Research Topics
| Daniel A WagenaarSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Searching for plasticity in dissociated cortical cultures on multi-electrode arraysDaniel A Wagenaar
Department of Physics, California Institute of Technology, Caltech 103 33, Pasadena, CA 91125, USA
J Negat Results Biomed 5:16. 2006..Changes concomitant with induction were no larger in magnitude than changes that occurred spontaneously, except in one novel protocol in which spontaneous bursts were quieted using elevated extracellular magnesium concentrations...
An extremely rich repertoire of bursting patterns during the development of cortical culturesDaniel A Wagenaar
Department of Physics, California Institute of Technology, Caltech 103 33, Pasadena, CA 91125, USA
BMC Neurosci 7:11. 2006..We followed 58 cultures of different densities--3000 to 50,000 neurons on areas of 30 to 75 mm2--growing on multi-electrode arrays (MEAs) during the first five weeks of their development...
Controlling bursting in cortical cultures with closed-loop multi-electrode stimulationDaniel A Wagenaar
Department of Physics, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 25:680-8. 2005..This nonpharmacological method of controlling bursts will be a critical tool for exploring the information processing capacities of neuronal ensembles in vitro and has potential applications for the treatment of epilepsy...
Effective parameters for stimulation of dissociated cultures using multi-electrode arraysDaniel A Wagenaar
Department of Physics, California Institute of Technology, Caltech 103 33, Pasadena, CA 91125, USA
J Neurosci Methods 138:27-37. 2004..These results suggest that voltage-control, with its inherent control over limiting electrochemistry, may be advantageous in a wide variety of stimulation scenarios, possibly extending to in-vivo experiments...
Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leechDaniel A Wagenaar
Broad Fellows Program and Division of Biology, California Institute of Technology, 1200 E California Blvd 216 76, Pasadena, CA 91125, USA
Neurosci Lett 485:151-6. 2010..Fictive swimming in isolated nerve cords was even more strongly disrupted, indicating that the toxin targets the CPGs and central coordination, while peripheral coordination partially rescues the behavior in intact animals...
Persistent dynamic attractors in activity patterns of cultured neuronal networksDaniel A Wagenaar
Department of Physics, California Institute of Technology, Pasadena, California 91125, USA
Phys Rev E Stat Nonlin Soft Matter Phys 73:051907. 2006..Instead, the complexity of the observed spatiotemporal patterns implies large-scale self-organization of neurons interacting in a precise temporal order even in vitro, in cultures usually considered to have random connectivity...
Real-time multi-channel stimulus artifact suppression by local curve fittingDaniel A Wagenaar
Department of Physics, California Institute of Technology, Caltech 103 33, Pasadena, CA 91125, USA
J Neurosci Methods 120:113-20. 2002..SALPA opens up a previously inaccessible window for studying transient neural oscillations and precisely timed dynamics in short-latency responses to electric stimulation...
A versatile all-channel stimulator for electrode arrays, with real-time controlDaniel A Wagenaar
Department of Physics, California Institute of Technology, Caltech 103 33, Pasadena, CA 91125, USA
J Neural Eng 1:39-45. 2004..In combination with our freely available data-acquisition software, MeaBench, this system can provide feedback stimulation in response to recorded action potentials within 15 ms...
Automated video analysis of animal movements using Gabor orientation filtersDaniel A Wagenaar
Division of Biology, California Institute of Technology, Pasadena, CA, USA
Neuroinformatics 8:33-42. 2010..A Matlab implementation with a graphical user interface is available online, and should make this algorithm conveniently usable in many other contexts...
A hormone-activated central pattern generator for courtshipDaniel A Wagenaar
Broad Fellows Program and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Curr Biol 20:487-95. 2010..The neural basis of this behavior is presently unknown and currently impossible to study directly because electrophysiological recording techniques disrupt the behavior...
Developmentally regulated multisensory integration for prey localization in the medicinal leechCynthia M Harley
California Institute of Technology, Department of Biology, 1200 California Boulevard, Pasadena, CA 91125, USA
J Exp Biol 214:3801-7. 2011..Indeed, when stimuli of the two modalities were placed in conflict with one another, adult leeches, unlike juveniles, were attracted to the mechanical stimulus much more strongly than to the visual stimulus...
Effects of random external background stimulation on network synaptic stability after tetanization: a modeling studyZenas C Chao
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0535, USA
Neuroinformatics 3:263-80. 2005..quot;..
Multi-site stimulation quiets network-wide spontaneous bursts and enhances functional plasticity in cultured cortical networksRadhika Madhavan
Coulter Dept of Biomed Eng, Emory Univ, Atlanta, GA, USA
Conf Proc IEEE Eng Med Biol Soc 1:1593-6. 2006..The methods developed for this study will help in the understanding of network dynamics and appreciation of their role in long-term plasticity and information processing in the brain...
Widespread inhibition proportional to excitation controls the gain of a leech behavioral circuitSerapio M Baca
Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
Neuron 57:276-89. 2008..This relatively simple mechanism for controlling behavioral gain could be prevalent in vertebrate as well as invertebrate nervous systems...
Photochemical control of endogenous ion channels and cellular excitabilityDoris L Fortin
Department of Molecular and Cell Biology, University of California Berkeley, 121 Life Sciences Addition, Berkeley, California 94720, USA
Nat Methods 5:331-8. 2008....
