Research Topics
Species | D L VeenstraSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysisD L Veenstra
Department of Pharmacy, University of Washington, Seattle, USA
JAMA 281:261-7. 1999..However, there remains some uncertainty regarding the efficacy of these catheters because of conflicting reports in the literature...
Systematic review of comparative effectiveness data for oncology orphan drugsMindy M Cheng
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, WA 98195 7630, USA
Am J Manag Care 18:47-62. 2012..To systematically assess clinical and economic evidence for oncology orphan drugs marketed in the United States and to highlight the challenges and opportunities for evidence development within this pharmaceutical category...
Cost-effectiveness of peginterferon alpha-2a compared with lamivudine treatment in patients with HBe-antigen-positive chronic hepatitis B in the United KingdomDavid L Veenstra
University of Washington, Seattle, Washington 98195, USA
Eur J Gastroenterol Hepatol 19:631-8. 2007..We assessed the clinical outcomes and costs, from the perspective of the UK National Health Service, of 48 weeks of peginterferon alpha-2a (40 kDa) vs. 4 years of lamivudine...
Cost effectiveness of entecavir versus lamivudine with adefovir salvage in HBeAg-positive chronic hepatitis BDavid L Veenstra
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Pharmacoeconomics 25:963-77. 2007..Previous economic analyses have been limited by the lack of comparative clinical data for entecavir and lamivudine beyond 1-year duration and for salvage therapy...
Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomesDavid L Veenstra
Institute for Public Health Genetics, Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Genet Med 9:695-704. 2007..Although the A1555G variant is very rare, it seems to confer a high risk of severe hearing loss in patients exposed to aminoglycosides...
A guideline for the use of pharmacoeconomic models of diabetes treatment in the US managed-care environmentDavid L Veenstra
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, Washington, USA
Pharmacoeconomics 20:21-30. 2002....
HBeAg-negative chronic hepatitis B: cost-effectiveness of peginterferon alfa-2a compared to lamivudine in TaiwanDavid L Veenstra
University of Washington, Seattle, WA, USA
Value Health 11:131-8. 2008..Our objective is to evaluate the incremental cost-effectiveness of 48 weeks of peginterferon alfa-2a compared to 48 weeks of lamivudine, from the perspective of the Taiwan Bureau of National Health Insurance...
Evaluating anti-viral drug selection and treatment duration in HBeAg-negative chronic hepatitis B: a cost-effectiveness analysisD L Veenstra
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, WA 98195, USA
Aliment Pharmacol Ther 27:1240-52. 2008..Several anti-viral treatments are now available for HBeAg-negative chronic hepatitis B (CHB), but the clinical and economic outcomes of potential treatment strategies and durations are unclear...
Assessing the cost-effectiveness of pharmacogenomicsD L Veenstra
Pharmaceutical Outcomes Research and Policy Program and Public Health Genetics Program, University of Washington, Department of Pharmacy, Seattle, WA 98195, USA
AAPS PharmSci 2:E29. 2000....
Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infectionD L Veenstra
Pharmaceutical Outcomes Research and Policy Program and Department of Pharmacy, University of Washington, Seattle 98195 7630, USA
JAMA 282:554-60. 1999....
A formal risk-benefit framework for genomic tests: facilitating the appropriate translation of genomics into clinical practiceDavid L Veenstra
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Genet Med 12:686-93. 2010..To address these issues, this study presents a risk-benefit framework for assessing the health-related utility of genomic tests...
Management strategies for ribavirin-induced hemolytic anemia in the treatment of hepatitis C: clinical and economic implicationsE B Devine
University of Washington, Department of Pharmacy, Box 357630, Seattle, WA 98195 7630, USA
Value Health 4:376-84. 2001..The objective of this study was to evaluate the direct health-care costs and management of RIHA during treatment of CHC in a clinical trial setting...
A cost-effectiveness analysis of currently approved treatments for HBeAg-positive chronic hepatitis BD Eldon Spackman
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, Washington, USA
Pharmacoeconomics 26:937-49. 2008..The goal of this analysis was to compare the cost effectiveness of adefovir, entecavir, lamivudine, pegylated interferon and telbivudine...
