Research Topics
| DENNIS WALLINGSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
The molecular epidemiology and evolution of Epstein-Barr virus: sequence variation and genetic recombination in the latent membrane protein-1 geneD M Walling
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 0835, USA
J Infect Dis 179:763-74. 1999..Thus, this LMP-1 sequence-based approach to EBV molecular epidemiology will facilitate the study of intrahost EBV infection, coinfection, and persistence...- Molecular markers of clonality and identity in Epstein-Barr virus-associated B-cell lymphoproliferative diseaseDennis M Walling
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, 77555 0435, USA
J Med Virol 74:94-101. 2004..Utilization of these three assays together may provide new insight into the pathogenesis of EBV-associated B-cell lymphoproliferative disease... - Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakiaDennis M Walling
Division of Infectious Diseases, Department of Internal Medicine, and Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
J Infect Dis 190:396-9. 2004..In vitro experiments suggested that a recombinant variant of the EBNA-2 gene may play a role in the pathogenesis of HLP, through modulation of EBNA-2 protein function... - Persistence and transition of Epstein-Barr virus genotypes in the pathogenesis of oral hairy leukoplakiaDennis M Walling
Division of Infectious Diseases, Department of Internal Medicine, and Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
J Infect Dis 190:387-95. 2004.... - Effect of Epstein-Barr virus replication on Langerhans cells in pathogenesis of oral hairy leukoplakiaDennis M Walling
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Texas 77555, USA
J Infect Dis 189:1656-63. 2004..This novel EBV strategy for eliminating oral Langerhans cells may facilitate the persistence of oral epithelial EBV and may contribute to the pathogenesis of HLP... - Epstein-Barr virus replication in oral hairy leukoplakia: response, persistence, and resistance to treatment with valacyclovirDennis M Walling
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston 77555 0435, USA
J Infect Dis 188:883-90. 2003..In summary, safe treatment of HLP and of EBV replication, with valacyclovir, provides new insight into the mechanisms of EBV persistence in oral mucosa... - A non-invasive technique for studying oral epithelial Epstein-Barr virus infection and diseaseDennis M Walling
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 0435, USA
Oral Oncol 39:436-44. 2003..73%) and negative predictive value (93% vs. 82%). This non-invasive brush biopsy technique should facilitate larger, prospective studies of oral EBV infection and pathogenesis... - Multiple Epstein-Barr virus infections in healthy individualsDennis M Walling
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston 77555, USA
J Virol 77:6546-50. 2003..These results support the hypothesis that multiple EBV infections of healthy individuals are common. The implications for the development of an EBV vaccine are discussed... - Persistent productive Epstein-Barr virus replication in normal epithelial cells in vivoD M Walling
Division of Infectious Diseases, Dept of Internal Medicine, University of Texas Medical Branch at Galveston, TX 77555 0435, USA
J Infect Dis 184:1499-507. 2001..These data suggest that normal oral epithelium supports persistent EBV infection in individuals infected with HIV and that productive EBV replication is necessary but not sufficient for the pathogenesis of oral hairy leukoplakia... - Unexpected absence of the Epstein-Barr virus (EBV) lyLMP-1 open reading frame in tumor virus isolates: lack of correlation between Met129 status and EBV strain identityKimberly D Erickson
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309, USA
J Virol 77:4415-22. 2003..Its absence from EBV isolates from tumors raises the possibility of selective pressure on Met129 in EBV-dependent tumors... - Oncogenic activity of Epstein-Barr virus latent membrane protein 1 (LMP-1) is down-regulated by lytic LMP-1Jyotsna Pandya
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555 0435, USA
J Virol 80:8038-46. 2006.... - Chronic herpesvirus reactivation occurs in agingRaymond P Stowe
Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, United States
Exp Gerontol 42:563-70. 2007..These findings indicate that the aged immune system is no longer able to control EBV and CMV reactivation that could now be characterized as chronic instead of latent... - Epstein-Barr virus infection of Langerhans cell precursors as a mechanism of oral epithelial entry, persistence, and reactivationDennis M Walling
Division of Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0435, USA
J Virol 81:7249-68. 2007..This new model contributes fresh insight into the natural history of EBV infection and the pathogenesis of EBV-associated epithelial disease... - Primary Nocardia osteomyelitis as a presentation of AIDSMoti Talpada
University of Texas, Medical Branch at Galveston, USA
AIDS Read 12:75-8. 2002..Nocardia osteomyelitis should be recognized as an unusual but important and treatable opportunistic infection in patients living with HIV infection... - Epstein-Barr virus latent membrane protein 1 (LMP-1) half-life in epithelial cells is down-regulated by lytic LMP-1Jyotsna Pandya
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0435, USA
J Virol 78:8404-10. 2004..This observed dominant negative effect of lyLMP-1 expression on the LMP-1 half-life in epithelial cells in vitro may have implications for EBV epithelial oncogenesis in vivo...
Research Grants
- EBV and HPV: Oral Infection, Persistence & PathogenesisDENNIS WALLING; Fiscal Year: 2003..abstract_text> ..
- EBV PATHOGENESIS IN HIV-ASSOCIATED HAIRY LEUKOPLAKIADENNIS WALLING; Fiscal Year: 2003..The results of this study will elucidate molecular mechanisms of EBV pathogenesis in HLP applicable to other EBV-associated diseases, including nasopharyngeal carcinoma and HIV-associated lymphomas. ..