Research Topics
Species | Russell N Van GelderSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Cataract surgery in the setting of uveitisRussell N Van Gelder
Department of Ophthalmology, University of Washington Medical School, Seattle, Washington 98195, USA
Curr Opin Ophthalmol 20:42-5. 2009..To describe recent evidence from the literature concerning optimal treatment of cataract in patients with concomitant uveitis...
Non-visual photoreception: sensing light without sightRussell N Van Gelder
Department of Ophthalmology, University of Washington Medical School, Seattle, Washington, USA
Curr Biol 18:R38-9. 2008..This system appears to subserve circadian photic entrainment, the pupillary light response, and a number of other aspects of neurophysiology and behavior...
Postcataract surgical inflammationParisa Taravati
Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Curr Opin Ophthalmol 23:12-8. 2012..To describe the epidemiology, pathogenesis, and recent developments in the diagnosis and management of postcataract surgery inflammation...
Melanopsin and mechanisms of non-visual ocular photoreceptionTimothy Sexton
Departments of Ophthalmology and and Biological Structure, University of Washington School of Medicine, Seattle, Washington 98104, USA
J Biol Chem 287:1649-56. 2012..This suggests that melanopsin employs a bistable sequential photon absorption mechanism typical of rhabdomeric opsins...
Melanopsin-dependent light avoidance in neonatal miceJuliette Johnson
Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 107:17374-8. 2010..These results strongly suggest that light activation of ipRGCs may regulate physiological functions such as sleep/wake cycles in preterm and neonatal infants...
Timeless genes and jetlagRussell N Van Gelder
Department of Ophthalmology, Washington University Medical School, St. Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:17583-4. 2006
Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosisMatthew L Batten
Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America
PLoS Med 2:e333. 2005..These complementary methods offer hope of developing treatment to restore vision in humans with certain forms of hereditary congenital blindness...
Making (a) sense of non-visual ocular photoreceptionRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University Medical School, Campus Box 8096, 660 S Euclid Avenue, St Louis, MO 63110, USA
Trends Neurosci 26:458-61. 2003....
Inner retinal photoreception independent of the visual retinoid cycleDaniel C Tu
Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:10426-31. 2006..These results demonstrate that the melanopsin-dependent ipRGC photocycle is independent of the visual retinoid cycle...
Physiologic diversity and development of intrinsically photosensitive retinal ganglion cellsDaniel C Tu
Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
Neuron 48:987-99. 2005..These results demonstrate that ipRGCs are the first light-sensitive cells in the retina and suggest previously unappreciated diversity in this cell population...
Melanopsin is required for non-image-forming photic responses in blind miceSatchidananda Panda
Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
Science 301:525-7. 2003..This indicates the importance of both nonvisual and classical visual photoreceptor systems for nonvisual photic responses in mammals...
Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless miceCarol L Thompson
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
J Biol Rhythms 19:504-17. 2004..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses...
Nonvisual photoreception in the chick irisDaniel C Tu
Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110 USA
Science 306:129-31. 2004..These data characterize a non-opsin photoreception mechanism in a vertebrate eye and suggest a conserved photoreceptive role for cryptochromes in vertebrates...
Loss of photic entrainment and altered free-running circadian rhythms in math5-/- miceRaymond Wee
Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
J Neurosci 22:10427-33. 2002....
Melanopsin-dependent persistence and photopotentiation of murine pupillary light responsesYanli Zhu
Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri, USA
Invest Ophthalmol Vis Sci 48:1268-75. 2007..To determine the relative contributions of inner and outer retinal photoreception to the pupillary light response...
How the clock sees the lightRussell N Van Gelder
Nat Neurosci 11:628-30. 2008
Reduced pupillary light responses in mice lacking cryptochromesRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63131, USA
Science 299:222. 2003
Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogasterYiing Lin
Department of Genetics, Washington University Medical School, St Louis, MO, 63110, USA
Proc Natl Acad Sci U S A 99:9562-7. 2002..Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent...
Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythmsRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
J Neurogenet 16:181-203. 2002..These results suggest that, similar to insect cryptochromes, mammalian cryptochromes function pleiotropically in both circadian rhythm generation and in photic entrainment and behavioral responses...
The imprinted gene Magel2 regulates normal circadian outputSerguei V Kozlov
Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, USA
Nat Genet 39:1266-72. 2007....
Action spectrum of Drosophila cryptochromeSarah J Vanvickle-Chavez
Departments of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
J Biol Chem 282:10561-6. 2007..The conferral of light-dependent degradation on a heterologous protein by fusion to cryptochrome may be a useful tool for probing protein function in cell expression systems...
Circadian rhythms: in the loop at lastRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63110, USA
Science 300:1534-5. 2003..Both the general script and the specific details of the murine and Drosophila circadian pathways are available at Science's Signal Transduction Knowledge Environment Connections Maps...
Metaplastic squamous epithelial downgrowth after clear corneal cataract surgeryDonald U Stone
Proctor Foundation, University of California-San Francisco, San Francisco, CA 94143, USA
Am J Ophthalmol 142:695-7. 2006....
Resetting the clock: Dexras1 defines a pathRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University Medical School, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Neuron 43:603-4. 2004..In this issue of Neuron, Cheng et al. analyze mice lacking Dexras1 (a Ras family GTPase protein) and demonstrate an important role for G(i/o) signaling mediating both photic and nonphotic phase shifts of the circadian clock...
Recent insights into mammalian circadian rhythmsRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Sleep 27:166-71. 2004..This review is intended as an overview of recent research activity for the interested sleep disorders clinician or researcher...
Clean thoughts about dirty genesRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
J Biol Rhythms 19:3-9. 2004..They conclude with a short list of recommendations for researchers working on circadian rhythms in mixed-strain mice...
Cryptochromes and inner retinal non-visual irradiance detectionRussell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University Medical School, CB# 8096, 660 S. Euclid Avenue, St Louis, MO 63110, USA
Novartis Found Symp 253:31-42; discussion 42-55, 102-9, 281-4. 2003..These findings suggest a model where either classical photopigments or inner retinal photopigments are sufficient for non-visual irradiance detection...
Tales from the crypt(ochromes)Russell N Van Gelder
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
J Biol Rhythms 17:110-20. 2002..The present review summarizes recent research on the functions of cryptochrome in the circadian timekeeping and photic entrainment pathways...
