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Species | Joseph P WaltonSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Sensorineural hearing loss and neural correlates of temporal acuity in the inferior colliculus of the C57BL/6 mouseJoseph P Walton
Otolaryngology Division of Department of Surgery, University of Rochester School of Medicine and Dentistry, Box 629, Rochester, NY 14642, USA
J Assoc Res Otolaryngol 9:90-101. 2008..Thus, the results suggest that moderate high frequency SNHL does not affect temporal processing as measured by the gap detection paradigm...- Age-related alterations in the neural coding of envelope periodicitiesJoseph P Walton
Department of Surgery, Otolaryngology Division, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
J Neurophysiol 88:565-78. 2002..We postulate that this age-related difference in rate coding of SAM noise carriers is consistent with a loss, or imbalance, of excitatory and inhibitory neural mechanisms known to shape encoding of envelope periodicities in the IC... - Timing is everything: temporal processing deficits in the aged auditory brainstemJoseph P Walton
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
Hear Res 264:63-9. 2010..Evidence from numerous investigations indicates an age-related decline in encoding of temporal sound features which may be a contributing factor to the deficits observed in speech recognition in many elderly listeners... - Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levelsPaul D Allen
Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
Hear Res 186:17-29. 2003..These results demonstrate that age-related changes in temporal acuity may interact with stimulus level, and suggest that adequate amplification may be critically important for maintaining temporal acuity with advancing age... - Neural correlates of age-related declines in frequency selectivity in the auditory midbrainU Cheng Leong
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA U Cheng
Neurobiol Aging 32:168-78. 2011..Collectively, these results support the view that aging alters frequency selectivity by widening excitatory FRAs and that these changes begin to appear in middle age... - Behavioral and neural measures of auditory temporal acuity in aging humans and miceKathy Barsz
University of Rochester Medical Center, NY 14642, USA
Neurobiol Aging 23:565-78. 2002..Age-related changes in temporal acuity appear comparable in humans and mice. The data suggest a common deficit in neural mechanisms... - Age reduces response latency of mouse inferior colliculus neurons to AM soundsHenry Simon
International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester, New York 14623, USA
J Acoust Soc Am 116:469-77. 2004..These latency changes will result in age-related timing variations in brainstem responses to stimulus onsets, and therefore affect the encoding of complex sounds... - Age-related structural and functional changes in the cochlear nucleusRobert D Frisina
Otolaryngology Department, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
Hear Res 216:216-23. 2006..To the extent that this sensory deficit resides in the central auditory system, including the cochlear nucleus, future neural therapies will be able to improve hearing in the elderly... - Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusisOlga N Vasilyeva
Otolaryngology Department, University of Rochester Medical School and Dentistry, 601 Elmwood Ave, Rochester, NY 14642 8629, USA
Hear Res 249:44-53. 2009..On the other hand, initial results of effects from very high blood glucose level (T1DM) on the auditory midbrain showed disruption of central inhibition, increased response synchrony or enhanced excitation in the inferior colliculus... - Kv1.1 channel subunits are not necessary for high temporal acuity in behavioral and electrophysiological gap detectionPaul D Allen
Department of Otolaryngology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Hear Res 246:52-8. 2008..These data suggest that the neural pathways encoding behaviorally relevant, rapid auditory temporal fluctuations are not limited by the absence of Kv1.1 expression... - Background noise improves gap detection in tonically inhibited inferior colliculus neuronsWillard W Wilson
Department of Surgery, Division of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurophysiol 87:240-9. 2002..Improved feature detection in background noise resulting from inhibitory adaptation would seem an efficient neural mechanism and one that might be generally useful in other signal detection tasks... - AMTAS(®): automated method for testing auditory sensitivity: II. air conduction audiograms in children and adultsRobert H Margolis
Department of Otolaryngology, University of Minnesota, Minneapolis, USA
Int J Audiol 50:434-9. 2011..This study was designed to evaluate an automated pure-tone audiometric procedure (AMTAS(®)) for 4-8 year-old children, and a quality assessment method (QUALIND(®)) that predicts the accuracy of the test... - The relative detectability for mice of gaps having different ramp durations at their onset and offset boundariesJames R Ison
Department of Brain and Cognitive Sciences, University of Rochester, New York 14627, USA
J Acoust Soc Am 112:740-7. 2002..These effects are specific to gaps: inhibition for fixed (70-dB SPL) or varied level pulses (30 to 60 dB) was unaffected by varying the ramped edges (experiments 3 and 4, n = 9)... - Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposureOksana Polesskaya
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Hear Res 270:21-7. 2010..Rather, other MLK family members such as MLK1, which is also expressed in cochlea, may have a previously unappreciated role in noise- and aminoglycoside-induced ototoxicity... - Lead exposure during development results in increased neurofilament phosphorylation, neuritic beading, and temporal processing deficits within the murine auditory brainstemLinda G Jones
Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA
J Comp Neurol 506:1003-17. 2008..These results provide evidence that Pb exposure during development alters axonal structure and function within brainstem auditory nuclei...