E K Wakeland

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Genetic dissection of systemic lupus erythematosus
    E K Wakeland
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235 9093, USA
    Curr Opin Immunol 11:701-7. 1999
  2. ncbi Delineating the genetic basis of systemic lupus erythematosus
    E K Wakeland
    Center for Immunology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Immunity 15:397-408. 2001
  3. ncbi Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes
    Q Z Li
    Department of Immunology and Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Clin Exp Immunol 159:281-91. 2010
  4. ncbi Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies
    C Mohan
    Simmon s Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235 8884, USA
    J Clin Invest 103:1685-95. 1999
  5. ncbi Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death
    C Mohan
    Simmons Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 162:6492-502. 1999
  6. ncbi Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis
    K Liu
    Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    Genes Immun 8:634-45. 2007
  7. ncbi The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis
    Q Z Li
    Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Immun 10:503-8. 2009
  8. ncbi Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations
    N Limaye
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Immun 9:61-8. 2008
  9. ncbi The genetics of lupus
    Y S Yim
    Center for Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Nephrol Hypertens 10:437-43. 2001
  10. ncbi Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes
    Q Z Li
    Center for Immunology, University of Texas Southwestern Medical Center, Dalls, TX, USA
    Clin Exp Immunol 147:60-70. 2007

Detail Information

Publications10

  1. ncbi Genetic dissection of systemic lupus erythematosus
    E K Wakeland
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235 9093, USA
    Curr Opin Immunol 11:701-7. 1999
    ..Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans...
  2. ncbi Delineating the genetic basis of systemic lupus erythematosus
    E K Wakeland
    Center for Immunology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Immunity 15:397-408. 2001
    ..Genes in multiple pathways appear to participate in specific elements of the disease, and epistatic interactions among these genes play an important role in both aggravating and suppressing disease development...
  3. ncbi Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes
    Q Z Li
    Department of Immunology and Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Clin Exp Immunol 159:281-91. 2010
    ..Furthermore, high levels of alpha IFN may promote autoantibody class-switch from IgM to the more pathogenic IgG class...
  4. ncbi Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies
    C Mohan
    Simmon s Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235 8884, USA
    J Clin Invest 103:1685-95. 1999
    ..Whereas loci such as Sle1 may serve to breach tolerance to chromatin, full-blown pathogenic maturation of the autoantibody response appears to require additional input from other loci (such as Sle3) and gender-based factors...
  5. ncbi Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death
    C Mohan
    Simmons Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 162:6492-502. 1999
    ..Epistatic interactions with other loci may be required to transform this relatively benign phenotype into overt autoimmunity, as seen in the NZM2410 strain...
  6. ncbi Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis
    K Liu
    Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    Genes Immun 8:634-45. 2007
    ..Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity...
  7. ncbi The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis
    Q Z Li
    Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Immun 10:503-8. 2009
    ..Sle3 congenics. Taken together with earlier studies, these findings indicate that kallikreins play an important protective role in autoantibody-initiated GN and could constitute potential candidate genes for anti-GBM-induced GN and SLN...
  8. ncbi Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations
    N Limaye
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Immun 9:61-8. 2008
    ..These findings support the interpretation that selection favoring the generation and retention of functional polymorphisms has played a role in the evolutionary origin of genetic polymorphisms that are predisposing to autoimmunity...
  9. ncbi The genetics of lupus
    Y S Yim
    Center for Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Nephrol Hypertens 10:437-43. 2001
    ..These findings suggest that mouse models of lupus may provide valuable insights into the genetic basis of human systemic lupus erythematosus...
  10. ncbi Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes
    Q Z Li
    Center for Immunology, University of Texas Southwestern Medical Center, Dalls, TX, USA
    Clin Exp Immunol 147:60-70. 2007
    ..Determining whether the IgM aurotreactivity that predominates in ILE represents an early stage prior to IgG switching or is persistent and relatively protective will require further longitudinal studies...