Research Topics
| G L VegaSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Effect of colesevelam hydrochloride on glycemia and insulin sensitivity in men with the metabolic syndromeGloria Lena Vega
The Metabolic Unit, Lipid, and Diabetes Clinics of the Veterans Affairs North Health Care System, Dallas, Texas, USA
Am J Cardiol 108:1129-35. 2011..Finally, an increase in triglycerides with colesevelam therapy might have been related to a lesser suppression of nonesterified fatty acids levels in the postprandial state...- Obesity and the metabolic syndromeG L Vega
Department of Clinical Nutrition, University of Texas, Southwestern Medical Center, Dallas, TX, USA
Minerva Endocrinol 29:47-54. 2004..Therefore, the metabolic alterations commonly associated with increased central obesity of the metabolic syndrome are pro-atherogenic partly because the metabolites are proinflammatory... - Management of atherogenic dyslipidemia of the metabolic syndrome: evolving rationale for combined drug therapyGloria Lena Vega
Department of Clinical Nutrition, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75390 9052, USA
Endocrinol Metab Clin North Am 33:525-44, vi. 2004.... - Influence of extended-release nicotinic acid on nonesterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemiaGloria Lena Vega
Center for Human Nutrition, University of Texas Southwestern Medical Center, and Veterans Affair Medical Center, Dallas, Texas 75390 9052, USA
Am J Cardiol 95:1309-13. 2005.... - Prevalence of the metabolic syndrome as influenced by the measure of obesity employedGloria Lena Vega
Departments of Clinical Nutrition, Internal Medicine, and Clinical Science and Center for Human Nutrition and Clinical and Translational Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
Am J Cardiol 105:1306-12. 2010..In conclusion, abridged ATP III MS appears to be preferable to ATP III MS for the detection of candidates for intensive cardiovascular risk reduction... - Impaired hepatic ketogenesis in moderately obese men with hypertriglyceridemiaGloria Lena Vega
Department of Clinical Nutrition, Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, TX 75390 9052, USA
J Investig Med 57:590-4. 2009..Several studies suggest that increased nonesterified fatty acid flux and increased de novo lipogenesis may contribute to hypertriglyceridemia, but few studies have examined fatty acid oxidation as a factor... - Oxandrolone enhances hepatic ketogenesis in adult menGloria Lena Vega
Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Investig Med 56:920-4. 2008..Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein... - Metabolic correlates of nonalcoholic fatty liver in women and menGloria Lena Vega
The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
Hepatology 46:716-22. 2007.... - Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: effects of gender, CYP46, and ApoE polymorphismsGloria Lena Vega
The Nutrition and Metabolism Laboratory, Metabolic Unit, Veterans Affairs Medical Center, Dallas, TX 75390, USA
J Mol Neurosci 33:51-5. 2007..There were no untoward effects of the standard doses of statin for the duration of treatment. Statins are currently in trial to determine their effect on the course of AD... - Free fatty acid metabolism during fenofibrate treatment of the metabolic syndromeGloria Lena Vega
Department of Clinical Nutrition, and Center for Human Nutrition, University of Texas Southwest Medical Center, and Metabolic Unit, Veterans Affairs Medical Center, Dallas, Texas 75390 9052, USA
Clin Pharmacol Ther 74:236-44. 2003..Our objective was to determine whether fenofibrate modifies the metabolism of nonesterified (free) fatty acids as a component of its triglyceride-lowering action in male patients with the metabolic syndrome... - Effects of N-3 fatty acids on hepatic triglyceride content in humansGloria Lena Vega
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9052, USA
J Investig Med 56:780-5. 2008..Because dietary N-3 fatty acids reduce plasma triglycerides, they may also decrease hepatic triglyceride content. If so, N-3 fatty acids might constitute a therapy for fatty liver... - Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer diseaseGloria Lena Vega
Department of Clinical Nutrition, The Center for Human Nutrition, University of Texas Southwestern Medical Center and Nutrition and Metabolism Laboratory, Veterans Affairs Medical Center, Dallas 75390, USA
Arch Neurol 60:510-5. 2003..Most of plasma 24S-hydroxycholesterol is derived from brain cholesterol; consequently, plasma levels of the oxysterol reflect brain cholesterol catabolism... - Effects of adding fenofibrate (200 mg/day) to simvastatin (10 mg/day) in patients with combined hyperlipidemia and metabolic syndromeGloria Lena Vega
The Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9052, USA
Am J Cardiol 91:956-60. 2003..Therefore, a combination of simvastatin 10 mg/day and fenofibrate 200 mg/day appears to be effective and safe for the treatment of atherogenic dyslipidemia in combined hyperlipidemia... - Cardiovascular outcomes for obesity and metabolic syndromeGloria Lena Vega
Department of Clinical Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USA
Obes Res 10:27S-32S. 2002 - Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trialScott M Grundy
The University of Texas Southwestern Medical Center, Room Y3206, 5323 Harry Hines Blvd, Dallas, TX 75390-9052
