Research Topics
| P M VespaSummaryAffiliation: University of California Country: USA Publications
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Publications
SAH pituitary adrenal dysfunctionP Vespa
Department of Neurosurgery, University of California at Los Angeles, Los Angeles, CA, USA
Neurocrit Care 15:365-8. 2011..During the months to years after subarachnoid hemorrhage, pituitary deficiency may occur in up to one in three patients. Limited data suggest modest outcome benefits with fludrocortisone and no benefit or harm from corticosteroids...- The implications of cerebral ischemia and metabolic dysfunction for treatment strategies in neurointensive carePaul M Vespa
David Geffen School of Medicine at UCLA, University of California, Los Angeles, 90095, USA
Curr Opin Crit Care 12:119-23. 2006..The intent is to guide clinicians in considering how best to monitor and treat brain metabolism in the intensive care unit... - Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography studyPaul Vespa
1David Geffen School of Medicine at UCLA, UCLA Medical Center, University of California, Los Angeles, 90095, USA
J Cereb Blood Flow Metab 25:763-74. 2005..001), but not with OEF or CvO(2). Traumatic brain injury leads to a state of persistent metabolic crisis as reflected by abnormal cerebral microdialysis LPR that is not related to ischemia... - High-volume centersP Vespa
Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California, Room 6236A Ronald Reagan UCLA Medical Center, 750 Westwood Blvd, Los Angeles, CA 90095, USA
Neurocrit Care 15:369-72. 2011..Furthermore, transfer to high-volume centers may be inadequately arranged. Several factors may influence the better outcome at high-volume centers, including the availability of neurointensivists and interventional neuroradiologists... - Deep venous thrombosis prophylaxisPaul Vespa
Division of Neurosurgery, University of California at Los Angeles, Los Angeles, CA 90095, USA
Neurocrit Care 15:295-7. 2011..Low molecular weight heparin has been linked to an increased risk for intracranial hemorrhage. Limited data are available to direct the timing and duration of prophylactic therapies... - Neurogenic pulmonary edema and other mechanisms of impaired oxygenation after aneurysmal subarachnoid hemorrhagePaul M Vespa
Division of Neurosurgery, Department of Neurology, University of California, Los Angeles 90028, USA
Neurocrit Care 1:157-70. 2004..Aneurysmal subarachnoid hemorrhage (SAH) affects 30,000 patients per year, causing neurologic morbidity and mortality. The etiology of hypoxemia and its role in comorbidity are controversial and unknown... - Regional heterogeneity of post-traumatic brain metabolism as studied by microdialysis, magnetic resonance spectroscopy and positron emission tomographyPaul Vespa
UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, CHS 18-218, Mail code 713909, Los Angeles, CA 90095, USA
Brain Pathol 14:210-4. 2004 - Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophyP M Vespa
UCLA Department of Neurosurgery, Los Angeles, CA 90095, USA
Neurology 75:792-8. 2010..To determine if posttraumatic nonconvulsive electrographic seizures result in long-term brain atrophy... - What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury?Paul Vespa
Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, USA
Neurosurg Focus 15:E4. 2003..The use of brain monitors of cerebral metabolism and oxygen supply may assist the clinician in the selection of the optimal CPP for an individual patient... - Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduction of hemorrhage volume and neurological improvementPaul Vespa
University of California, Los Angeles, David Geffen School of Medicine, USA
Neurocrit Care 2:274-81. 2005..This is a phase-2 safety trial to demonstrate the ability of frameless stereotactic aspiration and thrombolysis of ICH to safely remove blood... - Endocrine function following acute SAHPaul Vespa
Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California, Room 6236A Ronald Reagan UCLA Medical Center, 750 Westwood Blvd, Los Angeles, CA 90095, USA
Neurocrit Care 15:361-4. 2011..During the months to years after subarachnoid hemorrhage, pituitary deficiency may occur in one out of three patients. Limited data suggest modest outcome benefits with fludrocortisone and no benefit or harm from corticosteroids... - Intensive glycemic control in traumatic brain injury: what is the ideal glucose range?Paul M Vespa
Department of Neurosurgery, David Geffen School of Medicine at UCLA, 757 Westwood Blvd, Suite 6236A, Los Angeles, CA 90095, USA
