Research Topics
Genomes and GenesSpecies | Gaofeng WangSummaryAffiliation: University of Miami Country: USA Publications
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Detail Information
Publications
Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondriaGaofeng Wang
Miami Institute for Human Genomics, University of Miami, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 50:3084-90. 2009....
Analysis of the indel at the ARMS2 3'UTR in age-related macular degenerationGaofeng Wang
Dr John T Macdonald Foundation Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Hum Genet 127:595-602. 2010..Conclusively, the indel at 3'UTR of ARMS2 actually contains two side-by-side indels. The indels are associated with risk of AMD, but not correlated with ARMS2 mRNA level...
Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphismsDigna R Velez Edwards
Dr John T Macdonald Foundation Department of Human Genetics and John P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA
Invest Ophthalmol Vis Sci 51:1873-9. 2010..These results highlight the genetic and environmental complexity of the etiologic architecture of AMD; however, further replication is necessary to validate them...
Analysis of single nucleotide polymorphisms in the NOS2A gene and interaction with smoking in age-related macular degenerationJuan A Ayala-Haedo
John P Hussman Institute for Human Genomics and the Dr John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Ann Hum Genet 74:195-201. 2010..Our data suggests that SNPs in the NOS2A gene are associated with increased risk for AMD and might modulate the effect of smoking on AMD...
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson diseaseTodd L Edwards
John P Hussman Institute for Human Genomics, University of Miami, FL 33136, USA
Ann Hum Genet 74:97-109. 2010..79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD...
Copy number variations are a rare cause of non-CMT1A Charcot-Marie-Tooth diseaseJia Huang
Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
J Neurol 257:735-41. 2010..Their potential relevance as disease modifiers remains to be evaluated. The present study design cannot rule out that specific CMT forms exist where CNVs play a larger role...
