Research Topics
| Lawrence R WechslerSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Innovative strategies in the management of acute strokeLawrence R Wechsler
UPMC Stroke Institute, University of Pittsburgh School of Medicine, C 426 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Curr Cardiol Rep 4:135-40. 2002..For the millions of stroke survivors, investigations are now underway into the possibility of improvement of function through neuronal transplantation...- PFO and stroke: what are the data?Lawrence R Wechsler
Department of Neurology, UPMC Stroke Institute, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213 2582, USA
Cardiol Rev 16:53-7. 2008..Endovascular closure is technically feasible, but not without the possibility of periprocedural complications. Comparison of medical and endovascular closure of PFOs in patients with stroke is ongoing in 2 major randomized trials... - Stem cell transplantation for strokeLawrence R Wechsler
UPMC Stroke Institute, University of Pittsburgh Medical School, Pittsburgh, PA 15217, USA
Cleve Clin J Med 71:S40-1. 2004 - Does the Merci Retriever work? AgainstLawrence R Wechsler
University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA 15213, USA
Stroke 37:1341-2; discussion 1342-3. 2006 - Cell therapy: replacementLawrence R Wechsler
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Stroke 34:2081-2. 2003 - Factors influencing outcome and treatment effect in PROACT IILawrence R Wechsler
University of Pittsburgh, Pittsburgh, PA, USA
Stroke 34:1224-9. 2003..The purpose of the current study was to examine baseline factors to determine predictors of good outcome and response to treatment... - Reduced pretreatment ipsilateral middle cerebral artery cerebral blood flow is predictive of symptomatic hemorrhage post-intra-arterial thrombolysis in patients with middle cerebral artery occlusionRishi Gupta
Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
Stroke 37:2526-30. 2006..The threshold identified in this study may be useful for selection of patients with acute MCA occlusions for acute stroke thrombolysis... - Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalizationRishi Gupta
Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pennsylvania, USA
Stroke 37:986-90. 2006.... - Endovascular treatment of tandem extracranial/intracranial anterior circulation occlusions: preliminary single-center experienceAmer M Malik
UPMC Stroke Institute, 200 Lothrop Street, Suite C400, Pittsburgh, PA 15213, USA
Stroke 42:1653-7. 2011..We aimed to evaluate our single-center experience with endovascular treatment of this unique stroke population... - Protocol adherence and safety of intravenous thrombolysis after telephone consultation with a stroke centerKen Uchino
University of Pittsburgh Medical Center Stroke Institute, Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Stroke Cerebrovasc Dis 19:417-23. 2010..Our findings indicate the need for improved protocol adherence for stroke thrombolysis in patients presenting to small community hospitals... - Cell therapy for strokeSean I Savitz
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
NeuroRx 1:406-14. 2004..We emphasize the current, limited knowledge about the biology of implant sources and discuss special conditions in stroke that will impact the potential success of neurotransplantation in clinical trials... - Extensive brainstem ischemia on neuroimaging does not preclude meaningful recovery from locked-in syndrome: two cases of endovascularly managed basilar thrombosisNestor D Tomycz
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Neuroimaging 18:15-7. 2008..Following aggressive supportive care and rehabilitation, outcomes obtained prospectively revealed that both patients made a remarkable recovery, becoming fully independent with Barthel scores of 20 and modified Rankin scores of 2... - A 5-item scale to predict stroke outcome after cortical middle cerebral artery territory infarction: validation from results of the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) StudyNirav A Vora
Department of Neurology, St Louis University, St Louis, MO, USA
Stroke 42:645-9. 2011..The purpose of this study was to combine these parameters into a validated scale for outcome prognostication in patients with a middle cerebral artery territory infarction... - Mechanical approaches combined with intra-arterial pharmacological therapy are associated with higher recanalization rates than either intervention alone in revascularization of acute carotid terminus occlusionRidwan Lin
Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, Pittsburgh, PA 15213, USA
Stroke 40:2092-7. 2009..Historically, pharmacological thrombolysis alone has low recanalization rates. We sought to determine whether adjunctive mechanical approaches achieve better vessel recanalization and functional outcome... - Telestroke-guided intravenous tissue-type plasminogen activator treatment achieves a similar clinical outcome as thrombolysis at a comprehensive stroke centerSyed F Zaidi
University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA, USA
Stroke 42:3291-3. 2011..Telestroke networks offer an opportunity to increase tissue-type plasminogen activator use in community hospitals... - Comparison of safety and clinical and radiographic outcomes in endovascular acute stroke therapy for proximal middle cerebral artery occlusion with intubation and general anesthesia versus the nonintubated stateMouhammad A Jumaa
Center for Neuroendovascular Therapy, UPMC Stroke Institute, Suite C424, 200 Lothrop St, Pittsburgh, PA 15213, USA
Stroke 41:1180-4. 2010..We sought to compare clinical and radiographic outcomes between these 2 sedation modalities... - Emergent stenting of extracranial internal carotid artery occlusion in acute stroke has a high revascularization rateTudor G Jovin