Crit Care 12:175. 2008..The present article explores existing literature surrounding this controversy, and outlines the literature that raises concern. Finally, I suggest an alternative course of action that may enable control of glucose in an optimal range... - Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisisPaul M Vespa
Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA
Crit Care Med 35:2830-6. 2007..To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio... - Early and persistent impaired percent alpha variability on continuous electroencephalography monitoring as predictive of poor outcome after traumatic brain injuryPaul M Vespa
Department of Neurology, School of Medicine, University of California at Los Angeles, 90095, USA
J Neurosurg 97:84-92. 2002..The goal of this study was to determine the usefulness of continuous electroencephalography (EEG) monitoring in determining prognosis early after TBI, while the patient is in the intensive care unit... - Intensive care unit robotic telepresence facilitates rapid physician response to unstable patients and decreased cost in neurointensive carePaul M Vespa
Departments of Surgery Neurological Surgery and Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA
Surg Neurol 67:331-7. 2007..The timely assessment and treatment of ICU patients is important for neurosurgeons and neurointensivists. We hypothesized that the use of RTP can improve physician rapid response to unstable ICU patients... - Continuous EEG monitoring for the detection of seizures in traumatic brain injury, infarction, and intracerebral hemorrhage: "to detect and protect"Paul Vespa
Division of Neurosurgery, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
J Clin Neurophysiol 22:99-106. 2005..e., to detect seizures and protect the brain from seizure-related injury in critically ill patients, whose brains are often in a particularly vulnerable state... - Robotic telepresence in the intensive care unitPaul Vespa
David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
Crit Care 9:319-20. 2005 - Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressurePaul M Vespa
UCLA, Division of Neurosurgery, USA
Crit Care Med 35:1153-60. 2007..To determine whether pericontusional tissue exhibits neurochemical responsiveness to changes in cerebral perfusion pressure as measured by microdialysis lactate/pyruvate ratio... - Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcomeP M Vespa
Division of Neurosurgery, Department of Neurology, UCLA Stroke Center, UCLA Brain Injury Research Center, University of California Los Angeles School of Medicine, CA 90095 7039, USA
Neurology 60:1441-6. 2003..To determine whether early seizures that occur frequently after intracerebral hemorrhage (ICH) lead to increased brain edema as manifested by increased midline shift... - Multimodality monitoring and telemonitoring in neurocritical care: from microdialysis to robotic telepresencePaul M Vespa
Department of Neurology, Division of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
Curr Opin Crit Care 11:133-8. 2005..This review will highlight the state-of-the-art in brain monitoring in neurointensive care and define methods of integrating this technology into patient care using telemedicine methods... - Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis studyPaul M Vespa
Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, CA, USA
J Cereb Blood Flow Metab 23:865-77. 2003..These results suggest that the level of extracellular glucose is typically reduced after traumatic brain injury and associated with poor outcome, but is not associated with ischemia... - Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteomeR Lakshmanan
UCLA Department of Chemistry and Biochemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Neurocrit Care 12:324-36. 2010..To examine if the metabolic distress after traumatic brain injury (TBI) is associated with a unique proteome... - Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injuryM Bergsneider
UCLA Division of Neurosurgery, Harbor UCLA Medical Center, UCLA Brain Research Institute, Los Angeles, California 90095 7039, USA
J Neurotrauma 17:389-401. 2000.... - Partial recanalization of concomitant internal carotid-middle cerebral arterial occlusions promotes distal recanalization of residual thrombus within 24 hY Loh
Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurointerv Surg 3:38-42. 2011..Successful recanalization of the proximal aspect of the occlusion may allow for endogenous thrombolysis and facilitate further endogenous recanalization of any residual MCA occlusion... - Metabolic suppressive therapy as a treatment for intracranial hypertension--why it works and when it failsM Oertel