Gene expression profiling and breast cancer care: what are the potential benefits and policy implications?Nina Oestreicher
University of Washington, Seattle, Washington, USA
Genet Med 7:380-9. 2005..CONCLUSION: Although the use of gene expression profiling in breast cancer care holds great promise, our analysis suggests additional refinement and validation are needed before use in clinical practice...
A pharmacoeconomic analysis of pegaspargase versus native Escherichia coli L-asparaginase for the treatment of children with standard-risk, acute lymphoblastic leukemia: the Children's Cancer Group study (CCG-1962)Helen A Kurre
Clinical Services Administration, Children s Hospital and Regional Medical Center, Seattle, Washington, USA
J Pediatr Hematol Oncol 24:175-81. 2002..a newer chemotherapeutic agent used for treating acute lymphoblastic leukemia, with native Escherichia coli L-asparaginase in induction, delayed intensification 1 and delayed intensification 2...
The cost-effectiveness of interleukin-1 genetic testing for periodontal diseaseMitchell K Higashi
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle 98195-7630, USA
J Periodontol 73:1474-84. 2002..However, the model demonstrates that three clinical parameters are highly influential in determining if IL-1 testing can be implemented in a primary care setting in a cost-effective manner...
Cost-effectiveness of pancreatic cancer screening in familial pancreatic cancer kindredsStephen J Rulyak
University of Washington, Division of Gastroenterology, Department of Pharmacy, Seattle, Washington, USA
Gastrointest Endosc 57:23-9. 2003..Screening should be performed in centers that have experience with endoscopic screening for pancreatic dysplasia. The cost-effectiveness of repeated screening remains to be determined...
Economic evaluation of systemic treatments for cytomegalovirus retinitis in patients with AIDST A Lee
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle 98195, USA
Pharmacoeconomics 19:535-50. 2001..To determine the cost of using systemic therapy to treat newly diagnosed cytomegalovirus (CMV) retinitis in persons with AIDS...
Pharmacoeconomic evaluations in the treatment of non-small cell lung cancerJosh J Carlson
School of Public Health and Community Medicine, Institute for Public Health Genetics, University of Washington, Seattle, Washington, USA
Drugs 68:1105-13. 2008..Given the absence of studies on newer therapeutics and the lack of cost-utility studies, additional studies are warranted...
Modeling the cost and outcomes of pharmacist-prescribed emergency contraceptionK D Marciante
Department of Pharmacy, University of Washington, Seattle, 98195, USA
Am J Public Health 91:1443-5. 2001..This study investigated the effect on the risk and cost of unintended pregnancies of emergency contraceptive pills obtained directly from a pharmacist...
Health state preference assessment in diabetic peripheral neuropathySean D Sullivan
Department of Pharmacy, University of Washington, Seattle, Washington 98195 7630, USA
Pharmacoeconomics 20:1079-89. 2002..To assess patient preferences for health states associated with diabetic peripheral neuropathy (DPN)...
Screening for the alpha-adducin Gly460Trp variant in hypertensive patients: a cost-effectiveness analysisLisa M Meckley
University of Washington, Seattle WA 98195 7630, USA
Pharmacogenet Genomics 16:139-47. 2006..The objective of this study was to evaluate the potential cost effectiveness of screening for the alpha-adducin Gly460Trp variant among hypertensive patients...
The potential clinical and economic outcomes of pharmacogenomic approaches to EGFR-tyrosine kinase inhibitor therapy in non-small-cell lung cancerJosh J Carlson
School of Pharmacy, University of Washington, Seattle, WA 98195, USA
Value Health 12:20-7. 2009..The objective of this study was to evaluate the potential cost-utility of implementing epidermal growth factor receptor (EGFR) testing before initiating second-line therapy for advanced refractory non-small-cell lung cancer (NSCLC)...
A review of public policy issues in promoting the development and commercialization of pharmacogenomic applications: challenges and implicationsLouis P Garrison
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Drug Metab Rev 40:377-401. 2008..How well the numerous important stakeholders - both private and public - address these issues will be critical for pharmacogenomics to deliver on its promise...