Arch Intern Med 162:1568-76. 2002..No hepatotoxic effects or myopathy were observed. CONCLUSION: Low doses of ER niacin (1000 or 1500 mg/d) are a treatment option for dyslipidemia in patients with type 2 diabetes... - Effect of lifibrol on the metabolism of low density lipoproteins and cholesterolG L Vega
Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, USA
J Intern Med 246:1-9. 1999..This finding raises the possibility that lifibrol activates the LDL-receptor pathway through a different mechanisms which remains to be determined... - Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patientsF Baskin
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9036, USA
Neurology 60:2006-7. 2003..APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index... - Effects of combined therapy with lovastatin and colestipol in heterozygous familial hypercholesterolemia. Effects on kinetics of apolipoprotein BG L Vega
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75235
Arteriosclerosis 9:I135-44. 1989.... - Correlation of non-high-density lipoprotein cholesterol and low-density lipoprotein cholesterol with apolipoprotein B during simvastatin + fenofibrate therapy in patients with combined hyperlipidemia (a subanalysis of the SAFARI trial)Scott M Grundy
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Am J Cardiol 104:548-53. 2009.... - The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statinsGloria Lena Vega
Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
Curr Alzheimer Res 1:71-7. 2004..Polymorphisms of CYP46 or apo E do not explain levels of oxysterol or non-HDL cholesterol or the responsiveness to statin treatment in this study... - Variable contributions of fat content and distribution to metabolic syndrome risk factorsScott M Grundy
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, Center for Human Nutrition, Dallas, Texas 75390 9052, USA
Metab Syndr Relat Disord 6:281-8. 2008..However, the relative contributions of these two different parameters of body fat to the various components of the metabolic syndrome have not been well defined... - Hepatic lipase: new insights from genetic and metabolic studiesJ C Cohen
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, USA
Curr Opin Lipidol 10:259-67. 1999..Association studies using these polymorphisms are elucidating the effects of variation in hepatic lipase activity on plasma lipoprotein concentrations and susceptibility to coronary atherosclerosis... - Variability in postheparin hepatic lipase activity is associated with plasma adiponectin levels in African AmericansJacob J Clarenbach
Center for Human Nutrition, Donald W Reynolds Cardiovascular Clinical Research Center of the University of Texas Southwestern Medical Center and Metabolic Unit, Veterans Affairs Medical Center, Dallas, TX, USA
J Investig Med 55:187-94. 2007..The higher than expected HDL-C levels are usually attributed to low levels of hepatic triglyceride lipase (HTGL) activity. Factors that regulate HTGL in African Americans are not well delineated... - Adipose tissue mass and location affect circulating adiponectin levelsA T Turer
Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8521, USA
Diabetologia 54:2515-24. 2011..Plasma levels of adiponectin are inversely associated with body mass. We hypothesised that adipose tissue distribution and body composition influences adiponectin levels... - Tumor necrosis factor mediates hypertriglyceridemia during thermal injury in mice genetically susceptible to lipopolysaccharidesG L Vega
Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas 75235 9052
J Burn Care Rehabil 12:463-7. 1991..This is the first report that demonstrates that hypertriglyceridemia that is secondary to thermal injury is induced by tumor necrosis factor... - Relationship of apolipoprotein B levels to the number of risk factors for metabolic syndromeJacob J Clarenbach
Center for Human Nutrition, the Donald W Reynolds Cardiovascular Research Center of the University of Texas Southwestern Medical Center at Dallas, TX 75390 9052, USA
J Investig Med 55:237-47. 2007..Non-HDL-C correlates highly with total apo B in patients with metabolic syndrome and had advantages as a target of therapy over LDL-C or NMR apo B... - Influence of body fat content and distribution on variation in metabolic riskGloria Lena Vega
Donald W.Reynolds Cardiovascular Clinical Research Center and Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9052, USA
J Clin Endocrinol Metab 91:4459-66. 2006..Hence, obesity seemingly has more clinical impact than revealed in these correlative studies... - Responsiveness of plasma lipids and lipoproteins to plant stanol estersNilo B Cater
Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9052, USA
Am J Cardiol 96:23D-28D. 2005..This makes plant stanols an attractive dietary component to help to achieve the goals of LDL-lowering therapy in patients requiring an LDL-lowering drug... - Ten-year risk of cardiovascular incidence related to diabetes, prediabetes, and the metabolic syndromeJing Liu
Capital Medical University attached Beijing Anzhen Hospital, Beijing, China
Am Heart J 153:552-8. 2007..We aimed to compare MetS with dysglycemia in their association with the 10-year incidence risk of CVD... - Ethnic-specific criteria for the metabolic syndrome: evidence from ChinaJing Liu
Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital University of Medical Sciences attached Beijing Anzhen Hospital, Beijing-100029, China
Diabetes Care 29:1414-6. 2006 - Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group IV: lifestyle and medical management of risk factorsScott M Grundy
Circulation 105:e153-8. 2002