Division of Neurosurgery, UCLA Medical Center, Los Angeles, USA
Acta Neurochir Suppl 81:69-70. 2002..In conclusion, intact CO2R, normal or only moderately elevated ICP and normal MR are predictive of ICP reduction with high dose propofol after head injury... - Higher rates of mortality but not morbidity follow intracranial mechanical thrombectomy in the elderlyYince Loh
Division of Neurosurgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA
AJNR Am J Neuroradiol 31:1181-5. 2010..Mechanical thrombectomy is a promising means of recanalizing acute cerebrovascular occlusions in certain situations. We sought to determine if increasing age adversely affects prognosis... - Can hyperventilation improve cerebral microcirculation in patients with high ICP?M Oertel
Division of Neurosurgery, UCLA Medical Center, Los Angeles, CA, USA
Acta Neurochir Suppl 81:71-2. 2002..Hyperventilation unexpectedly reduced PI in patients with high ICP. Because decreased PI suggests decreased CVR, it is postulated that hyperventilation in the setting of raised ICP improves cerebral microcirculation... - Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhageC S Kidwell
Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
Neurology 57:1611-7. 2001..Diffusion-perfusion MRI provides a novel means of assessing injury in perihematomal regions in patients with ICH... - Validation of computed tomographic middle cerebral artery "dot"sign: an angiographic correlation studyMegan C Leary
Department of Neurology, Division of Stroke and Cerebrovascular Disease, Palmer 125, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Mass 02215, USA
Stroke 34:2636-40. 2003..The MCA dot sign has not been validated previously against the gold standard of conventional cerebral angiography... - Recanalization rates decrease with increasing thrombectomy attemptsY Loh
Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
AJNR Am J Neuroradiol 31:935-9. 2010..We sought to determine whether there is an optimum number of retrieval attempts that yields the highest recanalization rates and after which the probability of success decreases... - Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissueLudy C Shih
UCLA Stroke Center, UCLA Medical Center, Los Angeles, Calif, USA
Stroke 34:1425-30. 2003..Pretreatment perfusion MRI offers promise as a means to differentiate core from penumbral tissues... - PET investigation of post-traumatic cerebral blood volume and blood flowN Hattori
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Acta Neurochir Suppl 86:49-52. 2003..In conclusion, regional brain edema is likely to occur in contusion and pericontusion areas, while some of the contusional tissue may show vascular engorgement... - Is CPP therapy beneficial for all patients with high ICP?M Oertel
Division of Neurosurgery, UCLA Medical Center, Los Angeles, CA, USA
Acta Neurochir Suppl 81:67-8. 2002..We concluded that in the majority of studies increasing MAP was followed by an increase in ICP. CPP therapy has a selective indication in patients with high GCS, low SjvO2 and increased ICP... - Ethical issues in patient-physician communication about therapy for cancer: professional responsibilities of the oncologistNeil S Wenger
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Oncologist 15:43-8. 2010..In this way, oncologists can ensure value in cancer care... - Surgical management of adult hydrocephalusMarvin Bergsneider
Division of Neurosurgery, Department of Surgery, University of California Los Angeles, David Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, California 90095 6901, USA
Neurosurgery 62:643-59; discussion 659-60. 2008..For the condition of normal pressure hydrocephalus, recommendations are offered regarding the evaluation, surgical treatment, and postoperative management of this disorder... - Genomic profiles of damage and protection in human intracerebral hemorrhageS Thomas Carmichael
Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Cereb Blood Flow Metab 28:1860-75. 2008..These inflammatory and anti-inflammatory networks interact at several key points in neutrophil signaling, apoptotic cell death, and protease responses, and indicate that secondary damage in ICH activates opposing molecular systems... - Concurrent neurocysticercosis and pulmonary tuberculosisChad M Miller
Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 6236 B, Los Angeles, CA 90095, USA