Department of Neurology, University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA 15213, USA
Stroke 36:2426-30. 2005..Future prospective studies are necessary to determine which patients are most likely to benefit from this form of therapy... - The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusionTudor G Jovin
Department of Neurology, University of Pittsburgh Medical Center, Presbyterian University Hospital, 200 Lothrop, Pittsburgh, PA 15213, USA
Stroke 34:2426-33. 2003..This approach requires early determination of both irreversible (core) and reversible (penumbra) ischemia in acute stroke... - Intracranial hemorrhage associated with revascularization therapiesPooja Khatri
University of Cincinnati, Department of Neurology, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
Stroke 38:431-40. 2007..This review discusses the state of our current knowledge on hemorrhagic transformation (HT) and summarizes key factors to be considered when comparing risk associated with various approaches to revascularization... - Imaging evaluation of acute ischemic strokeLawrence R Wechsler
Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
Stroke 42:S12-5. 2011..Imaging is an important aspect of decisions regarding treatment for acute stroke. New imaging techniques using MRI and CT enable estimation of tissue viability. This information may be useful to select patients for acute stroke therapies... - Cell transplantation for strokeSean I Savitz
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Ann Neurol 52:266-75. 2002..The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion... - Management of patent foramen ovale and strokeMouhammad A Jumaa
Department of Neurology, UPMC Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, C400, Pittsburgh, PA, 15213, USA
Curr Treat Options Neurol 12:483-91. 2010..Until these data is available, antiplatelet therapy remains the first-line treatment and endovascular closure should be considered in selected cases... - Neuroimaging in ischemia and infarctionMaxim D Hammer
The Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Semin Neurol 28:446-52. 2008..Techniques for measuring cerebral blood flow, to quantify tissue at risk, are detailed and compared. The quantification of cerebral blood flow is discussed in detail. Methods of visualizing the cerebral circulation are illustrated... - Computed tomographic findings in patients undergoing intra-arterial thrombolysis for acute ischemic stroke due to middle cerebral artery occlusion: results from the PROACT II trialHeidi C Roberts
Department of Radiology, University of California, San Francisco, USA
Stroke 33:1557-65. 2002..The purpose of this study was to evaluate the role of noncontrast CT in the selection of patients to receive thrombolytic therapy for acute ischemic stroke and to predict radiological and clinical outcomes... - Cryptogenic stroke in relation to genetic variation in clotting factors and other genetic polymorphisms among young men and womenHarland Austin
Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA
Stroke 33:2762-8. 2002.... - Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTSMichael D Hill
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, Alberta, Canada
Stroke 34:1925-31. 2003.... - Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 studyMichael D Hill
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Stroke 37:2322-5. 2006..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set... - The MRA-DWI mismatch identifies patients with stroke who are likely to benefit from reperfusionMaarten G Lansberg
Stanford Stroke Center, 701 Welch Road, Suite B325, Palo Alto, CA 94304 9705, USA
Stroke 39:2491-6. 2008.... - Optimal definition for PWI/DWI mismatch in acute ischemic stroke patientsWataru Kakuda
Department of Rehabilitation Medicine, Jikei University School of Medicine, Minato ku, Tokyo, Japan
J Cereb Blood Flow Metab 28:887-91. 2008..Defining mismatch with a larger PWI/DWI ratio may provide greater power for detecting beneficial effects of reperfusion... - Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtableMarc Fisher
UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
Stroke 36:1808-13. 2005..A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval... - Absence of a diastolic velocity notch does not indicate hyperemia in traumatic brain injured patients without elevated cerebral blood flow velocityBarbara B Weber
University of Pittsburgh School of Nursing, Pennsylvania, USA
J Neurosurg Anesthesiol 14:279-86. 2002..7% and 57.9% respectively. The results showed that relative hyperemia was present without an elevation in blood flow velocities, and that the lack of a diastolic notch did not detect the presence of hyperemia in the TBI patient... - Training, competency, and credentialing standards for diagnostic cervicocerebral angiography, carotid stenting, and cerebrovascular intervention: a joint statement from the American Academy of Neurology, the American Association of Neurological Surgeons, John J Connors
Baptist Cardiac and Vascular Institute, Baptist Hospital Miami, 8900 N. Kendall Avenue, Miami, FL 33133, USA
Neurology 64:190-8. 2005 - Patients with acute stroke treated with intravenous tPA 3-6 hours after stroke onset: correlations between MR angiography findings and perfusion- and diffusion-weighted imaging in the DEFUSE studyMichael P Marks
Department of Radiology, Neurosurgery, Stanford University Medical Center, Stanford, CA 94305 5105, USA
Radiology 249:614-23. 2008..To study magnetic resonance (MR) angiography findings in patients with acute stroke treated with intravenous tissue plasminogen activator (tPA) in relationship to perfusion- and diffusion-weighted imaging changes and clinical outcome...