Madhuri Wadehra

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Steroid hormone regulation of EMP2 expression and localization in the endometrium
    Madhuri Wadehra
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Reprod Biol Endocrinol 6:15. 2008
  2. ncbi Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src
    Maoyong Fu
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e19945. 2011
  3. ncbi The tetraspan protein EMP2 regulates expression of caveolin-1
    Ashley Forbes
    Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 282:26542-51. 2007
  4. ncbi Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer
    Maoyong Fu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Clin Cancer Res 16:3954-63. 2010
  5. ncbi Peripheral myelin protein-22 (PMP22) modulates alpha 6 integrin expression in the human endometrium
    Rajiv G Rao
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, USA
    Reprod Biol Endocrinol 9:56. 2011
  6. ncbi Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2)
    Shawn A Morales
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:4949-56. 2009
  7. ncbi Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium
    Madhuri Wadehra
    Department of Pathology and Laboratory, University of California, Los Angeles, CA 90095, USA
    Dev Biol 287:336-45. 2005
  8. ncbi Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web
    Shawn A Morales
    Department of Ophthalmology, University of California at Los Angeles, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:5465-72. 2011
  9. ncbi Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines
    Kaori Shimazaki
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Clin Cancer Res 14:7367-77. 2008
  10. ncbi FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction
    Shawn A Morales
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:462-9. 2009

Collaborators

  • Lee Goodglick
  • Kathleen A Kelly
  • Anna M Wu
  • David B Seligson
  • James D Marks
  • Qin Zhou
  • Helen Su
  • Eric J Lepin
  • Jonathan Braun
  • Lynn K Gordon
  • Shawn A Morales
  • Kaori Shimazaki
  • Maoyong Fu
  • Sergey Mareninov
  • Rajiv G Rao
  • Ashley Forbes
  • Deepthi Sudhakar
  • Lucia Notterpek
  • Claire P Hogue
  • Omar Habeeb
  • Robert A Soslow
  • Shawn Morales
  • Catherine P Coulam
  • Ann M Chan
  • Katherine Dahlin
  • Rajiv Rao
  • STEPHANIE AMICI
  • Zach Rutta
  • David Telander
  • Erin L Maresh
  • Steve Horvath
  • Osvaldo Schirripa
  • Mohammad Alavi
  • Alexia Iasonos
  • Vei Mah
  • Agnes Nagy
  • Paige Coulam
  • Raymond J Moniz
  • Lily Zhang
  • Agnes K Nagy
  • Bo Wei
  • Sergei Mareninov
  • Pradeep Prasad
  • Zachary Tigue
  • Leland Dobbs
  • Edward M Mager
  • Lennell Allen

