Research Topics
Genomes and Genes
| Lixin WangSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Synergistic interaction between CCK and leptin to regulate food intakeL Wang
CURE, Digestive Diseases Research Center, University of California at Los Angeles, USA
Regul Pept 92:79-85. 2000..These observations provide a mean through which leptin and CCK integrate short- and mid-term meal-related input signals into long-term control of energy balance...- Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious miceLixin Wang
CURE Digestive Diseases Research Center, and Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Am J Physiol Gastrointest Liver Physiol 298:G45-56. 2010..These data established that PYY/PYY(3-36) potently inhibits basal and stress/serotonin/cholinergic-stimulated propulsive colonic motor function in conscious mice, likely via Y(2) receptors... - Peripheral activation of corticotropin-releasing factor receptor 2 inhibits food intake and alters meal structures in miceLixin Wang
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine Digestive Diseases Division, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Peptides 32:51-9. 2011..These data indicate that Ucns, through peripheral CRF(2) receptor-mediated induction of satiation, inhibit the eating response to a fast more potently than the physiological nocturnal feeding in mice... - Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgeryLixin Wang
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VAGLAHS, Los Angeles, CA 90073, USA
Brain Res 1415:34-46. 2011..Abdominal surgery activates CRF-ir neurons selectively in the PVN of rats without colchicine treatment... - Abnormal colonic motility in mice overexpressing human wild-type alpha-synucleinLixin Wang
CURE Digestive Diseases Center and Center for Neurobiology of Stress, David Geffen School of Medicine, University of California at Los Angeles and VAGLAHS, Los Angeles, California, USA
Neuroreport 19:873-6. 2008..These results indicate that Thy1-alphaSyn mice display altered basal and stress-stimulated propulsive colonic motility and will be a useful model to study gut dysfunction associated with Parkinson's disease... - Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brainLixin Wang
CURE Digestive Diseases Research Center and Center for Neurobiological Stress, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
Brain Res 1247:79-91. 2009..Activation of medullary catecholaminergic centers might reflect the afferent and efferent limbs of the functional responses associated to visceral pain... - 5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4 receptors in conscious miceL Wang
Digestive Diseases Research Center and Center for Neurovisceral Sciences and Woman s Health, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
Am J Physiol Gastrointest Liver Physiol 292:G419-28. 2007..These findings suggest an important role of activation of colonic myenteric neurons in the 5-HT4 receptor-mediated colonic propulsive motor response... - Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathwaysMuriel Larauche
CURE Digestive Diseases Research Center, Diseases Research Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 297:G215-27. 2009..Stresslike colonic alterations induced by ip cortagine in rats and mice through restricted activation of peripheral CRF(1) receptors support a role for peripheral CRF(1) signaling as the local arm of the colonic response to stress... - Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in ratsAndreas Stengel
Department of Medicine, Center for Ulcer Research and Education, Digestive Diseases Division, University of California Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Endocrinology 151:4224-35. 2010.... - Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fastingAndreas Stengel
Center for Ulcer Research and Education, Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90073, USA
Endocrinology 150:153-60. 2009..These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response... - Chronic injection of pansomatostatin agonist ODT8-SST differentially modulates food intake and decreases body weight gain in lean and diet-induced obese ratsAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Regul Pept 167:201-8. 2011..In DIO rats, ODT8-SST reduces lean mass but promotes food intake and fat mass, indicating differential responsiveness to somatostatin under obese conditions... - Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitisPallavi Garg
Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
Am J Physiol Gastrointest Liver Physiol 296:G175-84. 2009..Thus inhibition of MMP-9 may be beneficial in treatment of colitis even if resulting in inhibition of MMP-2... - A2B adenosine receptor gene deletion attenuates murine colitisVasantha L Kolachala
Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Gastroenterology 135:861-70. 2008..We have previously shown that A(2B)AR mRNA and protein levels are up-regulated during colitis. In this study, we addressed the role of the A(2B)AR in the development of murine colitis and the potential mechanism underlying its effects... - Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptorAndreas Stengel
Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 150:4911-9. 2009..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect... - Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOATAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
Peptides 31:1689-96. 2010..These data indicate that LPS induces a long-lasting reduction of AG and DG levels that may have a bearing with the decrease in food intake. The faster drop in AG than DG within 2 h is associated with reduced circulating GOAT... - Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosaAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, California, USA
Endocrinology 150:232-8. 2009..NUCB2 gene expression is significantly regulated by nutritional status, suggesting a regulatory role of peripheral nesfatin-1 in energy homeostasis... - Restraint stress activates nesfatin-1-immunoreactive brain nuclei in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
Brain Res 1300:114-24. 2009..These data demonstrate that nesfatin-1 neurons are part of the hypothalamic and hindbrain neuronal cell groups activated by restraint suggesting a possible role of nesfatin-1 in the response to stress... - Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2Andreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Digestive Diseases Division at University of California Los Angeles, USA
Am J Physiol Gastrointest Liver Physiol 301:G239-48. 2011.... - Adenosine 2B receptor expression is post-transcriptionally regulated by microRNAVasantha L Kolachala
Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 285:18184-90. 2010..Collectively, these data demonstrate that TNF-alpha-induced A(2B)AR expression in colonic epithelial cells is post-transcriptionally regulated by miR27b and miR128a and show that miR27b influences A(2B)AR expression in murine colitis... - Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammationVasantha L Kolachala
Division of Digestive Diseases, Department of Medicine, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
J Biol Chem 282:32965-73. 2007.... - Activation of brain somatostatin 2 receptors stimulates feeding in mice: analysis of food intake microstructureAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
Physiol Behav 101:614-22. 2010..The shortened inter-meal interval suggests an inhibitory effect of the sst(2) agonist on "satiety", whereas "satiation" is not altered as indicated by normal meal size... - Adenosine 2b receptor (A2bR) signals through adenylate cyclase (AC) 6 isoform in the intestinal epithelial cellsVasantha L Kolachala
Division of Digestive Diseases, Department of Medicine, Emory University, Room 201 F, 615 Michael Street, Whitehead Research Building, Atlanta, GA 30322, USA
Biochim Biophys Acta 1760:1102-8. 2006.... - Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implicationsAndreas Stengel
CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States
Peptides 32:2208-17. 2011..A better understanding of these mechanisms will allow targeting components of ghrelin signaling that may improve food intake and gastric motility alterations induced by stress... - Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodentsGuillaume Gourcerol
Center for Ulcer Research and Education CURE Digestive Diseases Research Center, and Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, USA
Obesity (Silver Spring) 15:2643-52. 2007..We aimed to investigate the effects of peripheral and intracisternal (IC) injection of obestatin on feeding, gastric motility, and blood glucose in rats as well as in diet-induced obese (DIO) mice... - LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implicationsLixin Wang
CURE Bldg. 115, Rm. 117B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 291:G611-20. 2006..These data showed that IL-1 and PG pathways are part of the early mechanisms by which LPS suppresses fasted plasma ghrelin and that exogenous ghrelin can normalize LPS-induced-altered digestive functions... - Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 31:263-70. 2010.... - Mice overexpressing corticotropin-releasing factor show brain atrophy and motor dysfunctionsMiriam Goebel
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, UCLA and VA GLA Healthcare System, Los Angeles, CA, USA
Neurosci Lett 473:11-5. 2010.... - Identification and characterization of multiple corticotropin-releasing factor type 2 receptor isoforms in the rat esophagusS Vincent Wu
Center for Ulcer Research and Education, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90073, USA, and Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