Comparative economic analyses of minimally invasive direct coronary artery bypass surgeryDarryl T Gray
Department of Community Research and Community Education, The Hope Heart Institute, Seattle, Wash, USA
J Thorac Cardiovasc Surg 125:618-24. 2003....
Epidermal growth factor receptor genomic variation in NSCLC patients receiving tyrosine kinase inhibitor therapy: a systematic review and meta-analysisJosh John Carlson
Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington, Seattle, WA 98195, USA
J Cancer Res Clin Oncol 135:1483-93. 2009....
A Bayesian approach to aid in formulary decision making: incorporating institution-specific cost-effectiveness data with clinical trial resultsShelby D Reed
Pharmaceutical Outcomes Research and Policy Program, University of Washington, USA
Med Decis Making 23:252-64. 2003..Among patients undergoing coronary stenting, the cost-effectiveness ratio of the addition of abciximab was at or below the $50,000 per life year saved threshold in 66.0% of the simulations...
Use of maximal sterile barriers during central venous catheter insertion: clinical and economic outcomesKent K Hu
Northwest Health Services Research and Development Program, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle 98108, USA
Clin Infect Dis 39:1441-5. 2004..Use of MSBs when placing CVCs may reduce the risk of infections but is more cumbersome, time-consuming, and expensive than other techniques...
Managed care in the genomics era: assessing the cost effectiveness of genetic testsMitchell K Higashi
Pharmaceutical Outcomes Research and Policy Program, Institute for Public Health Genetics, University of Washington, Seattle, Wash 98195, USA
Am J Manag Care 9:493-500. 2003..These criteria should be used to inform the decision-making process in the context of ethical, legal, and social issues related to genetic testing...
A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testingLisa M Meckley
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Pharmacoeconomics 28:61-74. 2010..Payers will be facing increasing demand for coverage decisions regarding this technology, but the potential clinical and economic impacts of testing are not clear...
Linking payment to health outcomes: a taxonomy and examination of performance-based reimbursement schemes between healthcare payers and manufacturersJosh J Carlson
Pharmaceutical Outcomes Research and Policy Program, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 7630, United States
Health Policy 96:179-90. 2010..To identify, categorize and examine performance-based health outcomes reimbursement schemes for medical technology...
Cost comparison of surgery vs organ preservation for laryngeal cancerGreg E Davis
Department of Otolaryngology Head and Neck Surgery, Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, WA 98195, USA
Arch Otolaryngol Head Neck Surg 131:21-6. 2005..To perform a cost minimization analysis of total laryngectomy with postoperative radiotherapy vs induction chemotherapy with subsequent radiotherapy in patients with advanced (stage III or IV) squamous cell carcinoma of the larynx...
Preference values associated with stage III colon cancer and adjuvant chemotherapyJennie H Best
University of Washington, Seattle, WA, USA
Qual Life Res 19:391-400. 2010..To elicit preference values for health states associated with Stage III colon cancer (CRC) and to explore the effect of neuropathy associated with current adjuvant treatment...
Cost-effectiveness of peginterferon alpha-2a compared to lamivudine treatment in patients with hepatitis B e antigen positive chronic hepatitis B in TaiwanSean D Sullivan
University of Washington, Seattle, Washington 98195, USA
J Gastroenterol Hepatol 22:1494-9. 2007....
The economic value of innovative treatments over the product life cycle: the case of targeted trastuzumab therapy for breast cancerLouis P Garrison
Department of Pharmacy, University of Washington, Health Sciences Building, Seattle, WA 98195 7630, USA
Value Health 12:1118-23. 2009....
The use of meta-analysis in cost-effectiveness analysis. Issues and recommendationsS Saint
Department of Medicine, University of Washington, Seattle, USA
Pharmacoeconomics 15:1-8. 1999..We conclude by providing guidance on the appropriate use of summary measures derived from meta-analyses for cost-effectiveness studies...
Which antimicrobial impregnated central venous catheter should we use? Modeling the costs and outcomes of antimicrobial catheter useKristin D Marciante
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle WA 98195, USA
Am J Infect Control 31:1-8. 2003..Policies for the use of antimicrobial catheters in high-risk patients should reflect patients' expected duration of catheterization...
Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC)Josh J Carlson
Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, United States
Lung Cancer 61:405-15. 2008..Various drug therapies are available for treatment of refractory stage IIIB/IV non-small cell lung cancer (NSCLC), but their comparative economic value is unclear...
An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosisJosh J Carlson
Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Washington 98195, USA
J Gastroenterol Hepatol 24:786-91. 2009..To assess the clinical and economic outcomes of non-invasive testing strategies in the diagnosis of significant liver fibrosis (Metavir score >or= 2) compared with liver biopsy...
The timing of elective colectomy in diverticulitis: a decision analysisLeon Salem
Department of Surgery, University of Washington, Seattle, WA 98195-6410, USA
J Am Coll Surg 199:904-12. 2004..CONCLUSIONS: This study suggests that expectant management is associated with lower rates of death and colostomy and is cost-saving for both younger and older patients...
Ancillary risk information and pharmacogenetic tests: social and policy implicationsN B Henrikson
Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
Pharmacogenomics J 8:85-9. 2008..Implications will vary with each test but tests should be evaluated individually within a framework that outlines the potential implications of ancillary information...
Can modeling of health outcomes facilitate regulatory decision making? The benefit-risk tradeoff for rosiglitazone in 1999 vs. 2007J T Cross
Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington, Seattle, Washington, USA
Clin Pharmacol Ther 89:429-36. 2011..We adapted a mathematical diabetes model to estimate NB and uncertainty of diabetes monotherapy...
Cost-consequences of ultrafiltration for acute heart failure: a decision model analysisSteven M Bradley
Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA 98101, USA
Circ Cardiovasc Qual Outcomes 2:566-73. 2009..Ultrafiltration for heart failure may reduce costs associated with acute heart failure by decreasing rehospitalization rates compared to intravenous diuretics...
The clinical and economic consequences of screening young men for genital chlamydial infectionRachel H S Ginocchio
Department of Health Services, Maternal and Child Health, University of Washington, Seattle, Washington 98104, USA
Sex Transm Dis 30:99-106. 2003..CONCLUSION: At a chlamydia prevalence of 5%, LE-LCR is the most efficient use of resources. If LCR cost decreases or chlamydia prevalence increases, the LCR strategy is favored...
An analysis of the relative effects of VKORC1 and CYP2C9 variants on anticoagulation related outcomes in warfarin-treated patientsLisa M Meckley
University of Washington, Department of Pharmacy, Seattle, WA 98195, USA
Thromb Haemost 100:229-39. 2008..This difference may be due, in part, to pharmacokinetics factors (e.g. drug half-life), which are influenced primarily by CYP2C9; these findings should be confirmed in additional studies...
Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodineNathorn Chaiyakunapruk
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, WA 98195-7630, USA
Clin Infect Dis 37:764-71. 2003..Use of chlorhexidine gluconate in place of the current standard solution for vascular catheter site care is a simple and cost-effective method of improving patient safety in the hospital setting...
A review of selected patient-generated outcome measures and their application in clinical trialsKavita K Patel
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, WA 98195-7630, USA
Value Health 6:595-603. 2003..Patient-generated outcome measures appear to be useful primarily in complementing traditional HRQoL measures, guiding individual patient treatment decisions, and assisting the design of new measures...
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin doseMark J Rieder
Department of Genome Sciences, University of Washington, Seattle, USA
N Engl J Med 352:2285-93. 2005..The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin...
Health economic evaluation of non-melanoma skin cancer and actinic keratosisMitchell K Higashi
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Pharmacoeconomics 22:83-94. 2004....
Using maximal sterile barriers to prevent central venous catheter-related infection: a systematic evidence-based reviewKent K Hu
Northwest Health Services Research and Development Program, Department of Medicine, University of Washington and VA Puget Sound HCS, 1660 South Columbian Way, HSR and D (152, Seattle, WA 98108, USA
Am J Infect Control 32:142-6. 2004..While we believe the available evidence does support the use of maximal sterile barriers during routine insertion of central venous catheters, prospective studies and economic analyses would better clarify its value...
