Richard E Waugh

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Membrane instability in late-stage erythropoiesis
    R E Waugh
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Blood 97:1869-75. 2001
  2. ncbi Active site formation, not bond kinetics, limits adhesion rate between human neutrophils and immobilized vascular cell adhesion molecule 1
    Richard E Waugh
    Department of Biomedical Engineering, University of Rochester, Medical Center, Rochester, New York, USA
    Biophys J 96:268-75. 2009
  3. ncbi Outside-in signal transmission by conformational changes in integrin Mac-1
    Craig T Lefort
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 183:6460-8. 2009
  4. ncbi Adhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects
    Elena B Lomakina
    Department of Pharmacology and Physiology, University of Rochester, Medical Center, Rochester, New York, USA
    Biophys J 96:276-84. 2009
  5. ncbi Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils
    Nubia K Kaba
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA
    Am J Physiol Cell Physiol 295:C1454-63. 2008
  6. ncbi Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM
    Sandrine A Hocdé
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA
    Biophys J 97:379-87. 2009
  7. ncbi Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils
    Thomas R Gaborski
    Department of Biomedical Engineering and Department of Mechanical Engineering, University of Rochester, Rochester, New York 14642, USA
    Biophys J 95:4934-47. 2008
  8. ncbi Activation of human neutrophil Mac-1 by anion substitution
    Elena Lomakina
    Department of Pharmacology and Physiology, School of Medicine, University of Rochester, Rochester, NY 14642, USA
    Blood Cells Mol Dis 42:177-84. 2009
  9. ncbi Dynamics of increased neutrophil adhesion to ICAM-1 after contacting immobilized IL-8
    Elena B Lomakina
    Department of Pharmacology and Physiology, University of Rochester, Medical Center, Rochester, 601 Elmwood Avenue, Box 711, NY 14642, USA
    Ann Biomed Eng 34:1553-63. 2006
  10. ncbi LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ
    Ronen Sumagin
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 185:7057-66. 2010

Collaborators

  • Elena B Lomakina
  • Philip A Knauf
  • James L McGrath
  • Jorge Arreola
  • Sandrine A Hocdé
  • Young Min Hyun
  • Minsoo Kim
  • Craig T Lefort
  • Ronen Sumagin
  • Ollivier Hyrien
  • Foon Yee Law
  • Thomas R Gaborski
  • Nubia K Kaba
  • Ingrid H Sarelius
  • Hen Prizant
  • Joanne B Schultz
  • Hung Li Chung
  • Joanne Schultz
  • Guadalupe Martel-Gallegos
  • Alfred Clark

Detail Information

Publications13

  1. ncbi Membrane instability in late-stage erythropoiesis
    R E Waugh
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Blood 97:1869-75. 2001
    ....
  2. ncbi Active site formation, not bond kinetics, limits adhesion rate between human neutrophils and immobilized vascular cell adhesion molecule 1
    Richard E Waugh
    Department of Biomedical Engineering, University of Rochester, Medical Center, Rochester, New York, USA
    Biophys J 96:268-75. 2009
    ....
  3. ncbi Outside-in signal transmission by conformational changes in integrin Mac-1
    Craig T Lefort
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 183:6460-8. 2009
    ..These data suggest the primacy of global conformational changes in the generation of Mac-1 outside-in signals...
  4. ncbi Adhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects
    Elena B Lomakina
    Department of Pharmacology and Physiology, University of Rochester, Medical Center, Rochester, New York, USA
    Biophys J 96:276-84. 2009
    ..The results indicate that the first step is rate limiting for VLA-4-VCAM-1 interactions. Changing divalent cation composition affects these coefficients, implicating molecular conformational changes as a key step in the process...
  5. ncbi Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils
    Nubia K Kaba
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA
    Am J Physiol Cell Physiol 295:C1454-63. 2008
    ..Taken together, these data suggest that the ability of NHE inhibitors such as HMA to reduce ischemia-reperfusion injury may be related to the nearly complete removal of L-selectin from the neutrophil surface...
  6. ncbi Cell adhesion molecule distribution relative to neutrophil surface topography assessed by TIRFM
    Sandrine A Hocdé
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA
    Biophys J 97:379-87. 2009
    ..The results confirm differences among adhesion molecules in their surface distribution and reveal how the availability of specific adhesion molecules is altered by mechanical compression of the surface in live cells...
  7. ncbi Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils
    Thomas R Gaborski
    Department of Biomedical Engineering and Department of Mechanical Engineering, University of Rochester, Rochester, New York 14642, USA
    Biophys J 95:4934-47. 2008
    ....
  8. ncbi Activation of human neutrophil Mac-1 by anion substitution
    Elena Lomakina
    Department of Pharmacology and Physiology, School of Medicine, University of Rochester, Rochester, NY 14642, USA
    Blood Cells Mol Dis 42:177-84. 2009
    ..This effect is substantial. The percentage of Mac-1 in the high affinity state approaches 100% in glutamate and 50% in glucuronate, a far greater response than what is observed after stimulation with fMLP...
  9. ncbi Dynamics of increased neutrophil adhesion to ICAM-1 after contacting immobilized IL-8
    Elena B Lomakina
    Department of Pharmacology and Physiology, University of Rochester, Medical Center, Rochester, 601 Elmwood Avenue, Box 711, NY 14642, USA
    Ann Biomed Eng 34:1553-63. 2006
    ..Heterogeneity in the cellular response and variability between donors was also noted...
  10. ncbi LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ
    Ronen Sumagin
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 185:7057-66. 2010
    ..Thus, mechanisms underlying leukocyte crawling are important in regulating the inflammatory responses by regulating the numbers of leukocytes that transmigrate...
  11. ncbi Molecular accessibility in relation to cell surface topography and compression against a flat substrate
    Sandrine A Hocdé
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA
    Biophys J 97:369-78. 2009
    ..Model predictions show good agreement with measurements of fluorescence intensity of different molecules labeled fluorescently on the surface of a human neutrophil compressed against a glass surface...
  12. ncbi Micromechanical tests of adhesion dynamics between neutrophils and immobilized ICAM-1
    Elena B Lomakina
    Department of Pharmacology and Physiology, University of Rochester, Medical Center, Rochester, New York, USA
    Biophys J 86:1223-33. 2004
    ..7 s(-1) and the product K(a)rho(c) approximately 2.4 x 10(-4), where rho(c) is the density of integrin on the cell surface...
  13. ncbi Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1
    Young Min Hyun
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, NY 14642, USA
    J Immunol 183:359-69. 2009
    ..These data suggest that a subpopulation of activated VLA-4 is mainly localized to the leading edge of polarized human T cells and is critical for T cell migration on VCAM-1...