Endocrinology 148:1675-87. 2007.... - Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA
Peptides 31:2229-35. 2010..The restoration of circulating AG levels inhibited by abdominal surgery may contribute to alleviate postoperative gastric ileus... - Urocortins and the regulation of gastrointestinal motor function and visceral painVicente Martinez
Department of Medicine, CURE/Digestive Diseases Research Center, Center for Neurovisceral Sciences and Women's Health, University of California, Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 25:1733-44. 2004..These observations suggest that, acting centrally and peripherally, Ucns might play a significant role in the modulation of gastrointestinal motor and pain responses during stress and stress-related pathophysiological conditions... - Localization of nesfatin-1 neurons in the mouse brain and functional implicationMiriam Goebel-Stengel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Brain Res 1396:20-34. 2011.... - Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclaseVasantha Kolachala
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 280:4048-57. 2005..We propose that IFN-gamma may acutely affect global cAMP-mediated responses in the intestinal epithelia, thereby decreasing secretory responses, which may consequently aggravate inflammatory processes... - Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nucleiMiriam Goebel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
Neurosci Lett 452:241-6. 2009..The features and distributions of nesfatin-1 IR and mRNA expression in the brain and spinal cord suggest that NUCB2/nesfatin-1 could play a wider role in autonomic regulation of visceral-endocrine functions besides food intake... - Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Brain Res 1351:150-64. 2010.... - Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosaAndreas Stengel
Center for Neurobiology of Stress, CURE Digestive Diseases Research Center, USA
Biochem Biophys Res Commun 392:67-71. 2010..Detection of GOAT in the plasma raises the possibility that ghrelin octanoylation may occur in the circulation and the fasting-induced increase in GOAT may contribute to the increase of acylated ghrelin after fasting... - Lipopolysaccharide increases plasma levels of corticotropin-releasing hormone in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, UCLA, and VA Greater Los Angeles Healthcare System, CA, USA
Neuroendocrinology 93:165-73. 2011..Whether these changes are reflected by increased circulating levels of CRH and adrenocorticotropic hormone (ACTH) is unknown... - Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleusLixin Wang
CURE: Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Department of Medicine, University of California at Los Angeles, Building 115, Room 203, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Neurosci Lett 325:47-51. 2002..About 90% of the Fos-positive neurons in the Arc expressed neuropeptide Y (NPY) messenger RNA. These data indicate that NPY neurons in the Arc are likely the primary target mediating i.p. ghrelin induced orexigenic effect... - Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterationsLixin Wang
Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 282:8219-27. 2007..Thus, our data uncover a novel function of these abundant cytoskeletal proteins, which may have implications in intestinal disorders such as inflammatory bowel disease wherein barrier dysfunction underlies the inflammatory response... - Modulation of gastric motility by brain-gut peptides using a novel non-invasive miniaturized pressure transducer method in anesthetized rodentsGuillaume Gourcerol
CURE Digestive Diseases Research Center, and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, University of California, Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 32:737-46. 2011..Using this method we established in mice that the gastric motility response to central vagal activation is impaired under chronic expression of CRF... - Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervalsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
Peptides 32:36-43. 2011..The lack of nesfatin-1 effect when injected peripherally at a 23-times higher dose indicates a primarily central site of the anorexigenic action for nesfatin-1 in mice... - Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weightAndreas Stengel
CURE Digestive Diseases Research Center and Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 31:357-69. 2010.... - Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteinsLixin Wang
Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Am J Physiol Gastrointest Liver Physiol 287:G1100-7. 2004.... - CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing miceLixin Wang