Detail Information

Publications22

  1. ncbi Steroid hormone regulation of EMP2 expression and localization in the endometrium
    Madhuri Wadehra
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Reprod Biol Endocrinol 6:15. 2008
    ..Because EMP2 is differentially expressed in the various stages of the murine and human estrous cycle, we tested the hypothesis that the steroid hormones progesterone and estrogen influence EMP2 expression and localization...
  2. ncbi Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src
    Maoyong Fu
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e19945. 2011
    ....
  3. ncbi The tetraspan protein EMP2 regulates expression of caveolin-1
    Ashley Forbes
    Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 282:26542-51. 2007
    ..These findings elucidate a new mechanism of caveolin-1 regulation and define an additional role for EMP2 as a key regulator of cell membrane composition...
  4. ncbi Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer
    Maoyong Fu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Clin Cancer Res 16:3954-63. 2010
    ..In this study, we assessed the role of EMP2 in human ovarian cancer...
  5. ncbi Peripheral myelin protein-22 (PMP22) modulates alpha 6 integrin expression in the human endometrium
    Rajiv G Rao
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, USA
    Reprod Biol Endocrinol 9:56. 2011
    ..In this study, we first characterized the expression of PMP22 in the human menstrual cycle and began to characterize its function in the endometrium...
  6. ncbi Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2)
    Shawn A Morales
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:4949-56. 2009
    ..Collagen gel contraction by ARPE-19 is controlled by epithelial membrane protein 2 (EMP2) through focal adhesion kinase (FAK) activation. The purpose of this study was to test the role of EMP2 in the cellular context of FAK activation...
  7. ncbi Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium
    Madhuri Wadehra
    Department of Pathology and Laboratory, University of California, Los Angeles, CA 90095, USA
    Dev Biol 287:336-45. 2005
    ....
  8. ncbi Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web
    Shawn A Morales
    Department of Ophthalmology, University of California at Los Angeles, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:5465-72. 2011
    ..Peripheral myelin protein 22 (PMP22), another member of the tetraspan web, is closely related to EMP2. The purpose of this study was to determine whether PMP22 also controls the contractile phase associated with PVR...
  9. ncbi Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines
    Kaori Shimazaki
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Clin Cancer Res 14:7367-77. 2008
    ..The present study assesses the suitability of EMP2 as a therapeutic target...
  10. ncbi FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction
    Shawn A Morales
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:462-9. 2009
    ..Since EMP2 is highly expressed in retinal pigment epithelium, this study investigates the role of EMP2 in collagen gel contraction...
  11. ncbi Epithelial membrane protein-2 expression is an early predictor of endometrial cancer development
    Omar Habeeb
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Cancer 116:4718-26. 2010
    ..Here the authors validate the expression of EMP2 in EC, and further examine whether EMP2 expression within preneoplastic lesions is an early prognostic biomarker for EC development...
  12. ncbi Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse
    Madhuri Wadehra
    Molecular Biology Institute, Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 292:430-41. 2006
    ..These studies indicate a previously unknown function of tetraspan proteins in implantation and could provide a molecular framework for the development of therapeutic modalities for both contraception and fertility...
  13. ncbi The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death
    Madhuri Wadehra
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1722, USA
    Clin Immunol 107:129-36. 2003
    ..This study demonstrates an unexpected role for a tetraspan protein in CTL-mediated cell death and MHC1 surface trafficking...
  14. ncbi Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye
    Madhuri Wadehra
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
    Exp Mol Pathol 74:106-12. 2003
    ..This distribution is distinct from other TM4SF proteins and may relate to a role in apical membrane recycling...
  15. ncbi Epithelial membrane protein 2 modulates infectivity of Chlamydia muridarum (MoPn)
    Kaori Shimazaki
    Molecular Biology Institute, Los Angeles, CA 90095, USA
    Microbes Infect 9:1003-10. 2007
    ..These findings identify EMP2 as a candidate host protein involved in infection of C. muridarum (MoPn)...
  16. ncbi The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins
    Madhuri Wadehra
    Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Mol Biol Cell 15:2073-83. 2004
    ..These findings suggest that EMP2 facilitates the formation and surface trafficking of lipid rafts bearing GPI-APs, and reduces caveolin expression, resulting in impaired formation of caveolae...
  17. ncbi Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model
    Kaori Shimazaki
    Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    FEMS Immunol Med Microbiol 55:240-9. 2009
    ..These findings support EMP2 as a potential preventative and therapeutic target for genital chlamydial infection...
  18. ncbi Collagen gel contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway
    Shawn A Morales
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Exp Eye Res 85:790-8. 2007
    ..Integrin ligation and FAK-Src activation is necessary for collagen gel contraction produced by the ARPE-19 cell line. Validation of these observations in primary RPE cells may suggest new targets for therapeutic intervention in PVR...
  19. ncbi The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion
    Madhuri Wadehra
    Molecular Biology Institute, The David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center, 108ee Le Conte Avenue, Los Angeles, CA 90095, USA
    J Biol Chem 277:41094-100. 2002
    ..This study demonstrates for the first time the interaction of a GAS3/PMP22 family member with an integrin protein and suggests that such interactions and their functional consequences are a physiologic role of GAS3/PMP22 proteins...
  20. ncbi Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome
    Madhuri Wadehra
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, California, USA
    Cancer 107:90-8. 2006
    ..CONCLUSIONS: EMP2 expression is a feature of some prognostically unfavorable endometrial cancers. Its utility for clinical decision making and its biologic role in endometrial cancer deserves further study in a larger series of patients...
  21. ncbi One-step RT-PCR for screening microdissected tissue samples
    Madhuri Wadehra
    UCLA School of Medicine, Los Angeles, CA, USA
    Biotechniques 32:242, 244, 246, 248. 2002
  22. ncbi Identification of genes differentially expressed in rat alveolar type I cells
    Katherine Dahlin
    Department of Medicine, University of California San Francisco, USA
    Am J Respir Cell Mol Biol 31:309-16. 2004
    ....