David W Volk

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Prefrontal cortical circuits in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, BST W1653, Pittsburgh, PA 15213, USA
    Curr Top Behav Neurosci 4:485-508. 2010
  2. ncbi Alterations in metabotropic glutamate receptor 1? and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
  3. ncbi Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
  4. ncbi Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Jaime G Maldonado-Aviles
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:450-9. 2009
  5. ncbi GABA neurons in the human prefrontal cortex
    Carol Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5.914, Dallas, TX 75390-9070, USA
    Am J Psychiatry 161:1764. 2004
  6. ncbi Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 174:143-50. 2004
  7. ncbi Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 71:114-9. 2012
  8. ncbi Impaired prefrontal inhibition in schizophrenia: relevance for cognitive dysfunction
    David W Volk
    Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:501-5. 2002
  9. ncbi Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
  10. ncbi Effects of a mediodorsal thalamus lesion on prefrontal inhibitory circuitry: implications for schizophrenia
    David W Volk
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 53:385-9. 2003

Research Grants

  1. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003

Collaborators

Detail Information

Publications12

  1. ncbi Prefrontal cortical circuits in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, BST W1653, Pittsburgh, PA 15213, USA
    Curr Top Behav Neurosci 4:485-508. 2010
    ..Increasing knowledge of the nature of the molecular alterations in these cortical circuits may lead to the development of new pathophysiologically informed treatment options for cognitive deficits in schizophrenia...
  2. ncbi Alterations in metabotropic glutamate receptor 1? and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
    ..The status of endocannabinoid ligands, such as 2-arachidonoylglycerol, can be inferred in part through measures of diacylglycerol lipase and monoglyceride lipase, which synthesize and degrade 2-arachidonoylglycerol, respectively...
  3. ncbi Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
    ....
  4. ncbi Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Jaime G Maldonado-Aviles
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:450-9. 2009
    ..The authors assessed the expression of GABA(A) receptor alpha4 and delta subunits, which coassemble to form receptors mediating tonic inhibition, in schizophrenia...
  5. ncbi GABA neurons in the human prefrontal cortex
    Carol Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5.914, Dallas, TX 75390-9070, USA
    Am J Psychiatry 161:1764. 2004
  6. ncbi Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 174:143-50. 2004
    ....
  7. ncbi Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 71:114-9. 2012
    ..However, whether this correlation reflects a cause-effect relationship is unknown...
  8. ncbi Impaired prefrontal inhibition in schizophrenia: relevance for cognitive dysfunction
    David W Volk
    Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:501-5. 2002
    ..Selective disruptions in inhibitory neurotransmission are likely to distort aspects of pyramidal neuron function important for working memory tasks, and thus may contribute to cognitive dysfunction in schizophrenia...
  9. ncbi Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
    ..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
  10. ncbi Effects of a mediodorsal thalamus lesion on prefrontal inhibitory circuitry: implications for schizophrenia
    David W Volk
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 53:385-9. 2003
    ..These results do not support the hypothesis that decreased PFC GAD(67) mRNA expression in schizophrenia is attributable to a reduction in MDTN neuron number...
  11. ncbi Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:57-67. 2012
    ..This compensation is thought to rebalance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control...
  12. ncbi Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia
    David W Volk
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Cereb Cortex 12:1063-70. 2002
    ..Thus, disturbances in inhibition at the chandelier neuron-pyramidal neuron synapse may be a critical component of prefrontal cortical dysfunction in schizophrenia...

Research Grants1

  1. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003
    ..After a 3 month survival period, we will quantify any changes in the mRNA expression of PFC GABA markers using in situ hybridization and grain counting techniques. ..