Division of Digestive Diseases, Department of Medicine, CURE and Center for Neurobiological Stress, David Geffen School of Medicine at University of California Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
PLoS ONE 6:e16377. 2011..These data support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress... - Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious ratsPu Qing Yuan
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073, USA
Peptides 26:653-64. 2005..These results indicate that increased central vagal outflow activates cholinergic neurons in the stomach while in the duodenum, VIP neurons are preferentially stimulated... - Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMPFlorencia E Castaneda
Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
Gastroenterology 129:1991-2008. 2005.... - Centrally injected kisspeptin reduces food intake by increasing meal intervals in miceAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, VA Greater Los Angeles Health Care System, California, USA
Neuroreport 22:253-7. 2011..The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety... - Role of corticotropin-releasing factor pathways in stress-related alterations of colonic motor function and viscerosensibility in female rodentsYVETTE TACHE
Center for Neurovisceral Sciences and Women s Health, and CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Gend Med 2:146-54. 2005..The activation of brain corticotropin-releasing factor (CRF) pathways has a key role in the behavioral and visceral responses to stress... - Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cellsYutong Zhao
Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 282:10172-9. 2007..Our data suggest a novel mechanism of regulation of IL-13Ralpha2 and IL-13 signaling that may be of physiological relevance to airway inflammation and remodeling... - Bacterial lipopolysaccharide shifts fasted plasma ghrelin to postprandial levels in ratsNicole R Basa
CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine and Brain Research Institute, University of California at Los Angeles, Building 115, Room 203, 11301 Wilshire Boulevard, 90073, USA
Neurosci Lett 343:25-8. 2003..Re-feeding decreased plasma ghrelin levels by 58+/-3% compared with pre-feeding fasting values in i.p. vehicle group. These data provide the first evidence that LPS shifts fasting ghrelin levels to those observed postprandially... - Polarized fibronectin secretion induced by adenosine regulates bacterial-epithelial interaction in human intestinal epithelial cellsBaljit Walia
Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
Biochem J 382:589-96. 2004..FN may be a critical host factor that modulates adherence and invasion of bacteria, thus playing a key role in mucosal immune responses during inflammation... - The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulationShanthi V Sitaraman
Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 277:33188-95. 2002..We speculate that such an interaction may not only anchor the A2bR to the plasma membrane but may also function to stabilize the receptor in a signaling complex in the plasma membrane... - TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells: critical role of SMAD-2Baljit Walia
Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
FASEB J 17:2130-2. 2003..Collectively, our data demonstrate a cross-talk between TGF-beta and IL-6, and TGF-beta may play a role in the negative regulation of IL-6 signaling in intestinal epithelial cells... - IL-6 induces NF-kappa B activation in the intestinal epitheliaLixin Wang
Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
J Immunol 171:3194-201. 2003..These data may have mechanistic and therapeutic implications in diseases such as IBD and rheumatoid arthritis in which IL-6 plays an important role in the pathogenesis... - CRF receptor type 1 and 2 expression and anatomical distribution in the rat colonEkaterini Chatzaki
Neurocrine Biosciences Inc, San Diego, CA 92121, USA
J Neurochem 90:309-16. 2004..These results demonstrate expression of both CRF receptor types in the rat colon and support a role for their involvement in regulating peripheral effects of CRF ligands... - Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodiesEkaterini Chatzaki
Neurocrine Biosciences Inc, San Diego, California 92121, USA
J Neurochem 88:1-11. 2004..These results indicate that both CRF receptor subtypes are expressed in the rat upper GI tissues with a distinct pattern and regional differences suggesting differential function... - Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathwaysChun Mei Zhao
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO 7006, Trondheim, Norway
Endocrinology 149:498-505. 2008..We suggest that there is a remodeling of the neuroendocrine mechanisms that regulate acid secretion in these mutant mice... - [Autologous skeletal myoblast cardiomyoplasty, an experimental study]Lixin Wang
Department of Cardiovascular Surgery, General Hospital of People's Liberation Army, Beijing 100853, China