Toward evidence-based assessment for coverage and reimbursement of laboratory-based diagnostic and genetic testsScott D Ramsey
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Manag Care 12:197-202. 2006....
Global epidemiology of hepatitis B virusBrian Custer
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, WA, USA
J Clin Gastroenterol 38:S158-68. 2004..Preventing the most severe HBV disease consequences in infected individuals, such as cirrhosis and hepatocellular carcinoma, will require appropriate therapeutic agents...
A cost-effectiveness analysis of intraoperative cholangiography in the prevention of bile duct injury during laparoscopic cholecystectomyDavid R Flum
Robert Wood Johnson Clinical Scholars Program, Department of Surgery, University of Washington, Seattle, WA 98195-7183, USA
J Am Coll Surg 196:385-93. 2003..Routine IOC use among less experienced surgeons and in high-risk operations is the most cost effective, but the cost implications of routine use for the general population should also be considered cost effective...
The efficacy and safety of sibutramine for weight loss: a systematic reviewDavid E Arterburn
Department of Veterans Affairs, Puget Sound Health Care System, Seattle, WA, USA
Arch Intern Med 164:994-1003. 2004..We conducted a systematic review to assess the efficacy and safety of sibutramine hydrochloride for weight loss...
Economic analyses of human genetics services: a systematic reviewJosh J Carlson
Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
Genet Med 7:519-23. 2005..To improve the relevance of these studies, researchers need to incorporate measures of outcome that are familiar to decision makers, including quality-adjusted life years...
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance doseGregory M Cooper
Department of Genome Sciences, University of Washington, Seattle, WA98195, USA
Blood 112:1022-7. 2008..Randomized clinical trials that account for these 2 genes should therefore produce results that are definitive and broadly applicable...
The cost of adjuvant chemotherapy in patients with early-stage breast carcinomaNina Oestreicher
Division of Research, Kaiser Permanente, Oakland, California 94612, USA
Cancer 104:2054-62. 2005..The objective of the current study was to evaluate the direct medical cost of adjuvant chemotherapy in women with early-stage breast carcinoma...
Genetic testing and pharmacogenomics: issues for determining the impact to healthcare delivery and costsKathryn A Phillips
Program in Pharmacogenomics and Population Screening, School of Pharmacy, Institute for Health Policy Studies, and UCSF Comprehensive Cancer Center, University of California, San Francisco, 94143, USA
Am J Manag Care 10:425-32. 2004..To determine the potential impact of genetic testing and pharmacogenomics on healthcare delivery and costs...
Cost of chronic hepatitis B infection in the United StatesTodd A Lee
Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, IL, USA
J Clin Gastroenterol 38:S144-7. 2004..To estimate the direct medical costs associated with chronic hepatitis B (CHB) infection in the United States...
Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient populationDavid L Veenstra
School of Pharmacy, The Chinese University of Hong Kong, Hong Kong
Pharmacogenet Genomics 15:687-91. 2005..To evaluate the association of VKORC1 genetic variants with warfarin dose requirements in a Hong Kong Chinese patient population...
Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in menAnke Hilse Maitland-van der Zee
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University Utrecht, The Netherlands
Pharmacogenetics 14:53-60. 2004..If other studies confirm that men with the DD genotype do not benefit from treatment with statins, screening for ACE genotype in men most likely will be a cost-effective strategy before initiating statin therapy...
Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysisNathorn Chaiyakunapruk
Department of Pharmacy Practice, School of Pharmacy, Naresuan University, Pitsanuloak 65000, Thailand
Ann Intern Med 136:792-801. 2002..Use of chlorhexidine gluconate is a simple and effective means of reducing vascular catheter-related infections...
Lipid-lowering drug use and cardiovascular events after myocardial infarctionOlaf H Klungel
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
Ann Pharmacother 36:751-7. 2002....
Bringing genomics to the bedside: a cost-effective pharmacogenomic test?David L Veenstra
School of Pharmacy, University of California, San Francisco, California 94143, USA
Pharmacogenetics 14:333-4. 2004
