in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Science 325:201-4. 2009..Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species... - Gene expression profiling of aging using DNA microarraysRichard Weindruch
Department of Medicine, University of Wisconsin-Madison and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA
Mech Ageing Dev 123:177-93. 2002..The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process... - Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeysShinichi Someya
Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
Curr Aging Sci 3:20-5. 2010..Here, we review studies on CR's ability to prevent cochlear pathology and AHL in laboratory animals and discuss potential molecular mechanisms of CR's actions... - Assessment of nutritional status in rhesus monkeys: comparison of dual-energy X-ray absorptiometry and stable isotope dilutionStephane Blanc
Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA
J Med Primatol 34:130-8. 2005.... - Age-related impairment of the transcriptional responses to oxidative stress in the mouse heartMichael G Edwards
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
Physiol Genomics 13:119-27. 2003..These results demonstrate that, at the transcriptional level, there is an age-related impairment of specific inducible pathways in the response to oxidative stress in the mouse heart... - The retardation of aging by caloric restriction: its significance in the transgenic eraJamie L Barger
Wisconsin Primate Research Center and Department of Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
Exp Gerontol 38:1343-51. 2003..In contrast, for nearly all of the genetically abnormal models of lifespan extension, such data are minimal and often unconvincing; additional studies will be required to validate these strains as suitable models for aging research... - Pennington scientific symposium on mechanisms and retardation of agingCraig S Atwood
Section of Geriatrics and Gerontology, University of Wisconsin Medical School, Madison, WI, USA
Exp Gerontol 38:1217-26. 2003 - Reference body composition in adult rhesus monkeys: glucoregulatory and anthropometric indicesAarthi Raman
Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
J Gerontol A Biol Sci Med Sci 60:1518-24. 2005..The estimated reference range for %BF was 9%-23% in male and 8%-18% in female monkeys, corresponding to body mass indices of 32-44 kg/m(2) for male and 27-35 kg/m(2) for female monkeys... - A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeysErik K Kastman
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
J Neurosci 30:7940-7. 2010..Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species... - Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in miceKevork Hagopian
Department of Medicine, University of Wisconsin Medical School, Madison, WI 53705, USA
Exp Gerontol 38:253-66. 2003..Increased ketone body levels indicate increased utilization of non-carbohydrate fuels while decreased fructose-2,6-bisphosphate level suggests its importance in the control of glycolysis in CR... - Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosisShinichi Someya
Department of Genetics and Medical Genetics, Veterans Administration Hospital, Geriatric Research Education and Clinical Center, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 106:19432-7. 2009..Thus, induction of a Bak-dependent mitochondrial apoptosis program in response to oxidative stress is a key mechanism of AHL in C57BL/6J mice... - Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidantsSang Kyu Park
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, 53706, USA
Aging Cell 8:484-95. 2009..These findings suggest that transcriptional biomarkers of aging in mice can be used to estimate the efficacy of aging interventions on a tissue-specific basis... - Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liverKevork Hagopian
Department of Medicine, University of Wisconsin Medical School, Madison, WI 53705, USA
Exp Gerontol 38:267-78. 2003..Our results demonstrate increased gluconeogenic activity in CR mice and are consistent with a state of increased hepatic gluconeogenesis and protein turnover during CR... - Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 miceMichael G Edwards
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, 53706, USA
Ann N Y Acad Sci 1019:85-95. 2004..These results demonstrate that, at the transcriptional level, there is an age-related impairment of specific inducible pathways in the response to oxidative stress in the mouse heart... - Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activityAsensio A Gonzalez
Department of Medicine, University of Wisconsin, Madison, WI 53706, USA
Am J Physiol Endocrinol Metab 287:E1032-7. 2004..We conclude that, although the metabolic adaptations to fasting and CR include changes in plasma leptin concentration and phosphorylated acetyl-CoA carboxylase, these effects occur without changes in AMPK activity... - The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gammaShinichi Someya
Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
Neurobiol Aging 29:1080-92. 2008.... - alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of miceSang Kyu Park
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
J Nutr 138:1010-8. 2008..These results demonstrate that middle age-onset dietary supplementation with alphaT and gammaT can partially prevent age-associated transcriptional changes and that these effects are tissue and tocopherol specific... - A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostateJoseph R Dobosy
Environmental and Molecular Toxicology, University of Wisconsin, Madison, Wisconsin 53792, USA
Prostate 68:1187-95. 2008..The region of the genome containing the imprinted genes insulin-like growth factor 2 (Igf2) and H19, both of which display oncogenic functions, may be particularly sensitive to environmental influences... - Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-RHui Li
Department of Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
Neurobiol Aging 30:2010-20. 2009..Such an event is opposed by caloric restriction, a model of delayed aging, and favored by the p44 transgene in p44(+/+) animals, a model of accelerated aging... - Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeysNolan G Gokey
University of Wisconsin, Department of Animal Health and Biomedical Sciences, Madison, WI 53706, USA
Aging Cell 3:319-26. 2004..Species-specific differences in the regions of the genomes lost as well as the presence of direct repeat sequences at the breakpoints suggest mechanistic differences in deletion mutation formation between rodents and primates... - A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during agingClaudio Costantini
Department of Medicine, University of Wisconsin Madison, Wm S Middleton Memorial Veteran s Hospital, Madison, WI 53705, USA
Biochem J 391:59-67. 2005.... - Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse heartsCheol-Koo Lee
Molecular and Environmental Toxicology Center, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 99:14988-93. 2002..These observations provide evidence that aging of the heart is associated with specific transcriptional alterations, and that CR initiated in middle age may retard heart aging by inducing a profound transcriptional reprogramming...