Research Topics
Genomes and GenesSpecies | Xiangyun WeiSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Molecular cloning of three zebrafish lin7 genes and their expression patterns in the retinaXiangyun Wei
Department of Biological Sciences, Center for Zebrafish Research, University of Notre Dame, Notre Dame, IN 46556, USA
Exp Eye Res 82:122-31. 2006..These results suggest that the three zebrafish Lin7 proteins possess partially redundant, yet essential, roles in retinal development...- Nok plays an essential role in maintaining the integrity of the outer nuclear layer in the zebrafish retinaXiangyun Wei
Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Pittsburgh, PA 15213, USA
Exp Eye Res 83:31-44. 2006..Thus, our study provides novel insights into the mechanisms by which the integrity of the ONL is maintained in the vertebrate retina... - Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulationXiaojun Yang
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 29:11426-40. 2009..Furthermore, precocious overexpression of Lin7c induces multiaxial mirror symmetry in zebrafish neurulation. Our data suggest that stepwise maturation of apicobasal polarity plays an essential role in vertebrate neurulation... - Intact retinal pigment epithelium maintained by Nok is essential for retinal epithelial polarity and cellular patterning in zebrafishJian Zou
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 28:13684-95. 2008..Our results show that the subcellular architecture and cellular pattern formation of a tissue may be regulated by neighboring tissues through tissue-tissue interactions... - Restricted localization of ponli, a novel zebrafish MAGUK-family protein, to the inner segment interface areas between green, red, and blue conesJian Zou
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Invest Ophthalmol Vis Sci 51:1738-46. 2010..This study was undertaken to identify such polarity proteins... - Expression of a 12-kb promoter element derived from the zebrafish enolase-2 gene in the zebrafish visual systemQing Bai
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
Neurosci Lett 449:252-7. 2009.... - The Fugu tyrp1 promoter directs specific GFP expression in zebrafish: tools to study the RPE and the neural crest-derived melanophoresJian Zou
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Pigment Cell Res 19:615-27. 2006..Thus, these transgenic lines are useful tools to study melanophores in zebrafish... - The zebrafish Pard3 ortholog is required for separation of the eye fields and retinal laminationXiangyun Wei
Center for Zebrafish Research, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Dev Biol 269:286-301. 2004..Overexpressing Pard3 by injection of wild-type pard3 mRNA resulted in cyclopia and eyeless embryos. Thus, Pard3 plays a critical role in the origination and separation of zebrafish eye fields and retinal lamination... - Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryosLarry Kagemann
University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Mol Vis 14:2157-70. 2008..To demonstrate a new imaging method for high resolution spectral domain optical coherence tomography (SD-OCT) for small animal developmental imaging... - Analysis of gene function in the zebrafish retinaJarema Malicki
Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Methods 28:427-38. 2002..Some of these rely on the overexpression of a gene product, others take advantage of antisense oligonucleotides to block function of selected loci. Here we describe these methods in the context of the developing eye... - Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retinaAnne E Catalano
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Dev Dyn 236:1295-306. 2007..Identification and further study of the dou yan gene will enhance our understanding of the molecular mechanisms regulating retinal cellular homeostasis, i.e., the balance between cell proliferation and cell death... - nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retinaXiangyun Wei
Department of Ophthalmology, Harvard Medical School/MEEI, 243 Charles Street, Boston, Massachusetts 02114, USA
Nat Genet 31:150-7. 2002..We propose that nok function in patterning of postmitotic neurons is mediated through neuroepithelial cells and is necessary for guiding neurons to their proper destinations in retinal laminae... - Forward and reverse genetic approaches to the analysis of eye development in zebrafishJarema J Malicki
Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02110, USA
Vision Res 42:527-33. 2002..These recent advances, combined with the genome project, have established the zebrafish as one of the leading models for studies of visual system development...
Research Grants
- Retinal Epithelial Polarity and Cellular PatterningXiangyun Wei; Fiscal Year: 2009....
- Retinal Epithelial Polarity and Cellular PatterningXiangyun Wei; Fiscal Year: 2007....
- Retinal Epithelial Polarity and Cellular Patterning:Crbs and their associatesXiangyun Wei; Fiscal Year: 2010....