Research Topics
Genomes and Genes
Species | Kai WangSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Pathway-based approaches for analysis of genomewide association studiesKai Wang
Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Hum Genet 81:1278-83. 2007....- Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMIJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 59:751-5. 2010..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood... - The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMIJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 17:2254-7. 2009..We conclude that among 13 loci that have been reported to associate with adult BMI, at least nine also contribute to the determination of BMI in childhood as demonstrated by their associations in our pediatric cohort... - BMD-associated variation at the Osterix locus is correlated with childhood obesity in femalesJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:1311-4. 2011..In conclusion, these findings indicate that a well established variant at the Osterix locus associated with increased BMD is also associated with childhood obesity primarily in females... - The role of height-associated loci identified in genome wide association studies in the determination of pediatric statureJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
BMC Med Genet 11:96. 2010..Despite environmental influences, genetic factors are known to play an important role in stature determination. A number of genetic determinants of adult height have already been established through genome wide association studies... - A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24Struan F A Grant
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
J Pediatr 155:909-13. 2009..To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P)... - Modeling genetic inheritance of copy number variationsKai Wang
Department of Genetics, Division of Human Genetics, Center for Applied Genomics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
Nucleic Acids Res 36:e138. 2008..In conclusion, our method produces accurate CNV calls, gives probabilistic estimates of CNV transmission and builds a solid foundation for the development of linkage and association tests utilizing CNVs... - Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effectsKai Wang
Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Hum Mol Genet 19:2059-67. 2010.... - Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platformsSharon J Diskin
Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Nucleic Acids Res 36:e126. 2008..With the wide application of whole-genome SNP genotyping techniques, our wave adjustment method will be important for taking full advantage of genotyped samples for CNV analysis... - Autism genome-wide copy number variation reveals ubiquitin and neuronal genesJoseph T Glessner
Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nature 459:569-73. 2009.... - A genome-wide study reveals copy number variants exclusive to childhood obesity casesJoseph T Glessner
Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, 19104, USA
Am J Hum Genet 87:661-6. 2010..Although these variants may be individually rare, our results indicate that CNVs contribute to the genetic susceptibility of common childhood obesity in subjects of both European and African ancestry... - Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight geneJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 58:2414-8. 2009..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait... - Gene-based interaction analysis by incorporating external linkage disequilibrium informationJing He
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Eur J Hum Genet 19:164-72. 2011..As our method operates at the gene level, it can be applied to a genome-wide association setting and used as a screening tool to detect gene-gene interactions... - Integrative genomics identifies LMO1 as a neuroblastoma oncogeneKai Wang
The Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nature 469:216-20. 2011.... - Genomic landscape of a three-generation pedigree segregating affective disorderShuzhang Yang
Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 4:e4474. 2009..Our analysis suggests that family based studies of the combined effect of common and rare CNVs at many loci may represent a useful approach in the genetic analysis of disease susceptibility of mental disorders... - Large copy-number variations are enriched in cases with moderate to extreme obesityKai Wang
Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 59:2690-4. 2010..We investigated whether large and rare copy-number variations (CNVs) differentiate moderate to extreme obesity from never-overweight control subjects... - Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility LociLe B Nguyen
Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
PLoS Genet 7:e1002026. 2011..2 (P = 4.20 × 10??) as being associated with the less aggressive form of the disease. These data demonstrate the importance of robust phenotypic data in GWAS analyses and identify additional susceptibility variants for neuroblastoma... - Variants of DENND1B associated with asthma in childrenPatrick M A Sleiman
Center for Applied Genomics, Philadelphia, PA 19104 4318, USA
N Engl J Med 362:36-44. 2010..Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown... - Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorderJosephine Elia
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Nat Genet 44:78-84. 2012..38 × 10(-10)) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts... - ANNOVAR: functional annotation of genetic variants from high-throughput sequencing dataKai Wang
Center for Applied Genomics, Children s Hospital of Philadelphia, PA 19104, USA
Nucleic Acids Res 38:e164. 2010..7?million variants, making it practical to handle hundreds of human genomes in a day. ANNOVAR is freely available at http://www.openbioinformatics.org/annovar/... - Population-based study of genetic variation in individuals with autism spectrum disorders from CroatiaLi San Wang
Department of Pathology, Laboratory Medicine, Biomedical Graduate Studies, University of Pennsylvania, Philadelphia 19104, USA
BMC Med Genet 11:134. 2010..Genome-wide studies on autism spectrum disorders (ASDs) have mostly focused on large-scale population samples, but examination of rare variations in isolated populations may provide additional insights into the disease pathogenesis... - Common variants at five new loci associated with early-onset inflammatory bowel diseaseMarcin Imielinski
Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Nat Genet 41:1335-40. 2009.... - ATOM: a powerful gene-based association test by combining optimally weighted markersMingyao Li
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Bioinformatics 25:497-503. 2009..One particularly challenging yet important question is how to best use all genetic information to test whether a gene or a region is associated with the trait of interest... - Characterizing dynamic changes in the human blood transcriptional networkJun Zhu
Department of Genetics, Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck and Co, Inc, Seattle, Washington, USA
PLoS Comput Biol 6:e1000671. 2010..The results could have broader implications for the design of studies of disease association and drug response in clinical trials... - Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn DiseaseKai Wang
Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Hum Genet 84:399-405. 2009..Our study suggests that examination beyond individual SNP hits, by focusing on genetic networks and pathways, is important to unleashing the true power of GWA studies... - Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseasesKai Wang
Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, USA
PLoS Comput Biol 5:e1000616. 2009..Taken together, our approach represents a novel step forward in integrating gene co-expression networks from multiple large scale datasets to leverage not only common information but also differences that are dataset-specific... - Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestryStruan F A Grant
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 17:1461-5. 2009..As such, variants 3' to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs... - Interpretation of association signals and identification of causal variants from genome-wide association studiesKai Wang
Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Hum Genet 86:730-42. 2010..Our results suggest that thinking beyond common variants is essential in interpreting GWAS signals and identifying causal variants... - Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortexShuzhang Yang
Department of Genetics and Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
Genome Biol 8:R247. 2007..Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances... - Effects of ooplasm manipulation on DNA methylation and growth of progeny in miceYong Cheng
The Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, Philadelphia, Pennsylvania, USA
Biol Reprod 80:464-72. 2009..These results indicate that some ooplasm manipulation procedures may exert subtle effects on growth early in life, while intergenotype GVT can result in significant growth deficiencies after birth... - Copy Number Variation Detection via High-Density SNP GenotypingKai Wang
Department of Genetics, University of Pennsylvania, Philadelphia, PA 19446, USA
CSH Protoc 2008:pdb.top46. 2008..Analyses of CNVs from SNP genotyping arrays will provide a more comprehensive view of genome variation, and complement current genome-wide association studies in identifying disease susceptibility loci... - GENIE: a software package for gene-gene interaction analysis in genetic association studies using multiple GPU or CPU coresSatish Chikkagoudar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
BMC Res Notes 4:158. 2011..abstract:.. - PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping dataKai Wang
Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genome Res 17:1665-74. 2007..3%. Our results demonstrate the feasibility of whole-genome fine-mapping of CNVs via high-density SNP genotyping...