Neurocrit Care 10:344-6. 2009..We discuss the case of a 24-year-old male with severe racemose neurocysticercosis... - Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case reportDarrin J Lee
Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 7039, USA
Neurosurgery 63:E1004-6; discussion E1006. 2008..The authors describe a case of severe traumatic arterial vasospasm and its subsequent management using angiography and multiple infusions of calcium channel blockers... - Contrast agent dose effects in cerebral dynamic susceptibility contrast magnetic resonance perfusion imagingJeffry R Alger
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
J Magn Reson Imaging 29:52-64. 2009..To study the contrast agent dose sensitivity of hemodynamic parameters derived from brain dynamic susceptibility contrast MRI (DSC-MRI)... - Predictors of subarachnoid hemorrhage in acute ischemic stroke with endovascular therapyZhong Song Shi
Division of Interventional Neuroradiology, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095 7437, USA
Stroke 41:2775-81. 2010..The purpose of this study was to describe the frequency and predictors of SAH in acute ischemic stroke patients treated endovascularly and its impact on clinical outcome... - Focal meningoencephalitis and mycotic aneurysms from suspected aneurysm coil seedingYince Loh
Manhattan Beach, CA, USA
Neurology 69:613. 2007 - Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury after human traumatic brain injuryHsiao-Ming Wu
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095-6901, USA
Neurosurgery 55:1306-15; discussio 1316-7. 2004..This pervasive finding may indicate that the concept of focal traumatic injury, although valid from a computed tomographic imaging standpoint, may be misleading when considering metabolic derangements associated with TBI... - Routine and quantitative EEG in mild traumatic brain injuryMarc R Nuwer
Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, CA, USA
Clin Neurophysiol 116:2001-25. 2005..There are no proven pathognomonic signatures useful for identifying head injury as the cause of signs and symptoms, especially late after the injury... - Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticusLara M Schrader
Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Room 1 194, Los Angeles, CA 90095, USA
Clin Neurophysiol 117:781-8. 2006..We delivered low frequency stimulation through subdural electrodes to suppress seizures in a case of refractory status epilepticus (RSE)... - Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injuryNaoya Hattori
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
J Nucl Med 45:775-83. 2004..The purpose of this study was to characterize contusional, pericontusional, and remote regions of TBI by estimating glucose transporter and hexokinase activities on the basis of (18)F-FDG kinetic modeling... - Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic strokeVictor J Marder
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles Orthopaedic Hospital, 2400 S Flower St, Los Angeles, California 90007, USA
Stroke 37:2086-93. 2006..Information regarding the histological structure of thromboemboli that cause acute stroke provides insight into pathogenesis and clinical management... - Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humansNaoya Hattori
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Nucl Med 45:765-70. 2004..The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers... - Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratiosChad M Miller
Division of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Neurocrit Care 6:22-9. 2007..The purpose of this study is to characterize the neurochemical changes in perihematomal tissue during frameless minimally invasive evacuation of spontaneous hematomas... - Selective metabolic reduction in gray matter acutely following human traumatic brain injuryHsiao Ming Wu
Department of Molecular and Medical Pharmacology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurotrauma 21:149-61. 2004..There was a selective CMRglc reduction in cortical GM following TBI. The pathophysiological basis for the reduction in GM-to-WM CMRglc ratio seen on FDG-PET imaging following TBI remains to be determined... - Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-13C2]glucose labeling study in humansJoshua R Dusick
Division of Neurosurgery and Cerebral Blood Flow Laboratory, University of California at Los Angeles, Los Angeles, California 90095 7039, USA
J Cereb Blood Flow Metab 27:1593-602. 2007..0006). This elevation in the PPC in the acute period after severe TBI likely represents a shunting of substrate into alternative biochemical pathways that may be critical for preventing secondary injury and initiating recovery... - Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injuryNaoya Hattori
