David W Walker

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain
    Jeffrey M Copeland
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 19:1591-8. 2009
  2. ncbi Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
    Michael Rera
    Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 14:623-34. 2011
  3. ncbi Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila
    Sepehr Bahadorani
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1527, USA
    Aging Cell 9:100-3. 2010
  4. ncbi Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan
    Sepehr Bahadorani
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095 1527, USA
    Aging Cell 9:191-202. 2010
  5. ncbi The role of mitochondria in Drosophila aging
    Jaehyoung Cho
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
    Exp Gerontol 46:331-4. 2011
  6. ncbi Aging: Dial M for Mitochondria
    Jae H Hur
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Aging (Albany NY) 2:69-73. 2010

Collaborators

  • Timothy J Bradley
  • Jeffrey M Copeland
  • Jaehyoung Cho
  • Jae H Hur
  • Sepehr Bahadorani
  • Thomas Lo
  • Michael Rera
  • Christopher L Koehler
  • D Leanne Jones
  • Matthew Ulgherait
  • William S Ansari
  • David E Krantz
  • Heidy Contreras
  • Kevin Vu
  • Hakeem O Lawal

Detail Information

Publications6

  1. ncbi Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain
    Jeffrey M Copeland
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 19:1591-8. 2009
    ..In the present study, we have used an in vivo RNA interference (RNAi) strategy to inactivate ETC genes in Drosophila melanogaster and examine the impact on longevity...
  2. ncbi Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
    Michael Rera
    Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 14:623-34. 2011
    ..Our findings point to the possibility that alterations in PGC-1 activity in high-turnover tissues, such as the intestine, may be an important determinant of longevity in mammals...
  3. ncbi Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila
    Sepehr Bahadorani
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1527, USA
    Aging Cell 9:100-3. 2010
    ..These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies...
  4. ncbi Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan
    Sepehr Bahadorani
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095 1527, USA
    Aging Cell 9:191-202. 2010
    ..These findings are consistent with the idea that enhanced respiratory chain activity in neuronal tissue can prolong fly lifespan...
  5. ncbi The role of mitochondria in Drosophila aging
    Jaehyoung Cho
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
    Exp Gerontol 46:331-4. 2011
    ..Finally, we review recent approaches to supplement the endogenous fly ETC with a single-subunit mitochondrial respiratory enzyme from yeast...
  6. ncbi Aging: Dial M for Mitochondria
    Jae H Hur
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Aging (Albany NY) 2:69-73. 2010
    ..In this Research Perspective, we discuss our findings and how they may relate to similar studies in worms and mice...