Zhonghua Yi Xue Za Zhi 82:100-3. 2002..CONCLUSION: Cellular cardiomyoplasty with satellite cell implantation is still immature for clinical use now. Further research must be done in the future... - Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileusAndrew Luckey
Department of Veternas Affairs, Greater Los Angeles Healthcare System, La Jolla, California 90073, USA
Gastroenterology 125:654-9. 2003..CONCLUSIONS: These data show that CRF(1) activation plays an important role in mediating the early phase of gastric ileus... - Bombesin, but not amylin, blocks the orexigenic effect of peripheral ghrelinPeter Kobelt
Department of Medicine, , Germany
Am J Physiol Regul Integr Comp Physiol 291:R903-13. 2006..4 +/- 0.8% of CRF-immunoreactive neurons in the PVN. These results suggest that peripheral bombesin, unlike amylin, inhibits peripheral ghrelin induced food intake and enhances activation of CRF neurons in the PVN... - MMP and TIMP expression in quiescent, dividing, and differentiating human lens cellsLisa M Hodgkinson
School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
Invest Ophthalmol Vis Sci 48:4192-9. 2007..Hence, a gene expression analysis was undertaken in epithelial and fiber cells dissected from clear human donor lenses... - Thresholds of physical activities necessary for living a self-supporting life in elderly womenHayato Nakao
Department of Sports Medicine, Osaka City University, Graduate School of Medicine, Japan
Osaka City Med J 53:53-61. 2007..To decide the minimal levels (thresholds) of physical activities necessary for a self-supporting life using discriminate analysis between community-dwelling elderly individuals and daycare-service-receiving elderly individuals in Japan... - Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transferEric Dobrzynski
The Children's Hospital of Philadelphia, Abramson Research Center 302, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
Blood 104:969-77. 2004..These data provide direct evidence that transgene expression following in vivo viral gene transfer can induce CD4+ T-cell tolerance to the transgene product, involving anergy and deletion mechanisms... - CCK inhibits the orexigenic effect of peripheral ghrelinPeter Kobelt
Department of Medicine, Division of Hepatology and Gastroenterology, Charite, Medical Faculty of Freie Universität and Humboldt Universität at Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 288:R751-8. 2005..These results suggest that CCK abolishes ghrelin-induced food intake through dampening increased ARC neuronal activity... - Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transferOu Cao
Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, USA
Blood 110:1132-40. 2007..Our study reveals a crucial role of CD4(+)CD25(+) T(regs) in preventing immune responses to the transgene product in gene transfer... - Muscle as a target for supplementary factor IX gene transferBrad E Hoffman
Department of Pediatrics and Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
Hum Gene Ther 18:603-13. 2007..IX gene transfer to skeletal muscle does not break tolerance achieved by liver-derived expression. The approach is efficacious, if the vector for muscle gene transfer does not express immunogenic viral proteins... - Ghrelin: a novel player in the gut-brain regulation of growth hormone and energy balanceDavid H St-Pierre
Faculty of Medicine, Department of Nutrition, , , , Canada
News Physiol Sci 18:242-6. 2003..The isolation of ghrelin has led to new insights into how this gastric hormone links the endocrine control of nutritional homeostasis with growth hormone secretion and gastrointestinal motility through gut-brain interactions... - Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivoLixin Wang
Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Mol Cell Biol 27:6497-505. 2007..Taken together, our results provide strong evidence that Grb10 is a negative regulator of insulin signaling and action in vivo... - AAV-mediated gene transfer for treatment of hemophiliaLixin Wang
Dept. Pediatrics, University of Pennsylvania Medical Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Curr Gene Ther 5:349-60. 2005..Taken together, these studies provide much encouragement for the possibility of future clinical success, but also point out hurdles that still have to be overcome... - Molecular cloning and expression of grass carp MyoD in yeast Pichia pastorisLixin Wang
Pearl River Fisheries Research Institute, CAFS Key Lab of Tropical and Subtropical Fish Breeding and Cultivation of CAFS, Guangzhou 510380, P R China
J Biochem Mol Biol 40:22-8. 2007..5% methanol in pH 8.0 BMGY medium, and the maximum yield was about 250 mg/L in shaking-flask fermentation. The results were expected to benefit for further studies on the crystal structure and physiological function of fish MyoD...