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Nucl Med 44:1709-16. 2003..The metabolic rate of glucose in these regions significantly correlated with the level of consciousness at the time of PET... - Cortical synchrony changes detected by scalp electrode electroencephalograph as traumatic brain injury patients emerge from comaDonald C Shields
Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA 90095, USA
Surg Neurol 67:354-9. 2007..This study explores the synchrony between multiple cortical surface sites as brain injury patients emerge from coma... - Autopsy findings after intracranial thrombectomy for acute ischemic stroke: a clinicopathologic study of 5 patientsNicole S Yin
Department of Pathology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
Stroke 41:938-47. 2010..Various devices (including most extensively the Mechanical Embolus Removal in Cerebral Ischemia [MERCI] Retriever device) have been used for this... - Endovascular mechanical clot retrieval in a broad ischemic stroke cohortD Kim
University of California at Los Angeles Stroke Center, Los Angeles, CA, USA
AJNR Am J Neuroradiol 27:2048-52. 2006..Our aim was to describe an expanded experience with endovascular mechanical embolectomy in a broad group of patients, including those not meeting entry criteria for the MERCI multicenter trials... - Impact of reperfusion after 3 hours of symptom onset on tissue fate in acute cerebral ischemiaOh Young Bang
Department of Neurology, University of California, Los Angeles, CA, USA
J Neuroimaging 19:317-22. 2009..However, there has been only sparse direct evidence that reperfusion after 3 hours prevents infarct growth... - Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysisLars Hillered
Division of Neurosurgery, Department of Surgery, The David Geffen UCLA School of Medicine, Los Angeles, California, USA
J Neurotrauma 22:3-41. 2005..Methodological issues that appeared critical for the future success of MD as a routine intracerebral sampling method were addressed... - Increased hippocampal CA3 vulnerability to low-level kainic acid following lateral fluid percussion injuryElisa Roncati Zanier
Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurotrauma 20:409-20. 2003..Neuronal excitation during a time of cellular vulnerability may trigger or amplify the cycle of secondary damage in functionally impaired, but potentially viable, tissue... - Perfusing the brain after traumatic brain injury: what clinical index should we follow?Paul M Vespa
Crit Care Med 32:1621-3. 2004 - Brain tissue oxygen monitoring: a measure of supply and demandPaul M Vespa
Crit Care Med 34:1850-2. 2006 - Treatment of critical care patients with substantial acute ischemic or traumatic brain injuryAnthony J Strong
Crit Care Med 33:2147-9; author reply 2149. 2005 - Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injuryJudith Marcoux
Department of Neurosurgery, Montreal Neurologic Institute, Montreal, QC, Canada
Crit Care Med 36:2871-7. 2008..To determine whether persistent metabolic dysfunction in normal-appearing frontal lobe tissue is correlated with long-term tissue atrophy... - A breath of fresh air: the potential use for hyperoxia in traumatic brain injuryPaul M Vespa
Crit Care Med 36:363-5. 2008 - Impact of collateral flow on tissue fate in acute ischaemic strokeO Y Bang
Department of Neurology, Samsung Medical Centre, Sungkyunkwan University, Seoul, South Korea
J Neurol Neurosurg Psychiatry 79:625-9. 2008..Collaterals may sustain penumbra prior to recanalisation yet the influence of baseline collateral flow on infarct growth following endovascular therapy remains unknown... - Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injuryMatthew O Hebb
Brain Repair Centre, Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
J Neurotrauma 24:579-90. 2007..PAV appears best utilized as a functional adjunct to traditional clinical and anatomical predictors... - The golden day after subarachnoid hemorrhagePaul M Vespa
Crit Care Med 32:902-4. 2004
Research Grants
- Post Traumatic Nonconvulsive Epileptiform ActivityPaul Vespa; Fiscal Year: 2005..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
- MRS Detects Metabolic Dysfunction after Brain InjuryPaul Vespa; Fiscal Year: 2007..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
- MRS Detects Metabolic Dysfunction after Brain InjuryPaul Vespa; Fiscal Year: 2009..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..